Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association

作     者：Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao Yihua Bei;Lei Wang;Rongjing Ding;Lin Che;Zhiqing Fan;Wei Gao;Qi Liang;Shenghui Lin;Suixin Liu;Xiao Lu;Yuqin Shen;Guifu Wu;Jian Yang;Guolin Zhang;Wei Zhao;Lan Guo;Junjie Xiao

作者机构：Institute of GeriatricsAffiliated Nantong Hospital of Shanghai UniversitySixth People’s Hospital of NantongSchool of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing LabInstitute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Department of Rehabilitation MedicineNanjing University of Chinese MedicineNanjing 210023China Department of CardiologyPeking University People’s HospitalBeijing 100044China Department of CardiologyTongji Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghai 200065China Department of CardiologyDaqing Oilfield General HospitalDaqing 163000China Department of Cardiology and Institute of Vascular MedicinePeking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Rehabilitation MedicineFirst Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China School of MedicineHuaqiao UniversityQuanzhou 362021China Division of Cardiac RehabilitationDepartment of Physical Medicine and RehabilitationXiangya Hospital of Central South UniversityChangsha 410008China Department of Rehabilitation MedicineFirst Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of CardiologyEighth Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518033China Guangdong Innovative Engineering and Technology Research Center for Assisted CirculationSun Yat-Sen UniversityShenzhen 518033China NHC Key Laboratory of Assisted CirculationSun Yat-Sen UniversityGuangzhou 510080China Department of Rehabilitation MedicineShanghai Xuhui Central HospitalShanghai 200031China Cardiac Rehabilitation DepartmentGuangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2021年第10卷第6期

页      面：660-674,F0003页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by grants from the National Key Research and Development Project(2020YFA0803800 to YB) National Natural Science Foundation of China(82020108002 and 81911540486 to JX,81772444 to LW,81772466 to RD) Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to JX) Science and Technology Commission of Shanghai Municipality(18410722200 and 17010500100 to JX) “Dawn”Program of the Shanghai Education Commission(19SG34 to JX) 

主　　题：Animal studies Cardiovascular disease Cardiovascular research Exercise Exercise models 

摘      要：Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be *** exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular ***,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular *** our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise *** also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic *** hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases.