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Label-free biosensing with singular-phaseenhanced lateral position shift based on atomically thin plasmonic nanomaterials

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Light(Science & Applications) 2024年第5期13卷 810-822页

作者： Shaodi Zhu Rodolphe Jaffiol Aurelian Crunteanu Cyrille Vézy Sik-To Chan Wu Yuan Ho-Pui Ho Shuwen Zeng Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research Institute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and molecular biology ***,it was still challenging for conventional angle-interrogating plasmonic sensors to obtain higher sensitivity without secondary amplifying labels such as plasmonic *** address this issue,we developed a plasmonic biosensor based on the enhanced lateral position shift by phase *** singularity presents as a sudden phase retardation at the dark point of reflection from resonating plasmonic substrate,leading to a giant position shift on reflected ***,for the first time,the atomically thin layer of Ge2Sb2Te5(GST)on silver nanofilm was demonstrated as a novel phase-response-enhancing plasmonic *** GST layer was not only precisely engineered to singularize phase change but also served as a protective layer for active silver *** new configuration has achieved a record-breaking largest position shift of 439.3μm measured in calibration experiments with an ultra-high sensitivity of 1.72×10^(8)nm RIU−1(refractive index unit).The detection limit was determined to be 6.97×10^(−7)RIU with a 0.12μm position ***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position shift interrogation,enabling the labelfree detection of trace amounts of *** targeted biosensing experiments,the optimized sensor has successfully detected small cytokine biomarkers(TNF-αand IL-6)with the lowest concentration of 1×10^(−16)*** two molecules are the key proinflammatory cancer markers in clinical diagnosis,which cannot be directly screened by current clinical *** further validate the selectivity of our sensing systems,we also measured the affinity of integrin binding to arginylglycylaspartic acid(RGD)peptide(a key protein interaction in cell adhesion)with different Mn2+ion concentrations,ranging from 1 nM to 1 mM.

关键词： diagnosis protective silver

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Intra-operative peritoneal lavage for colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 1935-1939页

作者： Guillaume Passot Kayvan Mohkam Eddy Cotte Olivier Glehen Departement of General and Surgical Oncology Hospices Civils de Lyon69495 Pierre BéniteFrance emr 3738 Université Lyon 1F-69364 LyonFrance

Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery. Peritoneal lavage in colorectal surgery for cancer is not used in routine, and the prognostic significance of intraperitoneal free cancer cells (IPCC) remains unclear. Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce. However, positive IPCC might be the first step of peritoneal spread in colorectal cancers, which could lead to early specific treatments. Because of the important heterogeneity of IPCC determination in reported studies, no treatment have been proposed to patients with positive IPCC. Herein, we provide an overview of IPCC detection and its impact on recurrence and survival, and we suggest further multi-institutional studies to evaluate new treatment strategies.

关键词： Peritoneal carcinomatosis Colorectal cancer Free intraperitoneal cells Immunocytochemistry

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Low Birth Weight and Intermittent Preventive Treatment of Malaria in Pregnant Women in Lomé (Togo) in 2021: A Cross-Sectional Study

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Open Journal of Epidemiology 2024年第1期14卷 31-44页

作者： Roméo Mèdéssè Togan Ounoo Elom Takassi Fifonsi Gbeasor-Komlanvi Arnold Junior Sadio Rodion Yao Konu Martin Kouame Tchankoni Iwone Oumarou Adama Latame Komla Adoli Dzayissé Yawo Atakouma Didier Koumavi Ekouévi Department of Public Health Faculty of Health Sciences University of Lomé Lomé Togo African Center for Research in Epidemiology and Public Health (CARESP) Lomé Togo Training and Research Center in Public Health University of Lomé Lomé Togo Department of Pediatrics Faculty of Health Sciences University of Lomé Lomé Togo Global Health in the Global South (GHIGS) Team Insem UMR 1219 IRD EMR 271 University of Bordeaux Bordeaux France

