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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Research 2024年第1期2023卷 281-299页

作者： Bitao Lu Enling Hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital ***,multiple hemostatic strategies are critical for treating large bleeding *** this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug *** aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug *** ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally *** novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

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家蚕二化性杂交品种部分数量性状遗传参数的初步评估(英文)

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昆虫学报 2005年第6期48卷 982-985页

作者： Gulam Nabi MALIK Syed Zia Ul Haque RUFAIE Tejender Paul SINGH Mohammed Farooq BAQUAL Habib Ullah DAR division of sericulture Mirgund Baramulla Sher-e-Kashmir University of Agricultural Sciencesand TechnologyPost Box 674 G.P.O Srinagar 190001 INDIA

采用完全随机设计法根据10头老熟幼虫体重、全茧重、茧层量、茧层率(%)、存活率、万蚕茧层量和茧丝长等指标,对两对二化性家蚕Bombyx moriL.杂交品系(SH6×NB4D2和CSR2×CSR4)杂交一代的22个子代个体进行了遗传参数估算,以缩小优质蚕品... 详细信息

采用完全随机设计法根据10头老熟幼虫体重、全茧重、茧层量、茧层率(%)、存活率、万蚕茧层量和茧丝长等指标,对两对二化性家蚕Bombyx moriL.杂交品系(SH6×NB4D2和CSR2×CSR4)杂交一代的22个子代个体进行了遗传参数估算,以缩小优质蚕品种的候选范围,并且计算出直接筛选的参数,如遗传力和遗传进度等,使这些信息可用于以筛选高产新品种为目的的育种和选择过程中。杂交子代2,4,5,6,7,10,14,16,19和20号个体在这几个指标中表现出显著的优越性。全茧重、万蚕茧层量和茧丝长的遗传力和遗传进度较大,可以简单地从表现型的差异对这些性状进行选择并取得遗传性状改良。其他几个指标(10头老熟幼虫体重、茧层量、茧层率(%)和存活率)的遗传力和遗传进度较低,对这些性状进行直接选择来改良品种的效果较差。

关键词：家蚕杂交一代遗传力遗传进度

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Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

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Research 2022年第4期2022卷 119-135页

作者： Haoyu Qiu Guangqian Lan Weiwei Ding Xinyu Wang Wenyi Wang Dahua Shou Fei Lu Enling Hu Kun Yu Songmin Shang Ruiqi Xie State Key Laboratory of ilkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityKowloonHong Kong

Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these *** this study,a Janus particle,SEC-Fe@CaT with dual-driven forces,bubble-driving,and magnetic field–(MF–)mediated driving,was prepared via in situ loading of Fe_(3)O_(4) on a sunflower sporopollenin exine capsule(SEC),and followed by growth of flower-shaped CaCO3 *** bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration,and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the *** the movement in blood flow,the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells(RBCs)to release procoagulants,thus promoting activation of platelet and rapid *** tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models,*** contrast,the similar commercial product Celox™required approximately 70 s to stop the bleeding in both bleeding *** study demonstrates a new hemostat platform for rapid hemostasis in deep and complex *** was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.

关键词： driving bubble eliminate

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Actinobacteria-enhanced plant growth, nutrient acquisition, and crop protection:Advances in soil, plant, and microbial multifactorial interactions

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Pedosphere 2022年第1期32卷 149-170页

