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Comparative Evaluation of Antitumor Chinese Patent medicine Injections based on evidence-based medicine and Markov Model

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World Journal of Traditional Chinese medicine 2024年第2期10卷 220-229页

作者： Jing Yang Yan-Peng Wang Wen-Gong Yu Yu-Yao Guan Prince Emmanuel Opoku Amponsah Xian-Shuai Tang Ying-Zi Sun Lei Zheng School of medicine and Pharmacy Ocean University of ChinaQingdaoChina Department of Pharmacy Shandong Medical CollegeJinanChina Department of Pharmacy Cheeloo College of MedicineShandong Provincial Third HospitalShandong UniversityJinanChina Biomedical Engineering Graduate School University of ArizonaTucsonAZUSA

Objective: The objective of this study was to explore the safety, efficacy, economy, and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection, rational drug use, public awareness of safe drug use, and medical insurance. Materials and Methods: The names of five frequently used antitumor Chinese patent medicine injections were used as search terms, including the compound Sophora flavescens injection, Kangai injection, Aidi injection, Kanglaite injection, and Brucea javanica oil emulsion injection. Relevant evidence-based medical research was extracted from the databases. A descriptive evaluation was conducted, and the Markov model was used for the cost-benefit analysis. Finally, the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method. Results: The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments, improving the quality of life for cancer patients, and reducing the incidence of adverse reactions. From the perspective of economy and other attributes, compound S. flavescens was superior to B. javanica oil, Aidi, Kangai, and Kanglaite. After a comprehensive evaluation of the above five injections, the compound S. flavescens injection received the highest score. Conclusions: Compound S. flavescens, Kangai, Aidi, B. javanica oil, and Kanglaite have their own advantages in effectiveness and no significant difference in safety. Compound S. flavescens injection has the highest comprehensive score. Clinical attention should be paid to monitoring the initial stage of medication and special groups.

关键词： Anti-tumor Chinese patent medicine comprehensive evaluation medication safety pharmacoeconomics rational drug use

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Application of evidence-based medicine methods in integrative oncology research

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 129-132页

作者： Jianping Liu Sijia Zhu Nicola Robinson Centre for evidence-based Chinese medicine Beijing University of Chinese MedicineBeijing100029China School of Health and Social Care London South Bank UniversityLondonSE10AAUnited Kingdom

To present the advances of evidence-based medicine and clinical research methodology in integrative oncology,we conducted a literature review of real-world studies of traditional Chinese medicine(TCM)in cancer care and summarized the available *** randomized controlled trials(pRCTs)and clinical registry studies are becoming more popular as they could compensate for the limitations of *** RCTs of TCM for cancer treatment as well as systematic reviews have been *** most investigated therapies are based on acupuncture,Chinese herbal compounds,and Chinese patent *** has a significant advantage in relieving cancer-related *** studies focus more on improving clinical symptoms and laboratory ***,the patient's quality of life deserves more attention.

关键词： evidence-based medicine Integrative oncology Traditional Chinese medicine Research design Pragmatic clinical trial Registries

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evidence-based medicine in China

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Chronic Diseases and Translational medicine 2019年第1期5卷 1-5页

作者： Wang Ji-Yao Jin Xue-Juan Department of Internal medicine Zhong Shan Hospital Fudan University Shanghai 200032 China Center of evidence-based medicine Fudan University Shanghai 200032 China Cardiovascular Diseases Institute Zhong Shan Hospital Fudan University Shanghai 200032 China

evidence-based medicine (EBM) has been promoted in China for the past 2 decades and has had a great in-fluence on the field of medicine. Medical students, practitioners, and policy makers have employed evidence from well-designed and well-conducted studies to optimize decision-making. This article summarizes the recent progress in EBM in China. Development of EBM in remote areas of China Ten years ago, many remote areas, such as Tibet, Xinjiang, the western edge of Yunnan Province, the northeast edge of Guizhou Province, and Western Sichuan Plateau, suffered from deep medical and social problems. There was a wide disparity in access to physicians practicing EBM between rural areas and big cities at that time.

