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Journal of Geriatric Cardiology 2013年第2期10卷 -页

作者： LiFeng Hong SongHui Luo JianJun Li Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College BeiLiShi Road 167 Beijing 100037 China divison of Cardiology the Fifth Hospital of Wuhan Wuhan 430050 China

Percutaneous coronary intervention (PCI) in an anomalous right coronary artery (RCA) can be technically difficult because selective cannulation of the vessel may not be easy. We thereby present two cases with unstable angina pectoris of anomalous originated RCA. The PCI were successfully performed in two patients with a special guiding wire manipulating skill which we called "gone with the flow" combined with balloon anchoring technology, providing excellent angiographic visualization and sound guide support for stent delivery throughout the procedure without severe cardiovascular adverse effects. Our primary data suggested that PCI for geriatric patients with an anomalous origin of RCA accompanied by severe atherosclerotic lesions might also be a safe, available, and feasible strategy.

关键词： Angina Anomalous right coronary artery Coronary angiography Percutaneous coronary intervention

Inflammation in coronary artery diseases

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Chinese medical Journal 2011年第21期124卷 3568-3575页

作者： LI Jian-jun divison of Dyslipidemia Cardiovascular Medicine Fu Wai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

The concept that atherosclerosis is an inflammation has been increasingly recognized, and subsequently resulted in great interest in revealing the inflammatory nature of the atherosclerotic process. More recently, a large body of evidence has supported the idea that inflammatory mechanisms play a pivotal role throughout all phases of atherogenesis, from endothelial dysfunction and the formation of fatty streaks to plaque destabilization and the acute coronary events due to vulnerable plaque rupture. Indeed, although triggers and pathways of inflammation are probably multiple and vary in different clinical entities of atherosclerotic disorders, an imbalance between anti-inflammatory mechanisms and pro-inflammatory factors will result in an atherosclerotic progression. Vascular endothelial dysfunction and lipoprotein retention into the arterial intima have been reported as the earliest events in atherogenesis with which inflammation is linked. Inflammatory has also been extended to the disorders of coronary microvasculature, and associated with special subsets of coronary artery disease such as silent myocardial ischemia, myocardial ischemia-reperfusion, cardiac syndrome X, variant angina, coronary artery ectasia, coronary calcification and in-stent restenosis. Inflammatory biomarkers, originally studied to better understand the pathophysiology of atheroscleresis, have generated increasing interest among researches and clinicians. The identification of inflammatory biomarkers and cellular/molecular pathways in atherosclerotic disease represent important goals in cardiovascular disease research, in particular with respect of the development of theraoeutic strategies to orevent or reverse atherosclerotic diseases.

关键词： coronary artery disease atherosclerosis inflammation

Molecular and biochemical basis of softening in tomato

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Molecular Horticulture 2022年第1期2卷 63-72页

作者： Duoduo Wang Graham B.Seymour College of Chemistry and Life sciences Zhejiang Normal UniversityJinhuaZhejiang 321004China School of Life sciences Jiangsu UniversityZhenjiang 212013China divison of Plant and Crop sciences University of NottinghamSutton BoningtonLoughboroughLeics LE125RDUK

We review the latest information related to the control of fruit softening in tomato and where relevant compare the events with texture changes in other fleshy *** of an acceptable texture is essential for consumer acceptance,but also determines the postharvest life of *** complex modern supply chain demands effective control of shelf life in tomato without compromising colour and *** control of softening and ripening in tomato(Solanum lycopersicum)are discussed with respect to hormonal cues,epigenetic regulation and transcriptional modulation of cell wall structure-related *** the last section we focus on the biochemical changes closely linked with softening in tomato including key aspects of cell wall *** important elements of the softening process have been identified,but our understanding of the mechanistic basis of the process in tomato and other fruits remains incomplete,especially the precise relationship between changes in cell wall structure and alterations in fruit texture.

