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A biosensing system employing nanowell microelectrode arrays to reco.d the intracellular potential of a single cardiomyocyte

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Microsystems & Nanoengineering 2022年第3期8卷 185-198页

作者： Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng Wang Tianxing Wang Ning Hu Diming Zhang Department of Obstetrics and Gyneco.ogy Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguan 523058China Research Center for Inelligent Sensing Systems Zhejiang LaboratoryHangzhou 311100China Research Center for Humanoid Sensing Zhejiang LaboratoryHangzhou 311100China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China School of Automation Nanjing University of Science and TechnologyNanjing 210094China co.lege of energy and Power engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China e-link care meditech co. LtdHangzhou 310011China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemitryZhejiang UniversityHangzhou 310058China

electrophysiological reco.ding is a widely used method to investigate cardiovascular pathology,pharmaco.ogy and developmental *** arrays reco.d the electrical potential of cells in a minimally invasive and highthroughput ***,co.monly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a reco.ding of the intracellular action potential of a single *** this study,we proposed a novel measuring method that is able to reco.d the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMeA).The NWMeA co.sists of five nanoscale wells at the center of each circular planar *** pulse electroporation was applied to the NWMeA to penetrate the cardiomyocyte membrane,and the intracellular action potential was co.tinuously *** intracellular potential reco.ding of cardiomyocytes by the NWMeA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when co.pared to those of the extracellular *** to previously reported nanopillar microelectrodes,the NWMeA co.ld ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication *** NWMeA-based biosensing system is a promising tool to reco.d the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation.

关键词： arrays potential reco.d

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A biosensing system using a multiparameter nonlinear dynamic analysis of cardiomyocyte beating for drug-induced arrhythmia reco.nition

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Microsystems & Nanoengineering 2022年第3期8卷 277-290页

作者： Hao Wang Yue Wu Quchao Zou Wenjian Yang Zhongyuan Xu Hao Dong Zhjing Zhu Depeng Wang Tanxing Wang Ning Hu Diming Zhang State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510006China Research Center for Itelligent Sensing Systems Zhejiang LabHangzhou 311121China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemistryThe Second Affiliated Hospital Zhejiang University School of MedicineDepartment of Clinical Medical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China co.lege of energy and Power engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China e-linkcare meditech co LtdHangzhou 310011China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai 200050China

Cardiovascular disease is the number one cause of death in ***,cardiotoxicity is one of the most important adverse effects assessed by arrhythmia reco.nition in drug ***,cell-based techniques developed for arhythmia reco.nition primarily employ linear methods such as time-domain analysis that detect and co.pare individual waveforms and thus fall short in some applications that require automated and efficient arrhythmia reco.nition from large *** carried out the frst report to develop a biosensing system that integrated impedance measurement and multiparameter nonlinear dynamic algorithm(MNDA)analysis for druginduced arrhythmia reco.nition and *** biosensing system cultured cardiomyocytes as physiologically relevant models,used interdigitated electrodes to detect the mechanical beating of the cardiomyocytes,and employed MNDA analysis to reco.nize drug-induced arrhythmia from the cardiomyocyte beating *** best performing MNDA parameter,approximate entropy,enabled the system to reco.nize the appearance of sertindoleand norepinephrine-induced arrhythmia in the *** MNDA reco.struction in phase space enabled the system to classify the different arrhythmias and quantify the severity of *** new biosensing system utilizing MNDA provides a promising and alternative method for drug-induced arrhythmia reco.nition and classification in cardiological and pharmaceutical applications.

关键词： arrhythmia cardio analysis

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