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Formation of water disinfection byproduct 2,6-dichloro-1,4-benzoquinone from chlorination of green algae

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Journal of environmental Sciences 2018年第1期30卷 1-8页

作者： Fei Ge Yao Xiao Yixuan Yang Wei Wang Birget Moe Xing-Fang Li College of environment and Resources Xiangtan University College of environment and Energy South China University of Technology Division of Analytical and environmental toxicology Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of Alberta College of environmental and Resource Sciences Zhejiang University Alberta Centre for toxicology Department of Physiology and Pharmacology Faculty of Medicine University of Calgary

We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone（HBQ） disinfection byproducts（DBPs） produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, produced 2,6-dichloro-1,4-benzoquinone（2,6-DCBQ）, the most prevalent HBQ DBP in disinfected water. Under varying p H conditions（p H 6.0–9.0）, 2,6-DCBQ formation ranged from 0.3 to 2.1 μg/mg C with maximum formation at p H 8.0. To evaluate the contribution of organic components of C. vulgaris to 2,6-DCBQ formation, we separated the organics into two fractions, the protein-rich fraction of intracellular organic matter（IOM） and the polysaccharide-laden fraction of extracellular organic matter（EOM）. Chlorination of IOM and EOM produced 1.4 μg/mg C and 0.7 μg/mg C of 2,6-DCBQ, respectively. The IOM generated a two-fold higher 2,6-DCBQ formation potential than the EOM fraction, suggesting that proteins are potent 2,6-DCBQ precursors. This was confirmed by the chlorination of proteins extracted from C. vulgaris： the amount of 2,6-DCBQ produced is linearly correlated with the concentration of total algal protein（R2= 0.98）. These results support that proteins are the primary precursors of 2,6-DCBQ in algae, and control of green algal bloom outbreaks in source waters is important for management of HBQ DBPs.

关键词： Disinfection byproducts Halobenzoquinones Green algae Proteins Precursors

In vitro assessment of thyroid hormone receptor activity of four organophosphate esters

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Journal of environmental Sciences 2016年第7期28卷 185-190页

作者： Xiaomin Ren Linying Cao Yu Yang Bin Wan Sufang Wang Lianghong Guo State Key Laboratory of environmental Chemistry and Eco-toxicology Research Centre for Eco-environmental Sciences Chinese Academy of Sciences Institute of environment and Health Jianghan University

Previous animal experiments have implied that organophosphate esters（OPEs） have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, the activities of four OPEs have been characterized against the thyroid hormone（TH） nuclear receptor（TR） using two in vitro models, with the aim of evaluating their toxicity mechanisms towards the TR. The results of a TH-dependent cell proliferation assay showed that tris（2-chloro-1-（chloromethyl）ethyl）phosphate（TDCPP） could induce cell growth, while the other three OPEs had no effect. The results of a luciferase reporter gene assay revealed that all four of the OPEs tested in the current study showed agonistic activity towards TRβ, with TDCPP being the most potent one. Moreover, molecular docking revealed that all the tested OPEs could fit into the ligand binding pocket of TRβ, with TDCPP binding more effectively than the other three OPEs. Taken together, these data suggest that OPEs might disrupt the thyroid endocrine system via a mechanism involving the activation of TR.

关键词： organophosphate esters disruption effect TDCPP TR pathway agonistic activity

Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products

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Journal of environmental Sciences 2017年第8期29卷 302-310页

作者： David Hanigan Lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff Department of Civil and environmental Engineering University of Nevada School of Sustainable Engineering and the Built environment Arizona State University Department of environmental and Molecular toxicology Oregon State University

Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products（DBPs）, many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP（s） drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order： acetamides 〉 acetic acids 〉 acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays.

关键词： Zebrafish Disinfection by-product Developmental Ecological Toxicity

Is there a silver lining? Aggregation and photo-transformation of silver nanoparticles in environmental waters

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Journal of environmental Sciences 2015年第8期27卷 259-262页

作者： Qi Zheng Michael Zhou Wenchao Deng X.Chris Le Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan University Institute of environment and Health Jianghan University Division of Analytical and environmental toxicology University of Alberta

The nanotechnology industry advances rapidly,and at the vanguard are the promising silver nanoparticles（Ag NPs）,which have diverse *** nanometer-sized particles have been shown to inhibit the ability of bacteria to produce adenosine triphosphate（ATP）,a molecule necessary for chemical energy transport in *** antimicrobial properties of Ag NPs（and Ag＋）make them valued antibacterial

关键词： Silver nanoparticles(AgNPs) Nanomaterials Water chemistry Aggregation Transformation toxicology Dissolved organic matter(DOM)

Characterization of natural organic matter in water for optimizing water treatment and minimizing disinfection by-product formation

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Journal of environmental Sciences 2016年第4期28卷 1-5页

作者： Qi Zheng Xiaoqiu Yang Wenchao Deng X.Chris Le Xing-Fang Li Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchool of Chemical and Environmental EngineeringJianghan University Institute of environment and Health Jianghan University Division of Analytical and environmental toxicology University of Alberta

Introduction Natural organic matter（NOM）present in source water has significant impact on water treatment processes and on the quality of drinking *** is a complex mixture of diverse groups of organic compounds,humi... 详细信息

关键词： Disinfection by-products(DBPs) Dissolved organic carbon(DOC) Dissolved organic matter(DOM) Fluorescence Natural organic matter(NOM) Nitrification Size exclusion chromatography Total organic carbon(TOC)

Crystallinity engineering of Au nanoparticles on graphene for in situ SERS monitoring of Fenton-like reaction

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Chinese Chemical Letters 2022年第3期33卷 1263-1266页

