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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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Hysteresis and Multi-state Behavior of Counterflow Flame in a Blowing Cylindrical Burner

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Journal of Thermal Science 2009年第3期18卷 276-283页

作者： Hsing-Sheng Chai General education division Aletheia University

This study focuses on flame hysteresis over a porous cylindrical burner. The hysteresis results from different operation procedure of the experiment. Gradually increasing inflow velocity can transform the envelope flame into a wake flame. The blow-off curve can be plotted by determining every critical inflow velocity that makes an envelope flame become a wake flame at different fuel-ejection velocities. In contrast, decreasing the inflow veiocity can transform the wake or lift-off flame into an envelope one. The reattachment curve can be obtained by the same method to explore the blow-off curve, but the intake process is reverse. However, these two curves are not coincident, except the origin. The discrepancy between them is termed as hysteresis, and it results from the difference between the burning velocities associated with both curves. At the lowest fuel-ejection velocity, no hysteresis exists between both curves owing to nearly no burning velocity difference there. Then, raising the fuel-ejection velocity enhances hysteresis and the discrepancy between the two curves. However, as fuel-ejection velocity exceeds a critical value, the intensity of hysteresis almost keeps constant and causes the two curves to be parallel to each other.

关键词： Hysteresis Blow-off curve Reattachment curve Cylindrical burner Counterflow flame

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Effectiveness of music intervention on cognitive function and neuropsychiatric symptoms in the elderly with dementia:a meta-analysis

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Frontiers of nursing 2022年第2期9卷 143-153页

作者： Cecilia Wong TT division of nursing education School of Continuing EducationHong Kong Baptist UniversityHong KongChina

Dementia is increasing dramatically with an increasing elderly *** interventions are proven to have limited efficacy to treat many of the features of *** such a situation,non-pharmacological means become important to help people with dementia,especially music *** efficacy of music intervention on cognition has been barely explored in the literature,and the few studies that are available present inconsistent *** aim of this systematic review is to have a meta-analysis on the effect of music therapy for improvements in cognitive functions as well as neuropsychiatric symptoms in the elderly with dementia.

关键词： Alzheimer’s disease cognitive function dementia music therapy neuropsychiatric symptoms

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Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

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Accretion onto the Magnetically Charged Regular Black Hole

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Chinese Physics Letters 2017年第7期34卷 38-40页

作者： M.Azam A.Aslam division of Science and Technology University of Education Lahore 54590 Pakistan

We investigate the accretion process for static spherically symmetric geometry, i.e., magnetically charged regular black hole with isotropic fluid. W＇e obtain generalized expressions for the velocity （u（r））, speed of sound （cs2）, energy density （ρ（r）） and accretion rate （M） at the critical point near the regular black hole during the accretion process. We also plot these physical parameters against fixed values of charge, mass and different values of equation of state parameter to study the process of accretion. We find that radial velocity and energy density of the fluid remain positive and negative as well as rate of change of mass is increased and decreased for dust, stiff, quintessence fluid and phantom-like fluid, respectively.

关键词： Accretion onto the Magnetically Charged Regular Black Hole

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Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants

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Journal of Integrative Medicine 2018年第5期16卷 358-366页

作者： The Su Moe Htet Htet Win Thin Thin Hlaing War War Lwin Zaw Min Htet Khin Mar Mya Pharmaceutical Research Laboratory Biotechnology Research DepartmentMinistry of EducationMandalay Division Department of Research and Innovation (DRI) Ministry of Education Cell Culture Laboratory Biotechnology Research DepartmentMinistry of EducationMandalay Division

Objective： Myanmar has a long history of using medicinal plants for treatment of various diseases. To the best of our knowledge there are no previous reports on antiglycation activities of medicinal plants from Myanmar. Therefore, this study was aimed to evaluate the antioxidant, antiglycation and antimicrobial properties of 20 ethanolic extracts from 17 medicinal plants indigenous to Myanmar. Methods： In vitro scavenging assays of 2,2-diphenyl-l-picrylhydrazyl （DPPH）, nitric oxide （NO）, superoxide （SO） radicals were used to determine the antioxidant activities. Folin-Ciocalteu＇s method was performed to determine the total phenolic content. Antiglycation and antimicrobial activities were detected by bovine serum albumin-fluorescent assay and agar well diffusion method. Results： Terminalia cbebula Retz. （Fruit）, containing the highest total phenolic content, showed high antioxidant activities with inhibition of 77.98% ± 0.92% 88.95% ± 2.42%, 88.56% ±1.87% and 70.74% ±2.57% for DPPH, NO, SO assays and antiglycation activity respectively. It also showed the antimicrobial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coil, Pseudomonas aeruginosa and Candida albicans with inhibition zone of 19, 18, 17, 25 and 15 ram, respectively. Garcinia mangostana Linn. showed the strongest activities for SO and antiglycation assays with inhibition of 93.68% ± 2.63% and 82.37%± 1.78%. Bark of Melia sp. was the best NO radical scavenger with inhibition rate of 89.39%± 0.60%. Conclusion： The results suggest that these plants are potential sources of antioxidants with free radical-scavenging and antiglycation activities and could be useful for decreasing the oxidative stress and glycation end-product formation in glycation-related diseases.

关键词： Medicinal plants Antiglycation Antioxidant2,2 -Diphenyl-1 -picrylhydrazyl Nitric oxide Superoxide Antimicrobial agents

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

作者： Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333TaiwanChina

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging

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Stability of Quark Star Models

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Communications in Theoretical Physics 2016年第5期65卷 575-584页

作者： M.Azam S.A.Mardan M.A.Rehman division of Science and Technology University of Education Department of Mathematics University of the Management and Technology

In this paper,we investigate the stability of quark stars with four different types of inner matter configurations;isotropic,charged isotropic,anisotropic and charged anisotropic by using the concept of *** this purpose,we have applied local density perturbations technique to the hydrostatic equilibrium equation as well as on physical parameters involved in the *** conclude that quark stars become potentially unstable when inner matter configuration is changed and electromagnetic field is applied.

关键词： quark stars cracking density perturbations electromagnetic field

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