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Structural and functional imaging of brains

Science China Chemistry 2023年第2期66卷 324-366页

作者： Zhichao Liu Ying Zhu Liming Zhang Weiping Jiang Yawei Liu Qiaowei Tang Xiaoqing Cai Jiang Li Lihua Wang Changlu Tao Xianzhen Yin Xiaowei Li Shangguo Hou Dawei Jiang Kai Liu Xin Zhou Hongjie Zhang Maili Liu Chunhai Fan Yang Tian Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200241China Interdisciplinary Research center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai201210China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan National Laboratory for OptoelectronicsWuhan430071China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Department of Chemistry Tsinghua UniversityBeijing100084China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai200240China Interdisciplinary center for Brain Information Brain Cognition and Brain Disease InstituteShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Lingang Laboratory Shanghai201602China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200240China Institute of Systems and physical biology Shenzhen Bay LaboratoryShenzhen518055China Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Analyzing the complex structures and functions of brain is the key issue to understanding the physiological and pathological *** neuronal morphology and local distribution of neurons/blood vessels in the brain have been known,the subcellular structures of cells remain challenging,especially in the live *** addition,the complicated brain functions involve numerous functional molecules,but the concentrations,distributions and interactions of these molecules in the brain are still poorly *** this review,frontier techniques available for multiscale structure imaging from organelles to the whole brain are first overviewed,including magnetic resonance imaging(MRI),computed tomography(CT),positron emission tomography(PET),serial-section electron microscopy(ss EM),light microscopy(LM)and synchrotron-based X-ray microscopy(XRM).Specially,XRM for three-dimensional(3D)imaging of large-scale brain tissue with high resolution and fast imaging speed is ***,the development of elegant methods for acquisition of brain functions from electrical/chemical signals in the brain is *** particular,the new electrophysiology technologies for neural recordings at the single-neuron level and in the brain are also *** also focus on the construction of electrochemical probes based on dual-recognition strategy and surface/interface chemistry for determination of chemical species in the brain with high selectivity and long-term stability,as well as electrochemophysiological microarray for simultaneously recording of electrochemical and electrophysiological signals in the ***,the recent development of brain MRI probes with high contrast-to-noise ratio(CNR)and sensitivity based on hyperpolarized techniques and multi-nuclear chemistry is ***,multiple optical probes and instruments,especially the optophysiological Raman probes and fiber Raman photometry,for imaging and biosensing in live brain are emphas

关键词： brain structure brain function brain chemistry chemical signal biosensing and bioimaging

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RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications

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World Journal of Cardiology 2010年第7期2卷 187-197页

作者： Alberto J Alves Nir Eynon José Oliveira Ehud Goldhammer The Research Centre in physical Activity Health and Leisure University of Porto Genetics and Molecular biology Laboratory Life Sciences Division The Zinman College of Physical Education and Sport Sciences at the Wingate Institute Heart Institute Bnai-Zion Haifa Medical Center Faculty of Medicine at the Technion - Israel Institute of Technology

It is well appreciated that several neurohormones and signaling cascades are activated that promote long-term deterioration of cardiac function and structure. Activation of the renin-angiotensin-aldosterone system (RAAS) and the adrenergic system is closely related to heart failure. Common gene variants that encode neurohormonal, adrenergic and intracellular proteins have been demonstrated to modulate the course and consequences of heart failure. However, the literature is replete with conflicting results and it remains uncertain as to whether particular gene variants predispose heart failure. Therefore, the main purpose of this review was to discuss the effects of single nucleotide polymorphisms (SNPs) that are located in genes encoding elements of the RAAS and the adrenergic system on the predisposition to and survival from heart failure. Most studies indicate that common SNPs encoding elements of the RAAS and the adrenergic system do not predispose individuals to heart failure. Conversely, it has been demonstrated that ARB1 Arg389Gly, GRK5 Gln41Leu, ACE I/D, CYP11B2 C-344T and AGTR1 A+1166C modulate pharmacological responses and have a considerable impact on cardiacrelated survival. It should not be expected, however, that a single polymorphism determines survival, given that multiple gene products and environmental factors contribute to the pathogenesis of heart failure. Therefore, future studies should consider the interaction effects of multiple genes in populations that are as homogeneous as possible with respect to environmental characteristics.