作者： Danni Guo Lixia Zhao Hui Zhang State Key Laboratory of environmental Chemistry and Eco-toxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Water environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China

Fabrication of multifunctional nanoplatform to in situ monitor Fenton reaction is of vital importance to probe the underlying reaction process and design high-performance catalyst. Herein, a hybrid catalyst comprising of single-crystalline Au nanoparticles (SC Au NPs) on reduced graphene oxide (RGO) sheet was prepared, which not only exhibited an excellent ^(1)O_(2) mediated Fenton-like catalytic activity in promoting rhodamine 6G (R6G) degradation by activating H_(2)O_(2), but also displayed a sensitive surface-enhanced Raman spectroscopy (SERS) detection performance to R6G with a linear response range from 1.0×10^(-8) mol/L to 1.0×10^(-5) mol/L thus providing a powerful and versatile nanoplatform for in situ SERS monitoring Fenton-like catalytic reaction. The integration of catalytic and SERS activities into a single nanostructure are expected to provide great potentials for practical applications in environmental catalysis.

关键词： Au nanoparticle Crystallinity engineering Fenton-like reaction SERS monitoring environmental remediation

circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM_(2.5)

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Journal of environmental Sciences 2024年第3期137卷 527-539页

作者： Qingping Liu Yaling Zhang Bin Han Mengruo Wang Huaifang Hu Jie Ning Wentao Hu Meiyu Chen Yaxian Pang Yuanyuan Chen Lei Bao Yujie Niu Rong Zhang Department of toxicology Hebei Medical UniversityShijiazhuang 050017China State Key Laboratory of environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China China CDC Key Laboratory of environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Occupational Health and environmental Health Hebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of environment and Human Health Hebei Medical UniversityShijiazhuang 050017China

As an environmental pollutant,ambient fine particulate matter (PM_(2.5)) was linked to cardiovascular *** molecular mechanisms underlying PM_(2.5)-induced extrapulmonary disease has not been elucidated *** this study the ambient PM_(2.5)exposure mice model we established was to explore adverse effects of vessel and potential ***-term PM_(2.5)exposure caused reduced lung function and vascular stiffness in *** chronic PM_(2.5)induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2B *** PM_(2.5)treatment,the circRNAs and mRNAs levels of exosomes released by BEAS-2B cells were detected by competing endogenous RNA (ceRNA) array,which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed m RNAs (DE-mRNAs).By bioinformatics analysis on host genes of DE-circRNAs,vascular diseases and some pathways related to vascular diseases including focal adhesion,tight junction and adherens junction were ***,ceRNA network was constructed,and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis,which indicated that hsa_circ_0012627,hsa_circ_0053261and hsa_circ_0052810 were related to vascular endothelial ***,it was verified experimentally that Exo^(PM2.5)could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in *** present study,we investigated in-depth knowledge into the molecule events related to PM_(2.5) toxicity and pathogenesis of vascular diseases.

关键词： Fine particulate matter Vascular stiffness Exosome ceRNA microarray Endothelial dysfunction

Allium cepa root tip assay in assessment of toxicity of magnesium oxide nanoparticles and microparticles

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Journal of environmental Sciences 2018年第4期30卷 125-137页

作者： Bhanuramya Mangalampalli Naresh Dumala Paramjit Grover toxicology Unit Pharmacology and Toxicology Division CSIR-Indian Institute of Chemical Technology Academy of Scientific and Innovative Research CSIR-Indian Institute of Chemical Technology

Allium cepa bioassay had been used from decades for the assessment of toxicants and their harmful effects on environment as well as human health. Magnesium oxide（MgO） particles are being utilized in different fields. However, reports on the adverse effects of MgO nanoparticles on the environment and mankind are scarce. Hence, the toxicity of MgO particles is of concern because of their increased utilization. In the current study, A. cepa was used as an indicator to assess the toxicological efficiency of MgO nano-and microparticles（NPs and MPs） at a range of exposure concentrations（12.5, 25, 50, and100 μg/m L）. The toxicity was evaluated by using various bioassays on A. cepa root tip cells such as comet assay, oxidative stress and their uptake/internalization profile. Results indicated a dose dependent increase in chromosomal aberrations and decrease in mitotic index（MI） when compared to control cells and the effect was more significant for NPs than MPs（at p 〈 0.05）. Comet analysis revealed that the Deoxyribonucleic acid（DNA） damage in terms of percent tail DNA ranged from 6.8–30.1 over 12.5–100 μg/m L concentrations of MgO NPs and was found to be significant at the exposed concentrations. A significant increase in generation of hydrogen peroxide and superoxide radicals was observed in accordance with the lipid peroxidation profile in both MgO NPs and MPs treated plants when compared with control. In conclusion, this investigation revealed that MgO NPs exposure exhibited greater toxicity on A. cepa than MPs.

关键词： Magnesium oxide nanoparticles Allium cepa root tip assay Histochemical staining Oxidative stress Internalization of nanoparticles

An improved and simple method for removal of arsenic from drinking water

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Journal of environmental Sciences 2019年第2期31卷 415-417页

作者： Jagdeesh S.Uppal Qi Zheng X.Chris Le Division of Analytical and environmental toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of Alberta Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationInstitute of Environment and HealthJianghan University

Arsenic (As)is a naturally occurring *** toxicity of arsenic is dependent on the specific arsenic species,and the concentration and duration of exposure to the arsenic species (Moe et al.,2016).Chronic human exposure to high concentrations of inorganic arsenic species has been associated with cardiovascular disease,diabetes,neurological diseases,skin lesions,and various cancers (Naujokas et al.,2013).

关键词： Arsenic species Activated carbon Water treatment Morphology of nanostructures Iron and manganese nanomaterials