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Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?

Asian Journal of Urology 2024年第3期11卷 391-405页

作者： Ria Margiana Younes Pilehvar Fatkhurrohmah LAmalia Silvia WLestari Supardi Supardi Reny I’tishom Department of Anatomy Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Master’s Programme Biomedical Sciences Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Andrology Program Faculty of MedicineUniversitas AirlanggaSurabayaIndonesia dr.Soetomo General Academic hospital SurabayaIndonesia Indonesia General Academic hospital DepokIndonesia Ciptomangunkusumo General Academic hospital JakartaIndonesia Cellular and Molecular Research Center Cellular and Molecular Medicine Research InstituteUrmia University of Medical ScienceUrmiaIran dr.kariadi hospital SemarangIndonesia Department of Medical Biology Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Department of Biomedical Science Faculty of MedicineUniversitas Airlangga SurabayaIndonesia

Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative *** review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology,particularly for treating erectile dysfunction(ED),and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales,mechanisms,preclinical investigations,and therapeutic potential of the MSC secretome in this ***:The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ***,it delved into the existing knowledge regarding the MSC secretome,exploring its therapeutic *** methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.

关键词： Erectiledysfunction Mesenchymal stem cell Mesenchymal stem cell secretome Mesenchymal stem cell-derived exosome

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Innovations in endoscopic ultrasound for portal hypertension and its role in managing complications in clinical practice:Lessons learned from a tertiary referral public hospital

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Portal Hypertension & Cirrhosis 2024年第1期3卷 31-35页

作者： Cosmas R.A.Lesmana Kemal F.Kalista Saut H.H.Nababan Juferdy Kurniawan Chyntia O.M.Jasirwan Andri S.Sulaiman Irsan Hasan Rino A.Gani Department of Internal Medicine Hepatobiliary DivisionDr.Cipto Mangunkusumo National General HospitalMedical Faculty Universitas IndonesiaJakartaIndonesia Digestive Disease&GI Oncology Center Medistra HospitalJakartaIndonesia Gastrointestinal Cancer Center MRCCC Siloam Semanggi HospitalJakartaIndonesia

Portal hypertension(PH)poses significant *** paper presents an innovative study on the utilization of endoscopic ultrasound(EUS)for both the diagnosis and management of *** at *** Mangunkusumo National General hospital in Jakarta,this retrospective case series included patients diagnosed with PH through clinical examination,imaging evaluation,and *** criteria comprised a history of reduced blood consumption within the last 5 days,hepatocellular carcinoma,massive ascites,or elevated international normalized ratio(>1.4).EUS-guided portal pressure gradient(PPG)measurements were performed using an innovative standard *** study involved 15 patients,with 14 having liver cirrhosis and 1 diagnosed with Budd–Chiari *** them,nine patients experienced bleeding due to gastroesophageal *** and large esophageal varices were identified in four and eight patients,*** varices type 1 were observed in two patients,and type 2 in four *** gastric fundal varices type 1 were present in one *** on EUS-PPG measurements,14 patients exhibited clinically significant portal *** patients underwent endoscopic band ligation and three underwent EUS-guided cyanoacrylate injection during the same session as the EUS-PPG measurement ***,no adverse events,such as abdominal pain,perforation,or bleeding were observed during or after the *** emerges as a promising and accurate tool for both diagnosis and management.

关键词： cyanoacrylate injection endoscopic ultrasound liver cirrhosis portal hypertension portal pressure gradient

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Kidney transplantation in Indonesia: An update

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Asian Journal of Urology 2019年第4期6卷 305-311页

作者： Tommy Supit Eriawan Agung Nugroho Ardy Santosa Moh Adi Soedarso Nanda Daniswara Sofyan Rais Addin Department of General Surgery Faculty of Medicine Diponegoro UniversityDr.Kariadi General HospitalSemarangJawa TengahIndonesia Department of Urology Faculty of Medicine Diponegoro UniversityDr.Kariadi General HospitalSemarangJawa TengahIndonesia

