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Colorectal cancer burden and trends:Comparison between China and major burden countries in the world

Chinese Journal of cancer Research 2021年第1期33卷 1-10页

作者： Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang wenqiang wei Department of Epidemiology and Biostatistics School of Public HealthXi’an Jiaotong University Health Science CenterXi’an 710061China National Central cancer registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and ***:Incidence and mortality data were extracted from the GLOBOCAN2018 and cancer Incidence in Five ***-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were ***:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in *** had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of *** incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising *** age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 ***:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the *** should be expanded to control CRC,and focused on young people in China.

关键词： Colorectal cancer burden China trend

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Fatal Complications and Early Death after Surgical Treatment of Lung cancer in 2000 and 2010. A Population Based Study

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Surgical Science 2013年第1期4卷 107-109页

作者： Hans Rostad cancer registry of Norway Norway

In the year 2000 lung cancer was operated in 349 patients in Norway, in 2010 the number was 461. In the first period fatal surgical hemorrhage occurred in eight patients, in four of them peroperatively. Postoperative hemorrhage occurred in four patients in the year 2000 and in two in 2010. Ten patients died intra- or postoperatively in the two periods which is a mortality rate within 30 days after surgery of 4.3% in the first and 1.1% in the second period. Pneumonectomy was performed in 34 patients in 2000 and eight in 2010, respectively. Altogether 19 patients died within six months after surgery without having experienced surgical complications. Pneumonectomy should not be performed in elderly and debilitated persons.

关键词： Lung cancer Complications

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worldwide trends in esophageal cancer survival,by sub-site,morphology,and sex:an analysis of 696,974 adults diagnosed in 60 countries during 2000-2014(CONCORD-3)

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cancer Communications 2023年第9期43卷 963-980页

作者： Melissa Matz Mikhail Valkov Mario Šekerija Sabine Luttman Adele Caldarella Michel P Coleman Claudia Allemani the CONCORD working Group cancer Survival Group Department of Non-Communicable Disease EpidemiologyLondon School of Hygiene and Tropical MedicineLondon WC1E 7HTGreater LondonUnited Kingdom Department of Radiology Radiotherapy and OncologyNorthern State Medical UniversityArkhangelskArkhangelsk OblastRussia Croatian National cancer registry Croatian Institute of Public HealthZagrebZagreb CountyCroatia Bremen cancer registry BremenBremenGermany Tuscany cancer registry Istituto per lo studio e la prevenzione oncologicaFlorenceTuscanyItaly cancer Division University College London Hospitals NHS Foundation TrustLondon NW1 2BUGreater LondonUnited Kingdom Members listed at the end of the article

Background Esophageal cancer survival is poor worldwide,though there is some *** in the distribution of anatomical sub-site and morphological sub-type may help explain international differences in survival for all esophageal cancers *** estimated survival by anatomic sub-site and morphological sub-type to understand further the impact of topography and morphology on international comparisons of esophageal cancer *** we estimated age-standardized one-year and five-year net survival among adults(15-99 years)diagnosed with esophageal cancer in each of 60 participating countries to monitor survival trends by calendar period of diagnosis(2000-2004,2005-2009,2010-2014),sub-site,morphology,and *** For adults diagnosed during 2010-2014,tumors in the lower third of the esophagus were the most common,followed by tumors of overlapping sub-site and sub-site not otherwise *** proportion of squamous cell carcinomas diagnosed during 2010-2014 was generally higher in Asian countries(50%-90%),while adenocarcinomas were more common in Europe,North America and Oceania(50%-60%).From 2000-2004 to 2010-2014,the proportion of squamous cell carcinoma generally decreased,and the proportion of adenocarcinoma *** time,there were few improvements in age-standardized five-year survival for each ***-standardized one-year survival was highest in Japan for both squamous cell carcinoma(67.7%)and adenocarcinoma(69.0%),ranging between 20%-60%in most other ***-standardized five-year survival from squamous cell carcinoma and adenocarcinoma was similar for most countries included,around 15%-20%for adults diagnosed during 2010-2014,though international variation was wider for squamous cell *** most countries,survival for both squamous cell carcinoma and adenocarcinoma increased by less than 5%between 2000-2004 and *** Esophageal cancer survival remains poor in many *** distributions

关键词： cancer esophagus morphology survival topography trends

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Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis:a single-center,prospective study in China

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Frontiers of Medicine 2024年第4期18卷 752-756页

作者： Yihui Chen Qiaozhi Cao Cong Peng Bingjing Zhou Yu Jiang Xiang Chen Jie Li Department of Dermatology Xiangya HospitalCentral South UniversityChangsha410008China Hunan Key Laboratory of Skin cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Furong Laboratory Changsha410008China

Dear Editor,Upadacitinib and abrocitiniboareselective,smallmolecule Janus kinase 1(JAK1)inhibitors approved in China for the treatment of moderate-to-severe atopic dermatitis(AD)[1].The favorable efficacy and tolerable safety of upadacitinib and abrocitinib have been determined in several clinical trials[2-5].However,realworld data,especially in Asian populations,are ***,we conducted a prospective,24-week,real-life observational study to assess the effectiveness and safety of abrocitinib and upadacitinib for the treatment of moderate-to-severe AD in a Chinese patient *** patients with moderate-to-severe AD(IGA score 3-4)in the Department of Dermatology.

