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Modeling of aggregation kernels for fluidized beds using discrete particle model simulations

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Particuology 2014年第2期12卷 134-144页

作者： Nageswara Rao Narni Mirko Peglow Gerald Warnecke Jitendra Kumar Stefan Heinriche J.A.M.Kuipers Department of Mathematics Rajiv Gandhi University of Knowledge TechnologiesGachibowliHyderabad 500032India Institute for Process Engineering Otto-von-Guericke-University MagdeburgUniversitatsplatz 2D-39106 MagdeburgGermany Institute for Analysis and Numerics Otto-von-Guericke-University MagdeburgUniversitatsplatz 2D-39106 MagdeburgGermany Department of Mathematics ⅡT KharagpurIndia Institute of Solids Process Engineering and Particle TechnologyHamburg University of TechnologyHamburgGermany eindhoven university of technology-smr P.O.Box 5135600 MB EindhovenThe Netherlands

Aggregation is one of the many important processes in chemical and process engineering. Several researchers have attempted to understand this complex process in fluidized beds using the macro-model of population balance equations （PBEs）. The aggregation kernel is an effective parameter in PBEs, and is defined as the product of the aggregation efficiency and collision frequency functions. Attempts to derive this kernel have taken different approaches, including theoretical, experimental, and empirical techniques. The present paper calculates the aggregation kernel using micro-model computer simulations, i.e., a discrete particle model. We simulate the micro-model without aggregation for various initial conditions, and observe that the collision frequency function is in good agreement with the shear kernel. We then simulate the micro-model with aggregation and calculate the aggregation efficiency rate.

关键词： Aggregation kernelsMulti-phase flowCollision frequency functionAggregation efficiency rateBed parameter

Numerical analysis of the unsteady behavior of cloud cavitation around a hydrofoil based on an improved filter-based model

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Journal of Hydrodynamics 2015年第5期27卷 795-808页

作者：张德胜王海宇施卫东张光建 Van ESCH B.P.M.(Bart) Research Center of Fluid Machinery Engineering and technology Jiangsu University Department of Mechanical Engineering Eindhoven University of Technology

The unsteady cavitation evolution around the Clark-Y hydrofoil is investigated in this paper, by using an improved filter-base model（FBM） with the density correction method（DCM）. To improve the prediction accuracy, the filter scale is adjusted based on the grid size. The numerical results show that a small filter scale is crucial for the unsteady simulations of the cavity shedding flow. The hybrid method that combines the FBM and the DCM could help to limit the overprediction of the turbulent viscosity in the cavitation region on the wall of the hydrofoil and in the wake. The large value of the maximum density ratio ρ1 /ρv, clip promotes the mass transfer rate between the liquid phase and the vapor phase, which results in a large sheet cavity length and the vapor fraction rise inside the cavity. The cavity patterns predicted by the improved method are verified by the experimental visualizations. The time-average lift, the drag coefficient and the primary oscillating frequency St for the cavitation number σ= 0.8, the angle of attack, α= 8°, at a Reynolds number Re= 7×10^5 are 0.735, 0.115 and 0.183, respectively, and the predicted errors are 3.29%, 3.36% and 8.93%. The typical three stages in one revolution are well-captured, including the initiation of the sheet/attached cavity, the growth toward the trailing edge（TE） with the development of the re-entrant jet flow, and the large scale cloud cavity shedding. It is observed that the cloud cavity shedding flow induces the vortex pairs of the TE vortices in the wake and the shedding vortices. The positive vorticity vortex of the re-entrant jet and the TE vortices interacts and merges with the negative vorticity vortex of the leading edge（LE） cavity to produce the shedding flow.

关键词： filter-based model(FBM) density correction method cloud cavitation hydrofoil unsteady behavior

Ultrasmall,elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1660-1670页

作者： Lu Su Kellie S.Dalby Hannah Luehmann Sussana A.Elkassih Sangho Cho Xun He Lisa Detering Yen-Nan Lin Nari Kang Dennis A.Moore Richard Laforest Guorong Sun Yongjian Liu Karen L.Wooley Department of Chemistry Department of Materials Science and Engineeringand Department of Chemical EngineeringTexas A&M UniversityCollege StationTX 77842USA Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems Eindhoven University of TechnologyEindhovenMB 5600The Netherlands Mallinckrodt Institute of Radiology Washington University School of MedicineSaint LouisMO 63110USA Bayer AG Creve CoeurMO 63167USA

To expand the single-dose duration over which noninvasive clinical and preclinical cancer imaging can be conducted with high sensitivity,and well-defined spatial and temporal resolutions,a facile strategy to prepare ultrasmall nanoparticulate X-ray contrast media(nano-XRCM)as dual-modality imaging agents for positron emission tomography(PET)and computed tomography(CT)has been *** from controlled copolymerization of triiodobenzoyl ethyl acrylate and oligo(ethylene oxide)acrylate monomers,the amphiphilic statistical iodocopolymers(ICPs)could directly dissolve in water to afford thermodynamically stable solutions with high aqueous iodine concentrations(>140 mg iodine/mL water)and comparable viscosities to conventional small molecule *** formation of ultrasmall iodinated nanoparticles with hydrodynamic diameters of ca.10 nm in water was confirmed by dynamic and static light scattering *** a breast cancer mouse model,in vivo biodistribution studies revealed that the64Cu-chelator-functionalized iodinated nano-XRCM exhibited extended blood residency and higher tumor accumulation compared to typical small molecule imaging ***/CT imaging of tumor over 3 days showed good correlation between PET and CT signals,while CT imaging allowed continuous observation of tumor retention even after 10 days post-injection,enabling longitudinal monitoring of tumor retention for imaging or potentially therapeutic effect after a single administration of nano-XRCM.

