Ultrasmall,elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers

作     者：Lu Su Kellie S.Dalby Hannah Luehmann Sussana A.Elkassih Sangho Cho Xun He Lisa Detering Yen-Nan Lin Nari Kang Dennis A.Moore Richard Laforest Guorong Sun Yongjian Liu Karen L.Wooley Lu Su;Kellie S.Dalby;Hannah Luehmann;Sussana A.Elkassih;Sangho Cho;Xun He;Lisa Detering;Yen-Nan Lin;Nari Kang;Dennis A.Moore;Richard Laforest;Guorong Sun;Yongjian Liu;Karen L.Wooley

作者机构：Department of ChemistryDepartment of Materials Science and Engineeringand Department of Chemical EngineeringTexas A&M UniversityCollege StationTX 77842USA Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular SystemsEindhoven University of TechnologyEindhovenMB 5600The Netherlands Mallinckrodt Institute of RadiologyWashington University School of MedicineSaint LouisMO 63110USA Bayer AGCreve CoeurMO 63167USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第4期

页      面：1660-1670页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：financial support from the National Science Foundation(DMR-1905818 and REU Grant CHE1062840,USA) the Robert A.Welch Foundation through the W.T.Doherty-Welch Chair in Chemistry(A-0001,USA) 

主　　题：Amphiphilic statistical iodocopolymer CT X-ray contrast media Ultrasmall nanoassembly PET/CT Longitudinal tumor monitoring 

摘      要：To expand the single-dose duration over which noninvasive clinical and preclinical cancer imaging can be conducted with high sensitivity,and well-defined spatial and temporal resolutions,a facile strategy to prepare ultrasmall nanoparticulate X-ray contrast media(nano-XRCM)as dual-modality imaging agents for positron emission tomography(PET)and computed tomography(CT)has been *** from controlled copolymerization of triiodobenzoyl ethyl acrylate and oligo(ethylene oxide)acrylate monomers,the amphiphilic statistical iodocopolymers(ICPs)could directly dissolve in water to afford thermodynamically stable solutions with high aqueous iodine concentrations(140 mg iodine/mL water)and comparable viscosities to conventional small molecule *** formation of ultrasmall iodinated nanoparticles with hydrodynamic diameters of ca.10 nm in water was confirmed by dynamic and static light scattering *** a breast cancer mouse model,in vivo biodistribution studies revealed that the64Cu-chelator-functionalized iodinated nano-XRCM exhibited extended blood residency and higher tumor accumulation compared to typical small molecule imaging ***/CT imaging of tumor over 3 days showed good correlation between PET and CT signals,while CT imaging allowed continuous observation of tumor retention even after 10 days post-injection,enabling longitudinal monitoring of tumor retention for imaging or potentially therapeutic effect after a single administration of nano-XRCM.