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Imported Mansonella perstans infection in Spain

infectious diseases of Poverty 2020年第4期9卷 158-158页

作者： Sabino Puente Mar Lago Mercedes Subirats Ismael Sanz-Esteban Marta Arsuaga Belén Vicente Montserrat Alonso-Sardon Moncef Belhassen-Garcia Antonio Muro Unidad de Medicina tropical Servicio de Medicina InternaHospital La Paz-Carlos IIIMadridSpain Microbiología Hospital La Paz-Carlos IIIMadridSpain Facultad de Fisioterapia Universidad Europea de MadridMadridSpain Laboratorio de Inmunología Parasitaria y Molecular CIETUSIBSALFacultad de FarmaciaUniversidad de Salamanca37007SalamancaSpain Área de Medicina Preventiva y Salud Pública IBSALCIETUSUniversidad de SalamancaSalamancaSpain Servicio de Medicina Interna Sección de Enfermedades InfecciosasCAUSAIBSALCIETUSUniversidad de SalamancaPaseo San Vicente 58-18237007SalamancaSpain

Background Mansonella perstans infection can be considered one of the most neglected tropical infectious *** few studies have reported on the clinical picture caused by infection with this ***,our study was aimed to describe the clinical patterns and treatment of imported *** infection by migrants from *** The present study evaluated a large cohort of migrants who have been diagnosed,examined and treated for imported *** infection at a Spanish reference center(Hospital Carlos III tropical Medicine Unit,Madrid,Spain)over a 19-year *** patients voluntarily attend the emergency unit or are referred from primary care or general hospitals in ***-square test was used to compare the association between categorical *** continuous variables were compared by Student’s t-test or the Mann–Whitney *** corresponding regression models were used for multivariate *** Five hundred three cases of migrants from tropical and subtropical areas with *** infection were *** hundred sixty-four patients were female(52.5%).The mean age(±SD)was 44.6±18.2 years(range:16–93 years).The mean time(±SD)between the arrival in Spain and the first consultation was 8.6±18.0 *** major origin of the patients was Equatorial Guinea(97.6%).Regarding the clinical picture,257 patients were asymptomatic(54.7%)and 228 were symptomatic(45.3%);190 patients had pruritus(37.8%),50(9.9%)had arthralgia,18 patients had Calabar-like swelling(3.6%),and 15(3%)had abdominal *** hundred forty-two(87.9%)migrants had hyper-IgE,and 340(67.6%)had *** hundred ninety-five patients had coinfections with other filarial nematodes(38.8%),and 308 migrants had only *** infection(61.2%).Four hundred thirty-seven cases(86.9%)had been treated with anti-filarial drugs;292 cases were treated with one anti-filarial drug,and 145 cases were treated with combined anti-filarial ***,20(4%)

关键词： Mansonellosis Mansonella perstans Clinical study Immigrant Imported diseases Spain

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Nitrapyrin effectiveness in reducing nitrous oxide emissions decreases at low doses of urea in an Andosol

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Pedosphere 2021年第2期31卷 303-313页

作者： Mayela MONGE-MUÑOZ Segundo URQUIAGA Christoph MÜLLER Juan Carlos CAMBRONEROHEINRICHS Mohammad ZAMAN Cristina CHINCHILLA-SOTO Azam BORZOUEI Khadim DAWAR Carlos E.RODRÍGUEZ-RODRÍGUEZ Ana Gabriela PÉREZ-CASTILLO Environmental Pollution Research Center(CICA) University of Costa RicaMontes de Oca 11501(Costa Rica) Embrapa Agrobiology Rod.BR 465km 7SeropédicaRJCEP 23891-000(Brazil) Institute of Plant Ecology Justus Liebig University GiessenHeinrich-Buff Ring 26Giessen 35392(Germany) School of Biology and Environmental Science University College DublinBelfieldDublin 4(Ireland) Soil and Water Management&Crop Nutrition Section Joint FAO/IAEA Division of Nuclear Techniques in Food and AgricultureDepartment of Nuclear Sciences and ApplicationsInternational Atomic Energy AgencyVienna International CentreVienna 1400(Austria) Nuclear Agriculture Research School Nuclear Science and Technology Research Institute(NSTRI)Karaj ***(Iran) Department of Soil and Environmental Sciences University of AgriculturePeshawar 25000(Pakistan)