关键词： Cardiac failure Polymorphisms Susceptibility Mortality

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Understanding that Addiction Is a Brain Disorder Offers Help and Hope

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Health 2022年第6期14卷 684-695页

作者： Kenneth Blum Abdalla Bowirrat David Baron Rajendra D. Badgaiyan Panayotis K. Thanos Igor Elman Eric R. Braverman Mark S. Gold division of Addiction Research & Education Center for Psychiatry Medicine & Primary Care (Office of the Provost) Western University Health Sciences Pomona USA Department of Molecular biology and Adelson School of Medicine Ariel University Ariel Israel Department of Psychiatry South Texas Veteran Health Care System Audie L. Murphy Memorial VA Hospital and Long School of Medicine University of Texas Health Science Center San Antonio USA Department of Psychiatry MT. Sinai School of Medicine New York USA Department of Psychology & Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA) Research Institute on Addictions University at Buffalo Buffalo USA Department of Psychiatry Harvard School of Medicine Cambridge USA division of Personalized Medicine The Kenneth Blum Behavioral & Neurogenetic Institute (Division of iVitalize Inc.) Austin USA Department of Psychiatry Washington University School of Medicine St. Louis USA

We refute the controversial statement that addiction is not a brain disorder. Extensive peer-reviewed studies support the underlying neurobiological and neurogenetic basis of addiction’s “disease model”. In the 70s and 80s, a few clinical scientists suggested that it is possible to use behavioral training to teach controlled drinking. However, this controversial model failed drastically and increased labeling and stigmatization. Additionally, it was unhelpful in the search for treatment. Instead, we assert that addiction is a neuropsychiatric disorder characterized by a recurring desire to continue taking substances despite harmful physical and mental consequences. Work from our laboratory in 1995 supported the Reward Deficiency Syndrome (RDS) concept based on a common neurogenetic mechanism (hypodopaminergia) that underlies all substance and non-substance addictions. Non-substance addictions include behaviors like pathological gambling, internet addiction, and mobile phone addiction. Certain impulsive and compulsive behaviors or the acute intake of psychoactive substances result in heightened dopaminergic activity, while the opposite, hypodopaminergia, occurs following chronic abuse. Patients with Substance Use Disorder (SUD) can have a genetic predisposition compounded by stress or other epigenetic insults that can impact recovery. Relapse will occur post-short-term recovery if dopaminergic dysfunction remains untreated. Addiction, a brain disorder, requires treatment with DNA-directed pro-dopamine regulation and rehabilitation.

关键词： Reward Deficiency Syndrome Abstinence Controlled Drinking Neurogenetic Brain Disorder

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LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis

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Journal of Molecular Cell biology 2018年第6期10卷 527-538页

作者： Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu Anhui Key Laboratory for Cellular Dynamics University of Science &Technology of China School of Life SciencesNational Science Center for Physical Sciences at Nanoscaleand Chinese Academy of Science Center of Excellence on Molecular Cell SciencesHefei 230027China Keck center for Molecular Imaging Department of PhysiologyMorehouse School of MedicineAtlantaGA 30310USA National Institutes of Health BethesdaMD 20892USA Department of Molecular Cell biology Harvard UniversityCambridgeMA 02138USA

Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate *** structural determinants account for HP1α Localization and function during cell division *** earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing ***,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during ***1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its ***,the LRIF1-HPla interaction is critical for Aurora B activity in the inner *** of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome *** findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division.

