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Deep electrical structures of Qinzhou-Fangcheng Junction Zone in guangxi and seismogenic environment of the 1936 Lingshan M6^(3/4)earthquake

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Science China Earth Sciences 2024年第2期67卷 584-603页

作者： Bin ZHOU Chunheng YAN Yan ZHAN Xiangyu SUN Sha LI Xiang WEN Yajun MO Yongdong YUAN Yuan YUAN Meili HUANG earthquake agency of guangxi zhuang autonomous region Nanning530022China State Key Laboratory of earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China guangxi Geophysical Survey Institute Liuzhou545005China

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in *** zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 Lingshan M6^(3/4)earthquake in ***,this region serves as an optimal location for researching the origins of intraplate earthquakes in South *** study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the guangxi QFJZ and the Lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the *** main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic *** analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal *** results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-Lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep *** electrical boundary zones,DXf and HBf2,were *** inclined towards the northwest,while HBf2 inclined towards the *** FangchengLingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper *** the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the Yangtze Block(YB).The southeastern side of this bloc

关键词： South China Block Qinzhou-Fangcheng Junction Zone Magnetotelluric 1936 Lingshan M6^(3/4)earthquake Deep seismogenic environment

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Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress

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World Journal of Gastroenterology 2024年第19期30卷 2564-2574页

作者： Yan-Fei Li Fang-Yuan Zheng Xin-Yu Miao Hai-Long Liu Yao-Yao Zhang Nai-Xia Chao Fa-Rong Mo School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Biological Molecular Medicine Research(guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Development and Disease Research(guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M *** research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely *** To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC *** Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down ***,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in *** proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,*** expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western ***,apoptosis was investigated using flow cytometry,qRT-PCR,and western *** CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in ***25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC *** The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signali

关键词： Cell division cyclin 25C Hepatocellular carcinoma Endoplasmic reticulum stress Proliferation Apoptosis

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Comparison of different preoperative objective nutritional indices for evaluating 30-d mortality and complications after liver transplantation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 143-154页

作者： Chuan Li Hong-Xia Chen Yan-Hua Lai Department of Transplantation People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Pharmacy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The nutritional status is closely related to the prognosis of liver transplant re-cipients,but few studies have reported the role of preoperative objective nutri-tional indices in predicting liver transplant *** To compare the predictive value of various preoperative objective nutritional indicators for determining 30-d mortality and complications following liver transplantation(LT).METHODS A retrospective analysis was conducted on 162 recipients who underwent LT at our institution from December 2019 to June *** This study identified several independent risk factors associated with 30-d mor-tality,including blood loss,the prognostic nutritional index(PNI),the nutritional risk index(NRI),and the control nutritional *** 30-d mortality rate was 8.6%.Blood loss,the NRI,and the PNI were found to be independent risk factors for the occurrence of severe postoperative *** NRI achieved the highest prediction values for 30-d mortality[area under the curve(AUC)=0.861,P<0.001]and severe complications(AUC=0.643,P=0.011).Compared to those in the high NRI group,the low patients in the NRI group had lower preoperative body mass index and prealbumin and albumin levels,as well as higher alanine aminotransferase and total bilirubin levels,Model for End-stage Liver Disease scores and prothrombin time(P<0.05).Furthermore,the group with a low NRI exhibited significantly greater incidences of intraabdominal bleeding,primary graft nonfunction,and *** The NRI has good predictive value for 30-d mortality and severe complications following *** NRI could be an effective tool for transplant surgeons to evaluate perioperative nutritional risk and develop relevant nutritional therapy.

