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Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Signal Transduction and Targeted Therapy 2021年第10期6卷 3132-3141页

作者： Yuanling Yu Meiyu Wang Xiaoai Zhang Shufen Li Qingbin Lu Haolong Zeng Hongyan Hou Hao Li Mengyi Zhang Fei Jiang Jiajing Wu Ruxia Ding Zehua Zhou Min Liu Weixue Si Tao Zhu Hangwen Li Jie Ma Yuanyuan Gu Guangbiao She Xiaokun Li Yulan Zhang Ke Peng Weijin Huang Wei Liu Youchun Wang division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)BeijingChina Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubeiChina Department of Laboratorial science and technology School of Public HealthPeking UniversityBeijingChina Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Sinovac Biotech Co. LtdBeijingChina Cansino Biotech Incorporation TianjinChina Stemirna Therapeutics LtdShanghaiChina Anhui Zhifeilongcom Biopharmaceutical Co. LtdHefeiChina University of Chinese Academy of sciences BeijingChina

Antibody-dependent cellular cytotoxicity(ADCC)responses to viral infection are a form of antibody regulated immune responses mediated through the Fc *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)triggered ADCC responses contributes to COVID-19 disease development is currently not well *** understand the potential correlation between ADCC responses and COVID-19 disease development,we analyzed the ADCC activity and neutralizing antibody response in 255 individuals ranging from asymptomatic to fatal infections over 1 year post *** was elicited by 10 days post-infection,peaked by 11-20 days,and remained detectable until 400 days *** general,patients with severe disease had higher ADCC ***,patients who had severe disease and recovered had higher ADCC activities than patients who had severe disease and ***,ADCC activities were mediated by a diversity of epitopes in SARS-COV-2-infected mice and induced to comparable levels against SARS-CoV-2 variants of concern(VOCs)(B.1.1.7,B.1.351,and P.1)as that against the D614G mutant in human patients and vaccinated *** study indicates anti-SARS-CoV-2 ADCC as a major trait of COVID-19 patients with various conditions,which can be applied to estimate the extra-neutralization level against COVID-19,especially lethal COVID-19.

关键词： patients ADCC Antibody

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Impacts of Field harvesting and Conservation Practices on the Physical Quality of Yam “Kponan” (Dioscorea cayenensis-rotundata) of Côte D’Ivoire

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Open Journal of Applied sciences 2022年第12期12卷 1979-1994页

作者： Yapo Hypolithe Kouadio Kouakou Nestor Kouassi Daouda Nimaga Yao Denis N’dri N’Guessan Georges Amani Laboratory of food Biochemistry and technology of Tropical Products Department of Food Science and Technology NANGUI ABROGOUA University Abidjan C&ocirc te D’Ivoire Swiss Center for Scientific Research in Cô te d’Ivoire (CSRS-CI) Abidjan C&ocirc te D’Ivoire Agronomic Forestry and Environmental Engineering Department University of Man Man C&ocirc te D’Ivoire

Yam “Kponan” (Dioscorea cayenensis-rotundata) is a popular staple food in Côte d’Ivoire. However, its rapid decay during conservation prevents regular supply of markets. The objective of this study was therefore to assess the impact of field cultivation and conservation practices on some physical quality parameters of “Kponan”. To this end, “Kponan” yam from three production areas (Bondoukou, Bouna, Kouassi-Kouassikro) was cultivated in each area. At maturity, physical parameters of yams at harvest and after 3 months of storage in field were analyzed. The results showed that injury was the most significant deterioration in yam harvest. The rate of injured yams was highest for hoe-harvested in Kouassi-Kouassikro area (16.67% - 22.22%) regardless of the origin of the cuttings. The main damage observed after the 3 months of storage was rots (22.86% - 60.00%) and weight loss (8.57% - 42.86%). However, yams stored in pits in Bouna zone had less damage (40% - 48.87%) than those stored under straw huts in Bondoukou locality (100%) and at shade under a tree in Kouassi-Kouassikro area (100%). In conclusion, the physical quality of “Kponan” in field is most affected by abusive use of herbicides during weeding and clearing, hoe harvesting and storage in the shade under a tree.

