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Journal of Rock Mechanics and Geotechnical engineering 2020年第4期12卷 802-810页

作者： Antonio P.Rinaldi Luigi Improta Sebastian Hainzl Flaminia Catalli Luca Urpi Stefan Wiemer Swiss Seismological Service ETHZurichSwitzerland Istituto Nazionale di Geofisica e Vulcanologia INGVRomeItaly deutsches geoforshung e zentrum GFZPotsdamGermany RatePAY GmbH BerlinGermany

In this work,an approach is developed to study the seismicity associated with the impoundment and level changes of a water reservoir(reservoir induced seismicity e RIS).The proposed methodology features a combination of a semi-analytical poroelastic model with an earthquake nucleation approach based on rate-and-state frictional *** combined approach was applied to the case of the Pertusillo Lake,located in the Val d’Agri area(Italy),whose large seasonal water level changes are believed to induce protracted micro-seismicity(local magnitude MLesults show that the lake impoundment in 1962 could have produced up to 0.5 bar(1 bar=100 kPa)changes in Coulomb failure stress(DCFS),while the seasonal water level variation is responsible for variation up to 0.05 *** results of the seismicity rates in 20012014 show that the observed earthquakes are well correlated with the modeled ***,the reason that the seismicity is only observed at southwest of the Pertusillo Lake is provided,which is likely attributed to different rock lithologies and depletion caused by significant hydrocarbon exploitation in the northeastern sector of the lake.

关键词： Reservoir induced seismicity(RIS) Poroelasticity Rate-and-state frictional law Pertusillo lake

Liver Fat Scores for Noninvasive Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease in epidemiological and Clinical Studies

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1212-1227页

作者： Mona Reinshagen Stefan Kabisch Andreas F.H.Pfeiffer Joachim Spranger Department of endocrinology and Metabolism Campus Benjamin FranklinCharitéUniversity MedicineBerlinGermany deutsches zentrum für Diabetesforschung e.V. Geschäftsstelle am Helmholtz-Zentrum MünchenNeuherbergGermany

Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term *** often asymptomatic but reversible,it would require population-wide screening,but direct diagnostics are either too invasive(liver biopsy),costly(MRI)or depending on the examiner’s expertise(ultrasonography).Hepatosteatosis is usually accommodated by features of the metabolic syndrome(***,disturbances in triglyceride and glucose metabolism),and signs of hepatocellular damage,all of which are reflected by biomarkers,which poorly predict NAFLD as single item,but provide a cheap diagnostic alternative when integrated into composite liver fat *** liver index,NAFLD LFS,and hepatic steatosis index are common and accurate indices for NAFLD prediction,but show limited accuracy for liver fat *** indices are rarely *** fibrosis scores are commonly used in clinical practice,but their mandatory reflection of fibrotic reorganization,hepatic injury or systemic sequelae reduces sensitivity for the diagnosis of simple ***-induced liver fat changes are poorly reflected by liver fat indices,depending on the intervention and its specific impact of weight loss on *** limited validity in longitudinal settings stimulates research for new ***,hepatokines,markers of cellular integrity,genetic variants but also simple and inexpensive routine parameters might be potential ***,liver fat indices lack precision for NAFLD prediction or monitoring in individual patients,but in large cohorts they may substitute nonexistent imaging data and serve as a compound biomarker of metabolic syndrome and its cardiometabolic sequelae.

关键词： NAFLD Liver fat indices Fatty liver index Prediction Dietary intervention

An efficient Topography Adaptive Filter for Insar Processing

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High Technology Letters 2001年第4期7卷 27-31页

作者：朱岱寅 Scheiber Rolf Sha Nansheng Zhu Zhaoda Department of electronic engineering Nanjing University of Aeronautics and Astronautics deutsches zentrum für Luft- und Raumfahrt (DLR) e.V. Department of Automatic Control Beijing University of Aeronautics and Astronautics

An efficient implementation of the topography adaptive filter based on local frequency estimation is proposed, where chirp z transform is applied to enhance the accuracy of the frequency estimation. As a by product of this adaptive filter, the linear approximated phase model of the interferogram is employed to improve the coherence estimation. The impacts of the adaptive filter on global and local phase unwrapping algorithms are discussed. Finally, aiming at the negative effect that the adaptive filter can bring to local phase unwrapping algorithms, a fusion scheme that takes advantage of least square and several local phase unwrapping algorithms is presented.