关键词： Liver transplantation Nutritional indicator Complications Prognosis Nutrition assessment

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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu Shen Yong Zhang Fang Wu Mei-Zhen Shen Jun-Lin Liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li Ren-Sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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Explosion of research on psychopathology and social media use after COVID-19:A scientometric study

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World Journal of Psychiatry 2024年第5期14卷 742-759页

作者： Meng-Di Zhang Rong-Quan He Jia-Yuan Luo Wan-Ying Huang Jing-Yu Wei Jian Dai Hong Huang Zhen Yang Jin-Liang Kong Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Psychology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Division of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019(COVID-19)*** To explore the status of research on psychopathology and social media use before and after the COVID-19 *** We used Bibliometrix(an R software package)to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection,PubMed,and Scopus *** Such research output was scarce before COVID-19,but exploded after the pandemic with the publication of a number of high-impact *** authors and institutions,located primarily in developed countries,maintained their core positions,largely uninfluenced by COVID-19;however,research production and collaboration in developing countries increased significantly after *** the analysis of keywords,we identified commonly used methods in this field,together with specific populations,psychopathological conditions,and clinical *** have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression,with depression detection becoming a new *** in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions,and more indepth clinical studies should be conducted in the *** After COVID-19,there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies.

关键词： Psychopathology Social media Bibliometrics Web of Science PubMed Scopus

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Application of texture signatures based on multiparameter-magnetic resonance imaging for predicting microvascular invasion in hepatocellular carcinoma:Retrospective study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1309-1318页

作者： Hai-Yang Nong Yong-Yi Cen Mi Qin Wen-Qi Qin You-Xiang Xie Lin Li Man-Rong Liu Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite continuous changes in treatment methods,the survival rate for advanced hepatocellular carcinoma(HCC)patients remains low,highlighting the importance of diagnostic methods for *** To explore the efficacy of texture analysis based on multi-parametric magnetic resonance(MR)imaging(MRI)in predicting microvascular invasion(MVI)in preoperative *** This study included 105 patients with pathologically confirmed HCC,categorized into MVI-positive and MVI-negative *** employed Original Data Analysis,Principal Component Analysis,Linear Discriminant Analysis(LDA),and Non-LDA(NDA)for texture analysis using multi-parametric MR images to predict preoperative *** effectiveness of texture analysis was determined using the B11 program of the MaZda4.6 software,with results expressed as the misjudgment rate(MCR).RESULTS Texture analysis using multi-parametric MRI,particularly the MI+PA+F dimensionality reduction method combined with NDA discrimination,demonstrated the most effective prediction of MVI in *** accuracy in the pulse and equilibrium phases was 83.81%.MCRs for the combination of T2-weighted imaging(T2WI),arterial phase,portal venous phase,and equilibrium phase were 22.86%,16.19%,20.95%,and 20.95%,*** area under the curve for predicting MVI positivity was 0.844,with a sensitivity of 77.19%and specificity of 91.67%.CONCLUSION Texture analysis of arterial phase images demonstrated superior predictive efficacy for MVI in HCC compared to T2WI,portal venous,and equilibrium *** study provides an objective,non-invasive method for preoperative prediction of MVI,offering a theoretical foundation for the selection of clinical therapy.

关键词： Magnetic resonance imaging Hepatocellular carcinoma Texture analysis Microvascular invasion

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Antibody Levels and Infection Status of Pertussis in the Population under Pertussis Resurgence in guangxi in 2018:A Cross-Sectional Survey

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Biomedical and Environmental Sciences 2024年第6期37卷 628-638页

作者： Liang Liang Qiuyun Deng Lili Deng Jinghang Wei Shiyi Chen Yizhi Wei Yuyan Ma Yue Qin Wei Liu guangxi zhuang autonomous region Center for Disease Control and Prevention Nanning 530028GuangxiChina

Objective Pertussis cases have increased markedly since 2018 in *** aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident *** A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay(ELISA).Results Of the collected samples,1,833(17.94%)tested positive for anti-pertussis IgG,with the median concentration of 16.06 IU/*** levelguangxi lacked immunity against pertussis,which was one of the main factors contributing to the resurgence of pertussis in *** addition,the prevalence of pertussis is relatively high in guangxi,and its incidence is seriously underestimated,especially in adolescents and adults.

