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Intergeneric chromosome-specific painting reveals differential chromosomal transmission from Tripidium arundinaceum in sugarcane progeny

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Journal of Integrative Agriculture 2024年第11期23卷 3751-3762页

作者： Fan Yu Zehuai Yu Jin Chai Xikai Yu Chen Fu Xinwang Zhao Hailong Chang Jiawei Lei Baoshan Chen Wei Yao Muqing Zhang Jiayun Wu Qinnan Wang Zuhu Deng State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangxi Key Laboratory for Sugarcane Biology College of AgricultureGuangxi UniversityNanning 530004China National Engineering Research Center for Sugarcane Fujian Agriculture and Forestry UniversityFuzhou 350002China Institute of Nanfan&Seed Industry Guangdong Academy of SciencesGuangzhou 510316China Key Laboratory of Sugarcane Biology and Genetic Breeding Ministry of Agriculture and Rural Affairs/Fujian Agriculture and Forestry UniversityFuzhou 350002China

Sugarcane has recently attracted increasing attention for its potential as a source of sugar and bioethanol,so increasing its yield is essential to ensure the sugar security and bioenergy *** hybridization is a highly efficient method to produce new genetic variants of crop plants,particularly those species with high ploidy such as sugarcane(Saccharum spp.).Tripidium arundinaceum exhibits many desirable agronomic traits,and has been widely studied to produce hybrids with improved stress tolerance and other characteristics in sugarcane ***,the genetic relationship between *** and Saccharum species,and the individual *** chromosomal compositions in sugarcane hybrids are still *** we used whole-genome single-nucleotide polymorphisms(SNPs)to ascertain the phylogenetic relationships between these species and found that *** is more closely related to Saccharum than Sorghum,in contrast to the previous narrow genetic analyses using chloroplast ***,oligonucleotide(oligo)-based chromosome-specific painting derived from Saccharum officinarum was able to distinctly identify the chromosomes of *** developed the oligo-genomic in situ hybridization(GISH)system for the first time,to unveil the novel chromosome translocations and the transmission of individual *** chromosomes in sugarcane ***,we discovered that the chromosomal transmission of *** exhibited several different inheritance modes,including n,2n,and over 2n in the BC1 *** inheritance patterns may have resulted from first division restitution(FDR)or FDR+nondisjunction of a chromosome with the sister chromatids in the second meiosis division/second division restitution(FDR+NSC/SDR)model during *** results will be of substantial benefit for the further selection of *** chromosomes for sugarcane genetic improvement.

关键词： sugarcane Tripidium arundinaceum chromosome painting Oligo-FISH chromosomal transmission

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sRNAanno-a database repository of uniformly annotated small RNAs in plants

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Horticulture Research 2021年第1期8卷 746-753页

作者： Chengjie Chen Jiawei Li Junting Feng Bo Liu Lei Feng Xiaoling Yu Guanliang Li Jixian Zhai Blake C.Meyers Rui Xia State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in South China Ministry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhouGuangdong 510640China Guangdong Litchi Engineering Research Center College of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510640China Department of Biology&Institute of Plant and Food Science Southern University of Science and TechnologyShenzhenGuangdong 518055China Donald Danforth Plant Science Center Saint LouisMO 63132USA division of Plant sciences University of Missouri-ColumbiaColumbiaMO 65211USA

Small RNAs(sRNAs)are essential regulatory molecules,and there are three major sRNA classes in plants:microRNAs(miRNAs),phased small interfering RNAs(phased siRNAs or phasiRNAs),and heterochromatic siRNAs(hc-siRNAs).Excluding miRNAs,the other two classes are not well annotated or available in public databases for most sequenced plant *** performed a comprehensive sRNA annotation of 143 plant species that have fully sequenced genomes and next-generation sequencing sRNA data publicly *** results are available via an online repository called sRNAanno(***).Compared with other public plant sRNA databases,we obtained was much more miRNA annotations,which are more complete and reliable because of the consistent and highly stringent criteria used in our miRNA *** also provides free access to genomic information for>22,721 PHAS loci and>22 million hc-siRNA loci annotated from these 143 plant *** miRNA and PHAS loci can be easily browsed to view their main features,and a collection of archetypal trans-acting siRNA 3(TAS3)genes were annotated separately for quick *** facilitate the ease of sRNA annotation,sRNAanno provides free service for sRNA annotations to the *** summary,the sRNAanno database is a great resource to facilitate genomic and genetic research on plant small RNAs.

