I_(2)/Ph I(OAc)2-assisted oxidative C–H amination protocols toward metal-free pragmatic synthesis of pyrrolo[2,3-b]indoles

作     者：Yuping Xiong Feihua Du Linghui Zeng Zhiyuan Chen Yuping Xiong;Feihua Du;Linghui Zeng;Zhiyuan Chen

作者机构：College of Chemistry&Chemical EngineeringJiangxi Normal UniversityNanchang 330022China School of MedicineZhejiang University City CollegeHangzhou 310015China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第1期

页      面：351-356页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(No.21961015) the Natural Science Foundation of Jiangxi Province(No.20202ACBL203005)for financial support the support from the Jiangxi Provincial Education Department Graduate Student Innovation Fund(No.YC2021-S236) 

主　　题：C–H activation C–H amination Indole Oxidative cyclization aza-Heterocycle 

摘      要：We report herein an I2/Ph I(OAc)2catalytic system for the pragmatic construction of C–N bonds through C–H/N–H oxidative coupling *** pyrrolo[2,3-b]indoles were efficiently prepared via I2-catalyzed intramolecular C–H amination reactions from(E/Z)-2-indolylenamines under metal-free *** functional groups are tolerated under mild reaction conditions and the resulting pyrrolo[2,3-b]indoles were obtained with mostly good to excellent *** was interesting to observe that both the(E)-and(Z)-isomers of the starting materials were efficiently transformed into the targeted *** I+-mediated catalytic cycle was proposed based on mechanistic studies for this reaction.