关键词： HP1α LRIF1 mitosis centromere chromosome segregation

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Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

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Light(Science & Applications) 2018年第1期7卷 583-592页

作者： Jing Liu Ranhua Xiong Toon Brans Saskia Lippens Eef Parthoens Francesca Cella Zanacchi Raffaella Magrassi Santosh K.Singh Sreekumar Kurungot Sabine Szunerits Hannelore Bové Marcel Ameloot Juan C.Fraire Eline Teirlinck Sangram Keshari Samal Riet De Rycke Gaëlle Houthaeve Stefaan C.De Smedt Rabah Boukherroub Kevin Braeckmans Laboratory of General Biochemistry and physical Pharmacy Faculty of PharmacyGhent UniversityGhent B-9000Belgium Centre for Nano-and Biophotonics Ghent UniversityGhent B-9000Belgium VIB-UGent Centre for Inflammation Research VIBGhent B-9000Belgium VIB bioimaging Core VIBGhent B-9000Belgium Department of Biomedical Molecular biology Ghent UniversityGhent B-9000Belgium Nanophysics(NAPH) Istituto Italiano di TecnologiaGenova 16163Italy Biophysics Institute(IBF) National Research Council(CNR)Via De Marini6-16149–GE GenovaItaly physical and Materials Chemistry division CSIR-National Chemical LaboratoryDr.Homi Bhabha RoadPune 411008India Academy of Scientific and Innovative Research Anusandhan Bhawan2 RafiMargNew Delhi 110001India Univ.Lille CNRSCentrale LilleISENUniv.ValenciennesUMR 8520-IEMNLille F-59000France Biomedical Research Institute Hasselt UniversityAgoralaan Building CDiepenbeek 3590Belgium Centre for Surface Chemistry and Catalysis KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium Inflammation Research center Image Core FacilityVIB9052 GhentBelgium Department of Biomedical Molecular biology Ghent University9052 GhentBelgium Department of Plant Biotechnology and Bioinformatics Ghent University9052 GentBelgium Univ Lille 1 Univ Lille Nord FranceLab Phys Lasers Atomes&MolVilleneuve Dascq UMR 852359655France College of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and ChemicalsNanjing Forestry University(NFU)Nanjing 210037China UMR 8523 Laboratoire de Physique des LasersAtomes et MoléculesUniversitéde LilleVilleneuve d’AscqFrance IEMN UMR 8520Universitéde LilleVilleneuve d’AscqFrance

In the replacement of genetic probes,there is increasing interest in labeling living cells with high-quality extrinsic labels,which avoid over-expression artifacts and are available in a wide spectral *** calls for a broadly applicable technology that can deliver such labels unambiguously to the cytosol of living ***,we demonstrate that nanoparticle-sensitized photoporation can be used to this end as an emerging intracellular delivery *** replace the traditionally used gold nanoparticles with graphene nanoparticles as photothermal sensitizers to permeabilize the cell membrane upon laser *** demonstrate that the enhanced thermal stability of graphene quantum dots allows the formation of multiple vapor nanobubbles upon irradiation with short laser pulses,allowing the delivery of a variety of extrinsic cell labels efficiently and homogeneously into live *** demonstrate high-quality time-lapse imaging with confocal,total internal reflection fluorescence(TIRF),and Airyscan superresolution *** the entire procedure is readily compatible with fluorescence(super resolution)microscopy,photoporation with graphene quantum dots has the potential to become the long-awaited generic platform for controlled intracellular delivery of fluorescent labels for live-cell imaging.

关键词： quantum enable replace

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Introduction to bioimaging-based spatial multi-omic novel methods

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Quantitative biology 2023年第3期11卷 231-245页

作者： Yan Yan Liheng Yang Leyuan Meng Haochen Su Cheng Zhou Le Yu Zhengtu Li Xu Zhang Huihua Cai Juntao Gao MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China center for Synthetic&Systems biology Tsinghua UniversityBeijing 100084China Seaver College Pepperdine UniversityMalibuCA 90263USA College of Animal Sciences Heping campusJilin UniversityJilin 130062China Sidney Sussex College Sidney StreetCambridge CB23HUUnited Kingdom Department of Radiation Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Foshan Protogene Tech.Co.Ltd Foshan 510168China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Beijing Institute of Collaborative Innovation Beijing 100094China Department of Automation Tsinghua UniversityBeijing 100084China Department of Obstetrics and Gynecology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 511436China Bioinformatics division BNRistTsinghua UniversityBeijing 100084China Institute for TCM-X Tsinghua UniversityBeijing 100084China

