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Effect of Chlorophytum Borivilianum Santapau and Fernandes on Sexual Dysfunction in Hyperglycemic Male Rats

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Chinese Journal of Integrative Medicine 2009年第6期15卷 448-453页

作者： Mayank Thakur Shilpi Bhargava Werner Praznik Renate Loeppert Vinod K Dixit Department of Pharmaceutical Sciences dr. hari singh gour university Department of Chemistry university of Natural and Applied Life Sciences dr.hari singh gour university

Objective:To investigate the effects of Chlorophytum borivilianum(CB) on sexual dysfunction, loss of body weight,and lack of libido in hyperglycemic rats induced with streptozotocin or ***: Wistar strain male albino rats were divided into five groups of six animals each:the control group(2% polyvinylpyrollidone solution),the streptozotocin control group(50 mg/kg),the alloxan control group(100 mg/kg), the streptozotocin + CB treated group(200 mg/kg),and the alloxan + CB treated group(200 mg/kg).O...

关键词： ayurvedic rasayana Chlorophytum borivilianum diabetes induced sexual dysfunction Safed Musli

A systematic review on the aboveground biomass and carbon stocks of Indian forest ecosystems

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Ecological Processes 2018年第1期7卷 165-176页

作者： Onkar Salunkhe P.K.Khare Richa Kumari M.L.Khan Laboratory of Ecology Department of BotanyDr.Hari Singh Gour UniversitySagarMadhya Pradesh 470003India

Background:Tropical forests play a crucial role as source and sink in global carbon *** and other anthropogenic activities have led to degradation of forest land,and ultimately,it results in loss of biodiversity and increases concentration of CO_(2) in ***,there is urgent need to estimate regional and national level carbon stock for making forest-based policies and strategies for mitigation of CO_(2).Patchy and sporadic information is available on biomass and carbon stock of Indian *** paper presents a systematic review and comprehensive account of studies conducted in different forest types in ***:There are six major forest types found in India consisting of 15 groups and other subgroups with peculiar *** used by researchers for biomass/carbon stock estimation are destructive,nondestructive,tree inventories data,species-specific biomass estimation,and remote *** of estimates are based on nondestructive allometric equation *** showed positive correlation between tree species,diameter at breast height,and biomass/carbon ***-and medium-sized growing trees,invasive species,mixed forest,Agroforestry,and Agrosilviculture also play an important role in atmospheric carbon *** results of diverse forest carbon stock studies are broadly categorized in North,Central,and Southern *** review will be helpful for developing conservation policies and decision to increase carbon stock and also REDD+program for particular forest ***:The systematic literature review was carried out to gather and summarize information from different studies conducted on forest ecosystems and quantification methods used for biomass estimation and carbon stock in different forests types and states of *** general,great variability occurs in aboveground biomass and carbon stock on account of climatic and geographic *** obtain good and accurate

关键词： Tropical forests Aboveground biomass Carbon stock

SIMULATION OF INVENTORY POLICY FOR PRODUCT WITH PRICE AND TIME-DEPENDENT DEMAND FOR DETERIORATING ITEM

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 1-30页

作者： D.SHUKLA U.K.KHEDLEKAR R.P.S.CHANDEL S.BHAGWAT Department of Mathematics and Statistics dr.hari singh gour Central university Sagar M.P.India Department of Mathematics and Computer Science Model Science College Jabalpur M.P.India Department of Business Management dr.hari singh gour Central university Sagar M.P.India

In a declining market for goods,we optimize the net profit in business when inventory management allows change in the selling prices n times over time *** are computing optimal number of changes in prices,respective optimal prices,and optimal profit in each of the cycle for a deteriorating *** paper theoretically proves that for any business setup there exists an optimal number of price settings for obtaining maximum *** results are supported by numerical examples for different setups(data set)and it is found that for every setup the dynamic pricing policy out-performs the static pricing *** our model,the deterioration factor has been taken into *** deteriorated units are determined by the recurrence *** we studied the effect of different parameters on optimal policy with *** managerial purposes,we have provided some“suggested intervals”for choosing parameters depending upon initial demand,which help to predict the best prices and arrival of customers(demand).