In the tropics,frequent nitrogen(N)fertilization of grazing areas can potentially increase nitrous oxide(N_(2)O)*** application of nitrification inhibitors has been reported as an effective management practice for potentially reducing N loss from the soil-plant system and improving N use efficiency(NUE).The aim of this study was to determine the effect of the co-application of nitrapyrin(a nitrification inhibitor,NI)and urea in a tropical Andosol on the behavior of N and the emissions of N_(2)O from autotrophic and heterotrophic nitrification.A greenhouse experiment was performed using a soil(pH 5.9,organic matter content 78 g kg^(-1),and N 5.6 g kg^(-1))sown with Cynodon nlemfuensis at 60%water-filled pore space to quantify total N_(2)O emissions,N_(2)O derived from fertilizer,soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-)),and *** study included treatments that received deionized water only(control,NI).No significant differences were observed in soil NH_(4)^(+)content between the UR and UR+NI treatments,probably because of soil mineralization and NO_(3)^(-)produced by heterotrophic nitrification,which is not effectively inhibited by *** 56 d,N_(2)O emissions in UR(0.51±0.12 mg N_(2)O-N concluded that the soil organic N mineralization and heterotrophic nitrification are the main processes of NH_(4)^(+)and NO_(3)^(-)***,it was found that N_(2)O emissions were partially a consequence of the direct oxidation of the soil's organic N via heterotrophic nitrification coupled to ***,the results suggest that nitrapyrin would likely exert significant mitigation on N_(2)O emissions only if a substantial N surplus exists in soils with high organic matter content.

关键词： autotrophic nitrification heterotrophic nitrification mineral N ^(15)N tracer nitrification inhibitor tropical grass

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Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

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四川生理科学杂志 2021年第10期43卷 1819-1819页

作者： Arabella S V Stuart [a]Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK [b]Chinese Academy of Medical Science Oxford Institute University of Oxford Oxford UK [c]Wellcome Centre for Human Genetics Nuffield Department of Medicine University of Oxford Oxford UK [d]Oxford University Hospitals NHS Foundation Trust Oxford UK [e]Statistics Modelling and Economics Department UK Health Security Agency London UK [f]Immunisation and Countermeasures division National Infection Service UK Health Security Agency London UK [g]Public Health Scotland Glasgow Scotland UK [h]UK Health Security Agency Porton Down Salisbury UK [i]Liverpool School of tropical Medicine Liverpool UK [j]Department of Infection Immunity and Cardiovascular Disease University of Sheffield Sheffield UK [k]Department of Infection and tropical Medicine Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK [l]The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK [m]Translational and Clinical Research Institute Newcastle University Newcastle UK [n]NIHR Southampton Clinical Research Facility and Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK [o]Faculty of Medicine and Institute for Life Sciences University of Southampton Southampton UK [p]School of Population Health Sciences and School of Cellular and Molecular Medicine University of Bristol Bristol UK [q]Department of Infection and NIHR BRC Guy's and St Thomas' NHS Foundation Trust London UK [r]MRC Clinical Trials Unit University College London London UK [s]NIHR/Wellcome Trust Clinical Research Facility University Hospitals Birmingham NHS Foundation Trust Birmingham UK [t]Institute of Microbiology and Infection University of Birmingham Birmingham UK [u]The Vaccine Institute St George's University of London London UK [v]North Bristol NHS Trust Bristol UK [w]NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre University College Lo

Background:Given the importance of flexible use of different COVID-19 vaccines within the same schedule to facilitate rapid deployment,we studied mixed priming schedules incorporating an adenoviral-vectored vaccine(ChAdOx1 nCoV-19[ChAd],AstraZeneca),two mRNA vaccines(BNT162b2[BNT],Pfizer-BioNTech,and mRNA-1273[m1273],Moderna)and a nanoparticle vaccine containing SARS-CoV-2 spike glycoprotein and Matrix-M adjuvant(NVX-CoV2373[NVX],Novavax).

关键词： Pfizer schedule COV

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Debate on Bacille Calmette-Guérin vaccination against COVID-19: Is it worth performing clinical trials?

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Biosafety and Health 2020年第3期2卷 113-114页

作者： Asma Binte Aziz Jennifer L.Dembinski Yasmin Jahan University of Oslo Faculty of MedicineOsloNorway Norwegian Institute of Public Health(NIPH) Division of Infection Control and Environmental HealthOsloNorway Graduate School of Biomedical and Health Sciences Hiroshima UniversityJapan

The non-specific beneficial effects of Bacille Calmette-Guérin(BCG)vaccination suggest that this vaccine might play a role in protecting individuals against severe coronavirus disease 2019(COVID-19).Several studies propose that BCG vaccination may increase the body's immunity,thereby preventing respiratory infections caused by other respiratory *** the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date,scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19,and the results were found to vary widely:from no significant effect being observed to a reduction in the time taken for clinical *** study thus aims to evaluate whether it is worth performing clinical trials to examine the effects of the BCG vaccine on *** herein emphasize the need to conduct phase III randomized controlled trials with adequate sample size and quality to investigate the effects of the BCG vaccine on *** the event that BCG vaccination provides non-specific protection against COVID-19,administering it could be helpful in controlling the transmission of COVID-19 and other infectious diseases during future pandemics.

关键词： Bacille Calmette-Guérin COVID-19 Non-specific effect RCT Clinical trial

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Establishing a treatment protocol for concomitant major burn and trauma patients:a tropical Asian hospital's experience

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Burns & Trauma 2017年第3期5卷 215-217页

作者： Yee Onn Kok Nadia Sim Priya Tiwari Ting Hway Wong Si Jack Chong Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Level 11 NUHS Tower Block Singapore 119228 Singapore division of Plastic Reconstructive and Aesthetic Surgery Department of Surgery National University Health System Level 8 NUHS Tower Block 1E Kent Ridge Road Singapore 119228 Singapore Department of General Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore

Dear Editor,Burns and trauma represent two of the most severe injuries that both developing and developed countries face today. Concomitant burn and traumatic injuries are significant in terms of disease burden and co... 详细信息

关键词： Burns Trauma Protocol

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Seroprevalence of dengue among healthy adults in a rural community in Southern Malaysia:a pilot study

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infectious diseases of Poverty 2018年第1期7卷 1-13页

作者： Amreeta Dhanoa Sharifah Syed Hassan Nowrozy Kamar Jahan Daniel D.Reidpath Quek Kia Fatt Mohtar Pungut Ahmad Cheong Yuet Meng Lau Wee Ming Anuar Zaini Zain Maude Elvira Phipps Iekhsan Othman Aman Bin Rabu Rowther Sirajudeen Ahmad Abdul Basitz Ahmad Fatan Faidzal Adlee Ghafar Hamdan Bin Ahmad Pascale Allotey Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Petaling JayaMalaysia Segamat District Public Health Office Ministry of Health MalaysiaPeti Surat 102Jalan Gudang UbatKampung Gubah85000 SegamatJohor Darul TakzimMalaysia Infection and Immunity Cluster Tropical Medicine and Biology PlatformMonash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Petaling JayaMalaysia South East Asia Community Observatory(SEACO) 146 Jalan Sia Her YamSuite 601-606Wisma Centrepoint85000 SegamatJohor Darul TakzimMalaysia Hospital Segamat Ministry of Health MalaysiaKM 6Jalan Genuang85000 SegamatJohor Darul TakzimMalaysia Universiti Sains Malaysia 11800 GelugorPenangMalaysia.

Background:The frequency and magnitude of dengue epidemics continue to increase exponentially in Malaysia,with a shift in the age range predominance toward adults and an expansion to rural *** this,information pertaining to the extent of transmission of dengue virus(DENV)in the rural community is *** communitybased pilot study was conducted to establish DENV seroprevalence amongst healthy adults in a rural district in Southern Malaysia,and to identify influencing ***:In this study undertaken between April and May 2015,a total of 277 adult participants were recruited from households across three localities in the Sungai Segamat subdistrict in Segamat *** were tested for immunoglobulin G(IgG)(Panbio®Dengue Indirect IgG ELISA/high-titer capture)and immunoglobulin M(IgM)(Panbio®)*** plaque reduction neutralization test(PRNT)was conducted on random samples of IgGpositive sera for further *** history and a recall of previous history of dengue were collected through interviews,whereas sociodemographic information was obtained from an existing ***:The overall seroprevalence for DENV infection was 86.6%(240/277)(95%CI:83-91%).Serological evidence of recent infection(IgM/high-titer capture IgG)was noted in 11.2%(31/277)of participants,whereas there was evidence of past infection in 75.5%(209/277)of participants(indirect IgG minus recent infections).The PRNT assay showed that the detected antibodies were indeed specific to *** multivariate analysis showed that the older age group was significantly associated with past DENV *** increased with age;48.5%in the age group of45 years(P<0.001).No associations with occupation,study site,housing type,comorbidity,educational level,and marital status were observed,although the latter two were statistically significant in the univariate *** of the studied factors were significantl

关键词： Dengue Dengue virus Rural Community-based study Seroprevalence Subclinical infection Malaysia

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Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek Kumar Anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar Department of Allied Medical Sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

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Heart‘omicsin’AGEing (HOMAGE):design,research objectives and characteristics of the common database

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The Journal of Biomedical Research 2014年第5期28卷 349-359页

作者： Lotte Jacobs Lutgarde Thijs Yu Jin Faiez Zannad Alexandre Mebazaa Philippe Rouet Florence Pinet Christophe Bauters Burkert Pieske Andreas Tomaschitz Mamas Mamas Javier Diez Kenneth McDonald John G F Cleland Hans-Peter Brunner-La Rocca Stephane Heymans Roberto Latini Serge Masson Peter Sever Christian Delles Stuart Pocock Timothy Collier Tatiana Kuznetsova Jan A Staessen Studies Coordinating Centre Research Unit Hypertension and Cardiovascular EpidemiologyKU Leuven Department of Cardiovascular Sciences University of Leuven Centre d'Investigation Clinique Pierre Drouin and U 961 Hypertension and Heart Failure UnitInstitut Lourrain du Coeur etdes VaisseauxInsermNancyFrance Department of Anesthesiology and Critical Care Medicine InsermUMR-S942Hopital LariboisiereUniversite Paris Diderot Equipe obesite et insuffisance cardiaque Universite UPSInserm I2MCUMR 1048ToulouseFrance Inserm U744CHRULilleFrance Department of Cardiology Medical University Graz Cardiovascular Institute University of ManchesterManchesterUK division of Cardiovascular Sciences Foundation for Applied Medical ResearchUniversity of Navarra Heart Failure Unit St Vincent's University Hospital University College Dublin Department of Cardiology University of HullUK Department of Cardiology Maastricht University Medical CentreNetherlands Center for Heart Failure Research Department of CardiologyMaastricht UniversityNetherlands Department of Cardiovascular Research IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" International Center for Circulatory Health Imperial College Institute of Cardiovascular and Medical Sciences BHF Glasgow Cardiovascular Research CenterUniversity of Glasgow London School of Hygiene and tropical Medicine

Heart failure is common in older people and its prevalence is *** Heart ＇omics＇ in AGEing（HOMAGE） project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on（1） prospective population studies or（2） cross-sectional,prospective studies or randomized controlled trials（RCTs） of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ＇omics＇-based biomarkers to identify the risk of developing heart failure and/or *** studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk ***,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy（n = 7,124）,patients with heart failure（n = 4,312） from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease（n = 31,629） in 13 *** is anticipated that more partners will join the consortium and enlarge the pooled *** large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.

