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Immunogenicity and safety of a recombinant fusion protein vaccine(V-01)against coronavirus disease 2019 in healthy adults:a randomized,double-blind,placebo-controlled,phaseⅡtrial

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Chinese Medical Journal 2021年第16期134卷 1967-1976页

作者： Ya-Jun Shu Jian-Feng He Rong-Juan Pei Peng He Zhu-Hang Huang Shao-Min Chen Zhi-Qiang Ou Jing-Long Deng Pei-Yu Zeng Jian Zhou Yuan-Qin Min Fei Deng Hua Peng Zheng Zhang Bo Wang Zhong-Hui Xu Wu-Xiang Guan Zhong-Yu Hu Ji-Kai Zhang Guangdong Provinc.al Institute of Biological Products and Materia Medica GuangzhouGuangdong 510440China Guangdong Provinc.al Center for Disease Control and Prevention GuangzhouGuangdong 511430China Wuhan Institute of Virology Chinese Academy of SciencesWuhanHubei 430071China National Institutes for Food and Drug Control Beijing 100050China Gaozhou Center for Disease Control and Prevention MaomingGuangdong 525000China Livzon Bio inc. ZhuhaiGuangdong 519045China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhenGuangdong 518112China.

Background:Innovative coronavirus disease 2019(COVID-19)vaccines,with elevated global manufacturing capacity,enhanced safety and efficacy,simplified dosing regimens,and distribution that is less cold chain-dependent,are still global imperatives for tackling the ongoing pandemic.A previous phase I trial indicated that the recombinant COVID-19 vaccine(V-01),which contains a fusion protein(IFN-PADRE-RBD-Fc dimer)as its antigen,is safe and well tolerated,capable of inducing rapid and robust immune responses,and warranted further testing in additional clinical ***,we aimed to assess the immunogenicity and safety of V-01,providing rationales of appropriate dose regimen for further efficacy ***:A randomized,double-blind,placebo-controlled phaseⅡclinical trial was initiated at the Gaozhou Municipal Centre for Disease Control and Prevention(Guangdong,China)in March *** younger(n=440;18–59 years of age)and older(n=440;≥60 years of age)adult participants in this trial were sequentially recruited into two distinc. groups:two-dose regimen group in which participants were randomized either to follow a 10 or 25 mg of V-01 or placebo given intramuscularly 21 days apart(allocation ratio,3:3:1,n=120,120,40 for each regimen,respectively),or one-dose regimen groups in which participants were randomized either to receive a single injection of 50 mg of V-01 or placebo(allocation ratio,3:1,n=120,40,respectively).The primary immunogenicity endpoints were the geometric mean titers of neutralizing antibodies against live severe acute respiratory syndrome coronavirus 2,and specific binding antibodies to the receptor binding domain(RBD).The primary safety endpoint evaluation was the frequencies and percentages of overall adverse events(AEs)within 30 days after full ***:V-01 provoked substantial immune responses in the two-dose group,achieving encouragingly high titers of neutralizing antibody and anti-RBDimmunoglobulin,which peaked at day 35(161.9[95%

关键词： COVID-19 PhaseⅡ Clinical trial Recombinant fusion protein vaccine Safety Immunogenicity

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Simulation of Thermodynamics and Kinetics for KR Desulphurization

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Journal of Iron and Steel Research International 2011年第S2期18卷 98-106页

作者： XU An-jun1, ZHANG Mao-lin2, ZHANG Hui-ning1, LI An-dong3 (1. School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083,China 2. Steel-Making and Continuous Casting Engineering Institute, Capital Engineering and Research inc.rporation Limited, Beijing 100176,China 3. Stainless Steel Company, Baosteel group, Shanghai 201900,China) Univ Sci & Technol Beijing Sch Met & Ecol Engn Beijing 100083 Peoples R China Capital Engn & Res inc.Ltd Steel Making & Continuous Casting Engn Inst Beijing 100176 Peoples R China Stainless Steel Co Baosteel Grp Shanghai 201900 Peoples R China

This paper seeks to optimize parameters, reduce the cost of desulphurization and the consumption of operation about KR pretreatment of hot metal at the Stainless Steel Company, Baosteel group. Based on the theoretical analysis of physical chemistry in metallurgy, simulation experiments of the KR desulphurization of hot metal were conducted in a laboratory and the composition of the desulphurization was optimized, by means of chemical analysis, DSC, SEM and EDS. The water modeling displays the fluid flow characteristics of KR desulphurization. Combination of the techniques and production at the Stainless Steel Company, Baosteel group, the optimized parameters of the process are put forward.

