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Current status and challenges in the application of microbial PHA particles

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Particuology 2024年第4期87卷 286-302页

作者： Jiaxuan Liu Ziqi Zhou Haoru Li Xinyu Yang Zeyu Wang jian Xiao Dai-Xu Wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi'an710069China School of Clinical Medicine Qujing Medical CollegeQujing655000China School of Physics and Electronic Information Shangrao Normal UniversityShangrao334001China Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong643002China

Polyhydroxyalkanoates(PHAs)are diversiform biopolyesters with a similar structure and different side chain groups,synthesized by a variety of *** to their excellent biodegradability and biocompatibility,PHAs have been used for many applications,including medical implants,antibacterial agents and ***-architecture is an emerging area for the use of *** review summarizes the current status and challenges of PHAs-based particles on the micro-and nano-scale,including their production,degradation,biological safety,and surface *** also focus on the applications of PHA particles in drug delivery systems,environment protection,tissue engi-neering,vaccine engineering,food science,biotechnology and ***,the future development trends of PHAs-based particles are prospected.

关键词： Polyhydroxyalkanoates(PHAs) Particles Synthetic biology Tissue engineering

Asymmetry in circulation system and cardiovascular diseases

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Medicine in Novel Technology and Devices 2024年第1期21卷 1-9页

作者： Chang Liu Sheng Xie Yangchen Li Da Zhang Deyu Li Chi Zhang Key Laboratory of Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Radiology China-Japan Friendship HospitalBeijing100029China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of Physics Sichuan Cancer HospitalChengdu610041China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing100191China

Asymmetries in the human vascular system and cardiovascular disease are *** physiological asymmetry can manifest in the morphological structure and blood flow state,whereas pathological asymmetry can reflect differences in the occurrence and cure of bilateral vascular *** causes associated with these asymmetrical differences may be demand-driven or due to vascular grading or asymmetries in other physiological *** article aims to review the asymmetry of several typical arteries,including cerebral,cervical,and limb arteries,and lists possible causes to emphasize the necessity of considering asymmetric factors in the prevention,treatment,and rehabilitation of vascular *** research on asymmetries in the vascular system may improve the risk assessment and personalized treatment of vascular diseases.

关键词： Vascular morphology Hemodynamics Cardiovasculardiseases Asymmetry

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

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Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing Hu Xiao-Jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products research center of Guizhou Province Guiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

开挖补偿法防控深部地下岩爆灾害——引汉济渭工程秦岭输水隧洞案例分析

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engineering 2024年第3期34卷 154-163页

作者： Jie Hu Manchao He Hongru Li Zhigang Tao Dongqiao Liu Tai Cheng Di Peng Department of Geotechnical engineering College of Civil EngineeringTongji UniversityShanghai 200092China State Key Laboratory for Geomechanics and Deep Underground engineering China University of Mining and TechnologyBeijing 100083China

Rockburst disasters occur frequently during deep underground excavation,yet traditional concepts and methods can hardly meet the requirements for support under high geo-stress ***,rockburst control remains challenging in the engineering *** this study,the mechanism of excavation-induced rockburst was briefly described,and it was proposed to apply the excavation compensation method(ECM)to rockburst ***,a field test was carried out on the Qinling Water Conveyance *** following beneficial findings were obtained:Excavation leads to changes in the engineering stress state of surrounding rock and results in the generation of excess energy DE,which is the fundamental cause of *** ECM,which aims to offset the deep excavation effect and lower the risk of rockburst,is an active support strategy based on high pre-stress *** new negative Poisson’s ratio(NPR)bolt developed has the mechanical characteristics of high strength,high toughness,and impact resistance,serving as the material basis for the *** field test results reveal that the ECM and the NPR bolt succeed in controlling rockburst disasters *** research results are expected to provide guidance for rockburst support in deep underground projects such as Sichuan-Xizang Railway.

关键词： Rockburst Excavation compensation method Pre-stressed support Negative Poisson’s ratio bolt Tunnel boring machine

The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties

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Phenomics 2024年第1期4卷 72-80页

作者： Dongsheng Bi Lingwei Shi Boyi Li Ying Li Chengcheng Liu Lawrence HLe Jingchun Luo Sijia Wang Dean Ta center for Biomedical engineering School of InformationScience and TechnologyFudan University2005 SonghuRoadYangpu DistrictShanghai 200438China Academy for engineering and Technology Fudan UniversityShanghai 200433China Department of Radiology and Diagnostic Imaging University of AlbertaEdmonton T6G2B7Canada Human Phenome Institute Fudan UniversityShanghai 201203China Shanghai Institute of Nutrition and Health Chinese Academyof SciencesShanghai 200031China

This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic(UBBD)***-energy X-ray absorptiometry(DXA)can be adopted to measure bone mineral density(BMD)in the hip,spine,legs and the whole *** muscle and fat mass in the legs and the whole body can be also calculated by DXA body composition *** on the proposed protocol for backscatter measurements by UBBD,ultrasonic backscatter signals can be measured in vivo,deriving three backscatter parameters[apparent integral backscatter(AIB),backscatter signal peak amplitude(BSPA)and the corresponding arrival time(BSPT)].AIB may provide important diagnostic information about bone *** and BSPT may be important indicators of muscle and fat *** standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics,providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders(MSDs),such as osteoporosis and muscular atrophy.

关键词： Ultrasonic backscatter Musculoskeletal disorders Bone mineral density Muscle mass Fat mass

Recent advances in the electrocatalytic oxidative upgrading of lignocellulosic biomass

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ChemPhysMater

ChemPhysMater 2024年第2期3卷 157-186页

作者： Yufeng Qi Hairui Guo Junting Li Li Ma Yang Xu Huiling Liu Cheng Wanga Zhicheng Zhang Institute for New Energy Materials and Low-Carbon Technologies School of Materials Science and EngineeringTianjin Key Laboratory of Advanced Functional Porous MaterialsTianjinUniversityof TechnologyTianjin 300384China Key Laboratory of Organic Integrated Circuit Minitry of Education&Tianjin Key Laboratoryof Molecular Optoelectronic Sciencespartment of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Collaborative Innovation center of Chemical Science and engineering(Tianjin) Tianjin 300072China

Lignocellulosic biomass is a critical renewable carbon resource,but most of its utilization is inefficient,and elec-trocatalytic oxidation is a promising method of upgrading lignocellulose into value-added fuels and chemicals under mild operating ***,efforts to enable conversion with a high efficiency and low energy con-sumption have been reported,but understanding the reaction mechanisms and realizing scaled-up applications of the electrooxidation of lignocellulosic biomass are still in their early stages.A timely overview of recently reported general reaction mechanisms,particularly the strategies developed for use in improving the reaction efficiencies,is necessary to inspire research regarding the highly efficient utilization of ***,we summa-rize the strategies developed to improve electrocatalytic performance in oxidative lignocellulose *** organized summary includes strategies ranging from designing efficient electrocatalysts and adding functional co-catalysts or electrolytes to employing advanced electrolyzers.A comprehensive overview of representative examples should provide universal principles to yield insight into the reaction processes and guide the design of efficient electrocatalytic ***,the challenges and opportunities in developing the electrocatalytic oxidative upgrading of lignocellulosic biomass in the near future are proposed.

关键词： Biomass conversion Lignocellulose Electrocatalysis Oxidative upgrading Electrocatalyst

通过高通量研究识别用于本征陡坡晶体管的原子级薄孤立能带沟道材料

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Science Bulletin 2024年第10期69卷 1427-1436页

作者：屈恒泽张胜利曹江吴振华柴扬李卫胜李连忠任文才王欣然曾海波 MIIT Key Laboratory of Advanced Display Materials and Devices College of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Electronic and Optical engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Microelectronics Device and Integrated Technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong 999077China National Laboratory of Solid State Microstructures School of Electronic Science and Engineering and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Department of Mechanical engineering The University of Hong KongHong Kong 999077China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Integrated Circuits Nanjing UniversitySuzhou 215163China Suzhou Laboratory Suzhou 215009China

Developing low-power FETs holds significant importance in advancing logic circuits,especially as the feature size of MOSFETs approaches sub-10 ***,this has been restricted by the thermionic limitation of SS,which is limited to 60 mV per decade at room ***,we proposed a strategy that utilizes 2D semiconductors with an isolated-band feature as channels to realize subthermionic SS in *** high-throughput calculations,we established a guiding principle that combines the atomic structure and orbital interaction to identify their sub-thermionic transport *** guides us to screen 192 candidates from the 2D material database comprising 1608 ***,the physical relationship between the sub-thermionic transport performances and electronic structures is further revealed,which enables us to predict 15 systems with promising device performances for low-power applications with supply voltage below 0.5 *** work opens a new way for the low-power electronics based on 2D materials and would inspire extensive interests in the experimental exploration of intrinsic steep-slope MOSFETs.

关键词： 2D materials Electronic band structures Transport properties Steep-slope transistors DFT-NEGF calculations

Parametric Analysis of A Submerged Cylindrical Shell Subjected to Shock Waves

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China Ocean engineering 2007年第1期21卷 125-136页

作者：李上明 FAN Sau-Cheong engineering Mechanics research center School of Civil Engineering and ArchitectureNanchang University Protective Technology research center School of Civil and Environmental EngineeringNanyang Technological University

In this study, an FEM-SBFEM （scaled boundary finite element method） coupling procedure proposed by Fan et al. （2005） is adopted to obtain the dynamic responses of a submerged cylindrical shell subjected to plane step or exponential acoustic shock waves. The coupling procedure can readily be applied to three-dimensional problem, however for clarity, the problems to be presented are hmited to two-dimeusional domain. In the analyses, the cylindrical shell is modeled by simple beam elements （using FEM）, while the effects of the surrounding infinite fluid is modeled by the SBFEM. In it, no free surface and seabed are involved. Compared with Fan and his co-authors＇ works, the FEM-SBFEM coupling procedure is further verified to be feasible for shock waves by benchmark examples. Furthermore, parametric studies are performed and presented to gain insight into effects of the geometric and material properties of the cylindrical shell on its dynamic responses.

关键词： cylindrical shell FEM-SBFEM coupling shock wave infinite fluid parametric study

Noninvasive Detection of Cerebral Blood Flow and Blood Oxygen Based on Inductive Sensing Technology and Near Infrared Spectroscopy

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Journal of Beijing Institute of Technology 2024年第3期33卷 204-212页

作者： Cheng Zhou Zexiang Lyu Maoting Zhang Xin Zou Liang Wei Feng Wang Mingxin Qin Jia Xu Jian Sun College of Biomedical engineering Army Medical UniversityChongqing 400038China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Medical engineering Xinqiao HospitalChongqing 400037China

The synchronous monitoring of cerebral blood flow and blood oxygen levels plays a pivotal role in the prevention,diagnosis,and treatment of cerebrovascular *** study introduces a novel noninvasive device utilizing inductive sensing and near-infrared spectroscopy technology to facilitate simultaneous monitoring of cerebral blood flow and blood oxygen *** device consists of modules for cerebral blood flow monitoring,cerebral blood oxygen monitoring,control,communication,and a host *** experiments conducted on healthy subjects,it was confirmed that the device can effectively achieve synchronous monitoring and recording of cerebral blood flow and blood oxygen *** results demonstrate the device’s capability to accurately measure these signals *** technology enables dynamic monitoring of cerebral blood flow and blood oxygen signals with potential clinical applications in preventing,diagnosing,treating cerebrovascular diseases while reducing their associated harm.

关键词： cerebrovascular disease synchronous monitoring inductive sensing near infrared spec-troscopy(NIRS)