关键词： evidence-based medicine Trends China

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Clinical effects of antidiabetic drugs on psoriasis:The perspective of evidence-based medicine

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World Journal of Diabetes 2021年第8期12卷 1141-1145页

作者： Mei-Xian Zhang Bo-Yuan Zheng Hai-Xiao Chen Ching-Wen Chien evidence-based medicine Center Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Public Laboratory Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen CampusShenzhen 518055Guangdong ProvinceChina Department of Orthopedics Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

Psoriasis and diabetes shared common underlying pathophysiological *** data suggested that antidiabetic medications may improve the psoriasis severity in patients with diabetes *** hypoglycemic agents including thiazolidinediones,glucagon-like peptide-1 receptor agonists,dipeptidyl peptidase-4 inhibitors,and biguanides have been reported to make a remarkable reduction in the Psoriasis Area and Severity Index score from *** antipsoriatic effect could be mediated not only by the glucoselowering action of these agents but also via inhibition of keratinocyte over proliferation,increase expression of differentiation markers,suppression the immune inflammatory pathway,and blocking the calcium channels and mitogen-activated protein kinase signaling *** the other hand,there was no significant increase in adverse reactions associated with the treatment of pioglitazone or ***,previous studies often had the relatively short duration of the trials,and did not have enough power to assess recurrence of *** bias in the study and missing data could undermine the reliability of the ***,the appropriately randomized controlled studies with large sample sizes and long-term durations in various psoriasis patients are warranted for further support.

关键词： Psoriasis Hypoglycemic agents Thiazolidinediones Glucagon-like peptide-1 receptor agonists Dipeptidyl peptidase-4 inhibitors Biguanides Antipsoriatic effect evidence-based medicine

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evidence-based rehabilitation medicine:definition,foundation,practice and development

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Medical Review 2024年第1期4卷 42-54页

作者： Jinlong Zhang Chengqi He Department of Rehabilitation medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Rehabilitation medicine West China HospitalSichuan UniversityNo.37 Guoxue AlleyChengdu 610041Sichuan ProvinceChina

To determine the definition,foundation,practice,and development of evidence-based rehabilitation medicine(EBRM)and point out the development direction for *** the database of PubMed,Cochrane Library,Embase,China national knowledge infrastructure(CNKI),Wanfang,and China science and technology journal database(CSTJ).The search was conducted from the establishment of the database to June *** key words are“rehabilitation medicine and evidence based”in Chinese and *** reading the abstract or full text of the literature,a summary analysis is conducted to determine the definition,foundation,practice,and development of EBRM.A total of 127 articles were *** development of 14 sub majors in EBRM are not balanced,evidence-based musculoskeletal rehabilitation medicine(EBMRM)(31 articles,mainly focuses on osteoarthritis,osteoporosis and musculoskeletal pain),evidence-based neurorehabilitation medicine(EBNM)(34 articles,mainly concentrated in stroke,traumatic brain injury and spinal cord injury)and evidencebased education rehabilitation medicine(EBEDRM)(17 articles,mainly focuses on educational methodology),evidence-based nursing rehabilitation medicine(EBNRM)(2 articles),evidence-based engineering rehabilitation medicine(EBENRM)(7 articles),evidence-based traditional Chinese rehabilitation medicine(EBTCRM)(3 articles),evidence-based internal rehabilitation medicine(EBIRM)(11 articles),evidence-based intensive care rehabilitation medicine(EBICRM)(4 articles),evidence-based oncology rehabilitation medicine(EBORM)(6 articles),evidence-based physical therapy medicine(EBPTM)(3 articles),evidencebased cardiopulmonary rehabilitation medicine(EBCRM)(6 articles),evidence-based speech therapy medicine(EBSTM)/evidence-based occupation therapy medicine(EBOTM)/evidence-based geriatric rehabilitation medicine(EBGRM)(1 article).The EBMRM,EBNM and EBEDRM are relatively well *** development of EBNRM,EBENRM,EBTCRM,EBIRM,EBICRM,EBGRM,EBORM,EBC

