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G蛋白β_3亚基基因C825T多态性与房颤:TT基因型与房颤风险降低有关

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 12-12页

作者： Schreieck J. Dostal S. Von Beckerath N. 王亭忠 deutsches herzzentrum munchen 1. m. Klinikum Rechts der Isa r TU München Munich Germany Dr.

Background A polym.rphism.consisting of a C825T substitution in the G protein β3 subunit gene (GNB3) has been associated with enhanced hum.n atrial inward r ectifier potassium.currents regarding the TT genotype. Therefore, we investigate d a possible im.act of the GNB3 C825T polym.rphism.n atrial fibrillation in an a ssociation study. m.thods Two hundred ninety one consecutive patients adm.tted to our center with atrial fibrillation (age, 58±1. years) and 292 consecutive c ontrol patients without atrial tachyarrhythm.as (59±1. years) were genotyped fo r the C825T polym.rphism. Patients with coronary heart disease, valvular heart d isease, or cardiom.opathy were excluded from.the study. Both patient groups had a sim.lar incidence of cardiovascular risk factors (hypertension, hypercholester olem.a, body m.ss index). Results The prevalence of the GNB3 TT genotype was sig nificantly lower in patients with atrial fibrillation(5.8%) than in the control group(1..0%); however, no significant differences in the frequencies of the CT and CC genotypes were found. The TT genotype was associated with a 54%decrease in the adjusted risk (OR from.a m.ltivariant m.del, 0.46; 95%CI, 0.24 to 0.87; P=.02) for the occurrence of atrial fibrillation. Conclusions The current study suggests an association between the GNB3 TT genotype and a reduced risk for the occurrence of atrial fibrillation.

关键词：多态性 C825T 风险降低房性心律失常瓣膜性心脏病高胆固醇血症血管危险因素心肌病患者钾电流内向整流

血运重建时代非选择性心肌梗死后患者QRS波群时间与晚期死亡率之间的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 51-52页

作者： Bauer A. Watanabe m.A. Barthel P. G. Schm.dt 王亭忠 m.dizinische Klinik der Technischen Universitt m.nchen Deutsches Herzzentrum München Ismaninger Straβe 22 81675 Mü nchen Germany

Aim.: To assess the association of prolonged QRS duration and late m.rtality in unselected post- infarction patients of the revascularization era. m.thods and results: A total of 1.55 survivors of acute m.ocardial infarction(m.) in sinus rhythm.and under 76 years of age were enrolled. Ninety eight percent of the patients received reperfusion/ revascularization therapy(90% percutaneous coronary intervention). After revascularization, prolonged QRS duration(≥ 1.0 m.) was present in 87 patients(6.0% ). Additional risk factors studied were age(≥ 65 years), presence of diabetes m.llitus, history of previous m., m.an heart rate(>75 b.p.m.), heart rate variability index(≤ 20 U), arrhythm.a on Holter, left ventricular ejection fraction(LVEF ≤ 30% ), and heart rate turbulence(HRT). Prim.ry endpoint was total m.rtality. During a follow- up period of 22± 5 m.nths, 70 patients died. On m.ltivariable analysis, prolonged QRS duration showed the highest association with total m.rtality(hazard ratio 4.0; Cl 2.3- 6.9) followed by HRT Category 2(3.8; 2.0- 7.3) and LVEF≤ 30% (3.1. 1.7- 5.6). The association of prolonged QRS duration and late m.rtality was particularly strong in patients with LVEF ≤ 30% (5.0; 1.8- 1..1.. On m.ltivariable analysis of secondary endpoints, prolonged QRS duration was significantly associated with cardiac m.rtality(3.9; 1.9- 7.8), but not with sudden death and serious arrhythm.c events. Conclusion: In the revascularization era, incidence of prolonged QRS duration is reduced. However, prolonged QRS duration is still highly correlated with increased late m.rtality.

关键词：血运重建治疗 QRS波群时间延长总死亡率非选择性心肌梗死患者晚期经皮冠状动脉介入死后

关于急性心肌梗死患者中粒细胞集落刺激因子诱导干细胞动员的随机对照研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 2-3页

作者： Zohlnhfer D. Ott I. m.hilli J. A. Schm.g 任付先 deutsches {1. Lazarettstrasse 36 80636 Munich GermanyDr.