关键词： desulphurization of hot metal KR, desulphurization thermodynamics water model

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Correction to:Application of long-reach directional drilling boreholes for gas drainage of adjacent seams in coal mines with severe geological conditions

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International Journal of Coal Science & Technology 2023年第3期10卷 225-225页

作者： Grzegorz Lesniak Daniel J.Brunner Tomasz Topor Matgorzata Stota-Valim Renata Cicha-Szot Bartomiej Jura Jacek Skiba Arnold Przystolik Ben Lyddall Grzegorz Plonka Oil and Gas Institute-National Research Institute Lubicz 25A31-503KrakowPoland REI Drilling INC.250 West Berger Lane84107 Salt Lake CityUTUSA Central Mining Institute 40-166 KatowicePoland Polish Mining group(PGG) Powstancow 3040-039 KatowicePoland

Correction:International Journal of Coal Science&Technology(2022)9:88 https:/***/10.1007/s40789-022-00553-6 In this article,the author would like to change the Ethics Declaration as below:EthicsDeclarations Scientific work published within the framework of an international project DD-MET co-financed by the Research Fund for Coal and Steel(RFCS),(Grant Agreement:847338)and by the Polish Ministry of Science and Higher Education(Contract no.5073/FBWiS/19/2020/2 and 5038/FBWiS/2019/2).

关键词： directional finance seam

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圣人之道,吾性自足:自我概念对生命意义的影响

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心理科学 2020年第6期43卷 1506-1513页

作者：张荣伟李丹 Pual T.P.Wong 中共福建省委党校福建行政学院公共管理教研部福州350001 Meaning-Centered Counselling Institute inc. TorontoCanadaM2M 4C5 上海师范大学教育学院心理学系上海200234 Department of Psychology Trent UniversityPeterboroughCanadaK9L 0G2

生命意义是人类生命存在的永恒追求。东西方的理论均认为意义源于个体内在的自我结构,即自我概念。为了验证自我概念对生命意义的影响,对68名大学生进行实验研究。现场实验结果显示,控制生命意义基线水平和正负情绪后,自我概念仍显著预... 详细信息

生命意义是人类生命存在的永恒追求。东西方的理论均认为意义源于个体内在的自我结构,即自我概念。为了验证自我概念对生命意义的影响,对68名大学生进行实验研究。现场实验结果显示,控制生命意义基线水平和正负情绪后,自我概念仍显著预测生命意义;且自我概念提高组的生命意义得分显著高于自我概念降低组。行为实验结果显示,在高、低生命意义词汇记忆任务中,相比于低生命意义词,自我概念提高组对高生命意义词的再认率更高;相比于高生命意义词,自我概念降低组对低生命意义词的再认率更高。这些结果均表明,自我概念影响生命意义。研究结果暗示,构建积极的自我概念,祛除世俗之心保存本心本性,形成强大的内心才是个体生命意义构建的根本途径。

关键词：自我概念生命意义实验研究

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Diffusion tensor imaging in the courtroom:Distinc.ion between scientific specificity and legally admissible evidence

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World Journal of Clinical Cases 2023年第19期11卷 4477-4497页

作者： Jennifer Christine van Velkinburgh Mark D Herbst Stewart M Casper Science Communication Filipodia Publishing LLCSanta FeNM 87505United States Diagnostic Radiology Independent Diagnostic Radiology IncSt PetersburgFL 33711United States Personal Injury Law Casper&DeToledo LLCStamfordCT 06905United States

Interest and uptake of science and medicine peer-reviewed literature by readers outside of a paper’s topical subject,field or even discipline is *** the application of knowledge from one field or discipline to others can stimulate innovative solutions to problems facing modern society,it is also fraught with danger for *** the practice of law in the United States,academic papers are submitted to the courts as evidence in personal injury litigation from both the plaintiff(complainant)and *** transcendence of an academic publication over disciplinary boundaries is immediately met with the challenge of application by a group that inherently lacks in-depth knowledge on the scientific method,the practice of evidence-based medicine,or the publication process as a structured and internationally synthesized process involving peer review and guided by ethical standards and norms.A modern-day example of this is the ongoing conflict between the sensitivity of diffusion tensor imaging(DTI)and the legal standards for admissibility of evidence in litigation cases of mild traumatic brain injury(mTBI).In this review,we amalgamate the peer-reviewed research on DTI in mTBI with the court’s rationale underlying decisions to admit or exclude evidence of DTI abnormalities to support claims of brain *** found that the papers which are critical of the use of DTI in the courtroom reflect a primary misunderstanding about how diagnostic biomarkers differ legally from relevant and admissible *** clinical use of DTI to identify white matter abnormalities in the brain at the chronic stage is a valid methodology both clinically as well as forensically,contributes data that may or may not corroborate the existence of white matter damage,and should be admitted into evidence in personal injury trials if supported by a *** also delve into an aspect of science publication and peer review that can be manipulated by scientists and clinicians to

