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Pre-treatment platelet counts as a prognostic and predictive factor in stage Ⅱ and Ⅲ rectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 42-49页

作者： Morgan Steele Ioannis A Voutsadakis clinical trials Unit Sault Area Hospital division of Medical Oncology Department of Internal Medicine Sault Area Hospital division of clinical Sciences Northern Ontario School of Medicine

AIM To investigate if pre-treatment platelet counts could provide prognostic information in patients with rectal adenocarcinoma that received neo-adjuvant treatment. METHODS Platelet number on diagnosis of stage II and III rectal cancer was evaluated in 51 patients receiving neoadjuvant treatment and for whom there were complete follow-up data on progression and survival, as well as pathologic outcome at the time of surgery. Pathologic responses on the surgical specimen of patients with lower platelet counts(150-300 × 10~9/L) were compared with these of patients with higher platelet counts(> 300 × 10~9/L) by the χ~2 test. Overall and progression free survival Kaplan-Meier curves of the two groups were constructed and compared with the Log-Rank *** A significant difference was present between the two groups in regards to pathologic response with patients with lower platelet counts being more likely to exhibit a good or complete response to neo-adjuvant treatment than patients with higher platelet counts(P = 0.015). Among other factors evaluated, there was also a significant difference between the carcinoembryonic antigen(CEA) at presentation of patients that exhibited a good or complete response and those that had no response or a minimal to moderate response. Patients with a good or complete response were more likely to present with a CEA of less than 5 μg/L(P = 0.00066). There was no significant difference in overall and progression free survival between the two platelet count groups(Log-Rank tests P = 0.42 and P = 0.35, respectively).CONCLUSION In this retrospective analysis of stage II and III rectal cancer patients, platelet counts at the time of diagnosis had prognostic value for neo-adjuvant treatment pathologic response. Pre-treatment CEA also held prognostic value in regards to treatment effect.

关键词： Rectal cancer Platelets Prognosis Treatment response neo-adjuvant Chemoradiation

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel

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Stroke & Vascular Neurology 2021年第1期6卷 103-108页

作者： Jason Philip Appleton Carla Richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath Stroke trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Stroke division Nottingham University Hospitals NHS TrustNottinghamUK Platelet Solutions Ltd Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK Platelet Research Group Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment *** primary aim was to assess the proportion of patients who are insensitive to *** secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular *** Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were *** function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or ***’general practitioners provided details on recurrent vascular events at least 90 days *** are mean(SD)and median[IQR].Resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 ***-parametric descriptors and tests were *** 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and *** of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin ***(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=*** Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed *** significant associations were noted between clopidogrel resistance and recurrent ischaemic events.

关键词： patients cerebral function

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer

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World Journal of Gastroenterology 2017年第14期23卷 2519-2526页

作者： Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine division of biostatistics Clinical Research Center Aichi Medical University Hospital

AIMTo identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative ***-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal gastrectomy or total gastrectomy) were included in the analysis. Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications (grade II or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease ***-six patients (21.1%) experienced grade II or higher postoperative complications. The platelet-lymphocyte ratio (PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value (0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71 (sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94 (95%CI: 1.66-5.35, P clinical disease stage, the low PLR group exhibited an increased incidence of postoperative *** preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer.

关键词： Gastric cancer Gastrectomy Platelet-lymphocyte ratio Postoperative complication Prediction

Usefulness of colonic tattooing using indocyanine green in patients with colorectal tumors

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World Journal of clinical Cases 2018年第13期6卷 632-640页

作者： Jae Ho Park Hee Seok Moon In Sun Kwon Gee Young Yun Seo Hee Lee Dae Hwa Park Ju Seok Kim Sun Hyung Kang Eaum Seok Lee Seok Hyun Kim Jae Kyu Sung Byung Seok Lee Hyun Yong Jeong division of Gastroenterology Department of Internal Medicine Chungnam National University Hospital Chungnam National University college of Medicine clinical trials Center Chungnam National University Hospital

AIM To prove that tattooing using indocyanine green(ICG) is feasible in laparoscopic surgery for a colon *** From January 2012 to December 2016, all patients who underwent laparoscopic colonic surgery were retrospectively screened, and 1010 patients with colorectal neoplasms were included. Their lesions were tattooed with ICG the day before the operation. The tattooed group(TG) included 114 patients, and the non-tattooed group(NTG) was selected by propensity score matching of subjects based on age, sex, tumor staging, and operation method(n = 228). In total, 342 patients were enrolled. Between the groups, the changes in [Delta(Δ), preoperative-postoperative] the hemoglobin and albumin levels, operation time, hospital stay, oral ingestion period, transfusion, and perioperative complications were compared. RESULTS Preoperative TG had a shorter operation time(174.76 ± 51.6 min vs 192.63 ± 59.9 min, P < 0.01), hospital stay(9.55 ± 3.36 d vs 11.42 ± 8.23 d, P < 0.01), and postoperative oral ingestion period(1.58 ± 0.96 d vs 2.81 ± 1.90 d, P < 0.01). The Δ hemoglobin(0.78 ± 0.76 g/dL vs 2.2 ± 1.18 g/dL, P < 0.01) and Δ albumin(0.41 ± 0.44 g/dL vs 1.08 ± 0.39 g/dL, P < 0.01) levels were lower in the TG. On comparison of patients in the "N0" and "N1 or N2" groups, the N0 colon cancer group had a better operation time, length of hospital stay, oral ingestion period, Δ hemoglobin, and Δ albumin results than those of the N1 or N2 group. The operation methods affected the results, and laparoscopic anterior resection(LAR) showed similar results. However, for left and right hemicolectomy, both groups showed no difference in operation time or hospital *** Preoperative tattooing with ICG is useful for laparoscopic colectomy, especially in the N0 colon cancer group and LAR.