关键词： evidence-based medicine rehabilitation medicine evidence-based rehabilitation medicine system evaluation

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Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1791-1802页

作者： Yin-Jie Zhou Zhi-E Tan Wei-Da Zhuang Xin-Hua Xu Department of Oncology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Nuclear medicine The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Athe and Intestinal Surgery Cancer Hospital of The Chinese Academy of Medical SciencesBeijing 100021China

BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical ***-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment ***,there is still li-mited research on the factors affecting CSS in mCRC patients and their *** To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with *** Data were extracted from the United States Surveillance,Epidemiology,and End Results database from 2018 to *** eligible patients were randomly divided into a training cohort and a validation *** Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external *** A multivariate Cox proportional risk model was used to identify independent risk factors for ***,new CSS columns were developed based on these *** consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:*** calibration map and clinical decision curve showed good agreement and good potential clinical *** risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different *** median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),*** Our study developed a new nomogram model to predict CSS in patients with synchronous *** addition,the risk-grading system helps to accurately ass

关键词： Colorectal tumor Surveillance epidemiology and end results database Nomogram analysis Survival prognosis Retrospective study

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Traditional Chinese medicine in the prevention and treatment of stable angina pectoris in patients with coronary heart disease based on the theory of "phlegm and blood stasis" under guidance of evidence-based medicine:a prospective cohort study

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Journal of Traditional Chinese medicine 2021年第1期41卷 150-156页

作者： CHEN Ying XIAO Xue XU Xiaolin DENG Yue ZHANG Zepeng Department of Cardiology the Affiliated Hospital to Changchun University of Chinese MedicineChangchunChina Research Center of Traditional Chinese medicine the Affiliated Hospital to Changchun University of Chinese MedicineChangchunChina Jilin Provincial Key Laboratory of BioMacromolecules of Chinese medicine Changchun University of Chinese MedicineChangchunChina

OBJECTIVE: To ascertain whether continuous treatment with Traditional Chinese medicine(TCM) combined with standardized drug therapy from Western medicine can further reduce the incidence of cardiovascular events in patients with coronary heart disease and angina and reduce the incidence of angina pectoris in patients with coronary heart ***: A multicenter, prospective cohort study of 1042 patients in 22 hospitals was conducted. A total of 423 patients with angina pectoris were treated with standardized Western medicine alone(control group) and 619 with a combination of Chinese and Western medicine(exposure group). The two groups underwent follow-up for 1 year to establish whether there was any improvement in the incidence of cardiovascular events or change in the curative ***: The incidence of primary endpoint events in the combined-exposure group decreased by 0.45%(P > 0.05) and the incidence of secondary terminal events decreased by 5.25% in comparison with the control group(P medicine group over the first 6 months, but the decline was more apparent in the combined-exposure ***: Compared with treatment using standardized Western medicine alone, providing TCM combined with Western medical treatment reduced the incidence of cardiovascular events in patients with stable angina pectoris(grade Ⅱ endpoint) and effectively improved the curative effect.

关键词： Coronary disease Angina pectoris cardiovascular events Prospective study Cohort study

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Are case reports valuable?Exploring their role in evidence based medicine and patient care

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World Journal of Clinical Cases 2024年第24期12卷 5452-5455页

作者： Tarun Kumar Suvvari Department of Clinical Research Squad Medicine and Research(SMR)Amadalavalasa 532185Andhra PradeshIndia Department of medicine Rangaraya Medical CollegeKakinada 533001Andhra PradeshIndia

Case reports,often overlooked in evidence-based medicine(EBM),play a pivotal role in healthcare *** provide unique insights into rare conditions,novel treatments,and adverse effects,serving as valuable educational tools and generating new *** their limitations in generalizability,case reports contribute significantly to evidence-based practice by offering detailed clinical information and fostering critical thinking among healthcare *** acknowledging their limitations and adhering to reporting guidelines,case reports can contribute significantly to medical knowledge and patient care within the evolving landscape of *** editorial explores the intrinsic value of case reports in EBM and patient care.