关键词： Tomato Cell walls Softening Pectin Ripening

Review of magnesium-based biomaterials and their applications

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Journal of Magnesium and Alloys 2018年第1期6卷 23-43页

作者： Nurettin Sezer Zafer Evis Said Murat Kayhan Aydin Tahmasebifar Muammer Koça Sustainable Development divison Hamad Bin Khalifa UniversityQatar FoundationEducation CityDohaQatar Engineering sciences Middle East Technical UniversityPO Box 06800AnkaraTurkey

In biomedical applications,the conventionally used metallic materials,including stainless steel,Co-based alloys and Ti alloys,often times exhibit unsatisfactory results such as stress shielding and metal ion *** surgical operation(s)usually become inevitable to prevent long term exposure of body with the toxic implant *** metallic biomaterials are being revolutionized with the development of biodegradable materials including several metals,alloys,and metallic *** such,the nature of metallic biomaterials are transformed from the bioinert to bioactive and multi-biofunctional(anti-bacterial,anti-proliferation,anti-cancer,etc.).Magnesium-based biomaterials are candidates to be used as new generation biodegradable ***(Mg)can dissolve in body fluid that means the implanted Mg can degrade during healing process,and if the degradation is controlled it would leave no debris after the completion of ***,the need for secondary surgical operation(s)for the implant removal could be *** its biocompatibility,the inherent mechanical properties of Mg are very similar to those of human *** have been working on synthesis and characterization of Mg-based biomaterials with a variety of composition in order to control the degradation rate of Mg since uncontrolled degradation could result in loss of mechanical integrity,metal contamination in the body and intolerable hydrogen evolution by *** was observed that the applied methods of synthesis and the choice of components affect the characteristics and performance of the Mg-based *** have synthesized many Mg-based materials through several synthesis routes and investigated their mechanical properties,biocompatibility and degradation behavior through in vitro,in vivo and in silico *** paper is a comprehensive review that compiles,analyses and critically discusses the recent literature on the important aspects of Mg-based biom

关键词： Mg-based biomaterials Mechanical properties Implant Biomedical applications Biodegradation

Comparison of Antioxidant Activities in Black Soybean Preparations Fermented with Various Microorganisms

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Agricultural sciences in China 2010年第7期9卷 1065-1071页

作者： QIN Yao JIN Xiao-nan Park Heui Dong Department of Food Science and Technology Kyungpook National University Daegu 702-701 Korea Applied Plant Stress Biology Lab/divison of Biotechnology/College of Life sciences and Biotechnology Korea University Seoul 136-713 Korea

Black soybeans [Glycine max（L.） Merrill] were fermented with various GRAS（generally recognized as safe） microorganisms,including Aspergillus sp.,Bacillus *** yeast（Issatchenkia orientalis） at 30°C for 3 *** antioxidant contents,including total phenolics and total flavonoids,and the antioxidant activities of 1,1-diphenyl-2-picrylhydrazine（DPPH）,ferric reducing antioxidant power（FRAP） and *** were analyzed in preparations of fermented black *** cultures proved to yield significant levels of antioxidants compared with non-fermented cultures（P 〈 0.05）.Fermented black soybean preparations possessed antioxidant activities could be attributed to the total phenolics and flavonoids present.

关键词： antioxidant activity black soybean microorganisms fermentation

Decadal Changes in Climatological Intraseasonal Fluctuation of Subseasonal Evolution of Summer Precipitation over the Korean Peninsula in the mid-1990s

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Advances in Atmospheric sciences 2011年第3期28卷 591-600页

作者： WonMoo KIM Jong-Ghap JHUN Kyung-Ja HA Masahide KIMOTO School of Earth and Environmental sciences/Research Institute of Oceanography Seoul National University151-742Korea divison of Earth Environmental System Pusan National University609-735Korea Atmosphere and Ocean Research Institute University of Tokyo277-8564Japan

Decadal changes in the subseasonal evolution and the phase-locked climatological intraseasonal fluctuation of summertime rainfall over the Korean Peninsula before and after the mid-1990s are *** activity and the migration speed of the monsoon rain band over the East Asian region are altered in the recent decade,resulting in the drier conditions in late spring and the earlier onset of *** early August when a climatological monsoon break was clear in the earlier decade,the precipitation has increased dramatically with a meridional *** response to the enhanced convection over the South China Sea and southeastern China provides a favorable condition for more precipitation in early August through the changes in moisture transport and tropical cyclone passage.

关键词： decadal change intraseasonal fluctuation East Asian summer monsoon

Emerging targets in cancer drug resistance

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Cancer Drug Resistance 2019年第2期2卷 161-177页

作者： Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta School of Basic and Applied sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Urology Case Western Reserve UniversityClevelandOhio 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOhio 44106USA Department of Nutrition Case Western Reserve UniversityClevelandOhio 44106USA divison of General medical sciences Case Comprehensive Cancer CenterClevelandOhio 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOhio 44106USA.

Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer *** cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and *** the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic *** review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.