关键词： “Kponan” Yam post-harvest Loss Cultivation Practices Conservation Practices Physical Quality

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Study of N7-（2-carbamoyl-2-hydroxyethyl）Guanine in Urine Samples Repeatedly Collected from Acrylamide-Exposed Workers

Study of N7-（2-carbamoyl-2-hydroxyethyl）Guanine in Urine S...

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第八届海峡两岸毒理学研讨会

作者： Yu-Fang Huang Mei-Lien Chen Chih-Chun Huang Saou-Hsing Liou Su-Yin Chiang Kuen-Yuh Wu Institute of Environmental and Occupational Health sciences National Yang Ming University Department of food science National Pingtung University of Science and Technology division of Environmental Health and Occupational Medicine National Health Research Institutes School of Chinese Medicine China Medical University Institute of Occupational Medicine and Industrial Hygiene National Taiwan University

Acrylamide（AA）is a widely-used industrial chemical,present in tobacco smoke and high-temperature processed foods,and classified as a probable human *** activation from AA to glycidamide（GA）to form DNA adducts is critical to AA carcinogenicity.N7-（2-carbamoyl-2-hydroxyethyl）guanine（N7-GAG）,the most abundant DNA adduct induced by GA,was recently detected in urine of smokers and *** study aims to analyze N7-GAG in urine samples repeatedly collected from AA-exposed workers to explore its elimination ***,8 exposed and 36 control workers were recruited for this ***-and post-shift urine samples were collected from the exposed group in parallel with personal sampling for 8 consecutive days and from the control group for one day.N7-GAG was analyzed with our newly-developed two-step SPEs and on-line SPE liquid chromatography-electronspray ionization/tandem mass spectrometry（LC-ESI-MS/MS）***-and GA-mercapturic acids（AAMA and GAMA）were also analyzed to serve as biomarkers for AA current *** exposed workers excreted significantly higher N7-GAG levels than the controls.N7-GAG was significantly associated with AAMA and GAMA,*** of the N7-GAG data with linear mixed-effect model reveals a mean half-life at 346.5 hrs with a 95%confidence interval（140.3-737.2）*** from this study suggest that urinary N7-GAG levels could be elevated by occupational exposures to AA and intra-and inter-individual differences were damped with the half-life of the biomarkers.

关键词： Acrylamide N7-(2-carbamoyl-2-hydroxyethyl)guanine glycidamide elimination kinetics

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Antifungal activity of HSAF against Colletotrichum fructicola and its possible mechanisms of action

Antifungal activity of HSAF against Colletotrichum fructicol...

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中国植物病理学会2019年学术年会

作者：李朝辉 Tang Bao Sun Weibo Zhao Yancun 刘凤权 Institute of Plant Protection Jiangsu Key Laboratory for Food Quality and SafetyState Key Laboratory Cultivation Base of Ministry of Science and TechnologyJiangsu Academy of Agricultural Sciences

Anthracnose caused by Colletotrichum fructicola is one of the most important diseases in pear fruit,result in huge economic *** anthracnose is primarily an orchard disease but also may lead to significant post-harvest losses during the storage *** is an antifungal natural product isolated from the biocontrol agent Lysobacter enzymogenes and is regarded as a potential biological pesticide with novel mode of *** was previously demonstrated to show antifungal activity against a number of plant pathogenic fungi,but its efficacy against Colletotrichum species remained *** current study,the substantially antifungal activities of HSAF on mycelial growth,conidia germination and apperssorium formation of *** were observed in a dose-dependent *** found that HSAF was fungicidal toward Colletotrichum fructicola with half maximal effective concentration(EC)of 0.69 μg/mL when assayed mycelia growth on ***,hyphae grown on HSAF added plates displayed defects such as clustered branching,curling,swelling and depolarized *** the presence of HSAF(4 μg/mL),conidia germination were significanly delayed and the germ tubes growth were inhibited,however appressorium could still formed after 24 h ***,many HSAF-treated conidia featured small surface protuberances that could reflect failed attempts at forming a germ *** at the concentration of 8 μg/mL could totally block the conidia germination of *** conclusion,our results validate HSAF as a potential drug to treat anthracnose caused by Colletotrichum fructicola.

