Emerging targets in cancer drug resistance

作     者：Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta 

作者机构：School of Basic and Applied SciencesDepartment of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of UrologyCase Western Reserve UniversityClevelandOhio 44106USA The Urology InstituteUniversity Hospitals Cleveland Medical CenterClevelandOhio 44106USA Department of NutritionCase Western Reserve UniversityClevelandOhio 44106USA Divison of General Medical SciencesCase Comprehensive Cancer CenterClevelandOhio 44106USA Department of UrologyLouis Stokes Cleveland Veterans Affairs Medical CenterClevelandOhio 44106USA. 

出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)

年 卷 期：2019年第2卷第2期

页      面：161-177页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Efforts are supported by the Department of Defense Grants(W81XWH-18-1-0618,W81XWH-15-1-0558) VA Merit Review(1I01BX002494)to Gupta S.Kushwaha PP acknowledges financial support from University Grants Commission,India in the form of CSIR-UGC Senior Research fellowship Kumar S acknowledges Department of Science and Technology,India,and University Grants Commission,India for providing financial support in the form of DST-SERB Grant[EEQ/2016/000350]and UGC-BSR Research Start-Up-Grant[No.F.30-372/2017(BSR)]respectively 

主　　题：Drug resistance transforming growth factor-β Keap1-Nrf2 PI3K-Akt FOXO transcription factors focal adhesion kinases annexins MIEN1 gene splicing sphingolipids microRNA 

摘      要：Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer *** cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and *** the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic *** review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.