关键词： Diffuse axonal injury Mild brain injury Magnetic resonance imaging Neuroimaging Medicolegal Litigation Medical jurisprudence Ethics Peer review Publishing

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New Year's greeting and overview of Artificial Intelligence in Medical Imaging in 2021

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Artificial Intelligence in Medical Imaging 2021年第1期2卷 1-4页

作者： Yun-Xiaojian Jun Shen Production Department Baishideng Publishing Group IncPleasantonCA 94566United States Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina

As editors of Artificial Intelligence in Medical Imaging(AIMI),it is our great pleasure to take this opportunity to wish all of our authors,subscribers,readers,Editorial Board members,independent expert referees,and staff of the Editorial Office a Very Happy New *** behalf of the Editorial Team,we would like to express our gratitude to all of the authors who have contributed their valuable manuscripts,our independent referees,and our subscribers and readers for their continuous support,dedication,and *** with an excellent of team effort by our Editorial Board members and staff of the Editorial Office,AIMI advanced in 2020 and we look forward to greater achievements in 2021.

关键词： New Year’s greeting Artificial Intelligence in Medical Imaging Baishideng Journal development

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Cholangioscopy-assisted guidewire placement in a malignant biliary stricture: A case report

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World Journal of Surgical Procedures 2020年第2期10卷 3-8页

作者： Grace E Kim David Yung-An Lo Internal Medicine University of Maryland Medical CenterBaltimoreMD 21201United States Department of Medicine The Ohio State University College of MedicineOhio Gastroenterology GroupIncColumbusOH 43214United States

BACKGROUND Cholangioscopy has been described in case reports and series to facilitate guidewire placement in difficult benign biliary ***,it has been infrequently used in difficult benign anastomotic liver transplant biliary strictures to visualize the stricture orifice for guidewire *** we describe a case of guidewire placement through a difficult malignant biliary stricture using single operator *** SUMMARY A 74-year-old female presented with jaundice and weight *** ultrasound and endoscopic retrograde cholangiopancreatography(ERCP)by other endoscopists demonstrated pancreatic adenocarcinoma with a dilated cystic duct(CD)and proximal common bile duct(CBD).The associated distal CBD stricture was dilated and stented with a plastic *** she subsequently developed cholangitis,prompting referral for a repeat *** stent was found to have migrated distally to the confluence of the dilated CD and CBD *** using multiple hydrophilic guidewires,the stricture could not be traversed due to preferential wire passage into the dilated *** DS(Boston Scientific Corp,Marlborough,MA,United States)was then used to visualize the orifices of the CD and CBD stenosis,enabling the guidewire to be placed directly through the stricture into the proximal CBD.A WallFlex covered metal stent(Boston Scientific Corp,Marlborough,MA,United States)was successfully placed,resulting in resolution of her *** To our knowledge,this is one of the first cases to describe successful cholangioscopic guidewire placement for malignant biliary strictures.

关键词： Cholangiopancreatoscopy Malignant biliary stricture Cholangioscopy Guidewire placement Obstructive jaundice Case report

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同步抽运飞秒光参量振荡器中的载波-包络相位控制及其应用

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科学通报 2008年第1期53卷 14-22页

作者：孙敬华 B.J.S.Gale D.T.Reid Ultrafast Optics group School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburgh EH14 4ASUK 中国科学院物理研究所光物理开放实验室北京100080

同步抽运飞秒光参量振荡器(OPO)以及抽运源所构成的飞秒脉冲系统具有内在同步、多波长脉冲输出以及各脉冲的载波-包络相位(CEP)的内在关联等特性,在超宽频率梳以及脉冲的相干合成方面具有先天的优势.本文阐述了一系列该研究方向的最新成... 详细信息

同步抽运飞秒光参量振荡器(OPO)以及抽运源所构成的飞秒脉冲系统具有内在同步、多波长脉冲输出以及各脉冲的载波-包络相位(CEP)的内在关联等特性,在超宽频率梳以及脉冲的相干合成方面具有先天的优势.本文阐述了一系列该研究方向的最新成果,诸如探讨了OPO内载波-包络相位与能量守恒的关系,并通过实验进行了检验;利用自参考法控制了作为抽运源的飞秒钛宝石激光器CEP,并通过压电陶瓷(PZT)锁定了其脉冲重复频率;利用OPO产生的非相位匹配可见光,并以抽运光的超连续作为参考,通过OPO端镜上的快速PZT控制了OPO产生的所有脉冲的CEP,从而获得400nm～2.4μm超宽频率梳,控制精度高于1.2kHz带宽;并利用波长相近相位锁定的抽运光以及信号光倍频实现了不同脉冲的相位相干,为产生极窄的合成光脉冲打下了基础.