关键词： dermatitis prospective treatment

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Liver cancer incidence and mortality in China: Temporal trends and projections to 2030

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Chinese Journal of cancer Research 2018年第6期30卷 571-579页

作者： Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li wenqiang wei wanqing Chen Jie He Office for cancer registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical College State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College cancer Research Institute Affiliated Tumor HospitalXinjiang Medical University Office of cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical College

Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths *** systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other ***: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries’ data selected from Chinese National cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to *** burden of liver cancer through 2030 was projected using age-period-cohort ***: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in *** regions of China had the highest incidence and mortality *** and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in *** young generation,particularly for those aged under 40 years,showed a faster down ***: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western *** cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups.

关键词： Liver cancer burden temporal trends prediction cancer registry China

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Current Status of Diagnosis And Treatment of Primary Breast cancerin Beijing,2008

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Chinese Journal of cancer Research 2011年第1期23卷 38-42页

作者： Xiao-mei Yuan Ning wang Tao OuYang Lei Yang Ming-yang Song Ben-yao Lin Yun-tao Xie Jin-feng Li Kai-feng Pan wei-cheng You Lian Zhang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Cancer EpidemiologyBeijing 100142 China Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Beijing Cancer RegistryBeijing 100142 China Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Breast Cancer Center Peking University School of OncologyBeijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To investigate the status of diagnosis and treatment of primary breast cancer in Beijing,***：All the patients who were diagnosed as primary breast cancer in Beijing in 2008 were enrolled in this *** of these patients,including the features of tumors,clinical diagnosis and treatment was collected,and filled in the well-designed questionnaire forms by trained *** missing data were partly complemented through telephone ***：A total of 3473 Beijing citizens were diagnosed as primary breast cancer（25 patients with synchronal bilateral breast cancer） in Beijing,*** them 82.09% were symptomatic.19.02% and 34.11% were diagnosed using fine needle aspiration biopsy（FNAB） and core needle biopsy（CNB）,respectively.15.92% received sentinel lymph node biopsy（SLNB） and 24.27% received breast conserving surgery（BCS）.Among 476 cases with Her-2 positive,only 96 received anti-Her-2 *** found that the standardization level varied in hospitals of different grades,with higher level in Grade-III *** note,some breast cancer patients received non-standard primary tumor therapy：65.63% of the patients with ductal carcinoma in situ（DCIS） received axillary lymph node dissection and 36.88% received chemotherapy;25.89% of the patients underwent breast conserving surgery without margin status;12.10% of the patients received chemotherapy less than 4 ***：Although most breast cancer patients received basic medical care,the mode of diagnosis and treatment should be improved and should be standardized in the future in Beijing.

关键词： Breast cancer Diagnosis Treatment Nonstandard treatment

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Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical cancer—China,2003–2017

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China CDC weekly 2022年第48期4卷 1070-1076,I0001-I0010页

作者： Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming wang Li Li Ru Chen Bingfeng Han Ji Peng wenqiang wei Jie He National Central cancer registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing MunicipalityChina Shenzhen Center for Chronic Disease Control Guangzhou CityGuangdong ProvinceChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing MunicipalityChina.

Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in ***:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in *** performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical ***:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−*** femaleswere observed in urban areas after *** the ASIR and ASMR kept increasing in rural areas during the whole *** females>50 years,the ASIR and ASMR increased both in urban and rural ***-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole *** cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural ***:The increases in cervical cancer incidence and mortality rates can be mostly explained by period *** observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas.