关键词： Biocontrol Antifungal activity Colletotrichum fructicola Anthracnose HSAF

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Grain Hermetic Storage Adoption in Northern Uganda: Awareness, Use, and the Constraints to technology Adoption

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Agricultural sciences 2022年第9期13卷 989-1011页

作者： Francis Okori Sam Cherotich Alex Abaca Emmanuel Baidhe Francis Adibaku James Denis Onyinge Department of Agricultural and Biosystems Engineering Makerere University Kampala Uganda National Agricultural Research Organization (NARO) Abi Zonal Agricultural Research and Development Institute Arua Uganda Department of Crop science Faculty of Agriculture and Environmental Sciences Muni University Arua Uganda Department of food science and postharvest technology Gulu University Gulu Uganda Agriculture and Market Support Programme United Nations World Food Programme Kampala Uganda

post-harvest storage losses (PHLs) remain significant in Sub-Saharan Africa (SSA) due to several factors mainly insect pests and molds. Hermetic storage technologies (HSTs) are being promoted to address these storage losses. In Uganda, HSTs were first introduced in 2012. However, its use among farming households remains low today. Data were collected from 306 smallholder farmers from four districts of Northern Uganda using a pre-tested semi-structured questionnaire to understand their knowledge, use, and constraints to the adoption of hermetic storage. A multivariate Logit regression model was used to find the significance of the factors affecting adoption. Results showed low awareness and use of hermetic storage among smallholder farmers. Only 53.3% of the interviewed farmers were aware of the use of hermetic storage for grain storage. The SuperGrain bag was the most known form of hermetic storage (35.3%), followed by the Purdue Improved Crop Storage (PICS) bag (34.9%), metallic silo (15.5%), and plastic silo (14.4%). Hermetic storage use was even lower as only 17.6% of the surveyed farmers were using one or more forms of hermetic storage to store their grains. Insect pest management without chemical insecticides was the main reason (83.1%) for hermetic storage use. About 75.5% of those aware of hermetic storage had received training in the technology. Hermetic storage use in farming households led to improved food availability, household income, and nutrition. Lack of local availability (50.2%), high costs (37.8%), and inadequate knowledge (6.9%) were the main constraints hindering the adoption of hermetic storage in Northern Uganda. The logit regression models showed that only training in hermetic storage significantly (p = 0.002) affected farmers’ decision to adopt hermetic storage. Understanding the factors that constrain the adoption of HSTs could provide policymakers with important information to initiate and design policies and programs aimed at reducing cro

关键词： Grain Crops post-harvest Storage Losses Hermetic Storage Smallholder Farmers food Security

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Analysis of PFAAs in American alligators part 2： Potential dietary exposure of South Carolina hunters from recreationally harvested alligator meat

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Journal of Environmental sciences 2017年第11期29卷 31-38页

作者： Jessica J.Tipton Louis J.Guillette Jr Susan Lovelace Benjamin B.Parrott Thomas R.Rainwater Jessica L.Reiner College of Charleston Charleston SC 29724 USA Medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29425 USA University of Georgia Odum School of Ecology Savannah River Ecology Laboratory Jackson SC 29831 USA Torn Yawkey Wildlife Center & Belle W. Baruch Institute of Coastal Ecology and Forest science Clemson University P.O. Box 59(5 Georgetown SC 29442 USA National Institute of Standards and technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 USA