关键词： sRNA database repository

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Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis

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Molecular Plant 2016年第8期9卷 1119-1131页

作者： Beiqing Kuang Xianhai Zhao Chun Zhou Wei Zeng Junli Ren Berit Ebert Cherie T. Beahan Xiaomei Deng Qingyin Zeng Gongke Zhou Monika S. Doblin Joshua L. Heazlewood Antony Bacic Xiaoyang Chen Ai-Min Wu State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural University Guangzhou 510642 China Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm College of Forestry and Landscape Architecture South China Agricultural University Guangzhou 510642 China ARC Centre of Excellence in Plant Cell Walls School of BioSciences The University of Melbourne ParkviHe VIC 3010 Australia State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China Institute of Botany The Chinese Academy of Science Beijing 100093 China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China Joint BioEnergy Institute and Physical Biosciences division Lawrence Berkeley Nationa Laboratory Berkeley CA 94720 USA Guangdong Province Research Center of woody forage engineering technology Guangzhou 510642 China These authors have contributed equay to this article.

UDP-xylose （UDP-Xyl） is the Xyl donor used in the synthesis of major plant cell-wall polysaccharides such as xylan （as a backbone-chain monosaccharide） and xyloglucan （as a branching monosaccharide）. The biosynthesis of UDP-Xyl from UDP-glucuronic acid （UDP-GIcA） is irreversibly catalyzed by UDP- glucuronic acid decarboxylase （UXS）. Until now, little has been known about the physiological roles of UXS in plants. Here, we report that AtUXS1, AtUXS2, and AtUXS4 are located in the Golgi apparatus whereas AtUXS3, AtUXS5, and AtUXS6 are located in the cytosoh Although all six single AtUXS T-DNA mu- tants and the uxsl usx2 uxs4 triple mutant show no obvious phenotype, the uxs3 uxs5 uxs6 triple mutant has an irregular xylem phenotype. Monosaccharide analysis showed that Xyl levels decreased in uxs3 uxs5 uxs6 and linkage analysis confirmed that the xylan content in uxs3 xus5 uxs6 declined, indicating that UDP-Xyl from cytosol AtUXS participates in xylan synthesis. Gel-permeation chromatography showed that the molecular weight of non-cellulosic polysaccharides in the triple mutants, mainly composed of xylans, is lower than that in the wild type, suggesting an effect on the elongation of the xylan backbone. Upon saccharification treatment stems of the uxs3 uxs5 uxs6 triple mutants released monosaccharides with a higher efficiency than those of the wild type. Taken together, our results indicate that the cytosol UXS plays a more important role than the Golgi-localized UXS in xylan biosynthesis.

关键词： UDP-Xylose xylan UDP-Glucuronic acid decarboxylase localization

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A New Cyrtodactylus Species(Reptila:Gekkonidae)from Nan Province,Northern Thailand

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Asian Herpetological Research 2022年第2期13卷 96-108页

作者： Siriwadee CHOMDEJ Waranee PRADIT Parinya PAWANGKHANANT Chakkrapong KUENSAEN Apichaya PHUPANBAI Mali NAIDUANGCHAN Promporn PIBOON Korakot NGANVONGPANIT Zhiyong YUAN Yinpeng ZHANG Jing CHE Phuping SUCHARITAKUL Chatmongkon SUWANNAPOOM Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Research Center in bioresources for Agriculture Industry and MedicineDepartment of BiologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand division of Fishery School of Agriculture and Natural ResourcesUniversity of PhayaoPhayao 56000Thailand International College of Digital Innovation Chiang Mai UniversityChiang Mai 50200Thailand Rabbit in the Moon Foundation Ratchaburi 70180Thailand Animal Bone and Joint Research Laboratory Department of Veterinary Biosciences and Public HealthFaculty of Veterinary MedicineChiang Mai UniversityChiang Mai 50100Thailand Excellence Center in Veterinary Bioscience Chiang Mai 50100Thailand Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationSouthwest UniversityChongqing 400715China State Key Laboratory of Genetic Resources and Evolution and Center for Excellence in Animal Evolution and GeneticsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunnanChina School of Environment Tsinghua UniversityBeijing 100084China

