Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment

作     者：Weimin Wang Siyu Zhao Yaqing Liu 

作者机构：Epilepsy Prevention and Treatment Center of Gansu Province Epilepsy Centre of the Second Hospital of Lanzhou University Lanzhou730030 Gansu Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第2期

页      面：155-160页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080903[工学-微电子学与固体电子学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：the Key Pro-ject of Gansu Province No. 432328 

主　　题：abnormal perfusion focus brain damage idiopathic epilepsy neural regeneration region of interest repair single-photon emission computed tomography 

摘      要：Epileptic seizure control and the disappearance of epileptJform discharge are not indicative of the absence of abnormal perfusion foci. Perfusion abnormalities are a major cause of epileptic discharge, and the existence of abnormal perfusion loci implies possible relapse. Very little is known about perfusion abnormality repair in epilepsy. The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months. Comparisons between interictal single-photon emission CT （SPECT） images and long-term electroencephalogram （EEG） pre- and post-treatment showed that cases of normal SPECT increased by 48% （12/25） following treatment, with a total number of 15 reduced loci （,36%, 15/41 ）. Perfusion foci, Le., region of interest, were altered following treatment. These changes included： normal to abnormal in 3 cases （7%, 3/43; 2 hyperperfusion and 1 hypoperfusion）; abnormal to normal in 14 cases （32%, 14/43; 10 pre-treatment hypopeffusion and 4 hyperperfusion）; abnormal to abnormal in 7 cases （16%, 7/43; hyperperfusion to hypoperfusion in 5 cases, hypoperfusion to hyperpeffusion in 2 cases）. Long-term EEG revealed in an increase in the number of normal cases by 20 （40%, 20/39）, and there were 25 fewer cases with epileptiform discharges （66%, 25/38）. These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy.