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Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

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Chinese Journal of Integrative medicine 2024年第10期30卷 877-885页

作者： BAI Rui-na GU Feng CHE Qian-zi ZHANG Xuan CAI Ya-jie XI Rui-xi ZHAO Yang GUO Ming DONG Guo-ju GAO Zhu-ye FU Chang-geng WANG Pei-li DU Jian-peng ZHANG Da-wu DUAN Wen-hui LI Li-zhi YANG Qiao-ning SHI Da-zhuo Department of Cardiovascular Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National clinical research Center for Chinese medicine Cardiology Beijing100091China Department of evidence-based medicine Basic research Laboratory Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing100700China Department of Traditional Chinese medicine Beijing Shangdi HospitalBeijing100193China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese MedicineBeijing100091China

Objectives:To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods:This multicentre prospective cohort study was conducted at 40 centers in *** with ACS after PCI entered either the QSYQ or Western medicine(WM)groups naturally based on whether they had received QSYQ before *** group received QSYQ(0.52 g,3 times a day for 12 months)in addition to *** primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent *** secondary endpoint included rehospitalization due to ACS,heart failure,stroke,and other thrombotic *** of life was assessed by the Seattle Angina Questionnaire(SAQ).Results:A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December ***,487 patients received QSYQ and *** a median follow-up of 566 days(inter quartile range,IQR,517–602),the primary endpoint occurred in 46(9.45%)and 65(14.48%)patients in QSYQ and WM groups respectively[adjusted hazard ratio(HR)0.60,95%confidence interval(CI)0.41–0.90;P=0.013].The secondary endpoint occurred in 61(12.53%)and 74(16.48%)patients in QSYQ and WM groups,respectively(adjusted HR 0.76,95%CI 0.53–1.09;P=0.136).In sensitivity analysis,the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(HR 0.67,95%CI 0.46–0.98;P=0.039).Moreover,QSYQ improved the disease perception domain of the SAQ(P<0.05).Conclusions:In patients with ACS after PCI,QSYQ combined with WM reduced the incidence of the primary *** findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent revascularization through intermittent administration of QSYQ.(Registration *** CTR-OOC-14005552).

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

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Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass:a systematic review and Meta-analysis

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Journal of Traditional Chinese medicine 2024年第1期44卷 1-15页

作者： QIN Xiaoyu WANG Chunai XUE Jianjun ZHANG Jie LU Xiaoting DING Shengshuang GE Long WANG Minzhen the First clinical Medical College Gansu University of Chinese MedicineLanzhou 730030China Department of Anesthesiology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China evidence-based medicine Center Lanzhou UniversityLanzhou 730030China Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730030China

OBJECTIVE:To evaluate the efficacy of electroacupuncture(EA)intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).METHODS:Eight databases,including Pub Med,Embase,the Cochrane Library,Web of Science,Chinese Bio Medical Literature Database,China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,and two clinical trial registries,were *** randomized controlled trials(RCTs)related to EA intervention in cardiac surgery with CPB were *** on the inclusion and exclusion criteria,two researchers independently screened articles and extracted *** the quality evaluation,RevMan 5.3 software was used for ***:Fourteen RCTs involving 836 patients were *** with the control treatment,EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping[relative risk(RR)=1.15,95%confidence interval(CI)(1.01,1.31),Pgroup than in the control ***,the postoperative tracheal intubation time[SMD=-0.92,95%CI(-1.40,-0.45),P<0.05;low]and intensive care unit stay[SMD=-1.