Objective:Indonesia has overcome several barriers to the growth of kidney transplantation within the past ***,the procedure is increasingly performed in several centers across the *** there are limited publications on kidney transplantation from Indonesia,especially from centers outside *** study aims to give a brief overview on transplantation performed,discuss current efforts and progresses of transplantation in Indonesia and chiefly ***:Retrospective analysis of 20 transplant cases in Semarang during 2014e2018 was *** from other transplant centers was acquired through formal correspondences with 11 central teaching hospitals in Jakarta,Surabaya,Yogyakarta,Malang,Bali,Solo,Palembang,Aceh,Medan,Bandung,and ***:There were 629 recorded kidney transplantations performed in 12 centers,and we report on 245 cases with viable *** average age of kidney recipients were younger(35.4 years old)compared to the donors(41.3 years old).Approximately half of the kidneys were obtained from related donors(49.0%)and there was only one case of cadaveric *** three leading etiologies of end-stage renal disease were hypertension(37.4%),diabetes mellitus(26.1%),and autoimmune disease(11.3%).There is only one center that has performed more than 100 kidney transplants in ***:Indonesia has successfully overcome several major hurdles that had previously hindered the growth of *** improvement should concentrate on the development of integrated organ transplant infrastructure,decentralization of transplant professionals,establishment of National kidney transplant database and changing the Nation’s paradigm on cadaveric organ donor through public education.

关键词： Kidney transplantation End-stage renal disease Chronic kidney disease Indonesia Semarang Epidemiology Update

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Ferritin and mortality in hemodialysis patients with COVID-19:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 4-11页

作者： Ni Wayan Anantika Riani I Gde Raka Widiana Yenny Kandarini Nephrology Division Department of Internal MedicineUdayana University/Udayana University HospitalBaliIndonesia Nephrology Division Department of Internal MedicineUdayana University/Prof.Dr.I.G.N.G.Ngoerah General HospitalBaliIndonesia

Objective:To investigate the difference in serum ferritin levels between deceased and surviving regular hemodialysis patients with ***:We conducted a systematic search across four databases following the PRISMA statement *** reporting ferritin levels and mortality of regular hemodialysis patients with COVID-19 were *** the random-effects model,we performed a meta-analysis to determine the mean difference in serum ferritin levels between the studied groups,along with their corresponding 95%confidence *** meta-analysis was carried out using Review Manager 5.4 and Stata ***:A total of 1013 patients from seven studies were included in this *** meta-analysis showed higher mean serum ferritin in the deceased compared to surviving regular hemodialysis patients with COVID-19,with a mean difference of 449.43 ng/mL[95%CI(244.07,654.80),P<0.0001;I2=58%,P=0.003].Conclusions:Our study found a higher mean of serum ferritin levels in the deceased compared to surviving regular hemodialysis patients with COVID-19.

关键词： Ferritin Mortality Hemodialysis COVID-19 Inflammation

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Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda Sánchez-Pérez JoséM Ramia Department of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in *** surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly *** advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving ***,ERAS could be another way to improve our oncological *** will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.

关键词： Enhanced recovery after surgery programs Liver surgery Key components Long-term oncological outcomes Enhanced recovery after surgery compliance

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Tumor necrosis factor-alpha, transforming growth factor-beta, degree of lower urinary tract symptoms as predictors of erectile dysfunction in benign prostatic hyperplasia patients

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Asian Journal of Urology 2024年第2期11卷 280-285页

作者： Gede W.K.Duarsa Yeremia G.Kusumah Ronald Sugianto Pande M.W.Tirtayasa Tjokorda G.B.Mahadewa Department of Urology Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Department of General Surgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Medical Doctor Study Program Faculty of MedicineUniversitas UdayanaBaliIndonesia Department of Urology Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Department of Neurosurgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (BPH) ***: Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in Bali, Indonesia, including medical records and other administrative data. The sample was BPH patients with several history ***: Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (p<0.0001). Despite these results, prostate volume is not significant with ED (p=0.947).Conclusion: TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in BPH, while prostatic volume was not significant.

关键词： Prostate enlargement Biomarker Erectiledysfunction Riskfactor

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Two big orifices in the second duodenal portion:A case of an atypical double papilla

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 83-85页

作者： Salvatore Francesco Vadalàdi Prampero Nikola Panic Marco Massidda Chiara Rocchi Pierluigi Maria Rinaldi Ana Malenkovic Milutin Bulajic Gastroenterology and GI Endoscopy Department Mater Olbia HospitalOlbia 07026Italy Digestive Endoscopy Unit University Clinic"Dr Dragisa Misovic-Dedinje"Belgrade 11000Serbia Radiology Department Mater Olbia HospitalOlbia 07026Italy

With the advent of endoscopic retrograde cholangiopancreatography(ERCP)in the early 1970s,anatomic anomalies of the Vaterian system were described endoscopically[1].Although the occurrence is rare,the common bile duct(CBD)and the pancreatic duct may fail to coalesce during embryologic *** leads to double major papilla because both ducts open into the duodenum separately[1].In this way the cranial duct communicates with the CBD,while the caudal orifice communicates with the pancreatic duct[2].