Background: Since 2012, the World Health Organization has recommended intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP) to prevent malaria-related complications in pregnant women. Ten years following these recommendations, we conducted this study to estimate the coverage for three doses of IPT-SP (IPT3) as well as the prevalence of low birth weight (LBW), and its associated factors in Lomé (Togo) in 2021. Methods: A cross-sectional study was conducted between January and March 2021. An exhaustive recruitment of women and their newborns was carried out in the maternity wards of the Sylvanus Olympio University Hospital Center. Data from antenatal consultations and clinical data of the newborns were collected. Multivariate logistic regression was carried out to determine factors associated with LBW. Results: A total of 252 mother-child pairs were included in this study. Median age of the mothers was 27 years, IQR [24-31]. More than a third (35.3%) of the mothers were primigravida. IPT3 coverage was 66.7% and 14.7% of newborns had a LBW. The prevalence of LBW was 33.3% [23.3-43.4] in women who had received fewer than 3 doses of IPT-SP and 5.4% [2.0-8.8] in those who had received at least 3 doses of IPT-SP (p Conclusion: Ten years following recommendations of the WHO on IPT-SP, malaria prevention based on IPT-SP is not optimal among pregnant women in Lomé, and the proportion of LBW children remains high. Actions to strengthen the three-dose IPT-SP policy are needed to prevent malaria and its consequences among newborns in Togo.

关键词： Malaria Intermittent Preventive Treatment Low Birth Weight Togo

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Coal petrology,sedimentology and depositional environment of the Parvadeh coais in the Upper Triassic,Tabas Block of Central-East Iran

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International Journal of Coal Science & Technology 2023年第3期10卷 58-77页

作者： Ziba Zamani Hossain Rahimpour-Bonab Ralf Littke School of Geology College of ScienceUniversity of TehranTehranIran Energy and Mineral Resources(emr) RWTH Aachen UniversityAachenGermany

Peat forming environment strongly influences the economic value of any coal seam and coal-bearing ***,pal-aeoenvironmental studies provide important information for coal resource *** this context,detailed studies on selected coals from the Parvadeh Area,Iran,were conducted using sedimentology,coal petrology,X-ray diffraction(XRD),scanning electron microscopy-energy dispersive X-ray analyzer(SEM-EDX),and proximate *** sedi-mentary facies above and below the coal seams are mainly marine or marine-influenced facies,supporting that the coal-forming mires in the Parvadeh Area developed in a paralic environment,where the base level must be closely related to sea *** contents are moderate to high and mark the influence of brackish/marine water,especially during transgres-sion after peat growth in a lower delta plain *** peat-forming mires extended on coastal/delta plain *** lower delta plain/coastal plain coals are characterized by lateral continuity and substantial thickness,whereas few coals possibly representing the upper delta plain are thin and more *** detrital nature and composition of the numerous partings and the overall high ash yield in the coal seams indicate an active tectonic area with high rates of creation of accommodation space over peat *** petrology and coal facies analysis exhibits a permanently high water table within a forest swamp and mostly rheotrophic conditions,sometimes with connection to the ***-ing to paleoenvironmental reconstructions,it seems that coal layers may be thicker,with less sulfur(pyrite),but more clastic minerals and partings toward the western part of the *** these coal seams presently have low economic potential for the mining operation,partly due to great depth,this humic,high-volatile to medium-volatile bituminous coal may be suitable for exploration of coal bed methane resources.

关键词： Coal petrology Sedimentology Coal facies analysis Upper Triassic Nayband Formation Tabas Block

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Organic petrology and geochemistry of Triassic and Jurassic coals of the Tabas Basin, Northeastern/Central Iran

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International Journal of Coal Science & Technology 2019年第3期6卷 354-371页

作者： Nazanin Zamansani Mohammad Ali Rajabzadeh Ralf Littke Laura Zieger Alireza Baniasad Department of Earth Sciences College of Sciences Shiraz University Shiraz Iran Energy and Mineral Resources Group (emr) RWTH Aachen University Aachen Germany

