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Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment

Neural Regeneration Research 2011年第2期6卷 155-160页

作者： Weimin Wang Siyu Zhao Yaqing Liu epilepsy prevention and treatment center of gansu province Epilepsy Centre of the Second Hospital of Lanzhou University Lanzhou730030 Gansu Province China

Epileptic seizure control and the disappearance of epileptJform discharge are not indicative of the absence of abnormal perfusion foci. Perfusion abnormalities are a major cause of epileptic discharge, and the existence of abnormal perfusion loci implies possible relapse. Very little is known about perfusion abnormality repair in epilepsy. The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months. Comparisons between interictal single-photon emission CT （SPECT） images and long-term electroencephalogram （EEG） pre- and post-treatment showed that cases of normal SPECT increased by 48% （12/25） following treatment, with a total number of 15 reduced loci （,36%, 15/41 ）. Perfusion foci, Le., region of interest, were altered following treatment. These changes included： normal to abnormal in 3 cases （7%, 3/43; 2 hyperperfusion and 1 hypoperfusion）; abnormal to normal in 14 cases （32%, 14/43; 10 pre-treatment hypopeffusion and 4 hyperperfusion）; abnormal to abnormal in 7 cases （16%, 7/43; hyperperfusion to hypoperfusion in 5 cases, hypoperfusion to hyperpeffusion in 2 cases）. Long-term EEG revealed in an increase in the number of normal cases by 20 （40%, 20/39）, and there were 25 fewer cases with epileptiform discharges （66%, 25/38）. These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy.

关键词： abnormal perfusion focus brain damage idiopathic epilepsy neural regeneration region of interest repair single-photon emission computed tomography

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment prevention and treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy

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Neural Regeneration Research 2013年第3期8卷 208-217页

作者： Weimin Wang Zhenyu Fan Yongqin Zhang Yuxia Yang Yaqing Liu Xiaoli Dang Wenjun Song Yinping Wu Jiang Ye epilepsy center Second HospitalLanzhou UniversityGansu Provincial Center for Prevention and Treatment of Epilepsy

One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 （34% of 86）; the total number of abnormal perfusion foci decreased by 52 （36%） and changes in abnormal loci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy.

关键词： neural regeneration traditional Chinese medicine neuroimaging brain injury tall gastrodis tuber antiepileptic drugs combination therapy focal epilepsy abnormal perfusion focus single photonemission computed tomography long-term vigilance-controlled electroencephalogram region ofinterest grant-supported paper photographs-containin^l paper: neuoreaeneration

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 389-405页

作者： Hongbin Wei Chunlu Dong Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhouGansuChina The First Hospital of Lanzhou University LanzhouGansuChina Key Laboratory Biotherapy and Regenerative Medicine of gansu province LanzhouGansuChina Cancer prevention and treatment center of Lanzhou University School of Medicine LanzhouGansuChina Hepatopancreatobiliary Surgery Institute of gansu province LanzhouGansuChina Clinical Research center for General Surgery of gansu province LanzhouGansuChina

Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of *** suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of *** this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to *** then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other *** may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent *** also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell *** then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.

关键词： Hepatocellular carcinoma Liver cancer Immunotherapy Vaccines

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Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2826-2841页

作者： Gang Wang Tao Liu Wen-Ting He School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor prevention and treatment and Translational Medicine Engineering Innovation center of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Translational Medicine Engineering Research center of gansu province Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Hospital&Clinical Medical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical *** over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is *** To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this *** The literature was collected from Web of Science ***-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst *** 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation ***‘online platform for bibliometric analysis(https://***/app)’was used to assess the total number of publications and the cooperation relationships between ***,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the *** Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor *** United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing *** most influential journal in this field is *** most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge *** focal points were further detailed based on the *** This bibl

关键词： Gastrointestinal tumor organoids Bibliometric analysis Drug development and screening Model CiteSpace

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Giant hemangioma of the caudate lobe of the liver with surgical treatment:A case report

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World Journal of Clinical Cases 2021年第21期9卷 5980-5987页

作者： Xin-Xin Wang Bao-Long Dong Biao Wu Shi-Yong Chen Yu He Xiao-Jun Yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu University of Chinese Medicine The 1st Clinical Medicine CollegeLanzhou 730000Gansu ProvinceChina Peoples Clinical Medicine College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu Research center of prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Caudate lobe hemangioma of the liver is relatively *** to the unique anatomical location of the caudate lobe,the caudate lobectomy accounts for only 0.5%to 4%of hepatic resection,which is difficult to operate and takes a long time,and even has many postoperative *** SUMMARY A 34-year-old female presented with a 1 year history of intermittent pain in the right side of the waist without obvious *** laboratory blood tests were within normal *** green 15 min retention was rated 2.9%,and Child-Pugh was rated *** tomography and magnetic resonance imaging diagnosed giant hemangioma of the caudate lobe with hemangioma of left lobe of *** discussion,surgical treatment was performed,which lasted 410 min,with intraoperative bleeding of about 600 mL and postoperative pathological findings of cavernous *** were no obvious postoperative complications,and the patient was discharged 10 d after *** Caudate lobectomy is difficult due to its special anatomical *** the condition of fully exposing the anatomy of the first porta hepatis,the second porta hepatis,the third porta hepatis,the fourth porta hepatis and middle hepatic vein and combining with the Pringle maneuver,caudate lobectomy can be performed in a precise and safe process.