Background: Spatial multi-omics are demonstrated to be a powerful method to assist researchers on genetic studies. In this review, bioimaging-based spatial multi-omics techniques such as seqFISH+, merFISH, integrated DNA seqFISH+, DNA merFISH, and MINA are introduced along with each technique’s probe design, development, and imaging ***: seqFISH employed 4–5 fluorophores to barcode and conducted multiple rounds of hybridization, in order that mRNA can be identified through color-coding. seqFISH+ added 60 pseudo-color and distributed them equally into three channels to enhance imaging power, in order that i.e., 24,000 genes can be imaged in total. merFISH utilized 4 out 16 Hamming distance to innovatively provide a robust error-detecting method. MINA, a methodology combining merFISH (multiplexed error-robust fluorescence in situ hybridization) and chromosomal tracing, enabled multiplexed genomic architecture imaged in mammalian single cells. Optical reconstruction of chromatin architecture (ORCA) a method that could conduct DNA path tracing in nanoscale manner with kilobase resolution, an FISH variation that improved genetic resolution, enable high-precision fiducial registration and sequential imaging, and utilized Oligopaint probe to hybridize the short genomic region ranging from 2 to 10 kilobase. ORCA then prescribes these short section primary probes with individual barcodes to attach fluorophore and to be ***: This review concentrated on providing a comprehensive overview for these spatial-multi-omics techniques with the intention on helping researchers on selecting appropriate technique for their research.

关键词： FISH multiplex FISH super-resolution imaging gene regulation

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The COVID-19 pandemic and physical activity

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Sports Medicine and Health Science 2020年第2期2卷 55-64页

作者： Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignUSA division of Nutritional Sciences University of Illinois at Urbana-ChampaignUSA Department of Applied Physiology and Kinesiology University of FloridaGainesvilleUSA Department of Family Medicine and Community Health University of Minnesota Medical SchoolMinneapolisUSA Freshage Research Group Department of Physiology Faculty of MedicineUniversity of Valencia and CIBERFES.Fundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain Research Institute of Sport Science University of Physical EducationBudapestHungary National University of Public Service BudapestHungary Department of Microbiology and Immunology University of Texas Medical Branch at GalvestonUSA Institute on Aging College of MedicineUniversity of FloridaGainesvilleUSA Universita Cattolica Del Sacro Cuore RomeItaly Fondazione Policlinico Universitario“Agostino Gemelli”IRCCS Universita Cattolica Del Sacro CuoreRomeItaly center for Mitochondrial biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anChina Department of Exercise Science Norman J.Arnold School of Public HealthUniversity of South CarolinaColumbiaUSA Institute of Sports Medicine and Health Chengdu Sport UniversityChengduChina The Laboratory of Physiological Hygiene and Exercise Science School of KinesiologyUniversity of Minnesota Twin CitiesMinneapolisUSA

The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and *** the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some ***,there is currently no effective treatment for this ***-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and *** immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the *** cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.

关键词： Aging Brain Cardiovascular COVID-19 Immune Muscle Nutrition physical inactivity Respiratory

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Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association

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Journal of Sport and Health Science 2021年第6期10卷 660-674,F0003页

作者： Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao Institute of Geriatrics Affiliated Nantong Hospital of Shanghai UniversitySixth People’s Hospital of NantongSchool of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Department of Rehabilitation Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Cardiology Peking University People’s HospitalBeijing 100044China Department of Cardiology Tongji Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghai 200065China Department of Cardiology Daqing Oilfield General HospitalDaqing 163000China Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Rehabilitation Medicine First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China School of Medicine Huaqiao UniversityQuanzhou 362021China division of Cardiac Rehabilitation Department of Physical Medicine and RehabilitationXiangya Hospital of Central South UniversityChangsha 410008China Department of Rehabilitation Medicine First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Cardiology Eighth Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518033China Guangdong Innovative Engineering and Technology Research center for Assisted Circulation Sun Yat-Sen UniversityShenzhen 518033China NHC Key Laboratory of Assisted Circulation Sun Yat-Sen UniversityGuangzhou 510080China Department of Rehabilitation Medicine Shanghai Xuhui Central HospitalShanghai 200031China Cardiac Rehabilitation Department Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdo

Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be *** exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular ***,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular *** our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise *** also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic *** hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases.

关键词： Animal studies Cardiovascular disease Cardiovascular research Exercise Exercise models

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Biological and Molecular Components for Genetically Engineering Biosensors in Plants

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BioDesign Research 2022年第1期2022卷 19-37页

作者： Yang Liu Guoliang Yuan Md MahmudulHassan Paul E.Abraham Julie C.Mitchell Daniel Jacobson Gerald A.Tuskan Arjun Khakhar June Medford Cheng Zhao Chang-Jun Liu Carrie A.Eckert Mitchel J.Doktycz Timothy J.Tschaplinski Xiaohan Yang Biosciences division Oak Ridge National LaboratoryOak RidgeTennessee37831USA The center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTennessee37831USA Department of Genetics and Plant Breeding Patuakhali Science and Technology UniversityDumkiPatuakhali8602Bangladesh Departmentof biology Colorado State UniversityFort CollinsColorado80523USA Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese A cademy of Agriculural SciencesShenzhen 518120China biology Department Brookhaven National LaboratoryUptonNew York 11973USA

Plants adapt to their changing environments by sensing and responding to physical,biological,and chemical *** to their sessile lifestyles,plants experience a vast array of external stimuli and selectively perceive and respond to specific *** repurposing the logic circuitry and biological and molecular components used by plants in nature,genetically encoded plant-based biosensors(GEPBs)have been developed by directing signal recognition mechanisms into carefully assembled outcomes that are easily *** allow for in vivo monitoring of biological processes in plants to facilitate basic studies of plant growth and *** are also useful for environmental monitoring,plant abiotic and biotic stress management,and accelerating design-build-test-learn cycles of plant *** the advent of synthetic biology,biological and molecular components derived from alternate natural organisms(e.g.,microbes)and/or de novo parts have been used to build *** this review,we summarize the framework for engineering different types of *** then highlight representative validated biological components for building plant-based biosensors,along with various applications of plant-based biosensors in basic and applied plant science ***,we discuss challenges and strategies for the identification and design of biological components for plant-based biosensors.

关键词： Plants Molecular monitoring

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Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size

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CCS Chemistry 2020年第1期2卷 42-51页

作者： Kuan Hu Wei Xiong Chengjie Sun Chan Wang Jingxu Li Feng Yin Yixiang Jiang Ming-Rong Zhang Zhou Li Xinwei Wang Zigang Li State Key Laboratory of Chemical Oncogenomics The School of Chemical Biology and BiotechnologyPeking UniversityShenzhen Graduate SchoolShenzhen 518055(China) School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055(China) Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083(China) Department of Advanced Nuclear Medicine Sciences The National Institute of Radiological SciencesThe National Institutes for Quantum and Radiological Science and TechnologyChiba263-8555(Japan) Pingshan Translational Medicine center Shenzhen Bay LaboratoryShenzhen 518055(China)

The de novo design of new peptide assemblies that expands the repertoire of biomaterial nanostructures has been of a tremendous ***,it is evident that a successful research achievement in this area would increase the understanding of molecular interactions in supramolecules and create novel scaffolds exploitable in biotechnology and synthetic *** manipulation of cyclic peptide self-assembly is particularly intriguing for this ***,we report that a novel type of cyclic peptides,referred to as chiral tether constrained cyclic peptides(CCP),shows promising self-assembly *** are the first example of a controllable assembly of all-L-α-cyclic peptides with different ring sizes.A noteworthy feature of the CCP system is good tolerance of different secondary structures,ring size,and peptide *** on this system,a variety of nanostructures could be constructed,which display different physical properties,rendering it an excellent platform for molecular interaction ***,demonstrate potential applications of these peptide assemblies in bioimaging and energy storage.

关键词： cyclic peptide self-assembly chiral center ring size nanostructure supramolecules supercapacitor

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