关键词：光参量振荡器载波-包络相位相干合成频率梳

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布地奈德对哮喘小鼠气道重塑及JAK1/STAT6表达的影响

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中华医学杂志 2007年第23期87卷 1627-1632页

作者：陈晓红钟南山张卫东曹智臻何梦璋罗群任筱兰李时悦 Li L 广州医学院第一附属医院广州呼吸疾病研究所510120 Centocor inc.USA

目的研究布地奈德(BUD)对支气管哮喘小鼠气道重塑及对 JAK1、信号转导子和转录激活子6(STAT6)表达的调控作用。方法将30只雌性 BALB/c 小鼠随机分为对照组、哮喘组和BUD 组。以鸡卵蛋白为过敏原致敏和激发动物,建立慢性哮喘气道重塑模... 详细信息

目的研究布地奈德(BUD)对支气管哮喘小鼠气道重塑及对 JAK1、信号转导子和转录激活子6(STAT6)表达的调控作用。方法将30只雌性 BALB/c 小鼠随机分为对照组、哮喘组和BUD 组。以鸡卵蛋白为过敏原致敏和激发动物,建立慢性哮喘气道重塑模型。对照组动物采用生理盐水致敏和激发动物,BUD 组在每次用过敏原激发前2 h 鼻腔滴入 BUD(1 mg/kg)。用 BUXCO 小鼠肺功能仪测定动物气道反应性,对肺组织切片行过碘酸雪夫(PAS)和 Masson 染色,就支气管周围炎细胞浸润及杯状细胞增殖进行评分,测定肺组织羟脯氨酸含量。应用免疫组化、免疫印迹及 RT-PCR方法分别检测 JAK1、STAT6、α-SMA 的蛋白及α-SMA mRNA 表达的变化。结果哮喘组动物气道反应性明显高于对照组,logPC100分别为0.62±0.78和1.88±0.34,P<0.01。BUD 组小鼠气道反应性低于哮喘组(1ogPC100为1.79±0.18,P<0.01)。与哮喘组相比,BUD 组气道上皮增生得到改善,上皮下胶原沉积减少,α-SMA 蛋白和 mRNA 表达也较哮喘组低。BUD 组黏液指数计分为(1.35±0.26)分,肺羟脯氨酸含量为(284±16)μg/100 mg,BALF 中 IL-4和 IL-13含量为(7.3±0.6)ng/L、(10.6±0.9)ng/L,与哮喘组比较差异有统计学意义(P<0.01)。STAT6主要表达于气道上皮,分布于细胞胞质、胞核。与对照组相比,哮喘组和 BUD 组的 STAT6分布未见明显变化。免疫印迹检测显示哮喘组的 JAK1和 STAT6蛋白表达均强于对照组,BUD 则能明显下调这两种信号蛋白的表达。相关分析表明,JAK1和 STAT6含量与气道 PAS 分数、α-SMA 蛋白表达及肺组织羟脯氨酸含量分别呈正相关,也与 BALF 中 IL-4和 IL-13水平呈正相关(均 P<0.05)。结论 BUD 抑制哮喘气道重塑。BUD可能通过下调 JAK1和 STAT6的表达,从而抑制了依赖于 JAK1/STAT6通路的气道重塑。

关键词：糖皮质激素类哮喘 JAK1 信号转导子和转录激活子6

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Characterization of DNA damage response deficiency in pancreatic cancer patients from China

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Cancer Communications 2022年第1期42卷 70-74页

作者： Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang State Key Laboratory of Oncogenes and Related Genes Department of OncologyShanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China The Medical Department 3D Medicines Inc.Shanghai 201321P.R.China Head of Laboratory of Cancer Progression and Translational Medicine Shanghai Institute of Nutrition and Health Chinese Academy of SciencesShanghai 200031P.R.China Department of Interventional Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pancreatic Surgery Huashan HospitalPancreatic Disease InstituteShanghai Medical CollegeFudan UniversityShanghai 200040P.R.China

To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic ***,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3].

关键词： damage patients chemotherapy

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