Jurassic and Triassic coals and organic matter-rich shales of the Tabas Basin, Iran, were investigated with respect to their thermal maturation and petrographic composition. The Triassic coals of the Parvadeh coal field range in vitrinite reflectance between 1.17% and 1.37% and the Jurassic coals of the Mazino coal field between 2.08% and 2.29% VRr. Maceral analysis revealed a predominance of vitrinite in all samples, with slightly higher percentages of inertinite in the Jurassic samples. Rock-Eval analyses confirm the presence of type III kerogen in the Triassic coals, while the Jurassic coals contain strongly carbonized residual kerogen. The range of sulfur contents for coals from the Parvadeh coal field (0.37% to 4.64%) and Mazino coal field (0.45% to 2.92%) is related to the effect of marine water in peat. The studied samples are characterized by the predominance of short- over long-chained n-alkanes. The relatively high Pr/Ph ratios indicate predominance of terrestrial organic matter whereas Pr/n-C17 and Ph/n-C18 ratios prove oxic conditions during deposition. In addition, the DBT/Phen ratio shows that these coals formed in fluvial/deltaic environments. Molecular geochemical parameters such as carbon preference index (CPI, 0.99-1.04), methyl phenanthrene index (MPI, 1.20-1.60), methyl naphthalene ratio (MNR, 1.61-3.45), and ethyl naphthalene ratio (ENR, 4-6.78) confirm the high maturity of the samples. Burial and thermal history reconstruction indicates necessity of an erosional thickness of about 4000 m in the Parvadeh area. Towards the Mazino area, a higher basal heat flow up to 80 mW m^-2 is assumed for the Paleogene leading to higher maturities.

关键词： Jurassic coal Triassic coal Vitrinite reflectance Maceral Organic geochemistry Coal petrography

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Defining strawberry shape uniformity using 3D imaging and genetic mapping

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Horticulture Research 2020年第1期7卷 1126-1138页

作者： Bo Li Helen M.Cockerton Abigail WJohnson Amanda Karlström Eleftheria Stavridou Greg Deakin Richard J.Harrison NIAB emr East MallingKent ME196BJUK University of the West of England Bristol BS161QYUK NIAB Huntingdon RoadCambridge CB30LEUK

Strawberry shape uniformity is a complex trait,influenced by multiple genetic and environmental *** complicate matters further,the phenotypic assessment of strawberry uniformity is confounded by the difficulty of quantifying geometric parameters‘by eye’and variation between *** in-depth genetic analysis of strawberry uniformity has not been undertaken to date,due to the lack of accurate and objective ***,uniformity remains one of the most important fruit quality selection criteria for the development of a new *** this study,a 3D-imaging approach was developed to characterise berry shape *** show that circularity of the maximum circumference had the closest predictive relationship with the manual uniformity *** five or six automated metrics provided the best predictive model,indicating that human assessment of uniformity is highly ***,visual assessment of strawberry fruit quality in a multi-parental QTL mapping population has allowed the identification of genetic components controlling uniformity.A“regular shape”QTL was identified and found to be associated with three uniformity *** QTL was present across a wide array of germplasm,indicating a potential candidate for marker-assisted breeding,while the potential to implement genomic selection is explored.A greater understanding of berry uniformity has been achieved through the study of the relative impact of automated metrics on human perceived ***,the comprehensive definition of strawberry shape uniformity using 3D imaging tools has allowed precision phenotyping,which has improved the accuracy of trait quantification and unlocked the ability to accurately select for uniform berries.

关键词： straw breeding shape

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Cytoreductive surgery and hyperthermic intraperitonealchemotherapy in gastric cancer

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World Journal of Gastroenterology 2016年第3期22卷 1114-1130页

作者： Ramakrishnan Ayloor Seshadri Olivier Glehen Department of Surgical Oncology Cancer Institute(WIA)Chennai 600036India Service de Chirurgie Viscérale et Endocrinienne Hospices Civils de LyonCentre Hospitalier Lyon-Sud69495 Pierre-Bénite CedexFrance UniversitéLyon 1 EMR 373869921 OullinsFrance

Gastric cancer associated peritoneal carcinomatosis(GCPC) has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in GCPC. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery( CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) have been investigated for GCPC. HIPEC has been used for three indications in GC- as an adjuvant therapy after a curative surgery, HIPEC has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, HIPEC along with CRS is the only therapeutic modality that has resulted in longterm survival in select groups of patients; as a palliative treatment in advanced PC with intractable ascites, HIPEC has been shown to control ascites and reduce the need for frequent paracentesis. While the results of randomised trials of adjuvant HIPEC from western centres are awaited, the role of HIPEC in the treatment of GCPC is still evolving and needs larger studies before it is accepted as a standard of care.

关键词： Gastric cancer Peritoneal carcinomatosis Cytoreductive surgery Hyperthermic intraperitonealchemotherapy

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Quantitative trait loci controlling Phytophthora cactorum resistance in the cultivated octoploid strawberry(Fragaria×ananassa)

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Horticulture Research 2019年第1期6卷 965-978页

作者： Charlotte F.Nellist Robert J.Vickerstaff Maria K.Sobczyk César Marina-Montes Fiona M.Wilson David W.Simpson Adam B.Whitehouse Richard J.Harrison Department of Genetics Genomics and BreedingNIAB EMRNew RoadEast Malling ME196BJUK

The cultivated strawberry,Fragaria×ananassa(Fragaria spp.)is the most economically important global soft *** cactorum,a water-borne oomycete causes economic losses in strawberry production globally.A biparental cross of octoploid cultivated strawberry segregating for resistance to ***,the causative agent of crown rot disease,was screened using artificial *** putative resistance quantitative trait loci(QTL)were identified and *** major effect QTL(FaRPc6C,FaRPc6D and FaRPc7D)explained 37%of the variation *** were no epistatic interactions detected between the three major *** a subset of the mapping population progeny against a range of *** isolates revealed no significant interaction(p=0.0593).However,some lines showed higher susceptibility than predicted,indicating that additional undetected factors may affect the expression of some quantitative resistance *** historic crown rot disease score data from strawberry accessions,a preliminary genome-wide association study(GWAS)of 114 individuals revealed an additional locus associated with resistance to *** of the Fragaria vesca Hawaii 4 v1.1 genome revealed candidate resistance genes in the QTL regions.

关键词： straw Fragaria

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Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds

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Horticulture Research 2020年第1期7卷 1109-1125页

作者： Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent Division of Biotechnology and Plant Health Norwegian Institute of Bioeconomy ResearchÅs N-1433Norway NOFIMA AS Norwegian Institute of Food Fisheries and Aquaculture ResearchÅs N-1433Norway Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorenceItaly Graminor Breeding Ltd. N-2322 RidabuNorway Department of Plant Sciences Norwegian University of Life SciencesRidabu N-1432ÅsNorway NIAB-emr East MallingME196BJ KentUK Department of Food Quality and Nutrition Fondazione Edmund MachCentro Ricerca e InnovazioneVia E.Mach 138010 San Michele all’AdigeTNItaly Department of Genetics Genomics and BreedingNIAB-EMREast MallingME196BJ KentUK

Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative *** addition,polyphenolic anthocyanins contribute to the attractive color of strawberry ***,the genetic basis of polyphenol biosynthesis has not been extensively studied in *** this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k *** and QTL analyses identified genetic loci controlling polyphenol *** were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside ***/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage *** of gene predictions in the *** reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside *** malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’*** study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry *** has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in *** above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects.

关键词： straw polyphenol breeding

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Advanced hybrid plasmonic nano-emitters using smart photopolymer

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Photonics Research 2022年第7期10卷 1552-1566页

作者： DANDAN GE ALI ISSA SAFI JRADI CHRISTOPHE COUTEAU SYLVIE MARGUET RENAUD BACHELOT Light NanomaterialsNanotechnologies(L2n)LaboratoryCNRS EMR 7004Universitéde Technologie de Troyes12 rue Marie Curie10004Troyes CedexFrance UniversitéParis Saclay CEACNRSNIMBEF-91191Gif sur YvetteFrance

The integration of nano-emitters into plasmonic devices with spatial control and nanometer precision has become a great *** this paper,we report on the use of a smart polymer to selectively immobilize nano-emitters on specific preselected sites of gold nanocubes(GNCs).The cunning use of the polymer is ***,it records both the selected site and the future emitters-GNC distance through plasmon-assisted ***,because the polymer is chemically functionalized,it makes it possible to attach the nano-emitters right at the preselected polymerized sites,which subsequently recognize the nano-emitters to be *** the resulting active medium is a spatial memory of specific plasmonic modes,it is anisotropic,making the hybrid nanosources sensitive to light *** ability to adjust their statistical average lifetime by controlling the thickness of the nanopolymer is demonstrated on two kinds of nano-emitters coupled to GNCs:doped polystyrene nanospheres and semiconductor colloidal quantum dots.

关键词： polymer plasmon attached

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