关键词： electroacupuncture cardiopulmonary bypass thoracic surgery myocardial ischaemia-reperfusion injury myocardial protection postoperative rehabilitation Meta-analysis randomized controlled trial

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Effectiveness of Acupoint Application in Patients with Pharyngeal Pain: evidence from CHUNBO, A Prospective Real-World Study

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Chinese Journal of Integrative medicine 2024年第1期30卷 18-24页

作者： MA Hang-kun WANG Yi-ming GUO Man-ping LI Chen-fei LI Rui GAO Rui Emergency Department Xiyuan Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing(100091)China National Medical Products Administration for Laboratory of clinical research and Evaluation of Traditional Chinese medicine Beijing(100091)China National clinical research Center for Chinese medicine Cardiology Beijing(100091)China Postdoctoral Workstation of Yabao Pharmaceutical group Co. Ltd.YunchengShanxi Province(044602)China

Objective: To assess the outcomes after acupoint application in patients with pharyngeal pain in a real-world settings, and analyze the characteristics of effective population and prescription characteristics of acupoint application. Methods: based on CHUNBO platform, patients with pharyngeal pain who were candidates for acupoint application on the basis of physician-evaluation, were enrolled in a nationwide, prospective, 69-week multicenter observational study from August 2020 to February 2022. Propensity score matching(PSM) was used to match the confounding factors and the association rules were used to analyze the characteristics of effective population and prescription characteristics of acupoint application. Outcome assessments included the disappearance rate of pharyngeal pain(within 3, 7, and 14 days), disappearance time of pharyngeal pain, as well as adverse events. Results: Of 7,699 enrolled participants, 6,693(86.9%) received acupoint application and 1,450(21.7%) with non-acupoint application. After PSM, there were 1,004 patients each in the application group(AG) and non-application group(NAG). The disappearance rate of pharyngeal pain in the AG at 3, 7, and 14 days were all higher than those in the NAG(Pgroup with tonsil diseases was 2.19 times higher than that in the NAG(P<0.05). The commonly used acupoints for the effective cases were Tiantu(RN 22), Shenque(RN 8) and Dazhui(DU 14). The commonly used herbs for the effective cases were Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae. Among them, Natrii sulfas was applied to RN 8 most frequently(support 84.39%). A total of 1,324(17.2%) patients experienced AEs, and mainly occurred in the AG, with s

关键词： acupoint application Chinese medicine pharyngeal pain multicentre effectiveness characters real-world study

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Hongjin Xiaojie Capsule,a Chinese patent medicine,for treating moderate to severe cyclical breast pain:A single-blind randomized controlled trial

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Journal of Integrative medicine 2024年第5期22卷 552-560页

作者： Qiong Zhang Ying-yi Fan Xue-qing Wu Yan-dan Huo Chun-hui Wang Shi-bing Liang Ting Wang Rong Zhong Xuan Wang Bao-yong Lai Xiao-hua Pei Jian-ping Liu Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Breast Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Breast Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Breast Sichuan Second Hospital of Traditional Chinese MedicineChengdu 610014Sichuan ProvinceChina Department of Breast Xiamen HospitalBeijing University of Chinese MedicineXiamen 361015Fujian ProvinceChina Center for evidence-based Chinese medicine Beijing University of Chinese MedicineBeijing 100029China

Background Moderate to severe breast pain has major effects on the quality of life for *** Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good *** To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule(HJXJC),a Chinese patent medicine,for the treatment of cyclical breast ***,setting,participants and intervention This is a multicenter,single-blind randomized controlled trial conducted in 3 medical centers in China from 2019 to *** with moderate to severe cyclic breast pain were randomly divided into the intervention group(who took HJXJC,four capsules per dose,three times a day for 12 weeks)and the control group(waiting for the treatment)in a 1:1 *** outcome measures The primary outcome was pain duration,and the patients recorded measurements at baseline and at the end of weeks 4,8,12 and 16 on a patient log *** The full analysis set(FAS)population included 298 participants(intervention group,n=150;control group,n=148),while the per-protocol analysis set(PPS)included 274 *** 12 weeks,the duration of breast pain was significantly shorter in the intervention group(FAS:mean difference,–6.69;95%CI,–7.58 to–5.80;Pgroup(FAS:mean difference,–12.55;95%CI,–13.90 to–11.21;Pgroup,breast lumps shrank after 12 weeks and the size of breast lumps was statistically smaller than that in the control group(Pgroup(P>0.05).At weeks 8 and 12,th

关键词： Hongjin Xiaojie Capsule Cyclical breast pain Randomized controlled trial Traditional Chinese medicine

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Development of international guidelines by Tuina practitioners for specific acupoints of paediatrics Tuina(2022 version)

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Journal of Traditional Chinese medicine 2024年第5期44卷 1044-1051页

作者： LAN Xiaoxue SUN Yanan WENG Zhiwen WANG Yue ZHANG Ying LIANG Yuanwen GU Sirui ZHOU Rong CHEN Qianji JIA Baolin BO Han WANG Fangying HE Qiang ZHANG Jie TAN Jiang YE Xingzhu WANG Xiyou YU Changhe CHEN Hong Department of Tuina and Pain Management the First Clinical DepartmentBeijing University of Chinese Medicine Department of Traditional Chinese medicine Xuanwu HospitalCapital Medical University Department of Tuina and Pain Management Dongzhimen Hospital of Beijing University of Chinese Medicine Department of Encephalopathy Beijing Huairou Hospital of Traditional Chinese Medicine Yungang Community Health service Center China Aerospace Science & Industry Corporation of 731 Hospital Department of Pediatrics China-Japan Friendship Clinical SchoolBeijing University of Chinese Medicine Department of Pediatrics the Second Clinical Medical College of Beijing University of Chinese Medicine Shenzhen Luohu Hospital of Traditional Chinese medicine Department of Chinese medicine Raffles Medical Group Department of Traditional Chinese medicine Beiing Children's HospitalCapital Medicine UniversityNational Center for Children's Health Anzhen Community Health service Center L. Ac. Ancient Healing Center Frederick Department of Tuina and Pain Management Dongzhimen HospitalBeijing University of Chinese Medicine

OBJECTIVE: To establish a standardized framework encompassing the precise locations, manipulations,functions and indications of specific acupoints in the field of paediatric Tuina. METHODS: The development of consensus involved three distinct stages. Initially, a list of paediatric Tuina specific acupoints was compiled based on an extensive literature review, which was subsequently supplemented through expert interviews. In the second stage, the Delphi method was employed to assess the significance of acupoint locations, manipulations, functions, and indications. In situations where the questionnaire survey failed to yield agreement or when the experts held reservations, the nominal group approach was utilized during the expert consensus meeting. The final version of the technical standardized material was ultimately determined during an expert consensus conference. After undergoing external peer review and evaluation, the completed draft was prepared for public dissemination RESULTS: The comprehensive list identified a total of 66 specific acupoints. The location and manipulation questionnaire consisted of 156 items based on the literature database, while the function and indication questionnaire contained 116 items. Two rounds of Delphi surveys were conducted for the location and manipulation category, and another two rounds of Delphi surveys were conducted for the function and indication category. During the experts consensus meeting The panel of experts conducted in-depth discussions on 61 questions, resulting in the formulation of technical guidelines for the locations, manipulations, functions, and indications of 64 paediatric Tuina acupoints. Subsequently, the research team compiled and edited the draft of the technical guidelines for acupoints of paediatric Tuina, which was finalized after external review and feedback. CONCLUSION: This study successfully established the recognized technical standards for practitioners of paediatric Tuina, thereby standardizi

关键词： Child Delphi technique Tuina acupoint guideline international paediatrics

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Temporal trends and practice variation of paediatric diagnostic tests in primary care:retrospective analysis of 14 million tests

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Family medicine and Community Health 2024年第4期12卷 1-8页

作者： Elizabeth T Thomas Diana R Withrow Cynthia Wright Drakesmith Peter J Gill Rafael Perera-Salazar Carl Heneghan Centre for evidence-based medicine Nuffield Department of Primary Care Health SciencesUniversity of OxfordOxfordUK Nuffield Department of Primary Care Health Sciences University of OxfordOxfordUK Department of Pediatrics University of TorontoTorontoOntarioCanada Hospital for Sick Children TorontoOntarioCanada

Objective The primary objective was to investigate temporal trends and between-practice variability of paediatric test use in primary *** and analysis This was a descriptive study of population-based data from clinical Practice research Datalink Aurum primary care consultation records from 1 January 2007 to 31 December *** aged 0–15 who were registered to one of the eligible 1464 general practices and had a diagnostic test code in their clinical record were *** primary outcome measures were(1)temporal changes in test rates measured by the average annual percent change,stratified by test type,gender,age group and deprivation level and(2)practice variability in test use,measured by the coefficient of *** 14299598 diagnostic tests were requested over 27.8 million child-years of observation for 2542101 *** test use increased by 3.6%/year(95%CI 3.4 to 3.8%)from 399/1000 child-years to 608/1000 child-years,driven by increases in blood tests(8.0%/year,95%CI 7.7 to 8.4),females aged 11–15(4.0%/year,95%CI 3.7 to 4.3),and children from the most socioeconomically deprived group(4.4%/year,95%CI 4.1 to 4.8).Tests subject to the greatest temporal increases were faecal calprotectin,fractional exhaled nitric oxide and vitamin *** classified as high-use and high-practice variability were iron studies,coeliac testing,vitamin B12,folate,and vitamin *** In this first nationwide study of paediatric test use in primary care,we observed significant temporal increases and practice variability in *** reflects inconsistency in practice and diagnosis rates and a scarcity of evidence-based *** test use generates more clinical activity with significant resource implications but conversely may improve clinical *** research should evaluate whether increased test use and variability are warranted by exploring test indications and test results and directly examine how increased test use impacts

关键词： vitamin nationwide stratified

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Effects of anterior sciatic nerve acupuncture on lower limb paralysis after cerebral infarction:study protocol for a randomized controlled trial

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Journal of Traditional Chinese medicine 2024年第1期44卷 205-211页

作者： LI Menghan WANG Yu RAN Dawei YANG Xinming DENG Shizhe SHI Lei MENG Zhihong Department of Acupuncture First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National clinical research Center for Chinese medicine Acupuncture and Moxibustion Tianjin 300193China Graduate department Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Massage and Rehabilitation Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Stroke is the main cause of disability in the middle and old ***,especially lower limb paralysis,often leads to the loss of self-care ability and a series of secondary *** main method to improve hemiplegic limb movement is exercise therapy,but there are still many patients with disabilities after rehabilitation *** one of the non-pharmacological therapies for stroke,acupuncture has been recognized to improve motor function in ***,we propose a new method,anterior sciatic nerve acupuncture,which can stimulate both the femoral nerve and the sciatic *** designed this study to determine the effect of this method on lower limb motor *** participants recruited with hemiplegia after cerebral infarction will be randomly assigned to the test group or control group in a 1:1 *** control group will receive Xingnao Kaiqiao acupuncture,and the test group will receive anterior sciatic nerve acupuncture on this *** participants will get acupuncture treatment once a day,6 times a week for 2 *** primary outcome is Fugl-Meyer Assessment of Lower Extremity and the secondary outcomes are Modified Ashworth Scale and Modified Barthel *** will be collected before treatment,1week after treatment,and 2 weeks after treatment,and then statistical analysis will be *** study can preliminarily verify the effect of anterior sciatic nerve acupuncture on improving lower limb motor function in patients with cerebral infarction,which may provide an alternative approach for clinical treatment of hemiplegia.

关键词： anterior sciatic nerve acupuncture paralysis cerebral infarction Xingnao Kaiqiao clinical protocols

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Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in Southern China

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Journal of Traditional Chinese medicine 2024年第3期44卷 586-594页

作者： YIN Lingjia STALSBY LUNDBORG Cecilia WU Darong YANG Jinghua ALVESSON Helle Molsted CAI Jianxiong LU Taoying XIE Qianwen MARRONE Gaetano Department of Global Public Health Karolinska InstitutetStockholm 17177Swede State Key Laboratory of Dampness Syndrome of Chinese medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Outcome Assessment research Team in Chinese medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Health Construction Administration Centre Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Guangdong Provincial Key Laboratory of clinical research on Traditional Chinese medicine Syndrome the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Pediatrics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

OBJECTIVE: To determine the effectiveness of pediatric Tuina(PT) in preventing recurrent acute respiratory tract infections(ARTIs) in children. METHODS: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. Children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes. RESULTS: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. Children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio(IRR): 0.59, 95% confidence interval(CI)(0.42-0.84)] and 2018 [IRR: 0.58, 95% CI(0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI(0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups. CONCLUSIONS: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

关键词： child massage pediatric Tuina respiratory tract infections

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Utility of Goal Attainment Scaling(GAS)in evaluating a multicomponent exercise programme for community-dwelling pre-frail older adults

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Family medicine and Community Health 2024年第1期12卷 36-44页

作者： Juan Fang Jianping Ren Jinjing Wang Xiantao Qiu Shiyan Zhang Shuang Yuan Liangfeng Wu Lin Xie Le Yu School of Public Health Hangzhou Normal UniversityHangzhouZhejiangChina School of medicine Huzhou UniversityHuzhouZhejiangChina School of clinical medicine Hangzhou Normal UniversityHangzhouZhejiangChina Ziyang Street Community Health service Center HangzhouZhejiangChina

Objectives This study aimed to investigate the effectiveness of Goal Attainment Scaling(GAS)in assessing an intervention for pre-frail senior ***,the study aimed to explain how the GAS goals were established based on the International Classification of Functioning,Disability and Health(ICF)categories,including body function,activity and participation and environmental *** In this study,220 pre-frail older adults were randomly selected to participate in a controlled *** intervention group engaged in multicomponent exercise three times a week,once at a community health service location and twice at *** control group received advice on physical activity but did not have supervised *** in both groups selected individualised GAS goals from 23 goals developed based on ICF by focus group *** study used generalised estimating equations to analyse the differences between the *** The study included 144 participants,72 in the exercise group and 72 in the control *** top three individualised goals for all participants were vestibular functions(53.5%),pain management(43.1%)and lifting and carrying objects(31.9%).Both groups saw a significant increase in GAS scores at week 8 and week 24 of the intervention(pgroup showed a more significant improvement(p<0.05).The participants living alone were associated with lower postintervention improvements in the GAS *** contrast,the participants who were using a smartphone were likely to get higher postintervention improvements in the GAS *** GAS can be a valuable tool for setting and evaluating individualised and meaningful goals in body functions,activity and participation and environmental *** multicomponent exercise interventions can help pre-frail older adults achieve their expected goals as measured by the GAS.

关键词： meaningful goals lifting

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Immunotherapy for gastric cancer and liver metastasis: Is it time to bid farewell

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2365-2368页

作者： Ahmed Dehal Department of clinical Sciences Kaiser Permanente School of MedicinePanoramaCA 91402United States

Patients with metastatic gastric cancer have a grim *** che-motherapy offers a limited survival improvement,but recent advancements in immunotherapy have sparked ***,the effectiveness of immunothe-rapy in patients with liver metastases remains *** article reviews a recent study by Liu et al and evaluates conflicting evidence on the impact of liver metastases on response to immunotherapy in metastatic gastric *** some studies suggest no significant difference in treatment response based on liver involvement,others report varied response *** present study,a re-trospective analysis of 48 patients by Liu et al,examines this issue and concludes that immunotherapy is less effective in patients with liver *** methodological limitations and a small sample size,the study contributes to the ongoing *** nuanced response to immunotherapy in certain patients underscores the importance of understanding the tumor microenvironment,immune cell infiltration,and the expression of immune *** than dismissing immunotherapy for patients with gastric cancer and liver metastases,a shift towards personalized treatment strategies and a more profound under-standing of tumor-specific biomarkers is *** unraveling the molecular intricacies of individual cases,clinicians may tailor more effective and customized treatments,offering a glimmer of hope for this challenging patient group.

关键词： Immunotherapy Gastric cancer Liver metastasis Efficacy Prognosis

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