关键词： Amphiphilic statistical iodocopolymer CT X-ray contrast media Ultrasmall nanoassembly PET/CT Longitudinal tumor monitoring

Design and implementation of a platform for configuring clinical dynamic safety checklist applications

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Frontiers of Information technology & Electronic Engineering 2018年第7期19卷 937-946页

作者： Shan NAN Xu-dong LU Pieter VAN GORP Hendrikus H.M.KORSTEN Richard VDOVJAK Uzay KAYMAK Hui-long DUAN Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China School of Industrial Engineering Eindhoven University of Technology Eindhoven 5600 MB the Netherlands Department of Aneasthiaology and Intensive-Care Catharina Ziekenhuis Eindhoven 5623 E J the Netherlands Philips Research eindhoven Eindhoven 5656 AE the Netherlands

In recent years, it has been demonstrated that checklists can improve patient safety significantly. To facilitate the effective use of checklists in daily practice, both the medical community and the informatics community propose to implement checklists in dynamic checklist applications that can be integrated into the clinical workflow and that is specific to the patient context. However, it is difficult to develop such applications because they are tightly intertwined with the content of specific checklists. We propose a platform that enables access to dynamic checklist applications by configuring the infrastructures provided in the platform. Then, the applications can be developed without time-consuming programming work. We define a number of design criteria regarding point of care and clinical processes by analyzing the existing checklist applications and the lessons learned from ***, by applying rule-based clinical decision support and workflow management technologies, we design technical mechanisms to satisfy the design criteria. A dynamic checklist application platform is designed based on these mechanisms. Finally, we build a platform in various design cycle iterations, driven by multiple clinical cases. By applying the platform, we develop nine comprehensive dynamic checklist applications with 242 dynamic *** results demonstrate both the feasibility and the overall generic nature of the proposed approach. We propose a novel platform for configuring dynamic checklist applications. This platform satisfies the general requirements and can be easily configured to satisfy different scenarios in which safety checklists are used.

关键词：应用程序设计标准动态安全平台基清单临床设置工作流管理技术

Network Visualization in Cell Biology

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Tsinghua Science and technology 2012年第4期17卷 365-382页

作者： Kasper Dinkla Michel A.Westenberg Department of Mathematics and Computer Science Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands

Many of the processes known to take place in biological cells are analyzed in the form of different types of network. The complexity of these networks increases along with our knowledge of these processes, making their analysis more difficult. Network visualization is a powerful analysis method that will have to be developed further to deal with this complexity. This survey provides a brief overview of network visualization in general, followed by an in-depth discussion of its application to three network types specific to cell biology, namely gene regulatory, protein interaction, and metabolic networks. Finally, we discuss the difficulty of visually integrating these network types and trying to compare networks of cells that belong to different organisms.

关键词： gene regulation metabolic network protein interaction visualization

Heritage attributes of post-war housing in Amsterdam

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Frontiers of Architectural Research 2020年第1期9卷 1-19页

作者： Lisanne Havinga Bernard Colenbrander Henk Schellen Department of the Built Environment Eindhoven University of TechnologyEindhoventhe Netherlands

Modern heritage,particularly post-war social housing estates,is struggling with negative ***,this research aims to contribute to a better understanding of the heritage significance of post-war housing estates in general and the Western Garden Cities-a post-war neighborhood in Amsterdam-in particular.A review of the limited body of literature on the heritage significance of modern and post-war housing estates was performed.A significance assessment was conducted on a sample of representative case studies by using expert interviews for data *** experts assigned significance levels to attributes based on whether or not they need to be preserved during a sustainable *** highest-valued attributes are parcellation,balconies,and semi-public green *** most negative value was assigned to the application of external insulation,replacement of the window frames by PVC-U,and closed character of the fa(c)ades on the ground floor *** lack of heritage recognition at the lower scale level may either be due to the important details already being lost or details not yet consistently being recognized as the architecture and buildings are understudied in comparison with the urban qualities of post-war heritage.