关键词： mortality Cervical downward

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Global patterns of breast cancer incidence and mortality:A population-based cancer registry data analysis from 2000 to 2020

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cancer Communications 2021年第11期41卷 1183-1194页

作者： Shaoyuan Lei Rongshou Zheng Siwei Zhang Shaoming wang Ru Chen Kexin Sun Hongmei Zeng Jiachen Zhou wenqiang wei Office for cancer registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Epidemiology and Biostatistics School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061P.R.China

Background:Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different *** study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and ***:Breast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online *** data from the cancer Incidence in Five Continents Time Trends,the International Agency for Research on cancer mortality and China National Central cancer registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression,and annual average percent changes of breast cancer incidence and mortality were *** between Human Development Index and breast cancer incidence and mortality were estimated by linear ***:There were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in *** incidence and mortality varied among countries,with the age-standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran,and the age-standardized mortality from the highest of 41.0 per 100,000 population in Fiji to the lowest of 6.4 per 100,000 population in South *** peak age of breast cancer in some Asian and African countries were over 10 years earlier than in European or American *** for the trends of breast cancer,the age-standardized incidence rates significantly increased in China and South Korea but decreased in the United States of America(USA)during ***,the age-standardized mortality rates significantly increased in China and South Korea but decreased in the United Kingdom,the USA,and Australia during 2000 and ***:The global burden of breast cancer is rising fast and varies greatly among *** inci

关键词： Breast cancer mortality patterns incidence time trends cancer registry cancer trends

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中国胃癌肝转移患者临床诊疗特征及预后分析:全国多中心队列研究(RECORD研究)（英文）

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Science Bulletin 2024年第3期 303-307页

作者：高云鹤郗洪庆商亮唐兆庆卫勃乔治唐云王鑫鑫周静汪学非黄昌明陆俊李国新余江梁延锐季加孚李子禹薛侃梁寒柯彬臧潞何子锐谢少华黄华徐泽宽田艳涛熊建平李佶阳崔秋霞李力卢婷婷宋奇嬴刘诗贺孙益红李乐平陈凛 RECORD研究协作组 Section of Gastric Surgery Senior Department of General Surgery The First Medical Center Chinese PLA General Hospital Section of Abdominal Trauma Surgery Senior Department of General Surgery The First Medical Center Chinese PLA General Hospital Institute of General Surgery The First Medical Center Chinese PLA General Hospital Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Department of General Surgery Fudan University Zhongshan Hospital Department of General Surgery Fujian Medical University Union Hospital Department of General Surgery Nanfang Hospital Affiliated to Southern Medical University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Gastric cancer Surgery Tianjin Medical University Cancer Institute and Hospital Department of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Institute of Population Medicine and School of Public Health Fujian Medical University Department of Gastric Surgery Fudan University Shanghai Cancer Center Department of General Surgery Jiangsu Province Hospital Nanjing Medical University Department of Pancreatic and Gastric Surgery National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging [1-3].Although nationwide registry data from SEER (Surveillance,Epidemiology,and End Results)[4] and the Nordic database [5] in western countries have provided epidemiological information for patients with gastric cancer liver metastasis (GCLM),little is known about the detailed clinical ***,emerging evidence has indicated that selective implementation of systemic chemotherapy,immune checkpoint inhibitor (ICI) therapy,surgical resection,

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Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma

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Chinese Journal of cancer Research 2020年第6期32卷 755-767页

作者： Minjuan Li Dantong Shao Jiachen Zhou Jianhua Gu Junjie Qin wen Chen wenqiang wei National Central cancer registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Epidemiology and Biostatistics School of Public HealthXi'an Jiaotong University Health Science CenterXi'an 710061China Promegene Translational Research Institute Shenzhen 518000China Department of cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: Esophageal squamous cell carcinoma(ESCC) is one of the dominant malignances worldwide, but currently there is less focus on the microbiota with ESCC and its precancerous ***: Paired esophageal biopsy and swab specimens were obtained from 236 participants in Linzhou, *** from 16 S ribosomal RNA gene sequencing were processed using quantitative insights into microbial ecology(QIIME2) and R Studio to evaluate differences. The wilcoxon rank sum test and Kruskal-wallis rank sum test were used to compare diversity and characteristic genera by specimens and participant groups. Ordinal logistic regression model was used to build microbiol prediction ***: Microbial diversity was similar between biopsy and swab specimens, including operational taxonomic unit(OTU) numbers and Shannon index. There were variations and similarities of esophageal microbiota among different pathological characteristics of ESCC. Top 10 relative abundance genera in all groups include Streptococcus, Prevotella, Veillonella, Actinobacillus, Haemophilus, Neisseria, Alloprevotella, Rothia, Gemella and Porphyromonas. Genus Streptococcus, Haemophilus, Neisseria and Porphyromonas showed significantly difference in disease groups when compared to normal control, whereas Streptococcus showed an increasing tendency with the progression of ESCC and others showed a decreasing tendency. About models based on all combinations of characteristic genera, only taken Streptococcus and Neisseria into model, the prediction performance was the ideal one, of which the area under the curve(AUC) was ***: Esophageal biopsy and swab specimens could yield similar microbial characterization. The combination of Streptococcus and Neisseria has the potential to predict the progression of ESCC, which is needed to confirm by large-scale, prospective cohort studies.

关键词： Esophageal squamous cell carcinoma precancerous lesions 16S rRNA Streptococcus Neisseria

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