Here,a new species of bent-toed gecko,Cyrtodactylus phukhaensis ***.,is described from Doi Phu Kha,Nan province,Thailand based on molecular and morphological evidence.A phylogeny based on NADH dehydrogenase subunit 2(ND2)and its flanking tRNAs places the new species in the chauquangensis group as a sister taxon to Cyrtodact ylus *** new species can be differentiated from other members of the chauquangensis group by having a unique combina tion of 7 or 8 suprala bials,23-28 longitudinal rows of dorsal tubercles,8-10 infrala bials,9 femoral pores,7 precloacal pores,40-47 ventral scales,and a lack of bands crossingthe temporal *** addition,results from a chromosome study of *** *** that the new species has a diploid chromosome number of 40 with a fundamental number of *** formula of the karyotype was as follows:2n(40)=2m+4sm+*** findings suggest that further studies of Cyrtodactylus biodiversity in northern Thailand are needed.

关键词： bent-toed gecko Cyrtodactylus wayakonei Cyrtodactylus chauquangensis karyotype phylogeny taxonomy

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CDC48B facilitates the intercellular trafficking of SHORT-ROOT during radial patterning in roots

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Journal of Integrative Plant Biology 2022年第4期64卷 843-858页

作者： Lihui Yang Mingyue Zhu Yi Yang Ke Wang Yulei Che Shurui Yang Jinxiang Wang Xin Yu Lixin Li Shuang Wu Klaus Palme Xugang Li Yong Wang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityDaizong Street 61Tai'an271018 China Institute of Biology II/Molecular Plant Physiology Faculty of BiologyAlbert-Ludwigs-University of FreiburgSchänzlestrasse 1FreiburgD-79104 Germany Department of Genetics Northwest Women's and Children's HospitalXi'an710061 China Shandong Engineering Research Center of Plant-Microbia Restoration for Saline-alkali Land Shandong Agricultural UniversityDaizong Street 61Tai'an271018 China Sino German Joint Research Center for Agricultural Biology College of Life SciencesShandong Agricultural UniversityDaizong Street 61Tai'an271018 China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources&College of Natural Resources and Environment South China Agricultural UniversityGuangzhou510640 China Citrus Research Institute Southwest UniversityChongqing400712 China Key Laboratory of Saline-alkali Vegetation Ecology Restoration Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin150040 China FAFU-UCR Joint Center and Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou350002 China 不详

CELL division CONTROL PROTEIN48(CDC48)is essential for membrane fusion,protein degradation,and other cellular ***,we revealed the crucial role of CDC48B in regulating periclinal cell division in roots by analyzing the recessive gen1 *** identified the GEN1 gene through map-based cloning and verified that GEN1 encodes ***1 showed severely inhibited root growth,increased periclinal cell division in the endodermis,defective middle cortex(MC)formation,and altered ground tissue patterning in *** with these phenotypes,CYCLIND 6;1(CYCD6;1),a periclinal cell division marker,was upregulated in gen1 compared to *** ratio of SHR_(pro):SHR-GFP fluorescence in pre-dividing nuclei versus the adjacent stele decreased by 33%in gen1,indicating that the trafficking of SHORT-ROOT(SHR)decreased in gen1 when endodermal cells started to *** findings suggest that the loss of function of CDC48B inhibits the intercellular trafficking of SHR from the stele to the endodermis,thereby decreasing SHR accumulation in the *** findings shed light on the crucial role of CDC48B in regulating periclinal cell division in roots.