关键词： Heritage Significance Attributes Management of change Sustainable refurbishment Heritage impact

Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues

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Bioactive Materials 2023年第1期19卷 268-281页

作者： Arwa Daghrery Jessica A.Ferreira Jinping Xu Nasim Golafshan Darnell Kaigler Sarit B.Bhaduri Jos Malda Miguel Castilho Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUnited States Department of Restorative Dental Sciences School of DentistryJazan UniversityJazanKingdom of Saudi Arabia Department of Orthopedics University Medical Center UtrechtUtrechtthe Netherlands Regenerative Medicine Center Utrechtthe Netherlands Department of Periodontics and Oral Medicine School of DentistryUniversity of MichiganAnn ArborMIUnited States Department of Mechanical Industrial and Manufacturing EngineeringUniversity of ToledoToledoOHUnited States EEC Division Directorate of EngineeringThe National Science FoundationAlexandriaVAUnited States Department of Clinical Sciences Faculty of Veterinary MedicineUtrecht UniversityUtrechtthe Netherlands Department of Biomedical Engineering Eindhoven University of TechnologyEindhoventhe Netherlands Institute for Complex Molecular Systems Eindhoven University of TechnologyP.O.Box 5135600 MB Eindhoventhe Netherlands Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUnited States

Periodontitis is a chronic inflammatory condition that often causes serious damage to tooth-supporting *** limited successful outcomes of clinically available approaches underscore the need for therapeutics that cannot only provide structural guidance to cells but can also modulate the local immune ***,three-dimensional melt electrowritten(i.e.,poly(ε-caprolactone))scaffolds with tissue-specific attributes were engineered to guide differentiation of human-derived periodontal ligament stem cells(hPDLSCs)and mediate macrophage *** investigated tissue-specific scaffold attributes comprised fiber morphology(aligned ***)and highly-ordered architectures with distinct strand spacings(small 250μm and large 500μm).Macrophages exhibited an elongated morphology in aligned and highly-ordered scaffolds,while maintaining their round-shape on randomly-oriented fibrous *** of periostin and IL-10 were more pronounced on the aligned and highly-ordered *** hPDLSCs on the scaffolds with 500μm strand spacing show higher expression of osteogenic marker(Runx2)over 21 days,cells on randomly-oriented fibrous scaffolds showed upregulation of M1 *** an orthotopic mandibular fenestration defect model,findings revealed that the tissue-specific scaffolds(i.e.,aligned fibers for periodontal ligament and highly-ordered 500μm strand spacing fluorinated calcium phosphate[F/CaP]-coated fibers for bone)could enhance the mimicking of regeneration of natural periodontal tissues.

关键词： Periodontitis Melt electrowriting 3D printing Inflammation Periodontal regeneration Scaffold

Space-time prism in multimodal supernetwork-Part 1:Methodology

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Communications in Transportation Research 2021年第1期1卷 130-138页

作者： Jing Qin Feixiong Liao Urban Planning and Transportation Group Eindhoven University of TechnologyEindhoven5600 MBthe Netherlands

Space-time prism(STP)modeling offers a theoretical base for various person-based space-time accessibility *** has been challenging to construct STPs in multimodal transportation networks because of the vast multimodal trip chaining options between private vehicles and public *** study suggests an effective method for narrowing down the trip chaining *** method involves three incremental strategies to eliminate parking locations that contribute little to enlarging the ***,an upper bound potential path area(PPA)is constructed to remove all inferior parking ***,the study area is partitioned and only complementary parking locations attractive to trip chaining are ***,triangular inequalities are applied for *** selected parking locations are used to construct a compact multimodal supernetwork encompassing one episode of activity ***,the STP and PPA can be found by an existing twostage bidirectional search *** tests are conducted to demonstrate the effectiveness of the *** is found that 1-2 orders of speedups can be achieved with little compromising the accuracy of measuring space-time *** suggested method is applicable for measuring space-time accessibility in large-scale multimodal transportation networks.

关键词： Space-time prism Accessibility Trip chaining Multimodal supernetwork

Nitridation of Ni-based alloys:thermodynamics,kinetics,and deformation phenomena accompanying internal precipitation

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Rare Metals 2006年第5期25卷 501-511页

作者： Alexander A.Kodentsov Jorma K.Kivilahti Frans J.J.van Loo Laboratory of Materials and Interface Chemistry Eindhoven University of TechnologyP.O.Box 5135600 MBEindhovenThe Netherlands Laboratory of Electronics Production technology Helsinki University of TechnologyFIN-02150 EspooFinland

When a moderately stable phase is precipitated out during an intemal reaction, the behaviour of the penetrating atoms within the diffusion zone can be interpreted based on thermodynamic considerations. Evidence for “up-hill” diffusion of the penetrating species through the matrix towards the precipitation front during the intemal nitridation of Ni-Cr alloys at 1125℃ and 6000 bar of N2-pressure was predicted. Such behaviour of nitrogen is opposite to the boundary conditions in Wagner＇s description of internal reactions. A volume change associated with the precipitation reaction resulted in a stress gradient between the alloys surface and the intemal nitridation front. Stress relief occurred mainly by transport of nickel to the gas/metal interface. Pipe diffusion-controlled creep is the dominant stress accommodation mechanism during nitriding of dilute Ni-Cr alloys at 700℃ under a flowing NH3 ＋ H2 gas mixture.

关键词： nitridation nickel alloys thermodynamics diffusion internal precipitation