关键词： Dynamic pricing deterioration time-dependent price sensitive demand optimal policy optimal number of change in price

Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 471-474页

作者： Abhishek K Jain V Ravichandran Madhvi Sisodiya RK Agrawal Pharmaceutical Chemistry Research Laboratory Department of Pharmaceutical SciencesDr.Hari Singh Gour UniversitySagar(M.P)-470 003India Faculty of Pharmacy AIMST UniversitySemeling-08100KedahMalaysia Pharmaceutical Chemistry Research Laboratory Department of Pharmaceutical SciencesDr.Hari Singh Gour UniversitySagar(M.P)-470003India

Objective:To synthesis 2-substituted-4,5-diphenyl-N- alkyl imidazole derivatives,and evaluate their antibacterial ***:A mixture of benzil（10 mmol） and ammonium acetate（0.1 mol）（immediately fused） in glacial acetic acid（25 mL） was stirred at 80-100℃for 1 h under nitrogen atmosphere（to prevent incorporation of any atmospheric impurities and moisture）. Substituted aldehydes（10 mmol） in glacial acetic acid（5 mL） was added drop-wise over a period of 15-20 min at the same temperature and stirred for another 4 h,the progress of the reaction was monitored by TLC test using ethyl acetate as *** newly synthesized compounds were characterized by IR,1HNMR,13CNMR and by mass ***:All the synthesized compounds were confirmed by spectroscopical techniques and evaluated for antimicrobial activity against Staphylococcus aureus（***）,Bacilus subtilus（***）,and Escheria coli （***）.These compounds showed antibacterial activity（zone of inhibition） against *** ranged from 3 mm to 9 mmin diameter,***,4 -8 mm,and *** 5 -12 *** of 2a-2e, only 2a and 2b showed some sort of activity but none of them had considerable activity compared with that of the ***:All the synthesized compounds show moderate activity against the tested bacteria ***,***,and ***,further structural modification is necessary to improve the antibacterial action of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives.

关键词： Antibacterial activity Imidazole derivatives N-alkyl imidazole

Novel targeting approaches and signaling pathways of colorectal cancer: An insight

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World Journal of Gastroenterology 2018年第39期24卷 4428-4435页

作者： Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain Pharmaceutics Research Projects Laboratory Department of Pharmaceutical SciencesDr. Hari Singh Gour Central University

Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.

关键词： Colorectal cancer Immunotherapy Gene therapy Signaling Targeted therapy

固定化介导提高苦味叶下珠中的海冰叶下珠脂素和叶下珠次素的含量(英文)

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中国天然药物 2012年第3期10卷 207-212页

作者： J.S.Thakur R.K.Agarwal M.D.Kharya Plant Biotechnology Laboratory Department of Pharmaceutical SciencesDr.Hari Singh Gour Central University

Phyllanthus amarus plant is used in the traditional system of medicine as a hepatoprotective drug for which the majorlignans phyllanthin and hypophyllanthin are *** far,no significant work has been done on the culture of this *** hepatoprotective potential,the present investigation was undertaken.A cost effective process was developed for enhancingphyllanthin and hypophyllanthin utilizing the immobilization *** was used to compare the phyllanthin and hypophyllanthincontents in calcium alginate immobilized cells obtained from fresh grown plants and MS medium was supplemented withdifferent abiotic elicitors,under aseptic conditions for the treatment with chitosan,copper sulphate,phenylalanine and silver nitratesolution to make the whole process commercially *** was revealed that silver nitrate and phenylalanine at low concentrationenhances phyllanthin and hypophyllanthin yield as compared to control immobilized cell *** study revealed that an increase inthe content of phyllanthin and hypophyllanthin was elicitor concentration dependent and silver nitrate treatment gave a maximum yieldof hepatoprotective bioactives as compared to the other abiotic elicitors used.