关键词： Pertussis resurgence Anti-pertussis IgG Anti-pertussis toxin IgG Antibody level Infection status

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Advances in the study of gastric organoids as disease models

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1725-1736页

作者： Yi-Yang Liu De-Kun Wu Ji-Bing Chen You-Ming Tang Feng Jiang Graduate School Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Teaching Experiment and Training Center Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Central Laboratory Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Digestive Disease Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina AIDS Research Center Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina

Gastric organoids are models created in the laboratory using stem cells and sophisticated three-dimensional cell culture *** models have shown great promise in providing valuable insights into gastric physiology and advanced disease *** review comprehensively summarizes and analyzes the research advances in culture methods and techniques for adult stem cells and induced pluripotent stem cell-derived organoids,and patient-derived *** potential value of gastric organoids in studying the pathogenesis of stomach-related diseases and facilitating drug screening is initially *** construction of gastric organoids involves several key steps,including cell extraction and culture,three-dimensional structure formation,and functional *** the structure and function of the human stomach by disease modeling with gastric organoids provides a platform to study the mechanism of gastric cancer induction by Helicobacter *** addition,in drug screening and development,gastric organoids can be used as a key tool to evaluate drug efficacy and toxicity in preclinical *** can also be used for precision medicine according to the specific conditions of patients with gastric cancer,to assess drug resistance,and to predict the possibility of adverse ***,despite the impressive progress in the field of gastric organoids,there are still many unknowns that need to be addressed,especially in the field of regenerative ***,the reproducibility and consistency of organoid cultures are major challenges that must be *** challenges have had a significant impact on the development of gastric ***,as technology continues to advance,we can foresee more comprehensive research in the construction of gastric *** research will provide better solutions for the treatment of stomach-related diseases and personalized medicine.

关键词： Organoids Stomach neoplasms Helicobacter pylori Drug evaluation Preclinical Precision

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Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites

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World Journal of Gastroenterology 2024年第29期30卷 3488-3510页

作者： Xia Liu Xing-Qiu Liang Tian-Cai Lu Zhe Feng Min Zhang Nan-Qing Liao Feng-Lian Zhang Bo Wang Li-Sheng Wang Medical College Guangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina Department of Traditional Chinese Medicine HIV/AIDS Clinical Treatment Center of Guangxi(Nanning)The Fourth People’s Hospital of NanningNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina General Manager’s Office Guangxi Fuxinyi Biological Technology Co.Ltd.Pingnan 537300Guangxi Zhuang Autonomous RegionChina Department of Joint and Sports Medicine Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Gerontology Nanning Social Welfare HospitalNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hyperuricemia(HUA)is a public health concern that needs to be solved *** lyophilized powder of Poecilobdella manillensis has been shown to significantly alleviate HUA;however,its underlying metabolic regulation remains *** To explore the underlying mechanisms of Poecilobdella manillensis in HUA based on modulation of the gut microbiota and host *** A mouse model of rapid HUA was established using a high-purine diet and potassium oxonate *** mice received oral drugs or ***,16S rRNA sequencing and ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry-based untargeted metabolomics were performed to identify changes in the microbiome and host metabolome,*** levels of uric acid transporters and epithelial tight junction proteins in the renal and intestinal tissues were analyzed using an enzyme-linked immunosorbent *** The protein extract of Poecilobdella manillensis lyophilized powder(49 mg/kg)showed an enhanced anti-trioxypurine ability than that of allopurinol(5 mg/kg)(P<0.05).A total of nine bacterial genera were identified to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which included the genera of Prevotella,Delftia,Dialister,Akkermansia,Lactococcus,Escherichia_Shigella,Enterococcus,and ***,22 metabolites in the serum were found to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which correlated to the Kyoto Encyclopedia of Genes and Genomes pathways of cysteine and methionine metabolism,sphingolipid metabolism,galactose metabolism,and phenylalanine,tyrosine,and tryptophan *** analysis found that changes in the gut microbiota were significantly related to these *** The proteins in Poecilobdella manillensis powder were effective for ***,they are associated with improvements in g

关键词： Gut microbiota Metabolism Multi-omics Poecilobdella manillensis Sphingolipid metabolism pathway Galactose metabolism pathway Hyperuricemia

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C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： Bai-Bei Li Lei-Jie Chen Shi-Liu Lu Biao Lei Gui-Lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for regional High Frequency Tumor(guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

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