检索结果-南通市图书馆

Infectious disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.Hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen Ian H.Spicknall Matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2020年第2期35卷 235-239页

作者： Li Zhang Shan Lei Hui Xie Qianqian Li Shuo Liu Qiang Liu Weijin Huang Xinyue Xiao Youchun Wang division of hiv/AIDS and sexually-transmitted Virus Vaccines National Institutes for Food and Drug ControlBeijing 102629China Institute for Reference Standards and Standardization National Institutes for Food and Drug ControlBeijing 102629China

Dear Editor,Marburg virus(MARV)belongs to the Filoviridae family,along with the related Ebola virus(EBOV).Although MARV is less renowned than EBOV,it causes an equally devastating disease,with clinical symptoms similar to EBOV infection and a remarkably high mortality *** date,about 600 MARV cases have been reported globally,with an average mortality rate of around 80%(Brauburger et al.2012).Due to the severity of disease caused by MARV,as well as its threat to global public health,MARV is classified as a risk group 4 pathogen by WHO,necessitating containment measures equivalent to biosafety level 4(BSL-4).

关键词： mortality al. clinical

Monitoring Neutralization Property Change of Evolving Hantaan and Seoul Viruses with a Novel Pseudovirus-Based Assay

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2021年第1期36卷 104-112页

作者： Tingting Ning Ling Wang Shuo Liu Jian Ma Jianhui Nie Weijin Huang Xuguang Li Yuhua Li Youchun Wang division of hiv/AIDS and sexually transmitted Virus Vaccines National Institutes for Food and Drug Control(NIFDC)Beijing 102629China division of Arboviruses Vaccine National Institutes for Food and Drug Control(NIFDC)Beijing 102629China Centre for Biologics Evaluation Biologics and Genetic Therapies DirectorateHealth CanadaOttawaON K2J 4X9Canada

The Hantaan virus(HTNV)and Seoul virus(SEOV)mutants have accumulated over *** is important to determine whether their neutralizing epitopes have evolved,thereby making the current vaccine ***,it is impossible to determine by using traditional plaque reduction neutralization test(PRNT),because it requires large numbers of live mutant ***-based neutralization assays(PBNA)were developed by employing vesicular stomatitis virus(VSV)backbone incorporated with HTNV or SEOV glycoproteins(VSVDG*-HTNVG or VSVDG*-SEOVG).56 and 51 single amino acid substitutions of glycoprotein(GP)in HTNV and SEOV were selected and introduced into the reference *** the mutant pseudoviruses were generated and tested by *** PBNA results were highly correlated with PRNT ones with R2 being 0.91 for VSVDG*-HTNVG and 0.82 for VSVDG*-SEOVG.53 HTNV mutant pseudoviruses and 46 SEOV mutants were successfully ***,by using PBNA,we found that HTNV or SEOV immunized antisera could neutralize all the corresponding 53 HTNV mutants or the 46 SEOV mutants *** novel PBNA enables us to closely monitor the effectiveness of vaccines against large numbers of evolving HTNV and *** the current vaccine remains to be effective for the naturally occurring mutants.

关键词： Hemorrhagic fever with renal syndrome(HFRS) Hantaan virus(HTNV) Seoul virus(SEOV) Pseudovirus-based neutralization assay(PBNA) Amino acid substitution Vaccine

Structural and functional insights into MCR-2 mediated colistin resistance

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第11期61卷 1432-1436页

作者： Xudong Wang Qiong Lu Jianxun Qi Yan Chai Youchun Wang George Fu Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products Division of HIV/AIDS and Sexually Transmitted Virus Vaccines National Institutes for Food and Drug Control National Institute for Viral disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences

Dear Editor,The spread of antibiotic resistance genes among bacteria is a serious and growing threat to global health (Peleg and Hoopet,2010).One emerging case is transferable genes found in bacteria-encoding enzymes resistant to *** is a cationic polypeptide antibiotic with broadspectrum activity against Gram-negative bacteria through interactions with the lipid A moiety of bacterial lipopoly-saccharide(LPS),subsequently destroying the cell *** late 2015,a plasmid-mediated gene,mcr-1,was first reported from Escherichia coli(***)in China to confer resistance to colistin(Liu et a1.,2016),and detected world-wide soon afterwards(Gao et a1.,2016;Hu et a1.,2016).