关键词： Arabidopsis CDC48B cell division control periclinal cell division SHR

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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Mutagenesis of SlNAC4 by CRISPR/Cas9 alters gene expression and softening of ripening tomato fruit

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Vegetable Research 2021年第1期1卷 66-77页

作者： Ying Gao Yi-Ping Zhang Zhong-Qi Fan Yuan Jing Jian-Ye Chen Donald Grierson Rui Yang Da-Qi Fu Laboratory of Fruit Biology College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijing 100083China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruit and Vegetables College of HorticultureSouth China Agricultural UniversityGuangzhou 510642China Institute of Postharvest Technology of Agricultural Products College of Food ScienceFujian Agriculture and Forestry UniversityFuzhouFujian 350002China Laboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou 310058China Plant sciences division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughboroughLE125RDUK Beijing Key Laboratory for Agricultural Application and New Technique Beijing University of AgricultureBeijing 102206China

Softening is one of the key fruit quality traits,which results from the selective expression of cell wall metabolism genes during *** identification of transcription factors(TFs)that regulate fruit softening is an important field in order to understand and control fruit *** tomato,NAC(NAM,ATAF,and CUC)TFs members have been demonstrated to be involved in fruit ripening regulation,including NAC-NOR(nonripening),NOR-like1,SlNAC4,***,we generated slnac4 mutant knockout(CR-SlNAC4)tomato plant by a clustered regularly interspaced short palindromic repeats genomic targeting system(CRISPR/Cas9)and SlNAC4 overexpressing(OE-SlNAC4)*** addition to confirming the previously reported results that SlNAC4 positively regulates fruit ripening,we found that SlNAC4 has a strong effect on tomato fruit *** with the control fruit,fruit softening was inhibited in slnac4 fruit and conversely was accelerated in OE-SlNAC4 tomato *** RNA-sequencing(RNA-seq)analysis,we found that expression levels of SlEXP1(expansin)and SlCEL2(endo-β-1,4 glucanase)genes involved in cell wall metabolism were significantly different in WT(wild type)/slnac4 and WT/OE-SlNAC4 *** study showed that these genes contained a NAC TF binding domain in their promoter *** vitro electrophoretic mobility shift assays(EMSA)and dual-luciferase reporter assays(DLR)demonstrated that these two genes were the direct targets of SlNAC4 binding and *** results enriched the function of SlNAC4 and provided a new dimension in understanding the regulation of tomato fruit softening.

关键词： CRISPR/Cas9 fir metabolism

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The Role of Anaplastic Lymphoma Kinase Receptor in Neuroblastoma

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Clinical Cancer Bulletin 2022年第3期1卷 149-156页

作者： Tianfeng LI Jianmin SUN Hui ZHAO Zhenjian ZHUO Reproductive Medicine Center Affiliated Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhen 518000GuangdonhChina Department of Pathogen Biology and Immunology School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004NingxiaChina division of Translational Cancer Research Department of Laboratory MedicineLund UniversityLundSweden Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology Chinese Academy of sciences-The Chinese University of Hong Kong Joint Laboratory of bioresources and Molecular Research of Common Diseases KunmingYunnanChina State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina

Neuroblastoma(NB),a frequently occurring pediatric disease,is derived from the neural crest cells in the sympathetic ganglia and adrenal ***,it is a heterogeneous tumor consisting of many affection factors,such as the diagnosis time within the first year and the diversity of the histology and genetic *** improved outcomes in NB patients,it remains a difficult clinical problem and requires new therapeutic targets and *** somatic acquired activation point mutations in the receptor tyrosine kinase anaplastic lymphoma kinase(ALK)represent potential targets for treating ***,we review the underlying mechanisms of ALK in NB development,the latest available strategies to block ALK constitutive activity to treat NB,and discuss the current clinical challenges of resistance to these therapies and the strategies to overcome them.

关键词： neuroblastoma anaplastic lymphoma kinase mutation ALK inhibitors therapeutic target

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Corrigendum to“SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip”[***.(2021)66(8)783-793]

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Science Bulletin 2021年第20期66卷 2144-2144页

作者： Yaqiong Guo Ronghua Luo Yaqing Wang Pengwei Deng Tianzhang Song Min Zhang Peng Wang Xu Zhang Kangli Cui Tingting Tao Zhongyu Li Wenwen Chen Yongtang Zheng Jianhua Qin CAS Key Laboratory of SSAC Division of BiotechnologyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute For Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China d.University of Chinese Academy of sciences Beijing 100049China Kunming National High-level Bio-safety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650107China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China KIZ-CUHK Joint Laboratory of bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

The authors would like to correct *** annotation error was introduced in the preparation of this figure for *** authors declare that this correction does not change the results or conclusions of this *** authors since... 详细信息

关键词： correction sincerely figure

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Biomarkers of aging

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Science China(Life sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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