关键词： Immobilization Elicitors Lignans Hepatoprotective HPTLC

PREPARATION AND CHARACTERIZATION OF PVA BASED SOLID POLYMER ELECTROLYTES FOR ELECTROCHEMICAL CELL APPLICATIONS

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Chinese Journal of Polymer Science 2013年第4期31卷 641-648页

作者： Anji Reddy Polu Ranveer Kumar Department of Physics K L UniversityGuntur 522502India Department of Physics Dr. Hari Singh Gour University (A Central University)Sagar M.P. 470003India

Solid polymer electrolyte films containing poly（vinyl alcohol）（PVA） and magnesium nitrate （Mg（NO3）2） were prepared by solution casting technique and characterized by using XRD, FTIR, DSC and AC impedance spectroscopic analysis. The amorphous nature of the polymer electrolyte films has been confirmed by XRD. The complex formation between PVA and Mg salt has been confirmed by FTIR. The glass transition temperature decreases with increasing the Mg salt concentration. The AC impedance studies are performed to evaluate the ionic conductivity of the polymer electrolyte films in the range of 303-383 K, and the temperature dependence seems to obey the Arrhenius behavior. Transport number measurements show that the charge transport is mainly due to ions. Electrochemical cell of configuration Mg/（PVA ＋ Mg（NO3）2）（70：30）/（12 ＋ C ＋ electrolyte） has been fabricated. The discharge characteristics of the cell were studied for a constant load of 100 kΩ.

关键词： Polymer electrolyte XRD DSC Ionic conductivity Electrochemical cell.

In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 385-388页

作者： Kamlesh singh Nisha singh Anish Chandy Ashish Manigauha Rawatpura Sarkar Institute of Pharmacy Barpali Institute of Pharmacy School of Pharmacy Choksey Engineering College Department of Pharmaceutical Sciences Dr.Hari Singh Gour University

Objective:To assess the In vivo anlioxid Fanl and hepaloproleclive activity of metlianolic exlracl of Daucus carota(***) seeds in experimental ***:Methanolic extracts of *** seeds is used for hepatoproleclion *** stress were induced in rats by thioacetamide 100 nig/kg *** four groups of rats(two test,standard and toxic control). Two test groups received *** seeds extract[DCSE) at doses of 200 mg/kg and 400 mg/kg. Standard group received silymarin(25 mg/kg) and toxic control received only thioacetamide. Control group received only *** the 8th day animals were sacrificed and liver enzyme like serum glutamic pyruvic transaminase(SGPT),serum glutamic-oxaloacetic transaminase(SCOT) and alkaline phosphatase(ALP)were estimated in blood serum and antioxidant enzyme like superoxide disnuituse(SOD),cululase(CAT),glutathione reductase(CKD),glutathione peroxidase(GPX),glutalhione-S-transferase(GST)and lipid peroxidation(LPO)were estimated in liver ***:A significant decrease in SGPT,SCOT and ALP levels was observed in all drug treated groups as compared to thioacetamide group(P<0.001) and in case of antioxidant enzyme a significant(P<0.001) increase in ***,GRD,GPX and GST was observed in all dmg treated groups as compared with thioacetamide *** in case of LPO a significant(P <0.001) reduction was observed as compared to toxic control ***:DCSE has contributed lo the reduction of oxidative stress and the protection of liver in experimental rals.

关键词： Daucus carota seeds extract Thioacetamide Silymarin Hepatoprotection Antioxidant Biochemical parameters

印度传统药用植物可因氏越橘的研究综述(英文)

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中西医结合学报 2011年第8期9卷 824-833页

作者： Priyanka Gupta Alok Nahata Vinod K.Dixit Department of Pharmaceutical Sciences Dr.Hari Singh Gour University

可因氏越橘又名调料九里香(Murraya koenigii,芸香科,九里香属),是一种常用的药用植物,在印度阿育吠陀医学中有数百年的使用历史。这种植物的叶子、果实、根及树皮均富含咔唑生物碱。已有的很多研究报道这些生物碱具有多种药理活性如抗... 详细信息

可因氏越橘又名调料九里香(Murraya koenigii,芸香科,九里香属),是一种常用的药用植物,在印度阿育吠陀医学中有数百年的使用历史。这种植物的叶子、果实、根及树皮均富含咔唑生物碱。已有的很多研究报道这些生物碱具有多种药理活性如抗肿瘤、抗病毒、抗炎、止泻、利尿、抗氧化等。除了这些药理活性,该植物还具有多种多样的生物活性。可因氏越橘作为一种能够治疗多种疾病的有价值的药用植物,有关其植物化学及药理学的研究数量众多,因此有必要对其作一系统的综述。本文对有关可因氏越橘的植物化学、药理学、临床及基础研究进行了系统的整理,以期更全面地发掘其作为药用植物的价值。

关键词：芸香科九里香属医学印度传统植物提取物综述