关键词： Colorectal neoplasm Laparoscopic surgery Endoscopic tattoo Indocyanine green Perioperative

Prostate cancer prediction forest algorithm that takes using the random into account transrectal ultrasound findings, age, and serum levels of prostate-specific antigen

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Asian Journal of Andrology 2017年第5期19卷 586-590页

作者： Li-Hong Xiao Pei-Ran Chen Zhong-Ping Gou Yong-Zhong Li Mei Li Liang-Cheng Xiang Ping Feng Institute of clinical trials West China Hospital Sichuan University Chengdu China Department of Epidemiology and biostatistics West China School of Public Health Sichuan University Chengdu China Department of Ultrasound West China Hospital Sichuan University Chengdu China

The aim of this study is to evaluate the ability of the random forest algorithm that combines data on transrectal ultrasound findings, age, and serum levels of prostate-specific antigen to predict prostate carcinoma. Clinico-demographic data were analyzed for 941 patients with prostate diseases treated at our hospital, including age, serum prostate-specific antigen levels, transrectal ultrasound findings, and pathology diagnosis based on ultrasound-guided needle biopsy of the prostate. These data were compared between patients with and without prostate cancer using the Chi-square test, and then entered into the random forest model to predict diagnosis. Patients with and without prostate cancer differed significantly in age and serum prostate-specific antigen levels （P 〈 0.001）, as well as in all transrectal ultrasound characteristics （P 〈 0.05） except uneven echo （P = 0.609）. The random forest model based on age, prostate-specific antigen and ultrasound predicted prostate cancer with an accuracy of 83.10%, sensitivity of 65.64%, and specificity of 93.83%. Positive predictive value was 86.72%, and negative predictive value was 81.64%. By integrating age, prostate-specific antigen levels and transrectal ultrasound findings, the random forest algorithm shows better diagnostic performance for prostate cancer than either diagnostic indicator on its own. This algorithm may help improve diagnosis of the disease by identifying patients at high risk for biopsy.

关键词： diagnosis prostate cancer prostate-specific antigen random forest algorithm transrectal ultrasound characteristics

Statistical considerations for high throughput screening data

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Frontiers in Biology 2010年第4期5卷 354-360页

作者： Xian-Jin XIE division of biostatistics Department of Clinical Sciences&Simmons Comprehensive Cancer CenterThe University of Texas Southwestern Medical CenterDallasTexas 75390USA

High throughput screening(HTS)is a widely used effective approach in genome-wide association and large scale protein expression studies,drug discovery,and biomedical imaging *** to accurately identify candidate‘targets’or biologically meaningful features with a high degree of confidence has led to extensive statistical research in an effort to minimize both false-positive and false-negative rates.A large body of literature on this topic with in-depth statistical contents is *** examine currently available statistical methods on HTS and aim to summarize some selected methods into a concise,easy-tofollow introduction for experimental biologists.

关键词： high throughput screen false-positive rate false-negative rate target discovery predictive modeling

Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

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World Journal of Gastroenterology 2013年第36期19卷 6020-6025页

作者： Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters Internal Medicine Marien Hospital Department of Gastroenterology Radboud University Nijmegen Medical Center division of biostatistics German Cancer Research Center Department of clinical Pharmacology Technical University of Dresden

AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic ***:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal *** were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)*** storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as ***:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by *** activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the *** of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer *** means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for ***:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.

关键词： Glutathione S-transferase UDP-glucuronosyltransferase Detoxification Colon adenoma Colon carcinoma

Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

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World Journal of Gastroenterology 2019年第33期25卷 4933-4944页

作者： Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang Department of Gastroenterology and Hepatology Changi General HospitalSinghealth 529889Singapore clinical trials and Research Unit Changi General HospitalSinghealth 529889Singapore biostatistics Unit Yong Loo Lin School of MedicineNational University of SingaporeSingapore 160608Singapore

BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear *** are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic ***,PPI users and PPI exposure in some studies have been poorly defined with many confounding *** To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose *** Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to *** users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic *** regression analysis for comparison was done after propensity score *** risk of hepatic decompensation was analysed by Poisson *** Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were *** users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P90 increases the risk of mortality.

关键词： Proton pump inhibitor Liver cirrhosis Mortality Hospitalisation Complications Portal hypertension Variceal bleeding Ascites Spontaneous bacterial peritonitis Hepatic encephalopathy