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Organization of microtubule plus-end dynamics by phase separation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 24-35页

作者： Fengrui Yang Mingrui Ding Xiaoyu Song Fang Chen Tongtong Yang Chunyue Wang Chengcheng Hu Qing Hu Yihan Yao Shihao Du Phil YYao Peng Xia Gregory Adams Jr Chuanhai Fu Shengqi Xiang Dan Liu Zhikai Wang Kai Yuan Xing Liu MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics Hefei National Research Center for Cross-disciplinary SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science&Technology of ChinaHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology University of Science&Technology of ChinaHefei 230027China Keck Center for Organoids Plasticity Morehouse School of MedicineAtlantaGA 30310USA Hunan Key Laboratory of Molecular Precision Medicine Central South UniversityChangsha 410083China

In eukaryotes,microtubule polymers are essential for cellular plasticity and fate ***-binding(EB)proteins serve as scaffolds for orchestrating microtubule polymer dynamics and are essential for cellular dynamics and chromosome segregation in ***,we show that EB1 forms molecular condensates with TIP150 and MCAK through liquid–liquid phase separation to compartmentalize the kinetochore–microtubule plus-end machinery,ensuring accurate kinetochore–microtubule interactions during chromosome segregation in *** of EB1–TIP150 polymer formation by a competing peptide prevents phase separation of the EB1-mediated complex and chromosome alignment at the metaphase equator in both cultured cells and Drosophila ***220 of EB1 is dynamically acetylated by p300/CBP-associated factor in early mitosis,and persistent acetylation at Lys220 attenuates phase separation of the EB1-mediated complex,dissolves droplets in vitro,and harnesses accurate chromosome *** data suggest a novel framework for understanding the organization and regulation of eukaryotic spindle for accurate chromosome segregation in mitosis.

关键词： phase separation mitosis microtubule dynamics EB1 acetylation

Modeling ice thickness distribution and storage volume of glaciers in Chandra Basin,western Himalayas

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Journal of Mountain Science 2020年第8期17卷 2011-2022页

作者： Ankur PANDIT RAAJ RAMSANKARAN Inter disciplinary program(IDP)in Climate Studies Indian Institute of Technology BombayMumbai 400076India TCS Research and Innovation Thane400601 India Department of Civil Engineering Indian Institute of Technology BombayMumbai 400076India

This article reports modeled ice thickness distribution and total ice volume of the 65 selected glaciers(>0.5 km^2)of Chandra basin,located in the Western *** is a first-of-its-kind study that gives detailed insights about the current ice thickness distribution at an individual glacier level in the Western *** estimates are obtained using an optimally parameterized Glab Top2_IITB[Glacier Bed Topography Indian Institute of Technology Bombay(IITB)version]model with highresolution Digital Elevation Model(DEM)as an *** total estimated volume of all the 65 selected glaciers is about 55.32 km^3 covering a total area of about 591.03 km^*** hypsometric analysis,it is found that the maximum amount of ice volume,i.e.,about 12.79 km^3,is currently residing at the elevation range of 5200–5400 m *** thickness estimates obtained in the current study are compared with the ensemble estimates obtained in the Global Glacier Thickness Initiative(G2TI)project for three large glaciers,namely,Bada Shigri,Samudra Tapu,and Gepang Gath *** obtained results indicate that the difference between both the studies is marginal in terms of mean ice thickness and maximum ice thickness estimates except Samudra Tapu ***,the uncertainty of the estimated glacier ice volume from this study is about±15%whereas,from the G2TI project,it is about 25%.The main reasons for the difference could be the quality of the inputs used,model structure,model parameterization as well as the time stamp of the input *** obtained results from this study indicate that the use of appropriate shape factor and better DEM would result in more reliable glacier ice thickness estimates even by using a simple slopedependent model like Glab Top2_IITB.

关键词： Glacier ice thickness Glacier volume Glab Top2_IITB TanDEM-X DEM

An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases

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Science China Life Sciences 2024年

作者： Yudai Xu Zijian Wang Shumin Li Jun Su Lijuan Gao Junwen Ou Zhanyi Lin Oscar Junhong Luo Chanchan Xiao Guobing Chen Department of Microbiology and immunology School of Medicine Institute of Geriatric Immunology School of Medicine Jinan University Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University) Ministry of Education Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory School of Medicine Jinan University First Affiliated Hospital Jinan University Anti Aging Medical Center Clifford Hospital Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Department of Systems Biomedical Sciences School of Medicine Jinan University The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital) Jinan University Zhuhai Institute of Jinan University Jinan University

T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell agingrelated diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.

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SYNTHESIS OF STYRENIC TONER PARTICLES BY SPG EMULSIFICATION TECHNIQUE

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Chinese Journal of Polymer Science 2000年第4期18卷 309-322页

作者： Suda Kiatkamjornwong Roongkan Nuisin Guang-HuiMa Shinzo Omi Department of Imaging and Printing Technology Faculty of ScienceChulalongkorn University.Bangkok 10330Thailand Multi-disciplinary program of Petrochemistry and Polymer Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Graduate School of Bio-application and System Engineering Tokyo University of Agriculture and TechnologyNakamachiKoganeiTokyo 184-8588Japan

This research studied the initiator efficiency for producing polymeric particles of poly(styrene-co-methyl methacrylate)copolymers by a Shirasu porous glass membrane(SPG)emulsification technique followed by suspension ***,ADVN,and AIBN were used as initiators and we found that BPO is the most suitable *** for various feed ratios of styrene/methyl methacrylate were thus synthesized by benzoyl peroxide,and their copolymer particle size,molecular weight distribution and pat-ride size distribution were *** n-BMA or 2-EHMA was added as the third monomer to decrease the terpolymer glass transition *** article describes the preparation technique,recipes and polymerization conditions for producing both copolymer and terpolymer particles,particle size changes,the corresponding particle morphologies and glass transition temperatures.

关键词： Shirasu porous glass emulsification n-butyl methacrylate 2-ethylhexyl methacrylate toner binder

Model-based Tracking for Agent-based Control Systems in the Case of Sensor Failures

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International Journal of Automation and computing 2012年第6期9卷 561-569页

作者： R.P.Yadav P.V.Varde P.S.V.Nataraj P.Fatnani C.P.Navathe Accelerator Control Section Accelerator Control and Beam Diagnostics DivisionRaja Ramanna Centre for Advanced Technology Life Cycle Reliability Engineering Lab Safety Evaluation and Manpower Training and Development SectionBhabha Atomic Research Centre Inter disciplinary program in Systems and Control Engineering Group Indian Institute of Technology Bombay

The study on artificial intelligence(AI) methods for tuning of particle accelerators has been reported in many *** paper presents tuning method for agent-based control systems of transport lines in the case of sensor/actuator *** method uses model-based tracking concept to relax the demand on sensor *** condition for successful operation of the stated scheme is derived,and the concept is demonstrated through simulation by applying it to the model of microtron,transport line-1 and booster of indus *** results show that this approach is very effective in transport line control during sensor/actuator failures.

关键词： Agent agent-based control model-based tracking transport line control artificial intelligence(AI).

A viewpoint on catalytic origin of boron nitride in oxidative dehydrogenation of light alkanes

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Chinese Journal of Catalysis 2018年第5期39卷 908-913页

作者： Lei Shi Dongqi Wang An-Hui Lu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina Center for Multi-disciplinary Research Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Oxidative dehydrogenation of light alkanes to alkenes is an attractive alternative route for industrial direct dehydrogenation because of favorable thermodynamic and kinetic characteristics,but encounters difficulties in selectivity control for alkenes because of over-oxidation reactions that produce a substantial amount of undesired carbon *** progress has revealed that boron nitride is a highly promising catalyst in the oxidative dehydrogenation of light alkanes because of its superior selectivity for and high productivity of light alkenes,negligible formation of CO2,and remarkable catalyst *** this viewpoint,recent works on boron nitride in the oxidative dehydrogenations of ethane,propane,butane,and ethylbenzene are reviewed,and the emphasis of this viewpoint is placed on discussing the catalytic origin of boron nitride in oxidative dehydrogenation *** analyzing recent progress in the use of boron nitride for oxidative dehydrogenation reactions and finding much new evidence,we conclude that pure boron nitride is catalytically inert,and an activation period is required under the reaction conditions;this process is accompanied by an oxygen functionalization at the edge of boron nitride;the B-O species themselves have no catalytic activity in C-H cleavage,and the B-OH groups,with the assistance of molecular oxygen,play the key role in triggering the oxidative dehydrogenation of propane;the dissociative adsorption of molecular oxygen is involved in the reaction process;and a straightforward strategy for preparing an active boron nitride catalyst with hydroxyl groups at the edges can efficiently enhance the catalytic efficacy.A new redox reaction cycle based on the B-OH sites is also ***,as this is a novel catalytic system,there is an urgent need to develop new methods to optimize the catalytic performances,clarify the catalytic function of boron species in the alkane ODH reactions,and disclose the reaction mechanism u