作者： Debasis MITRA Rittick MONDAL Bahman KHOSHRU Ansuman SENAPATI T.K.RADHA Bhaswatimayee MAHAKUR Navendra UNIYAL Ei Mon MYO Hanane BOUTAJ Beatriz Elena GUERRA SIERRA Periyasamy PANNEERSELVAM Arakalagud Nanjundaiah GANESHAMURTHY Snežana ANÐELKOVIĆ Tanja VASIĆ Anju RANI Subhadeep DUTTA Pradeep K.DAS MOHAPATRA Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India Department of sericulture Raiganj UniversityRaiganjWest Bengal 733134India Department of Soil Science Faculty of AgricultureUniversity of TabrizTabriz 51664Iran Crop Production division Indian Council of Agricultural Research(ICAR)National Rice Research InstituteCuttackOdisha 753006India division of Soil Science and Agricultural Chemistry ICAR Indian Institute of Horticultural ResearchBengaluruKarnataka 560089India Department of Botany and Biotechnology Ravenshaw UniversityCuttackOdisha 753003India Genetics and Tree Propagation division Forest Research InstituteUttarakhand 248003India Biotechnology Research Department Department of Research and InnovationMinistry of EducationKyaukse 05151Myanmar Laboratory of Biotechnology and Molecular Bioengineering Faculty of Sciences and TechnologyCadi Ayyad UniversityMarrakesh 40000Morocco Universidad de Santander Facultad de Ciencias Exactas Naturales y AgropecuariasGrupoMicrobiotaCampus Universitario Lagos del CaciqueBucaramanga 680002Colombia Institute for Forage Crops Kruševac 37251Republic of Serbia Plant Protection Faculty of AgricultureUniversity of NišKosančićeva 4Kruševac 37000Republic of Serbia Department of Life Sciences Graphic Era(Deemed to be University)DehradunUttarakhand 248002India Professor A.K.Bothra Environment Conservation Centre Raiganj UniversityRaiganjWest Bengal 733134India

Agricultural areas of land are deteriorating every day owing to population increase, rapid urbanization, and industrialization. To feed today’s huge populations, increased crop production is required from smaller areas, which warrants the continuous application of high doses of inorganic fertilizers to agricultural land. These cause damage to soil health and, therefore, nutrient imbalance conditions in arable soils. Under these conditions, the benefits of microbial inoculants (such as Actinobacteria) as replacements for harmful chemicals and promoting ecofriendly sustainable farming practices have been made clear through recent technological advances. There are multifunctional traits involved in the production of different types of bioactive compounds responsible for plant growth promotion, and the biocontrol of phytopathogens has reduced the use of chemical fertilizers and pesticides. There are some well-known groups of nitrogen-fixing Actinobacteria, such as Frankia, which undergo mutualism with plants and offer enhanced symbiotic *** addition to nitrogen fixation, increasing availability of major plant nutrients in soil due to the solubilization of immobilized forms of phosphorus and potassium compounds, production of phytohormones, such as indole-3-acetic acid, indole-3-pyruvic acid, gibberellins, and cytokinins, improving organic matter decomposition by releasing cellulases, xylanase, glucanases, lipases, and proteases, and suppression of soil-borne pathogens by the production of siderophores, ammonia, hydrogen cyanide, and chitinase are important features of Actinobacteria useful for combating biotic and abiotic stresses in *** positive influence of Actinobacteria on soil fertility and plant health has motivated us to compile this review of important findings associated with sustaining plant productivity in the long run.

关键词： biocontrol agents microbial inoculant metabolites mitrogen fixation plant growth promoters sustainable agriculture

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Rice(Oryza sativa L.)plant protection using dual biological control and plant growth-promoting agents:Current scenarios and future prospects

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Pedosphere 2023年第2期33卷 268-286页

作者： Debasis MITRA Sergio DE LOS SANTOS-VILLALOBOS Fannie Isela PARRA-COTA Ana María Garcia MONTELONGO Erika Lorena BLANCO Vanessa L.LIRA Adeyemi N.OLATUNBOSUN Bahman KHOSHRU Rittick MONDAL Parameswaran CHIDAMBARANATHAN Periyasamy PANNEERSELVAM Pradeep K.DAS MOHAPATRA Department of Microbiology Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Instituto Tecnológico de Sonora 5 de febrero 818.Col.CentroCd.ObregónSonora 85000(Mexico) Campo Experimental Norman E.Borlaug-Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias(INIFAP)Norman E.Borlaug Km.12C.P.Ciudad ObregónSonora 85000(Mexico) Laboratorio de Investigación en Biotecnología y Química de Polímeros Decanato de InvestigaciónUniversidad Nacional Experimental del TáchiraSan Cristóbal 5001(Venezuela) Departamento de Micologia Federal University of PernambucoRecifePE 50670-901(Brazil) Department of Plant Physiology and Crop Production Federal University of AgricultureAbeokuta 111101(Nigeria) Department of Soil Science Faculty of AgricultureUniversity of TabrizTabriz 51664(Iran) Department of sericulture Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Biotechnology Crop Improvement DivisionIndian Council of Agricultural Research(ICAR)-National Rice Research InstituteCuttackOdisha 753006(India) Microbiology Crop Production DivisionICAR-National Rice Research InstituteCuttackOdisha 753006(India) Professor A.K.Bothra Environment Conservation Centre Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India)

Various microorganisms live in association with different parts of plants and can be harmful,neutral,or beneficial to plant *** microbial inhabitants of plants can control plant diseases by contesting with,predating on,or antagonizing plant pathogens and by inducing systems for plant defense.A range of methods,including plant growth-promoting microorganisms(PGPMs)as biological control agents(BCAs)(BCA-PGPMs)are used for the biological management and control of plant *** BCAs interact with plants by inducing resistance or priming plants without direct interaction with the *** BCAs operate via nutrient competition or other mechanisms to modulate the growth conditions for the ***,PGPMs can be applied alone or together with other chemicals or carriers to control various crop *** review highlights the effective types of BCA-PGPMs and their applications,roles,carrier based-formulations,and responses to rice(Oryza sativa L.)*** plant disease management prospects are promising,and growers’increasing demand for BCA-PGPM products can be exploited as an effective approach to the management of plant diseases,as well as to improve yield,environmental protection,biological resources,and agricultural system sustainability.

关键词： biological control agent plant disease plant growth-promoting microorganism plant health plant pathogen

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Quantitative Proteomic Study on Allotriploid Populus and its Full-sib Diploid Reveal Molecular mechanism of vegetative growth advantage in Populus allotriploid

Quantitative Proteomic Study on Allotriploid Populus and its...

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中国蚕学会2018年学术年会

作者： Yi Wang Tong Qiu Qiang Han Xiangyang Kang Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry University National Engineering Laboratory for Tree Breeding Beijing Forestry University College of Biological Sciences and Biotechnology Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of EducationBeijing Forestry University sericulture ＆ Agri-Food Research Institute Guangdong Academy of Agricultural Sciences

Although plant allotriploid has a prominent vegetative growth advantages, the underlying molecular mechanisms haves not yet been revealed and elucidated. In the present study, a newly synthesized F1 hybrid diploid and two allotriploid populations driven by 2 n female gametes [FDR（First division restitution）, SDR（Second division restitution）] were used. Label-free proteome quantitative method were used to analyze the proteomics divergence between allotriploid and diploid with the same parents in the different leaf positions. The results showed that there were 417 differentially expressed proteins between Populus allotriploid and diploid, including 64 differentially expressed proteins associated with vegetative growth. Functional classification analysis showed that there were 14 differentially expressed proteins（DEPs） related to photosynthetic, 8 DEPs related to starch and sucrose synthesis and metabolism, 14 DEPs associated with respiratory chain, 8 DEPs were involved in TCA cycle. Among them, the β and γ subunit PsbQ NPsbR N, PsbP NRN, Lhca2, Lhca6 FBA, PPDK, PsaE N, PsaL N, F-ATPase, GBSS, Iglg C, UGP2 SS, polysaccharide phosphorylase, NADH-dehydrogenase complex I, cytochrome c reductase,NDUFS4, NDUFV2, NDUFAB1, ATPF0 A0, ATPF0 B, ATPeF 1 E,ATPeV 0 C, ATPeV 1 F, ATPeV 0 C, ATPeV 1 F, OGDH, ACO, IDH1,FBA, GLDC and PPS were upregulated in Populus allotriploid. Some DEPs involved in TCA cycle, amino acid metabolism and carbohydrate metabolism increased with the leave positions and DEPs related to photosynthesis mainly increased first and then decreased. Furthermore, the resistance related proteins mainly showed an increasing *** increased abundance of photosynthetic proteins, enzymes of starch and sucrose metabolism, oxidative phosphorylation respiratory chain assembly proteins and TCA cycle enzymes might promoted the accumulation of carbonhydrate and increased energy metabolism efficiency in allotriploid. In addition, the relative high expression level of stres

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