In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

作     者：Kamlesh Singh Nisha Singh Anish Chandy Ashish Manigauha 

作者机构：Rawatpura Sarkar Institute of Pharmacy Barpali Institute of Pharmacy School of PharmacyChoksey Engineering College Department of Pharmaceutical SciencesDr.Hari Singh Gour University 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2012年第2卷第5期

页      面：385-388页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Daucus carota seeds extract Thioacetamide Silymarin Hepatoprotection Antioxidant Biochemical parameters 

摘      要：Objective:To assess the In vivo anlioxid Fanl and hepaloproleclive activity of metlianolic exlracl of Daucus carota(***) seeds in experimental ***:Methanolic extracts of *** seeds is used for hepatoproleclion *** stress were induced in rats by thioacetamide 100 nig/kg *** four groups of rats(two test,standard and toxic control). Two test groups received *** seeds extract[DCSE) at doses of 200 mg/kg and 400 mg/kg. Standard group received silymarin(25 mg/kg) and toxic control received only thioacetamide. Control group received only *** the 8th day animals were sacrificed and liver enzyme like serum glutamic pyruvic transaminase(SGPT),serum glutamic-oxaloacetic transaminase(SCOT) and alkaline phosphatase(ALP)were estimated in blood serum and antioxidant enzyme like superoxide disnuituse(SOD),cululase(CAT),glutathione reductase(CKD),glutathione peroxidase(GPX),glutalhione-S-transferase(GST)and lipid peroxidation(LPO)were estimated in liver ***:A significant decrease in SGPT,SCOT and ALP levels was observed in all drug treated groups as compared to thioacetamide group(P0.001) and in case of antioxidant enzyme a significant(P0.001) increase in ***,GRD,GPX and GST was observed in all dmg treated groups as compared with thioacetamide *** in case of LPO a significant(P 0.001) reduction was observed as compared to toxic control ***:DCSE has contributed lo the reduction of oxidative stress and the protection of liver in experimental rals.