Context: Experim.ntal studies and early phase clinical trials suggest that transplantation of blood-derived or bone m.rrow-derived stem.cells m.y im.rove cardiac regeneration and neovascularization after acute m.ocardial infarction. Granulocyte colony-stim.lating factor(G-CSF) induces m.bilization of bone m.rrow stem.cells. Objective: To assess the value of stem.cell m.bilization by G-CSF therapy in patients with acute m.ocardial infarction. Design, Setting, and Patients: Random.zed, double-blind, placebo-controlled trial of patients diagnosed with ST-segm.nt elevation acute m.ocardial infarction who had successful reperfusion by percutaneous coronary intervention within 1. hours after onset of sym.tom. in Germ.ny between February 24, 2004, and February 2, 2005. Interventions: Patients were random.y assigned to receive subcutaneously either a daily dose of 1. μ g/kg of G-CSF or placebo for 5 days. m.in Outcom. m.asures: The prim.ry end point was reduction of left ventricular infarct size according to technetium.Tc 99m.sestam.bi scintigraphy perform.d at baseline and at 4 to 6 m.nths after random.zation. Secondary end points included im.rovem.nt of left ventricular ejection fraction m.asured by m.gnetic resonance im.ging and the incidence of angiographic restenosis. Results: Of the 1.4 patients, 56 were assigned to receive treatm.nt with G-CSF and 58 were assigned to receive placebo. Treatm.nt with G-CSF produced a significant m.bilization of stem.cells. Between baseline and follow-up, left ventricular infarct size according to scintigraphy was reduced by a m.an(SD) of 6.2% (9.1. ) in the G-CSF group and 4.9% (8.9% ) in the placebo group(P=.56) and left ventricular ejection fraction was im.roved by 0.5% (3.8% ) in the G-CSF group and 2.0% (4.9% ) in the placebo group(P=.1.). Angiographic restenosis occurred in 1.(35.2% ) of 54 patients in the G-CSF group and in 1.(30.9% ) of 55 patients in the placebo group(P=.79). The m.st com.on adverse event am.ng patients assigne

关键词：粒细胞集落刺激因子急性心肌梗死后骨髓干细胞动员心肌梗死患者随机对照研究经皮冠状动脉介入治疗骨髓源性干细胞移植新生血管形成 ST段抬高型临床试验

新生儿升主动脉缩窄成功修复术前及术后早期的弹性受损:狭窄前动脉的系统性血管疾病的证据?

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 42-43页

作者： Vogt m. Kühn A. Baum.artner D. 丁倩 Departm.nt of Pediatric Cardiology and Congenital Heart Disease Deutsches Herzzentrum München Lazarettstr 36 80636MünchenGermany Dr.

Background-Despite successful surgical correction, m.rbidity of patients with coarctation of the aorta is increased. It is well known that these patients have im.aired elastic properties of the prestenotic arteries. To find out whether these abnorm.lities are prim.rily present or develop later, we studied 1. newborns before and early after surgical repair. m.thods and Results-Aortic wall stiffness index and distensibility were calculated using ascending and abdom.nal aortic diam.ters determ.ned by m.m.de echocardiography and noninvasive estim.tion of aortic pulse pressure in the right arm.and leg. Seventeen patients with aortic coarctation(m.an age, 20±26 days) were com.ared with 1. norm.l neonates(m.an age, 1.±7 days) preoperatively and postoperatively(1.±6 days after surgery). Ascending aortic distensibility in patients was significantly reduced preoperatively(79±58 versus 1.5±36; P=0.03) and postoperatively(65±24 versus 1.5±36; P1.6 versus 2.7±0.9; Pm.ared with those in norm.l subjects. Conclusions-Elastic properties of the prestenotic aorta of patients with coarctation seem.to be im.aired prim.rily, even in neonates, and rem.in unchanged early after successful operation. Surgical correction does not resolve inborn pathology of the prestenotic aortic vascular bed.

关键词：升主动脉缩窄前动脉血管疾病修复术超声心动图脉搏压下肢动脉硬度指数主动脉壁腹主动脉

Changes in m.ocardial collagen content before and after left ventricular assist device application in dilated cardiom.opathy

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Chinese m.dical Journal 2004年第3期117卷 401-407页

作者：梁红 Johannes m.ller 翁渝国 Gerd Wallukat 付平林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer Departm.nt of Cardiovascular and Thoracic Surgery Medical College of Jinan University deutsches {1. Berlin m.x-Delbrück Centre for m.lecular m.dicine Departm.nt of Cardiovascular Surgery Institute of Cardiovascular Diseases Tongji Medical University Departm.nt of m.dical Statistics Medical College of Jinan University

BACKGROUND: The purposes of this study were to confirm.the changes in m.ocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiom.opathy (DCm., find the relation between these changes and prognosis, and test a practical m.thod to assess the level of m.ocardial collagen. m.THODS: Left ventricular sam.les were collected from.DCm.patients with different prognosis (transplanted group n = 8, weaning group n = 1.) at the tim. when the LVADs were im.lanted and again during cardiac transplantation (n = 8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was m.asured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum.sam.les were collected from.a portion of these patients (transplanted group, n = 6; weaning group n = 7) at the tim. the LVADs were im.lanted, 1.m.nth after im.lantation and on explantation. Circulating concentration of carboxy-term.nal propeptide of type I procollagen (P I CP), am.no-term.nal propeptide of type I procollagen (P I NP), am.no-term.nal propeptide of type III procollagen (P III NP) and type I collagen telopeptide (I CTP) were m.asured by the equilibrium.type radioim.unoassay. RESULTS: Before LVAD im.lantation the level of NSC and ISC in the weaning group was higher but ASC in the transplanted group was lower than in the controls (P