Exposure to perfluorinated alkyl acids（PFAAs） has been linked to many harmful health effects including reproductive disorders, developmental delays, and altered liver and kidney function. Most human exposure to environmental contaminants, including PFAAs,occurs through consumption of contaminated food or drinking water. This study uses PFAA data from meat samples collected from recreationally harvested American alligators（Alligator mississippiensis） in South Carolina to assess potential dietary exposure of hunters and their families to PFAAs. Consumption patterns were investigated using intercept surveys of 23 hunters at a wild game meat processor. An exposure scenario using the average consumption frequency, portion size, and median perfluorooctane sulfonic acid（PFOS） concentration in alligator meat from all hunt units found the daily dietary exposure to be 2.11 ng/kg body weight per day for an adult human. Dietary PFOS exposure scenarios based on location of harvest suggested the highest daily exposure occurs with alligator meat from the Middle Coastal hunt unit in South Carolina. Although no samples were found to exceed the recommended threshold for no consumption of PFOS found in Minnesota state guidelines, exposure to a mixture of PFAAs found in alligator meat and site-specific exposures based on harvest location should be considered in determining an appropriate guideline for vulnerable populations potentially exposed to PFAAs through consumption of wild alligator meat.

关键词： Public hunt American alligator Dietary exposure PFOS Consumption advisory Contaminant consumption

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Effects of micro-oxygenation on the aroma of Cabernet Sauvignon wine from Ningxia,China

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 251-263页

作者： Zhong Zhang Qingchen Zhang Huiqing Wang Hongchuan Xia Lijun Sun Junxiang Zhang School of Life sciences Ningxia UniversityYinchuan 750021China College of Pharmacy University of FloridaGainesville FL32610USA School of Agriculture Ningxia UniversityYinchuan 750021China School of food and Wine Ningxia UniversityYinchuan 750021China China Wine Industry technology Institute Yinchuan 750021China

Micro-oxygenation (MOX) is an effective post-harvest technique for the flavor improvement of grape wine. This study investigated the effect of MOX on the aroma quality of Ningxia wine for the first time. Three sub-region Cabernet Sauvignon dry red wines were treated with different levels of oxygen before or after malolactic fermentation. The wine aroma was analyzed through gas chromatography-mass spectrometry (GC-MS) and quantitative descriptive analysis (QDA) after six months of aging. The data obtained demonstrated that the dose and timing of oxygen addition were key factors influencing the effectiveness of MOX. The most noticeable modifications in wine aroma compounds were generated by an oxygen dosage of 30 (mL/L)/month added before malolactic fermentation. Predominantly, the concentrations of 2-phenylethanol, benzaldehyde, diacetyl, and 2,3-pentanedione showed an increased pattern upon MOX treatments. The sensory analysis revealed that MOX improved the aroma quality of wine by decreasing green and animal odors, meanwhile enhancing the olfactory intensities of dried fruits, flowers, and nuts. This work confirmed that MOX was suitable for aroma modification of Cabernet Sauvignon dry red wine from Ningxia and established a preliminary MOX procedure that can serve as a reference for future applications.

关键词： grape wine micro-oxygenation volatile organic compounds aroma profiles Ningxia

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Impact of industrial effluent on growth and yield of rice(Oryza sativa L.) in silty clay loam soil

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Journal of Environmental sciences 2015年第4期27卷 231-240页

作者： Mohammad Anwar Hossain Golum Kibria Muhammad Mustafizur Rahman Mohammad Mizanur Rahman Abul Hossain Molla Mohammad Mostafizur Rahman Mohammad Khabir Uddin Department of Environmental sciences Jahangirnagar University Department of Soil science Bangabandhu Sheikh Mujibur Rahman Agricultural University Department of Bioenvironmental science Bangabandhu Sheikh Mujibur Rahman Agricultural University

Degradation of soil and water from discharge of untreated industrial effluent is alarming in Bangladesh. Therefore, buildup of heavy metals in soil from contaminated effluent, their entry into the food chain and effects on rice yield were quantified in a pot experiment. The treatments were comprised of 0, 25%, 50%, 75% and 100% industrial effluents applied as irrigation water. Effluents, initial soil, different parts of rice plants and post-harvest pot soil were analyzed for various elements, including heavy metals. Application of elevated levels of effluent contributed to increased heavy metals in pot soils and rice roots due to translocation effects, which were transferred to rice straw and grain. The results indicated that heavy metal toxicity may develop in soil because of contaminated effluent *** metals are not biodegradable, rather they accumulate in soils, and transfer of these metals from effluent to soil and plant cells was found to reduce the growth and development of rice plants and thereby contributed to lower yield. Moreover, a higher concentration of effluent caused heavy metal toxicity as well as reduction of growth and yield of rice, and in the long run a more aggravated situation may threaten human lives,which emphasizes the obligatory adoption of effluent treatment before its release to the environment, and regular monitoring by government agencies needs to be ensured.

关键词： Biomass Crop yield Heavy metal Industrial effluent Soil pollution

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Nondestructive perception of potato quality in actual online production based on cross-modal technology

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International Journal of Agricultural and Biological Engineering 2023年第6期16卷 280-290页

作者： Qiquan Wei Yurui Zheng Zhaoqing Chen Yun Huang Changqing Chen Zhenbo Wei Shuiqin Zhou Hongwei Sun Fengnong Chen School of Automation Hangzhou Dianzi UniversityHangzhou 310018China School of Information Engineering and Internet of Things Huzhou Vocational and Technical CollegeHuzhou 313000ZhejiangChina Jinhua Academy of Agricultural sciences Jinhua 321017ZhejiangChina College of Biosystems Engineering and food science Zhejiang UniversityHangzhou 310058China Fair Friend Institute of Intelligent Manufacturing Hangzhou Vocational and Technical CollegeHangzhou 310018China

Nowadays,China stands as the global leader in terms of potato planting area and total potato *** rapid and nondestructive detection of the potato quality before processing is of great significance in promoting rural revitalization and augmenting farmers’***,existing potato quality sorting methods are primarily confined to theoretical research,and the market lacks an integrated intelligent detection ***,there is an urgent need for a post-harvest potato detection method adapted to the actual production *** study proposes a potato quality sorting method based on cross-modal ***,an industrial camera obtains image information for external quality detection.A model using the YOLOv5s algorithm to detect external green-skinned,germinated,rot and mechanical damage ***/NIR spectroscopy is used to obtain spectral information for internal quality detection.A convolutional neural network(CNN)algorithm is used to detect internal blackheart disease *** mean average precision(mAP)of the external detection model is 0.892 when intersection of union(IoU)=*** accuracy of the internal detection model is 98.2%.The real-time dynamic defect detection rate for the final online detection system is 91.3%,and the average detection time is 350 ms per *** contrast to samples collected in an ideal laboratory setting for analysis,the dynamic detection results of this study are more applicable based on a real-time online working *** also provides a valuable reference for the subsequent online quality testing of similar agricultural products.

关键词： cross-modal technology potato quality YOLOv5s VIS/NIR spectroscopy online nondestructive detection

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Mathematical Modeling for Isotherms of Mango Pulp Powder,Obtained by Atomization

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Journal of Encapsulation and Adsorption sciences 2014年第1期4卷 8-14页

作者： Erica Milôde Freitas Felipe Rocha Sueli Rodrigues Marcos Rodrigues Amorim Afonso José Maria Correia da Costa Federal Institute of Education Science and Technology of Rio Grande do NorteFortalezaBrazil Federal University of Ceará FortalezaBrazil

Mango, as the other fruits, is a perishable food that can be easily deteriorated and presents high levels of post-harvest loss. Therefore, dehydration is an important alternative to use the production excess. In this context, this work aimed at evaluating the hygroscopic behavior of the integral mango pulp powder, obtained by atomization, by means of adsorption isotherm. After applying BET’s, GAB’s, Henderson’s and Oswin’s mathematical models, it was possible to identify that the equations for two models were perfectly adjusted to the experimental results of mango pulp powder. Henderson’s model was the best adjusted experimental curve and showed the lowest average error (E) and the highest determination coefficient (R2) at all temperatures studied.

关键词： Spray-Dryer Water Activity Hygroscopicity Mathematical Models

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