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DETECTION　OF　POINT　MUTATIONS　IN　EXON　2　OF　THE　G6PD　GENE　IN　CHINESE　G6PD　VARIANT

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Chinese Medical Sciences Journal 1994年第1期9卷 20-23页

作者：许卫明王菁华小云杜传书 DepartmentofMedicalGenetics SunYat-SenUniversityofMedicalSciencesGuangzhou510089

In the past few years. a total of 6 different mutations of the G6PD gene have been reported in china. One of these, the C6 mutation (A￣(95)→G). accounted for about 1 5. 4 % of the Chinese G6PD variants. In ordet to develop a strategy for rapid detection of mutation-containing exons of the G6PD gene. we applied the single-strand conformation polymorphism (SSCP) technique to the detection of mutations in exon 2 of this gene. We observed four patients with abnormal migration patterns of the exon 2 bend among 20 cases of G6PD variants. Direct PCR sequencing confirmed a T to C substitution in exon 2 that has previously been reported. This procedure is therefore of particular importance for the rapid detection of mutation-containing exons in the G6PD gene.

关键词： G6PD deficiency polymerase chain reaction DNA sequencing

Survey of Smoking Rates Among Residents 35—41 Years Old in Guangodong Province

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中山医科大学学报 2002年第3期23卷 229-231,S006页

作者： WANGZhi－Jin LIZhi－bin 等 DepartmentofEpidemiology SunYat－senUniversityofMedicalSciencesGuangzhou510089China

目的为了解广东省35－44岁居民吸烟情况。方法 1996年10－12月和1997年3－5月采有多阶段整群随机抽样方法选择样本，共调查35－44岁居民1554人。结果 35－44岁居民男、女吸烟率分别为81．4％和4．1％。城市居民786人，乡村768人，... 详细信息

目的为了解广东省35－44岁居民吸烟情况。方法 1996年10－12月和1997年3－5月采有多阶段整群随机抽样方法选择样本，共调查35－44岁居民1554人。结果 35－44岁居民男、女吸烟率分别为81．4％和4．1％。城市居民786人，乡村768人，男性吸烟率分别为78．1％和84．8％，接近全国最高水平。结论建议把35－44岁年龄段居民作控烟的重点人群，为今后在广东省有组织、有计划，有针对性地进行控烟运动提供依据。

关键词：吸烟抽样调查广东

A O-Memory Model for Single Ion Channel

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生物数学学报 1998年第3期 323-328页

作者： ZhouWenqing,FangJiqian,GuanYongyuan SunYat-senuniversityofmedicalsciences!Guangzhou510089 China SunYat-senuniversityofmedicalsciences!Guangzhou510089 China DepartmentofMedicalStatistics DepartmentofPharmacology

***-classandtheclose-classareproposedtodescribekineticpropertiesofasingleionchannelFurthermore,aproceduretoestimatetheparametersinthemodelissuggestedandillustratedwithexamplesinpharmacology.

关键词： 0-Memory renewalrate maximumlikelihood singleionchannel patchclamp

STUDY OF THE EXTERNAL COUNTERPULSATION (ECP) THERAPY FOR SENILE DEMENTIA OF THE ALZHEIMER'S TYPE (SDAT)

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Chinese Medical Journal 1994年第10期 37-42页

作者：李卫平姚志彬杨文俊陈以慈彭武和胡平 DepartmentofBrainResearch DepartmentofBrainResearch DepartmentofAnatomy DepartmentofNeurology SunYat-SenUniversityofMedicalSciencesGuangzhou510515 DepartmentofNuclearMedicine DepartmentofNuclearMedicine NanfangHospiatlGuangzhoutheFirstTeachingHospitalofSunYat-SenUniversityofMedicalSciencesGuangzhouTenpatientswithSDATreceivedtheECPtherapy.TheexaminationofHasegawa'sDementiaScale(HDS)singlephotoremissioncomputedtomography(SPECT)brainimagingandsomebiochemicalparametersinbloodandCSFwereselectedtoevaluatetheeffectofECPforSDAT.

Ten patients with SDAT received the ECP *** examination of Hasegawa’s Dementia Scale(HDS),single photor emission computed tomography (SPECT) brain imaging,and some biochemical parameters in blood and CSF were selecte... 详细信息

关键词： ECP THERAPY FOR SENILE DEMENTIA OF THE ALZHEIMER’S TYPE STUDY OF THE EXTERNAL COUNTERPULSATION SDAT

Fresh Amniotic Membrane Transplantation for Conjunctival Surface Reconstruction

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眼科学报 1999年第3期15卷 169-173页

作者： ZhouSY ChenJQ ZhongshanOphthalmicCentre SunYat－senUniversityofMedicalSciencesGuangzhou510060China ZhongshanOphtha

Purpose:To determine whether fresh human amniotic membrane can be used to reconstruct the conjunctiveal defect creates during symblepharon ***:Forth-two eyes of 39 consecutive patients with eye burns and Stevens-Johnson syndrome were randomized to accept fresh or preserved human amniotic membrane transplantation(AMT) during the period of severe *** cytology was performed in 12 eyes with normal tear secretion which received fresh ***:During a mean follow-up of 11 months (range,6 to 18 months),thirty-five patients (37 eyes)showed successful ocular surface reconstruction and resolution of motility restriction while four patients (2 eyes with fresh AMT,3 eye with preserved AMT)with minimal recurrence of *** was no significant difference statistically between two groups(Chi-square test).Amniotic epithelial cells can survive about three months after being transplanted onto ocular surfaces with normal tear ***:Both fresh and preserved human amniotic membrane can be considered an ideal alternative substrate for conjunctival surface reconstruction during removal of severe symblepharon.

关键词：新鲜羊膜羊膜移植结膜表面重建

Influence of the Application of MRI on the T, N Staging System of Nasopharyngeal Carcinoma

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Chinese Journal of Clinical Oncology 2004年第5期1卷 348-353页

作者： ChuanmiaoXie BilingLiang HaogaoUn PeihongWu DepartmentofMedicalImagingandInterventionalRadiology CancerCenterSunYat-senUniversityofMedicalSciencesGuangzhou510060China

OBJECTIVE To investigate the influence of utilizing MRI on the T, N staging system (the 5th edition, UICC) and on the 1992 China staging systems (Fuzhou-Guangzhou,China) by comparing the results of CT and MRI examinations of nasopharyngeal carcinoma (NPC).METHODS All 56 NPC patients, which were confirmed by histology,accepted both CT and MRI examinations. CT system scans were obtained by using an Elscient CT Twin Flash with the conventional axial scan. Three cases were examined by an additional coronary scan and 16 patients received an enhanced CT. The MR imaging was performed with a 0.5T MR system (Philips T5- II Ultra-Magnetic). The conventional axial, sagittal and coronary sections with SE sequences were obtained. The scan field was from the supra sellar cistern to the inferior border of C2. Most patients (50/56) accepted contrast enhanced *** The pharyngobasilar fascia can clearly be seen on MRI but not on CT, so MRI can accurately determine the lesion in the nasopharyngeal cavity. MRI is more sensitive for evaluation of tumor involvement of soft tissue such as the Iongus colli muscle (14 cases by CT and 26 by MRI), tensor veli patalini muscle and levator veli palatini muscle (17 cases by CT and 23 by MRI), and skull-base bone marrow invasion (15 cases by CT and 42 by MRI). MRI can also demonstrate the invasion of the carotid sheath area and the enlargement of retropharyngeal lymph nodes more definitely than *** involvement of the trigeminal nerve can be detected on MRI, which may influence the clinical staging *** Of the 56 cases examined, 16 (28.6%) changed the staging based on UICC staging; while 33.9% (19/56) cases changed based on the 1992 China-stagin9 system. The major influence of MRI examinations on the 1992 staging was to differentiate the involvement of the carotid sheath area from metastasis of the retropharyngeal lymph nodes. There also was a significant difference in finding early invasion of the skull base.

关键词：敷贴剂 MRI 分段运输系统鼻咽癌肿瘤 NPC

Preliminary Study on in Vitro Induced Differentiation of Embryonic Stem Cells into Neurons

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眼科学报 2000年第1期16卷 1-6页

作者： JianGe ShunongLI 等 ZhongshanOphthalmicCenter PathophysiologicalDepartmentSunYat－senuniversityofmedicalsciences Guangzhou

Purpose:To study preliminarily in vitro induced differentiation of embryonic stem cells into neurons for further investigation of an alternative for the treatment of glaumatous *** and methods:Supernatant of cultured Buffalo rat liver cells(buffalorat liver cell-conditioned medium,BRL-CM)was used for culturing embryonic stem cells(ES-D3 cell line),Morphological features of undifferentiated EScells were studied by HE staining and electron *** on the methods used by Bain et al,we modified the methods and used retinoic acid(RA)as an inducer to differentiate ES-D3 cells and cytosine arabinoside(Ara-C)as inhibitor of proliferative *** growth of the cells was observed under phase contrast ***:ES-D3cells cultured by BRL-CMgrew in aggregates and remained *** showed large nucleus and a large amount of mitochondria in undifferentiated ES cells and many processes on the *** the first day after the adding of retinoic acid,some neuron-like cells with one,two or more processes were *** the second day after adding RAand the first day after the plus of 10μm Ara-C,a large amount of neuron-like cells appeared,with the formation of neuron-like *** clusions:Combined use of RA and Ara-Ccan induce ES cells to differentiate into neuron-like *** present preliminary study might provide insights into an alternative for the treatment of glaucomatous neuropathy by the transplantation of embryonic stem *** Science2000;16:1-6.

关键词：青光眼神经元胚胎干细胞干细胞移植

KAI1/CD82 gene expression in benign prostatic hyperplasia and late-stage prostate cancer in Chinese

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Asian Journal of Andrology 2000年第3期2卷 221-224页

作者： Wei-LieHU Ying-QiuLI Hui-XuHE Qing-RongLI YeTIAN Ri-QuanLAI HuaMEI DepartmentofUrology theGeneralHospitalofGuangJumMilitaryAreaChinesePeople＇sLiberationArmyGuangzhouChina LifeScienceCollege SunYat-SenUniversityGuangzhouChina FirstAffiliatedHospital SunYat-SenUniversityofMedicalSciencesGuangzhouChina DepartmentofUrology theGeneralHospitalofGuangJumMilitaryAreaChinesePeople＇sLiberationArmyGuangzhouChina

Aim: To evaluate KAII/CD82 expression in Chinese patients with benign prostatic hyperplasia (BPH) and late-stage carcinoma of prostate (CaP). Methods: Thirty Chinese patients with benign prostatic hyperplasia and 34 withCaP (adenocarcinoma clinical stage C and D) were analyzed by means of immunohistochemical methods. Results:The KAII/CD82 expression in BPH tissue was all positive, which was uniformly located on the glandular cell mem-brane at the cell-to-cell borders, but KAII/CD82 expression in metastasis CaP tissues was either significantly lower thanthat of BPH or negative, and the immunostaining pattern was not continuous. In late-stage CAP KAII/CD82 expressionwas correlated inversely to the pathological grade ( P 0.05). Conclusion:The authors believe that decreased and negative KAII/CD82 expression in late-stage CaP may be related to tumor pro-gression and metastasis, and appears to be a prognostic marker.

关键词： KAII/CD82 metastasis suppressor gene expression benign prostatic hyperplasia prostatic neoplasms immunohistochemistry

High Frequency Color Doppler Image of Choroidal Detachment

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眼科学报 2002年第1期18卷 61-64页

作者： JinghongWu LijuanZou 等 ZhongshanOphthalmicCenter SunYat－senUniversityofMedicalSciencesGuangzhou510060China

Purpose:To study the Color Doppler Image (CDI) characteristics of choroidal detachment and the applied value of ***:Seventy-two cases (74 eyes) of choroidal detachment were studied ***:The typical ultragraph of chroridal detachment displayed one or several smooth hemispherical or lobuler circular thick bands, with convex side toward vitreous *** of the choroidal detachments were located before the equator, a few of them were beyond the *** displayed blood flow singnal in the *** Doppler showed the frequency spectrum features of retinal detachment band were similar to those of central retinal vessels, whereas the frequency spectum features of choroidal detachment bend resembled those of ciliary artery in some cases of retinal detachment (RD) accompanied by choroidal ***:CDI could make a correct and precise diagnosis of choroidal *** Science 2000;16:61-64.

关键词：脉络膜脱离高频彩色多普勒图像 CDI 诊断