关键词： Drug resistance transforming growth factor-β Keap1-Nrf2 PI3K-Akt FOXO transcription factors focal adhesion kinases annexins MIEN1 gene splicing sphingolipids microRNA

Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms

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Cancer Drug Resistance 2020年第4期3卷 742-761页

作者： Shiv Verma Kumari Sunita Prajapati Prem Prakash Kushwaha Mohd Shuaib Atul Kumar Singh Shashank Kumar Sanjay Gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA School of Basic and Applied sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA divison of General medical sciences Case Comprehensive Cancer CenterClevelandOH 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOH 44106USA

Androgen deprivation therapy targeting the androgens/androgen receptor(AR)signaling continues to be the mainstay treatment of advanced-stage prostate *** use of second-generation antiandrogens,such as abiraterone acetate and enzalutamide,has improved the survival of prostate cancer patients;however,a majority of these patients progress to castration-resistant prostate cancer(CRPC).The mechanisms of resistance to antiandrogen treatments are complex,including specific mutations,alternative splicing,and amplification of oncogenic proteins resulting in dysregulation of various signaling *** this review,we focus on the major mechanisms of acquired resistance to second generation antiandrogens,including AR-dependent and AR-independent resistance mechanisms as well as other resistance mechanisms leading to CRPC *** knowledge of resistance mechanisms to AR targeted treatments will lead to additional research on designing more effective therapies for advanced-stage prostate cancer.

关键词： Prostate cancer second-generation antiandrogens androgen receptor castration resistance prostate cancer

Association of dyslipidemia with vasospastic angina

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Chinese medical Journal 2014年第7期127卷 1370-1376页

作者： Hong Lifeng Luo Songhui Li Jianjun Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China divison of Cardiology Guangci Hospital affiliated Medical College of Wuhan University & the Fifth Hospital of Wuhan Wuhan Hubei 430050 China

Variant angina(VA)has been described the clinical entity whereby a sudden intense,spontaneous and reversible vasoconstriction of a coronary artery branch,subsequently resulted in subtotal or total occlusion during the duration of attack or provocative *** is used to appear frequently at rest in the absence of any augment of myocardial oxygen demand and associated with

关键词： vasospastic angina dyslipidemia therapy

Heterogeneous fenton oxidation of methylene blue with Fe-impregnated biochar catalyst

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Biochar 2020年第2期2卷 164-175页

作者： Jong‑Hwan Park Jim J.Wang Ki Hun Park Dong‑Cheol Seo divison of Applied Life Science(BK21 Plus)and Institute of Agriculture and Life Science Gyeongsang National UniversityJinju 52828South Korea School of Plant Environmental and Soil SciencesLouisiana State University Agricultural CenterBaton RougeLA 70803USA

Fe-impregnated biochar(Fe-BC)as high-efficiency heterogeneous Fenton catalyst was synthesized and evaluated in detail for its catalytic activity,stability and reusability under various *** optimal conditions for the Fenton oxidation of methylene blue(MB)as model dye were determined as 0.075 g/L H_(2)O_(2),0.5 g/L Fe-BC for 0.1 g/L MB,which resulted in optimum Dye:Fe_(cat):H_(2)O_(2) ratio of 1:5:0.75(on g/L basis)or[Dye]:[Fe_(total)]:[H_(2)O_(2)]molar ratio of 1:6.2:7.0 *** effective degradation of MB was identified over a wider pH range,and even after four consecutive runs Fe-BC maintained above 95%MB removal rate within 3 min of treatment with low Fe release,indicating strong stability and *** the optimum Dye:Fe_(cat):H_(2)O_(2)(g/L)condition at initial pH 4,the Fe-BC achieved 99.9%removal efficiency of MB within 3 min in heterogeneous Fenton reaction(HEFR)with much less H_(2)O_(2) concentration and low catalyst dosage,demonstrat-ing its efficiency and cost-effectiveness compared to other Fenton reaction *** removal velocity of MB showed two rate steps:a fast first stage followed by a slow stage with the rate in the order of H_(2)O_(2)/Fe-BC⋙H_(2)O_(2)/biochar>biochar>H_(2)O_(2).Overall,the developed Fe-BC is more economical with strong stability and recyclability for use in HEFR for treating recalcitrant pollutants.

关键词： Fe-impregnated biochar catalyst Heterogeneous fenton reaction Impregnation and pyrolysis Removal velocity Methylene blue Sugarcane residue