关键词： orifice Vater atypical

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Knowledge, attitudes, and practices regarding Covid-19 and their relationship with Covid-19 booster vaccination status among women with infertility

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Asian pacific Journal of Reproduction 2024年第2期13卷 68-75页

作者： Gita Pratama Mila Maidarti Kanadi Sumapradja Achmad Kemal Harzif Natasha Talya Kevin Ezekia Irfan Arieqal Hatta Ampri Reproductive Immunoendocrinology Division Department of Obstetrics and GynecologyFaculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia Yasmin IVF Clinic dr.Cipto Mangunkusumo General hospital JakartaIndonesia Human Reproduction Infertilityand Family Planning ClusterIndonesia Reproductive Medicine Research and Training CenterFaculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia

Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with ***:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,*** assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic ***:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 *** the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination *** significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding *** participants had poor knowledge about the relationship between infertility and the Covid-19 *** general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.

关键词： Covid-19 Booster vaccine Infertility Knowledge Attitude Practice Human reproduction Pandemic

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Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum:A Literature Review

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Maternal-Fetal Medicine 2024年第2期6卷 97-101页

作者： Putri Mirani Peby Maulina Lestari Krisna Murti Iche Andriyani Liberty Hana Andrina Cindy Kesty Bella Stevanny Division of Maternal-Fetal Medicine Department of Obstetrics and GynecologyDr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangSouth SumateraIndonesia Division of Hematolymphoid and Endocrinology Department of Pathological AnatomyDr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangIndonesia Department of Public Health and Community Medicine Faculty of MedicineSriwijaya UniversityPalembangIndonesia Department of Obstetrics and Gynecology Dr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangSouth SumateraIndonesia.

The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections.A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of *** metalloproteinase(MMP)is crucial in every step of wound healing as it alters the wound matrix,facilitating cell migration,as well as tissue ***-9 expression is higher in placental and decidual tissue in cases of placenta *** on these findings,assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker.

关键词： Biomarker Etiopathogenesis Matrix metalloproteinase MMP-9 Placenta accreta spectrum disorder

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Arterial Duct Stenting Versus Modified Blalock-Taussig Shunt in Patient with Ductal-Dependent Pulmonary Circulation: Systematic Review & Meta-Analysis

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Congenital Heart Disease 2024年第2期19卷 139-156页

作者： Ketut Putu Yasa Nyoman Satria Sadu Bhaskara Putu Febry Krisna Pertiwi Department of Cardiothoracic&Vascular Surgery Prof.Dr.I.G.N.G Ngoerah General HospitalDenpasar80113Indonesia Faculty of Medicine Udayana UniversityDenpasar80232Indonesia

Objective:Patients with ductal-dependent pulmonary circulation require alternative bloodflow to provide and maintain adequate *** Blalock-Taussig Shunt(MBTS)has been the standard for providing such a ***,less invasive methods such as Arterial Duct(AD)stenting have been performed as *** study aims to compare the outcome of AD stenting and ***:Systematic research was performed in online databases using the PRISMA *** outcomes measured were 30-day mortality,com-plication,unplanned intervention,oxygen saturation,duration of hospital,and ICU length of *** compara-tive study provided with full text is *** outcome of each study was analyzed using a trandom effects model with relative risk and mean difference as the effect *** risk assessment was conducted using the New-castle-Ottawa *** analyses were performed using Review Manager ***:A total of 11 studies with 3154 samples included in this *** is no significant difference in 30-day mortality between the two groups(p-value=0.10).However,there is significantly less complication(RR 0.53[0.35,0.82];p-value=0.004)and unplanned intervention(RR 0.59[0.38,0.92];p-value=0.02)in the AD stent *** of the Nakata index showed no significant difference(p-value=0.88).Post-operative oxygen saturation was measured signifi-cantly higher in the AD stenting(MD 1.80[0.85,2.74];p-value=0.0002).However,AD stent group shows sig-nificantly lower long-term oxygen saturation(MD-8.43[-14.38,-2.48];p-value=0.005).Both hospital and ICU length of stay was significantly shorter in the AD stent group(MD-8.30[-11.13,-5.48];p-value<0.00001;MD-5.09[-7.79,-2.38];p-value=0.0002).Conclusion:AD stenting provides comparable outcomes relative to MBTS as it provides less complication and unplanned intervention and higher post-procedural O2 ***,MBTS proved its superiority in maintaining higher long-term oxygen saturation and still beca

关键词： Duct-dependent pulmonary circulation arterial duct stenting modified Blalock-Taussig shunt

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