关键词： Clinical cases Case reports evidence based medicine Editorial Healthcare research

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Toward evidence-based Chinese medicine：Status Quo,Opportunities and Challenges

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Chinese Journal of Integrative medicine 2018年第3期24卷 163-170页

作者： CHEN Yao-long ZHAO Chen ZHANG Li LI Bo WU Chuan-hong MU Wei WANG Jia-ying YANG Ke-hu LI You-ping CHEN Chiehfeng WANG Yong-yan WANG Chen BIAN Zhao-xiang SHANG Hong-cai Key Laboratory of Chinese Internal medicine of Ministry of Education Dongzhimen Hospital Beijing University of ChineseMedicine Beijing 100007 China evidence based medicine Center School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000 China Key Laboratory of evidence based medicine and Knowledge Translation of Gansu Province Lanzhou 730000 China Chinese GRADE Center Lanzhou 730000China China School of Chinese medicine Hong Kong Baptist University Hong Kong SAR 999077 China Departmentof Clinical Pharmacology Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Gastroenterology Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing 100091 China State Key Laboratory of Quality Researchin Chinese medicine Institute of Chinese Medical SciencesUniversity of Macao Macao 999078 China Departmentof Acupuncture and Moxibustion Wuxi People's HospitalJiangsu 214023 China Chinese Cochrane Centre West China Hospital Sichuan University Chengdu 610041 China Division of Plastic Surgery Department of Surgery Wan Fang Hospital Taipei Medical University Taipei 106 China Instituteof Basic Research in Clinical medicine China Academy of Chinese Medical Sciences Beijing 100700 China Department of Respiratory and Critical Care medicine China-Japan Friendship Hospital. Beiiina 100029. China

How to test the treatments of Chinese medicine（CM） and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of *** centuries,various approaches have been used to identify and measure the efficacy and safety of ***,the high-quality evidence related to CM that produced in China is still *** the recent years,evidence-based medicine（EBM） has been increasingly applied to CM,strengthening its theoretical *** paper reviews the past and present state of CM,analyzes the status quo,challenges and opportunities of basic research,clinical trials,systematic reviews,clinical practice guidelines and clinical pathways and evidence-based education developed or conducted in China,pointing out how EBM can help to make CM more widely used and recognized worldwide.

关键词： evidence-based medicine Chinese medicine randomized controlled trial systematic review clinical practice guidelines

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Hepatocellular carcinoma review:Current treatment,and evidence-based medicine

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World Journal of Gastroenterology 2014年第15期20卷 4115-4127页

作者： Ali Raza Gagan K Sood Department of Internal medicine St. Luke’s Episcopal HospitalBaylor College of MedicineHoustonTX 77030United States Division of Gastroenterology and Hepatology Baylor College of MedicineSt. Luke’s Liver CenterHoustonTX 77030United States

Hepatocellular carcinoma(HCC)is the fifth most common tumor *** treatment options are available for HCC including curative resection,liver transplantation,radiofrequency ablation,trans-arterial chemoembolization,radioembolization and systemic targeted agent like *** treatment of HCC depends on the tumor stage,patient performance status and liver function reserve and requires a multidisciplinary *** the past few years with significant advances in surgical treatments and locoregional therapies,the short-term survival of HCC has improved but the recurrent disease remains a big *** pathogenesis of HCC is a multistep and complex process,wherein angiogenesis plays an important *** patients with advanced disease,sorafenib is the only approved therapy,but novel systemic molecular targeted agents and their combinations are *** article provides an overview of treatment of early and advanced stage HCC based on our extensive review of relevant literature.

关键词： Hepatocellular carcinoma Trans-arterial chemoembolization Drug-eluting beads Radiofrequency ablation Liver transplantation Chemotherapy Sorafenib Radioembolization

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