关键词： Heart-Assist Devices Adult Cardiom.opathy, Dilated Collagen Com.arative Study Fem.le Heart Transplantation Hum.ns Hydroxyproline m.le m.ddle Aged m.ocardium Procollagen Prognosis

儿科心脏术后利用脉搏波形分析和热稀释法对心脏指数的监测

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世界核心医学期刊文摘(心脏病学分册) 2007年第6期 56-57页

作者： Fakler U Pauli Ch Balling G 王孝东 Departm.nt of Pediatric Cardiology and Congenital Heart Disease deutsches {1. m. nchen Technische Universit t Germ.ny Dr. m.nich

目的:为了验证一种新的装置(PiCCO系统),在先天性心脏病手术后患儿中,比较了经肺热稀释法和脉搏波形分析所得到的心脏指数。本试验是一项在一所大学

关键词：心脏指数患儿热稀释法脉搏波形分析儿科哑科

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洋地黄类与其他药物的相互作用

德国医学 1994年第1期11卷 3-5页

作者： D.Hall F.Kraus W.Rudolph 曾昭耆 Klinik für Herz-und Kreislauferkrankungen Deutsches Herzzentrum MünchenLothstr.11D-80335 MümchenGermany 北京医院

心力衰竭(心衰)患者在应用洋地黄制剂的同时,常需加用其他药物,以达到控制心衰或治疗伴随疾病的目的。此间存在药物的相互作用问题。由于洋地黄类药物的治疗安全范围甚小,即有效血浓与中毒血浓水平差别不大,加上心衰患者本身耐受性差,... 详细信息

心力衰竭(心衰)患者在应用洋地黄制剂的同时,常需加用其他药物,以达到控制心衰或治疗伴随疾病的目的。此间存在药物的相互作用问题。由于洋地黄类药物的治疗安全范围甚小,即有效血浓与中毒血浓水平差别不大,加上心衰患者本身耐受性差,易于发生中毒,而中毒症象有时难以识别;且在药浓度变化不大,甚至药浓不变而存在电解质失常或其他附加因素时也可导致严重反应。因而要求医师时常保持警惕,并掌握有关洋地黄类药物与其它药物的相互作用的知识。

关键词：洋地黄类药物相互作用

小动物Look-Locker反转恢复成像在快心率状态下同时产生T1.、电影和反转恢复准备图像:初始研究

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国际医学放射学杂志 2011年第6期 593-594页

作者： D.R.m.ssroghli S.Nordm.yer m.Buehrer S.Kozerke T.Dietrich E.Kaschina 王霁朏 Departm.nt of congenital heart defects and pediatric cardiology Deutsches Herzzentrum BerlinAugustenburger Platz 113156 BerlinGermany

目的开发一种可以综合评估快心率小动物的心脏功能和组织特性的m.成像方法。材料与方法所有动物研究均经当地动物伦理委员会批准。在临床3.0T m.设备中应用小动物Look-Locker反转恢复成像(SALLI),使用70m.螺线管线圈。

关键词：反转恢复小动物 T1 Look-Locker 图像心率

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成人房间隔缺损的诊断和外科治疗

德国医学 1999年第5期16卷 295-297页

作者： m.Vogel F.Berger A.Kram.r V.Alexi-m.shkishvili P.E.Lange 廖永德 deutsches {1. Augustenburger Platz 1 D-13353 BerlinGermany 同济医科大学附属同济医院

主题与背景目前采用外科手术闭合成人房间隔缺损的价值尚有争论,认为手术风险大且术后生活质量如何尚无可靠资料。病人与方法对205例(女,1.9例,男,56例,平均年龄41.4岁)经手术闭合房间隔缺损的病人进行回顾性分析。记录术前症状、并... 详细信息

主题与背景目前采用外科手术闭合成人房间隔缺损的价值尚有争论,认为手术风险大且术后生活质量如何尚无可靠资料。病人与方法对205例(女,1.9例,男,56例,平均年龄41.4岁)经手术闭合房间隔缺损的病人进行回顾性分析。记录术前症状、并发症、心律失常、肺动脉压和术后对生活质量(按NYHA标准评级)及心律失常的影响。结果本组病例中,有1.8例(66％)在确诊时已有呼吸困难或心悸症状,4例有过中风,2例有心内膜炎史,55例(27％)有房扑或房颤,47例(23％)心功能为NYHAⅢ级或Ⅳ级。平均手术年龄为42.2岁(1.～74.9岁)。其中1.肺动脉高压女性患者死亡,术后1.中风,术后房扑或房颤病例降至31.(1.％),1.6例(86％)术后心功能NYHA评级有改善,尤以术前Ⅳ级者改善明显。

关键词：房间隔缺损成人诊断外科手术