关键词： left ventricle heart failure heart failure with reduced ejection fraction heart failure with preserved ejection fraction population science morbidity mortality

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青藏高原及其下游地区降水厚度季、日变化的气候特征分析

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大气科学 2010年第2期34卷 387-398页

作者：胡亮杨松李耀东中国科学院大气物理研究所北京100029 中国科学院研究生院北京100049 Satellite Meteorology and Climatology division Center for Satellite Applications and ResearchNational Oceanic and Atmospheric AdministrationCamp Springs 北京航空气象研究所北京100085

利用10年的TRMM卫星降水雷达观测资料,首次对青藏高原及其下游平原及海洋地区降水厚度的地区差异进行了对比分析,并对青藏高原及其周边地区对流和层云降水厚度的水平分布及其日变化和季节变化进行了统计分析,结果表明:(1)青藏高原地区... 详细信息

利用10年的TRMM卫星降水雷达观测资料,首次对青藏高原及其下游平原及海洋地区降水厚度的地区差异进行了对比分析,并对青藏高原及其周边地区对流和层云降水厚度的水平分布及其日变化和季节变化进行了统计分析,结果表明:(1)青藏高原地区对流和层云降水厚度都要比下游平原地区更为浅薄,东部海洋地区对流降水厚度比平原地区小,而层云降水厚度与平原地区相当。青藏高原及其下游平原地区对流降水厚度的日变化特征非常明显,海洋地区对流降水厚度日夜差异则不大。层云降水厚度在各地区的日变化特征都不明显。青藏高原、下游平原及海洋地区对流和层云降水厚度的季节变化都非常明显,从冬至夏,对流和层云降水逐渐变得深厚,而从夏入冬,对流和层云降水则逐渐变得浅薄。(2)青藏高原及其周边地区对流和层云平均降水厚度的分布形式和降水量分布具有较好的对应关系,降水量大的地区其降水厚度一般较为深厚,降水少的地区则降水厚度比较浅薄。对流和层云降水厚度存在明显差异,对流降水一般要比层云降水深厚。青藏高原及其周边地区降水厚度水平分布的日夜差距不大,但季节变化非常明显,且与气候系统的季节变化紧密相关。

关键词：热带测雨卫星对流降水层云降水降水厚度日变化青藏高原

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Shock Wave of a New Pandemic: Response of Antenatal Women in Ebonyi State, Nigeria to Corona Virus 19 Infection—Knowledge, Attitude and Practice

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Advances in infectious diseases 2021年第1期11卷 29-41页

作者： Chidi Esike Justus Eze Okechukwu Anozie Emeka Onwe Richard Ewah Esther Emeka-Irem Ndukwe Nwigboji Emeka Ukaegbe Ugochukwu Nnadozie Odidika Umeora Department of Obstetrics and Gynecology Alex Ekwueme Federal University Teaching Hopital Abakaliki Ebonyi State Nigeria Department of Pediatrics Alex Ekwueme Federal University Teaching Hopital Abakaliki Ebonyi State Nigeria Department of Anesthesia Alex Ekwueme Federal University Teaching Hopital Abakaliki Ebonyi State Nigeria division of Plastic Surgery Department of Surgery Alex Ekwueme Federal University Teaching Hopital Abakaliki Ebonyi State Nigeria

Background: There are no known effective vaccines or drugs for curing the corona 19 virus infection as at present knowlede. This leaves the world with mainly controlling the source of infection and cutting off the transmission route through preventive measures to contain the pandemic. These entail active participation of people, high level of discipline and strict and meticulous adoption of preventive measures. Since it is known that knowledge, precautionary behavior and active social participation of the public are important to control the pandemic, this study sets out to evaluate these in the antenatal population in Ebonyi State. Objective: To evaluate the Knowledge, attitude and practice of the respondents to the corona virus 19 infection and its prevention. Methods: A self-administered pre-tested questionnaire was administered to pregnant women attending antenatal clinics in the chosen Mission hospitals and the only tertiary health institution that offer antenatal care to the bulk of antenatal population in the state. The results were analyzed using SPSS version 20 and Microsoft Excel 2016. Result: The participants had very good knowledge of corona virus 19 infection and its prevention but there were some gaps and misconceptions in knowledge and some of their attitudes and perceptions that raised concerns. Their practice of corona virus 19 preventive measures was poor despite their good knowledge. Conclusion: There is need to fashion out programs and policies that will address the gaps and concerns unearthed in the study to enhance the protection of this vulnerable study population and the general public.

关键词： Knowledge Practice Antenatal Population Ebonyi Nigeria

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