Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds
作者机构：State Key Laboratory of ilkworm Genome BiologyCollege of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern TextileChongqing 400715China Division of Trauma and Surgical Intensive Care UnitResearch Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Institute of Textiles and ClothingThe Hong Kong Polytechnic UniversityKowloonHong Kong
出 版 物：《Research》 (研究（英文）)
年 卷 期：2022年第2022卷第4期
页 面：119-135页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.52103096) Natural Science Foundation of Chongqing,China(grant number cstc2020jcyjmsxmX0383) Fundamental Research Funds for the Central Universities(grant number SWU-KT22004) Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars(cx2019050) Innovation Project for Graduate Student of Chongqing(CYB21121)
摘 要：Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these *** this study,a Janus particle,SEC-Fe@CaT with dual-driven forces,bubble-driving,and magnetic field–(MF–)mediated driving,was prepared via in situ loading of Fe_(3)O_(4) on a sunflower sporopollenin exine capsule(SEC),and followed by growth of flower-shaped CaCO3 *** bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration,and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the *** the movement in blood flow,the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells(RBCs)to release procoagulants,thus promoting activation of platelet and rapid *** tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models,*** contrast,the similar commercial product Celox™required approximately 70 s to stop the bleeding in both bleeding *** study demonstrates a new hemostat platform for rapid hemostasis in deep and complex *** was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.
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