关键词： colistin resistance genes bacteria

hiv and syphilis infections among street-based female sex workers in China, 2010-2012

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第4期127卷 707-711页

作者： Li Dongmin Wang Lu Lin Wen Li Peilong Wang Lan Guo Wei Ge Lin Ding Zhengwei Cui Yan Wang Ning division of Epidemiology National Center for Acquired Immune Definciency Syndrome/Sexually Transmitted Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Santa Clara County Public Health Department California 95126USA

Background Female sex workers （FSW） were high-risk population for hiv and other sexually transmitted diseases （STD） earlier,and now are an important driver of the hiv/AIDS epidemic in *** surveillance for FSW was set up to monitor the trend of hiv prevalence and risk behavior-related hiv *** study collected the data on street-based FSW from hiv sentinel surveillance system to understand hiv and syphilis infections,risk behaviors,and intervention in China from 2010 to *** The study population was the street-based FSW who were recruited for the national hiv integrated biological and behavioral surveillance between 2010 and *** information,hiv-related risk behaviors,and hiv and syphilis testing results were described and trend analysis was *** Between 2010 and 2012,the number of street-based FSW surveyed was 3725,3425,and 3335,*** knowledge awareness rate significantly increased from 74.6% in 2010 to 76.8% in 2011 and 82.2% in 2012 （P 〈0.01）.More FSW consistently used condom in the last month （49.0% in 2010; 51.0% in 2011; and 59.0% in 2012） and in the last commercial sex （72.0% in 2010; 78.5% in 2011; and 80.0% in 2012） over *** proportions of individuals who received hiv testing in the last year were 31.2% （2010）,37.0% （2011）,and 36.9% （2012）（P-trend 〈0.01）.hiv prevalence rate changed from 1.5% in 2010 to 1.4% in 2011 and 2.3% in 2012 （P-trend=0.01）.Syphilis prevalence rate was 6.9%,7.2%,and 7.1% in the same *** top three provinces with the highest average hiv prevalence rates over the 3 years were Guangxi （5.9%）,Yunnan （4.2%）,and Sichuan （1.2%）.Conclusions Street-based FSW are at high risk of hiv and syphilis *** efforts need to target streetbased FSW who are of old age and minority,who use illicit drugs and have syphilis infection.

关键词： street-based female sex worker hiv syphilis prevalence risk behaviors

The Prevalence of Syphilis Is Associated with the Prevalence of Male Point-Concurrency: An Ecological Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of AIDS 2015年第2期5卷 131-139页

作者： Chris Richard Kenyon Kara Osbak sexually transmitted Infections hiv/STI Unit Institute of Tropical Medicine Antwerp Belgium division of Infectious diseases and hiv Medicine University of Cape Town Cape Town South Africa hiv/STI Unit Institute of Tropical Medicine Antwerp Belgium

Objective: The prevalence of syphilis differs considerably between different populations and indi-vidual level risk factors such as number of sex partners seem unable to completely explain these differences. The effect of network level factors, such as the prevalence of partner concurrency, on syphilis prevalence has not hitherto been investigated. Study design: Linear regression was per-formed to assess the relationship between the prevalence of male concurrency and prevalence of syphilis in each of 11 countries for which we could obtain comparable data. The data for concur-rency prevalence was taken from the WHO/Global Programme on AIDS (GPA) sexual behavioural surveys. Syphilis prevalence rates were obtained from antenatal syphilis serology surveys done in the same countries. In addition, we used linear regression to assess if there was a relationship between syphilis and concurrency prevalence of various racial and ethnic groups within the United States and South Africa. Results: In the international study, we found a strong relationship between the prevalence of male concurrency and syphilis prevalence (r = 0.79, P = 0.003). In the subnational studies, the relationship between concurrency and syphilis prevalence was positive in all cases but was only statistically significant so in the case of South Africa’s racial groups (r = 0.98, P = 0.01). Conclusions: The findings of an ecological-level association between syphilis and partner concurrency need to be replicated but suggest that efforts directed towards decreasing partner concurrency may reduce syphilis prevalence.