关键词： Caudate lobe hemangioma Caudate lobectomy Case report

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Present situation of minimally invasive surgical treatment for early gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1154-1165页

作者： Chun-Yan Li Yi-Feng Wang Li-Kang Luo Xiao-Jun Yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina gansu Research center of prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical *** addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer *** minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so *** new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

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Efficacy and safety of intraoperative radiotherapy in rectal cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 69-86页

作者： Bin Liu Long Ge Jing Wang Ya-Qiong Chen Shi-Xun Ma Pei-Lan Ma Yun-Qiang Zhang Ke-Hu Yang Hui Cai gansu Provincial Hospital General Surgery Clinical Medical CenterLanzhou 730000Gansu ProvinceChina Evidence Based Social Science Research center School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina gansu University of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Evidence Based Medicine center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND In recent years,intraoperative radiotherapy(IORT)has been increasingly used for the treatment of rectal ***,the efficacy and safety of IORT for the treatment of rectal cancer are still *** To evaluate the value of IORT for patients with rectal *** We searched PubMed,Embase,Cochrane Library,Web of Science databases,and conference abstracts and included randomized controlled trials and observational studies on IORT vs non-IORT for rectal *** variables were evaluated by odds ratio(OR)and 95%confidence interval(CI),hazard ratio(HR)and 95%CI was used as a summary statistic of survival *** analyses were performed using Stata V.15.0 and Review Manager 5.3 *** In this study,3 randomized controlled studies and 12 observational studies were included with a total of 1460 patients,who are mainly residents of Europe,the United States,and *** results did not show significant differences in 5-year overall survival(HR=0.80,95%CI=0.60-1.06;P=0.126);5-year disease-free survival(HR=0.94,95%CI=0.73-1.22;P=0.650);abscess(OR=1.10,95%CI=0.67-1.80;P=0.713),fistulae(OR=0.79,95%CI=0.33-1.89;P=0.600);wound complication(OR=1.21,95%CI=0.62-2.36;P=0.575);anastomotic leakage(OR=1.09,95%CI=0.59-2.02;P=0.775);and neurogenic bladder dysfunction(OR=0.69,95%CI=0.31-1.55;P=0.369).However,the meta-analysis of 5-year local control was significantly different(OR=3.07,95%CI=1.66-5.66;P=0.000).CONCLUSION The advantage of IORT is mainly reflected in 5-year local control,but it is not statistically significant for 5-year overall survival,5-year disease-free survival,and complications.

关键词： Intraoperative radiotherapy Rectal cancer Systematic review External beam radiation therapy Randomized controlled trials Meta-analysis

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Post-traumatic cauda equina nerve calcification:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1356-1364页

作者： Yan-Dong Liu Qiang Deng Jun-Jie Li Hai-Yun Yang Xian-Fu Han Kai-Dong Zhang Ran-Dong Peng Qian-Qian Xiang Graduate School Gansu University of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina Spinal Disease Diagnosis and treatment center Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina First Orthopedic Department Lanzhou Traditional Chinese Medicine Orthopedic HospitalLanzhou 730050Gansu ProvinceChina Department of Osteomyelitis Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Post-traumatic cauda equina nerve calcification is extremely rare in clinical practice,and its etiology,pathogenesis,treatment and prognosis are *** are few studies and reports on Post-traumatic cauda equina nerve calci-fication,and this review reports a case of Post-traumatic cauda equina nerve calcification for *** SUMMARY A 52-year-old patient presented to our hospital with a history of lumbar spinal stenosis and a lumbar vertebral fracture caused by *** patient's right lower limb had weakness in hip flexion,knee extension and plantarflexion with muscle strength grade 3,right ankle dorsiflexion and thumb dorsiflexion with muscle strength grade *** patient's skin sensation below the right knee plane *** patient's Computed tomography(CT)data showed signs of cauda equina nerve calcification and the terminal filaments in the plane of the third to fifth lumbar *** treatment the patient's symptoms were slightly *** We provide an extremely rare case of Post-traumatic cauda equina nerve calcification and offer a conservative treatment ***,the etiology,mechanism and treatment of Post-traumatic cauda equina nerve calcification are still *** requires scholars to conduct more research and exploration in this area.

关键词： Post-traumatic Calcification Cauda equina nerve Spinal Cord Injury Case report

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