An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases
作者机构：Department of Microbiology and Immunology School of Medicine Institute of Geriatric Immunology School of Medicine Jinan University Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University) Ministry of Education Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory School of Medicine Jinan University First Affiliated Hospital Jinan University Anti Aging Medical Center Clifford Hospital Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Department of Systems Biomedical Sciences School of Medicine Jinan University The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital) Jinan University Zhuhai Institute of Jinan University Jinan University
出 版 物：《Science China Life Sciences》 (中国科学:生命科学(英文版))
年 卷 期：2024年
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：supported by the R&D Program of Guangzhou Laboratory (SRPG22-006) the National Natural Science Cross Disciplinary Major Research Program (92374203) the National Natural Science Foundation of China (92169102) the GuangDong Basic and Applied Basic Research Foundation (2022B1515120043) the Open Project Fund of Guangdong Provincial People’s Hospital (YKY-KF202208) the Key R&D Program Key Special Projects for International Science and Technology Innovation Cooperation between Governments (2023YFE0118700) the Fundamental Research Funds for the Central Universities (21623406) the Guangdong Basic and Applied Basic Research Foundation (2023A1515140117) the Fellowship of the China Postdoctoral Science Foundation (2023TQ0136, 2023M741379) the Open Research Project of the Key Laboratory of Viral Pathogenesis & Infection Prevention and Control of the Ministry of Education (2023VPPC-R08)
摘 要：T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell agingrelated diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.
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