关键词： Concurrency Sexual Network hiv Syphilis

Spatial-temporal Analysis of Tuberculosis at the Community Level in the Baoshan District, Shanghai 2014–2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第5期35卷 458-462页

作者： MA Zhi Tao WANG Na HE Fan LIU Xiao Feng SHEN Xin Department of Tuberculosis and hiv/AIDS Prevention Baoshan Centers for Disease Control and PreventionBaoshan 201901ShanghaiChina division of Tuberculosis and hiv/AIDS Prevention Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Institutes of Preventive Medicine Shanghai 200336China

Mycobacterium tuberculosis is the primary bacteria that leads to human tuberculosis(TB),which usually affects the pulmonary *** is one of the top 10 causes of death worldwide;however,China is one of eight countries th... 详细信息

关键词： organs tuberculosis death

Animal models for COVID-19:advances,gaps and perspectives

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第8期7卷 2817-2840页

作者： Changfa Fan Yong Wu Xiong Rui Yuansong Yang Chen Ling Susu Liu Shunan Liu Youchun Wang division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)National Rodent Laboratory Animal Resources CenterBeijing 102629China Department of Microbiology&Infectious disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100083China College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceNorthwest UniversityXi’an 710069China division of hiv/AIDS and sexually transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)BeijingChina

COVID-19,caused by SARS-CoV-2,is the most consequential pandemic of this *** the outbreak in late 2019,animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy,as well as understanding the pathogenesis of SARS-CoV-2 infection and immune responses of ***,the current animal models have some deficits and there is an urgent need for novel models to evaluate the virulence of variants of concerns(VOC),antibodydependent enhancement(ADE),and various comorbidities of *** review summarizes the clinical features of COVID-19 in different populations,and the characteristics of the major animal models of SARS-CoV-2,including those naturally susceptible animals,such as non-human primates,Syrian hamster,ferret,minks,poultry,livestock,and mouse models sensitized by genetically modified,AAV/adenoviral transduced,mouse-adapted strain of SARS-CoV-2,and by engraftment of human tissues or *** understanding the host receptors and proteases is essential for designing advanced genetically modified animal models,successful studies on receptors and proteases are also *** improved alternatives for future mouse models are proposed,including the reselection of alternative receptor genes or multiple gene combinations,the use of transgenic or knock-in method,and different strains for establishing the next generation of genetically modified mice.

关键词： prevention drugs establishing

Hepatitis E: Epidemiology and prevention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2011年第12期3卷 285-291页

作者： Eyasu H Teshale Dale J Hu division of Viral Hepatitis Centers for Disease Control and Prevention National Center for HIV Viral Hepatitis STD TB Prevention Atlanta GA 30333 United States

Hepatitis E is caused by the hepatitis E virus (HEV), the major etiologic agent of enterically transmitted non-A hepatitis worldwide. HEV is responsible for major outbreaks of acute hepatitis in developing countries, especially in many parts of Africa and Asia. The HEV is a spherical, non-enveloped, single-stranded, positive sense RNA virus that is approximately 32 nm to 34 nm in diameter and is the only member in the family Hepeviridae and genus Hepevirus. There are four distinct genotypes of HEV (genotypes 1-4). While genotype 1 is predominantly associated with large epidemics in developing countries, genotype 3 has recently emerged as a significant pathogen in developed countries. The clinical manifestations and the laboratory abnormalities of hepatitis E are not distinguishable from that caused by other hepatitis viruses. However, high mortality among pregnant women particularly during the third trimester distinguishes HEV from other causes of acute viral hepatitis. Specific etiologic diagnosis among infected cases can be made by serological testing or detection of viral nucleic acid by reverse transcription polymerase chain reaction. Although there are vaccine candidates that had been shown to be safe and efficacious in clini-cal trials, none are approved currently for use. There is no specific therapy for acute hepatitis E as treatment remains supportive.

关键词： Hepatitis E virus Acute viral hepatitis Outbreak Epidemiology Serology Prevention

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei Zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China division of hiv/AIDS and sexually transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation