检索结果-南通市图书馆

Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第1期68卷 158-175页

作者： Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang Er-Dan Dong Research center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health and Life SciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Instituteof vascular Medicine Peking University Third HospitalTheInstituteofCardiovascular SciencesPeking UniversityState Key Laboratoryof Vascular Homeostasisand RemodelingPeking UniversityBeijing 100191China

Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart *** function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking ***,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are *** article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial *** exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart ***,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play *** the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment *** the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词： cardiac rehabilitation coronary heart disease endothelial function

Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第9期31卷 43-53页

作者： Qiu-Xia Ye Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Yi-Fan Lv Shao-Li You Sa Lv Hui-Guo Ding Ying Han Yong-Ping Yang Bing Zhu Fu-Quan Liu Liver Disease Minimally Invasive Diagnosis and Treatment center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver vascular Disease Diagnosis and Treatment center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China Department of Gastroenterology and Hepatology Beijing You’an HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Wedged hepatic venous pressure(WHVP)is a crucial variable for accurately assessing the hepatic venous pressure gradient(HVPG)and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension(PH).AIM To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure(PVP).METHODS This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June *** and innovative hepatic venous angiography was performed during transjugular intrahepatic portosystemic shunt procedures to measure hepatic venous and *** patients'angiographic images were collected for *** associations between WHVP and PVP in each group were analyzed via linear regression analysis,and a predictive model was *** The 877 patients had a mean age of 52.6±13.0 years,with 582 males and 295 *** were categorized into four groups on the basis of their anatomical *** groups showed strong correlations between WHVP and *** regression coefficient between the WHVP and PVP in the hepatic right vein-portal venous angiography group was 0.884(P<0.05);in the hepatic right vein-accessory hepatic venous angiography group,it was 0.721(P<0.05);in the hepatic right vein-middle hepatic venous angiography group,it was 0.344(P<0.05);and in the hepatic right vein-nonangiography group,it was 0.293(P<0.05).CONCLUSION The presence and anatomical classification of hepatic venous collaterals are key factors influencing the relationship between WHVP with and *** on the different anatomical classifications of hepatic veins,WHVP can be used to estimate PVP,improving the accuracy of PVP prediction.

关键词： Wedged hepatic venous pressure Portal venous pressure Portal hypertension Collateral branches of the hepatic vein Transjugular intrahepatic portosystemic shunt

Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 502-514页

作者： Zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510080China Department of Physiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of vascular Surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510062China

Despite substantial advancements in modern medicine,the management of hypertension remains a major *** cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases,including ***,the antihypertensive mechanism of mesenchymal stem cells(MSCs)has not been extensively *** study aimed to investigate the role of injected MSCs in regulating blood pressure *** previous study demonstrated that human induced pluripotent stem cellderived mesenchymal stem cells(hiPSC-MSCs)are functional and homogeneous sources for MSC-based *** the injection of hiPSCMSCs,a significant reduction in blood pressure and end target organ inflammation were observed in spontaneously hypertensive rats(SHRs).Cell tracking assays demonstrated that the injected hiPSC-MSCs accumulated in the spleens of the *** injected hiPSC-MSCs accumulated adjacent to the splenic nerve,potentially contributing to the antihypertensive ***,the hiPSC-MSCs released abundant glutamate,which acts as a neuromodulator to activate the splenic sympathetic *** inhibition of glutamate synthesis by siRNA,the ability of hiPSC-MSCs to activate sympathetic nerves was significantly *** addition,the antihypertensive effects of hiPSC-MSCs were eliminated after splenic nerve denervation(SND),underscoring the critical role of the splenic ***,activation of the splenic nerve resulted in increased release of norepinephrine(NE),which increased the number of choline acetyltransferase-positive(ChAT^(+))cells in the spleen and peripheral ***,the acetylcholine(ACh)produced by elevated ChAT+cells could act as a vasodilator,lowering blood pressure and mitigating inflammation in end target *** summary,our findings indicate that hiPSC-MSCs effectively lower blood pressure in hypertension by influencing the splenic nerves and regulating ChAT+*** connection between blood pressur

关键词： hiPSC-MSCs hypertension splenic nerve ChAT+cells

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research center of Stem Cells Translational Medicine ShanghaiChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health Sciences National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University Shenyang Key Laboratory of vascular Biology Science and Research Center Department of Pharmacology Shenyang Medical College Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University

Ischemic stroke(IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc.(commonly known as Japanese knotweed), has been recognized for its potent neuroprotective ***, the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl) quinoline(RV02), against ischemic stroke remains inadequately explored. This study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in vivo. The research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic conditions. The findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS) through mitophagy activation. Furthermore, Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in vitro. These results suggest that RV02 shows promise as a neuroprotective agent, with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3,5-dimethoxystyryl) quinoline Ischemic stroke Mitophagy Parkin Resveratrol

Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2025年第3期70卷 342-346页

作者： Nana Yang Jiahong Chen Yujie Zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi Ding Huiqing Wang Yaobo Zhao Liang Ji Rui Zhan Yufei Wu Zhaomeng Wang Manyuan Dong Lemin Zheng School of Bioscience and Technology Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular DiseasesShandong Second Medical UniversityWeifang 261053China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China Beijing Tiantan Hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionBeijing Institute of Brain DisordersThe Capital Medical UniversityBeijing 100050China Research center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdao 266071China

Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart ***(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关键词： metabolism cardiovascular diseases

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of vascular Homeostasis and Remodeling Peking University center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

关键词：

Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第03期 593-609页

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua Zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

关键词：

同方期刊数据库

Vacuum ammonia stripping from liquid digestate:Effects of pH,alkalinity,temperature,negative pressure and process optimization

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第3期149卷 638-650页

作者： Qiuhong Chen Donghai Yang Xiang Chen Xiankai Wang Bin Dong Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China YANGTZE Eco-Environment Engineering Research center National Engineering Research Center of Eco-environment Protection for Yangtze River Economic BeltChina Three Gorges CorporationWuhan 430010China

High ammonia-nitrogen digestate has become a key bottleneck limiting the anaerobic digestion of organic solid *** ammonia stripping can simultaneously remove and recover ammonia nitrogen,which has attracted a lot of attention in recent *** investigate the parameter effects on the efficiency and mass transfer,five combination conditions(53℃ 15 kPa,60°C 20 kPa,65°C 25 kPa,72°C 35 kPa,and 81°C 50 kPa)were conducted for ammonia stripping of sludge *** results showed that 80%of ammonia nitrogen was stripped in 45 min for all experimental groups,but the ammonia transfer coefficient varied under different conditions,which increased with the rising of boiling point temperature,and reached the maximum value(39.0 mm/hr)at 81°C 50 *** ammonia nitrogen removal efficiency was more than 80%for 30 min vacuum stripping after adjusting the initial pH to above 9.5,and adjustment of the initial alkalinity also affects the pH value of liquid *** was found that pH and alkalinity are the key factors influencing the ammonia nitrogen dissociation and removal efficiency,while temperature and vacuum mainly affect the ammonia nitrogen mass transfer and removal *** terms of the mechanism of vacuum ammonia stripping,it underwent alkalinity destruction,pH enhancement,ammonia nitrogen dissociation,and free ammonia *** this study,two-stage experiments of alkalinity destruction and ammonia removal were also carried out,which showed that the two-stage configuration was beneficial for ammonia *** provides a theoretical basis and practical technology for the vacuum ammonia stripping from liquid digestate of organic solid waste.

关键词： Liquid digestate Vacuum ammonia stripping Alkalinity Mass transfer Process optimization