Debate on Bacille Calmette-Guérin vaccination against COVID-19: Is it worth performing clinical trials?

作     者：Asma Binte Aziz Jennifer L.Dembinski Yasmin Jahan 

作者机构：University of OsloFaculty of MedicineOsloNorway Norwegian Institute of Public Health(NIPH)Division of Infection Control and Environmental HealthOsloNorway Graduate School of Biomedical and Health SciencesHiroshima UniversityJapan 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2020年第2卷第3期

页      面：113-114页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Bacille Calmette-Guérin COVID-19 Non-specific effect RCT Clinical trial 

摘      要：The non-specific beneficial effects of Bacille Calmette-Guérin(BCG)vaccination suggest that this vaccine might play a role in protecting individuals against severe coronavirus disease 2019(COVID-19).Several studies propose that BCG vaccination may increase the body s immunity,thereby preventing respiratory infections caused by other respiratory *** the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date,scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19,and the results were found to vary widely:from no significant effect being observed to a reduction in the time taken for clinical *** study thus aims to evaluate whether it is worth performing clinical trials to examine the effects of the BCG vaccine on *** herein emphasize the need to conduct phase III randomized controlled trials with adequate sample size and quality to investigate the effects of the BCG vaccine on *** the event that BCG vaccination provides non-specific protection against COVID-19,administering it could be helpful in controlling the transmission of COVID-19 and other infectious diseases during future pandemics.