关键词： Boron nitride Zig-zag edge B-OH group Light alkanes Oxidative dehydrogenation Induction period

Factors influencing the use of heart rate variability for evaluating autonomic nervous function in mind-body research

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实用心电学杂志 2017年第2期26卷 84-90页

作者： Shin Lin Zhong-Yuan Shen Timothy Ross Department of Biophysical Research Center University of California Irvine 92697 Irvine California USA Qigong Research Institute Shanghai University of Traditional Chinese Medicine200030 Shanghai China Project Department Building Research Across Inter-Disciplinary Gaps (BRIDG) Program University of Washington98195 Seattle Washing-ton USA

心率变异性(HRV)分析是非侵入性评估自主神经功能的常用方法 .在许多研究中,低频变异性(LF,如通过快速傅立叶变换产生的功率谱中所示的0.15 Hz)作为副交感神经功能的指标.通过对15位心-身锻练习练者和20位非习练者的对照研究,我们发现... 详细信息

心率变异性(HRV)分析是非侵入性评估自主神经功能的常用方法 .在许多研究中,低频变异性(LF,如通过快速傅立叶变换产生的功率谱中所示的0.15 Hz)作为副交感神经功能的指标.通过对15位心-身锻练习练者和20位非习练者的对照研究,我们发现以下是影响HRV的重要因素.第一,呼吸周期的频率反映在由呼吸性窦性心律不齐(RS A)产生的功率谱中的峰值频率中.在涉及年轻受试者的情况下,即使以单一速率严格控制他们的呼吸,也能在功率谱中看到多个峰;第二,由RSA产生的HRV峰的大小取决于每次呼吸的潮气量和受试者的姿势;第三,在相同条件下,与年龄较大的受试者(年龄在50~70岁)相比,年轻受试者(年龄在20~25岁)通常显示更大的RSA峰值.这种效应常常掩盖了基于其他因素的差异,例如多年的心-身锻练.总之,这项研究表明了HRV分析用于评估自主神经功能的心-身研究可以作为一个有用的工具,但需注意必须采取措施控制所有上述因素.

关键词： heart rate variability respiratory sinus arrhythmia autonomic nervous function mind body research

Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2023年第10期15卷 26-38页

作者： Fengge Wu Hameed Akbar Chunyue Wang Xiao Yuan Zhen Dou McKay Mullen Liwen Niu Liang Zhang Jianye Zang Zhikai Wang Xuebiao Yao Xiaoyu Song Xing Liu MOE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of Institute of Health and Medicine(IHM)University of Science and Technology of China School of Life SciencesHefei 230026China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Center for Cross-disciplinary SciencesHefei 230027China Keck Center for Cellular Dynamics Morehouse School of MedicineAtlantaGA 30310USA

Shugoshin-1(Sgo1)is necessary for maintaining sister centromere cohesion and ensuring accurate chromosome segregation during *** has been reported that the localization of Sgo1 at the centromere is dependent on Bub1-mediated phosphorylation of histone H2A at ***,it remains uncertain whether other centromeric proteins play a role in regulating the localization and function of Sgo1 during ***,we show that CENP-A interacts with Sgo1 and determines the localization of Sgo1 to the centromere during *** biochemical characterization revealed that lysine and arginine residues in the C-terminal domain of Sgo1 are critical for binding ***,the replacement of these basic amino acids with acidic amino acids perturbed the localization of Sgo1 and Aurora B to the centromere,resulting in aberrant chromosome segregation and premature chromatid *** together,these findings reveal a previously unrecognized but direct link between Sgo1 and CENP-A in centromere plasticity control and illustrate how the Sgo1–CENP-A interaction guides accurate cell division.

关键词： mitosis centromere kinetochore Sgo1 CENP-A Aurora B

Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3, Mai-Li LIU3, Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* Department of Physics and Bio-X disciplinary Laboratory, Zhejiang University, Hangzhou 310027,China 1 Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2Institute of High Energy Physics and Key Laboratory of Nuclear Analysis Techniques, Chinese Academy of Sciences, P.O. Box 918, Beijing 100039, China 3Wuhan Institute of Physics and Mathematics, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Chinese Academy of Sciences, Wuhan 430071, China Department of Physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan Institute of Physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China Institute of High Energy Physics and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser396/Ser404 and Ser199/Ser202 was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis