检索结果-南通市图书馆

Effect of hormonal status and metabolic changes of restricted ewes during late pregnancy on their fetal growth and development

引用

Science China(Life Sciences) 2007年第6期50卷 766-772页

作者： GAO Feng1, HOU XianZhi1 & LIU YingChun2 1 college of Animal Science and Animal medicine, Inner Mongolia Agricultural University, Huhhot 010018, China 2 college of Biotechnology and Bioengineering, Inner Mongolia Agricultural University, Huhhot 010018, China college of Animal Science and Animal medicine Inner Mongolia Agricultural University Huhhot China college of Biotechnology and Bioengineering Inner Mongolia Agricultural University Huhhot China

This study investigated the effects of hormonal status; metabolic changes of restricted ewes during late pregnancy on the ovine fetus growth; development. One hundred Mongolian ewes, synchronized for oestrus; mated, were divided into three groups; offered 0.175 MJME·kgw[0.75]·d[1] (Restricted Group 1, RG1), 0.33 MJME·kgw[0.75]·d[1] (Restricted Group 2, RG2); ad libitum access to feed (Control Group, CG) during their late pregnancy respectively. The results suggested that with the supply of exogenous energy decreasing during late pregnancy, maternal body weight; net body weight loss in RG2; RG1 were lower than those of CG (Ps0.01). The insulin; IGF-1 concentrations of ewes in RG2; RG1 tended to be lower than those of CG (P>0.05), but the GH concentrations in RG2; RG1 were enhanced; there was significant difference between RG1; CG on d 120 of gestation (P0.05). However, the NEFA; FAA concentrations of ewes in RG1 were reduced from d 90 to d 120 of gestation, then enhanced from d 120 to d 140 of gestation. During the late pregnancy, with the supply of nutrition decreasing, the negatively physiological; biochemical maternal reactions to restriction became worse, which significantly reduced the average lamb birth weight; daily growth rate of fetus in RG2 (P<0.05); RG1 (P<0.01).

关键词： late pregnancy restricted ewes fetus growth development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Do you have what it takes for challenging endoscopic submucosal dissection cases?

引用

World Journal of Gastroenterology 2011年第31期17卷 3580-3584页

作者： Kyoung-Oh Kim Sung Jung Kim Tae Hyeon Kim Jong-Jae Park Division of Gastroenterology and Hepatology Department of Internal MedicineHallym University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineWonkwang University Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Guro Hospital Korea University college of medicine

Endoscopic submucosal dissection(ESD) is a widely accepted treatment for early gastric cancer(EGC),especially in Korea and *** criteria for the therapeutic use of ESD for EGC have been expanded ***,attention should be drawn to the technical feasibility of the ESD treatment which depends on a lesion's location,size or fibrosis level,or operator's *** the case of a lesion with a high level of difficulty,a more experienced operator is ***,the treatment for a lesion with a high level of difficulty should be performed according to the degree of the operator's *** this paper,the authors describe the ESD procedure for lesions with a high level of difficulty.

关键词： Endoscopic submucosal dissection Anatomical location Technical feasibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

I_(2)/Ph I(OAc)2-assisted oxidative C–H amination protocols toward metal-free pragmatic synthesis of pyrrolo[2,3-b]indoles

引用

Chinese Chemical Letters 2023年第1期34卷 351-356页

作者： Yuping Xiong Feihua Du Linghui Zeng Zhiyuan Chen college of Chemistry&Chemical Engineering Jiangxi Normal UniversityNanchang 330022China School of medicine Zhejiang University City CollegeHangzhou 310015China

We report herein an I2/Ph I(OAc)2catalytic system for the pragmatic construction of C–N bonds through C–H/N–H oxidative coupling *** pyrrolo[2,3-b]indoles were efficiently prepared via I2-catalyzed intramolecular C–H amination reactions from(E/Z)-2-indolylenamines under metal-free *** functional groups are tolerated under mild reaction conditions and the resulting pyrrolo[2,3-b]indoles were obtained with mostly good to excellent *** was interesting to observe that both the(E)-and(Z)-isomers of the starting materials were efficiently transformed into the targeted *** I+-mediated catalytic cycle was proposed based on mechanistic studies for this reaction.

关键词： C–H activation C–H amination Indole Oxidative cyclization aza-Heterocycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Is the Mortality Trend of Ischemic Heart Disease by the GBD2013 Study in China Real?

引用

Biomedical and Environmental Sciences 2017年第3期30卷 204-209页

作者： WAN Xia YANG Gong Huan Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic medicine Peking Union Medical College

To determine the reason for the different mortality trends of ischemic heart disease （IHD） for China between Global Burden of Disease （GBD） 2010 and GBD2013, and to improve garbage code （GC） redistribution. All data were obtained from the disease surveillance points system, and two proportions for assigning chronic pulmonary heart disease （PHD） as GC to IHD were from GBD2010 and GBD2013,

关键词： IHD PHD Is the Mortality Trend of Ischemic Heart Disease by the GBD2013 Study in China Real

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

引用

Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park Department of Internal medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unilateral foveomacular retinitis resembling solar retinopathy among young soldiers in Korean army and associated multimodal imaging findings

引用

International Journal of Ophthalmology(English edition) 2020年第1期13卷 112-119页

作者： Chang Ki Yoon Kyu Hyung Park Se Joon Woo Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Korea Department of Ophthalmology Hallym University College of MedicineHallym University Kangnam Sacred Heart HospitalSeoul 07441Korea

AIM: To describe the clinical features and multimodal images of unilateral foveomacular retinitis in young Korean soldiers. METHODS: Ten patients having foveomacular retinitis were included. Fluorescein angiography, fundus autofluorescence(FAF), infrared reflectance(IR), and spectral-domain optical coherence tomography(SD-OCT) were ***: All patients were young males experienced insidious visual decline without exposure to bright light. Initial and final vision ranged from hand movement to 20/20(median 20/200) and 20/2000 to 20/20(median 20/500), respectively. Vision decreased in 6 patients while improved in two. Typical macular abnormality was yellow granular spots. SD-OCT showed ellipsoid zone(EZ) or interdigitation zone(IZ) disruption of fovea. The degree of EZ/IZ damage correlated with vision. Lesions were clearly visualized through IR and matched with SD-OCT ***: This is the first case series of foveomacular retinitis diagnosed with multimodal imaging. Foveomacular retinitis should be suspected in sudden unilateral visual decline especially in young soldiers. SD-OCT is the most important diagnostic modality.

关键词： foveomacular retinitis Korean multimodal imaging solar retinopathy soldiers unilateral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts

引用

Journal of Genetics and Genomics 2024年第2期51卷 222-229页

作者： Wenbin Huang Shiying Zhang Jiuxiang Lin Yi Ding Nan Jiang Jieni Zhang Huaxiang Zhao Feng Chen Department of Orthodontics Peking University School and Hospital of StomatologyBeijing100081China Key Laboratory of Shaanxi Province for Craniofacial Precision medicine Research College of StomatologyXi’an Jiaotong UniversityXi’anShaanxi710004China Guangdong Provincial High-level Clinical Key Specialty Guangdong Province Engineering Research Center of Oral Disease Diagnosis and TreatmentDepartment of OrthodonticsStomatological CenterPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi710049China National Center for Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100101China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China

Orofacial clefts (OFCs) are the most common congenital craniofacial disorders, of which the etiology is closely related to rare coding variants. Filamin B (FLNB) is an actin-binding protein implicated in bone formation. FLNB mutations have been identified in several types of syndromic OFCs and previous studies suggest a role of FLNB in the onset of non-syndromic OFCs (NSOFCs). Here, we report two rare heterozygous variants (p.P441T and p.G565R) in FLNB in two unrelated hereditary families with NSOFCs. Bioinformatics analysis suggests that both variants may disrupt the function of FLNB. In mammalian cells, p.P441T and p.G565R variants are less potent to induce cell stretches than wild type FLNB, suggesting that they are loss-of-function mutations. Immunohistochemistry analysis demonstrates that FLNB is abundantly expressed during palatal development. Importantly, Flnb^(−/−) embryos display cleft palates and previously defined skeletal defects. Taken together, our findings reveal that FLNB is required for development of palates in mice and FLNB is a bona fide causal gene for NSOFCs in humans.

关键词： Or ofacial clefts FLNB Loss-of-function mutati on Cleft palate Filamin B Actin flannent Knockout mouse

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of micro RNAs in fibroblast of pterygium

引用

International Journal of Ophthalmology(English edition) 2016年第7期9卷 967-972页

作者： Joon H.Lee Sun-Ah Jung Young-A Kwon Jea-Lim Chung Ungsoo Samuel Kim Myung-Gok Eye Research Institute Konyang University College of Medicine Seoul 07301 Korea Department of Ophthalmology Kim's Eye Hospital Seoul 07301 Korea Department of Ophthalmology Konyang University College of Medicine Daejeon 35356 Korea

AIM：To screen microRNAs（miRNAs） and set up target miRNAs in ***：Primary fibroblasts were isolated from pterygium and Tenon＇s capsule and *** analysis and Western blotting were performed to confirm the culture of *** all,1733 miRNAs were screened in the first step by using GeneChip miRNA3.0 *** miRNAs involved in the pathogenesis of pterygium were subsequently determined using the following criteria：1） high reproducibility in a repetitive test;2） base log value of 〉7.0 for both control and pterygial fibroblasts;and 3） log ratio of 〉1.0 between pterygial fibroblasts and control ***：Primary screening showed that 887/1733 miRNAs were up-regulated and 846/1733 miRNAs were down-regulated in pterygial fibroblasts compared with those in control *** the 1733 miRNAs screened,4 miRNAs,namely,miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p,met the above-mentioned *** screening showed that these 4 miRNAs were up-regulated in pterygial fibroblasts compared with control fibroblasts and that miRNA-143a-3p had the highest mean ratio compared with the miRNAs in control ***：miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p are up-regulated in pterygial fibroblasts compared with control fibroblasts,suggesting their involvement in the pathogenesis of pterygium.

关键词： microRNA pterygium fibroblast

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells

引用

The Journal of Biomedical Research 2019年第1期33卷 17-23页

作者： Niradiz Reyes Ines Benedetti Juan Rebollo Oscar Correa Jan Geliebter Department of Basic Sciences School of MedicineUniversity of Cartagena Research Group of Genetics and Molecular Biology New York Medical College Research Group of Histopathology New York Medical College School of medicine Department of Microbiology and Immunology New York Medical College

Atypical chemokine receptors have recently emerged as important molecular players in health and diseases; they affect chemokine availability and function and impact a multitude of pathophysiological events, including the tumorigenesis process. This family of atypical receptors comprises five members: ACKR1/DARC, ACKR2/D6,ACKR3/CXCR7, ACKR4/CCRL1, and ACKR5/CCRL2. This work evaluated the differential expression of these receptors in prostate cancer using quantitative PCR. Further evaluation of CCRL2 at the protein level confirmed its overexpression in a metastatic cell line and in malignant prostatic tissues from patients. CCRL2, a presumed member of the atypical chemokine receptor family, plays a key role in lung dendritic cell trafficking to peripheral lymph *** studies have reported the expression of CCRL2 in different human cancer cell lines and tissues. However, its function and expression in prostate cancer has not been previously addressed.

关键词： chemokine receptor prostatic neoplasms CCRL2 receptor real-time polymerase chain reaction tissue array analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

引用

Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The Brain Cognition and Brain Disease Institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China Jan and Dan Duncan Neurological Research Institute Baylor College of MedicineHouston77030USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various ***,their role in transmitting visual information remains ***,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual *** applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole ***,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual ***,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic ***,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual *** results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：