关键词： Interferometric SAR Local frequency estimation Chirp z transform Phase unwrapping

Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy

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World Journal of Gastroenterology 2015年第28期21卷 8492-8507页

作者： Daniela Ploen eberhard Hildt Paul-ehrlich-Institut Department of Virology deutsches zentrum für Infektionsforschung

Autophagy is a highly-regulated,conserved cellular process for the degradation of intracellular components in lysosomes to maintain the energetic balance of the *** is a pro-survival mechanism that plays an important role during development,differentiation,apoptosis,ageing and innate and adaptive immune ***,autophagy has been described to be involved in the development of various human diseases,e.g.,chronic liver diseases and the development of hepatocellular *** hepatitis C virus(HCV) is a major cause of chronic liver *** has recently been described that HCV,like other RNA viruses,hijacks the autophagic machinery to improve its ***,the mechanisms underlying its activation are *** replication and assembly occurs at the so-called membranous web that consists of lipid droplets and rearranged endoplasmic reticulum-derived membranes including single-,doubleand multi-membrane *** double-membrane vesicles have been identified to contain NS3,NS5 A,viral RNA and the autophagosomal marker microtubuleassociated protein 1 light chain 3,corroborating the involvement of the autophagic pathway in the HCV *** this review,we will highlight the crosstalk of the autophagosomal compartment with different steps of the HCV life-cycle and address its implications on favoring the survival of infected hepatocytes.

关键词： Hepatitis C virus Hepatitis Autophagy Morphogenesis Replication

environmental analysis of innovative sustainable composites with potential use in aviation sector -A life cycle assessment review

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Science China(Technological Sciences) 2017年第9期60卷 1301-1317页

作者： BACHMANN Jens HIDALGO Carme RICOUT Stephanie deutsches zentrum fiir Lufi- und Raumfahrt e. V. (German Aerospace Centre) Institute of Composite Structures and Adaptive Systems-Department of Multifunctional Materials Lilienthalplatz 7 38108 Braunsehweig Germany Leitat Technological Center C/Innovacio 2 08225 Terrassa Spain Airbus Group Innovations Fuels and Environment 12 rue Pasteur 92152 Suresnes France

The forecast of growing air transport in the upcoming decades faces the challenge of an increasing environmental *** industry is working on promising technologies to mitigate this environmental *** design is a strong lever to lower the fuel consumption and,consequently,with it the emissions of *** performance composites are a key technology to help achieve these aims thanks to their favourable combination of mechanical properties and low weight in primary ***,mainly synthetic materials such as petrol based carbon fibres and epoxy resins are used nowadays to produce composite in *** materials like bio-based fibres and resin systems offer potential environmental ***,they have not found their way into aviation,*** reasons are reduced mechanical properties and,especially for the use of natural fibres,their *** of these shortcomings are under *** the application of bio-based and recycled materials in certain areas of the aircraft could be possible in the *** examples for applications are furnishings and secondary *** motivation for this paper is to give an overview of potential environmental properties by using such eco-materials in *** cycle assessment(LCA) is a tool to calculate environmental impacts during all life stages of a *** main focus is laid on the bio-fibres flax and ramie,recycled carbon fibres and bio-based thermoset resin *** an overview of environmental aspects of existing composite materials used in aviation is ***,a lack of LCA results for the substitution of synthetic materials by bio-based/recycled composite materials in aviation applications has been ***,available information from other transport areas,such as automotive,has been *** detailed LCA data for eco-composite materials and technologies to improve their properties is import

关键词： aviation composite natural fibre recycled carbon fibre bio-resin cabin interior secondary structure,fife cycle assessment (LCA)

Numerical Aerodynamics at DLR

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Chinese Journal of Aeronautics 2006年第2期19卷 134-150页

作者： Cord-Christian ROSSOW Norbert KROLL Dieter SCHWAMBORN DLR Deutsches Zentrum für Luft-und Raumfahrt e. V.in the Helmholtz-AssociationInstitute of Aerodynamics and Flow Technology 38108 Braunschweig 37073 GttingenGermany

Some years ago the national CFD project MeGAFLOW was initiated in Germany to combine many of the CFD development activities from DLR, universities and aircraft industry. Its goal was the development and validation of a dependable and efficient numerical tool for the aerodynamic simulation of complete aircraft which met the requirements of industrial implementations. The MeGAFLOW software system includes the block-structured Navier-Stokes code FLOWer and the unstructured Navier-Stokes code TAU. Both codes have reached a high level of maturity and they are intensively used by DLR and the German aerospace industry in the design process of new aircraft. Recently, the follow-on project MeGADeSIGN and MeGAOPT were set up which focus on the development and enhancement of efficient numerical methods for shape design and optimization. This article highlights recent improvements of the software and its capability to predict viscous flows for complex industrial aircraft applications.

关键词： numerical aerodynamics Navier-Stokes solver MeGAFLOW DLR

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社会经济地位对大脑结构与功能的影响

科学通报 2019年第20期64卷 2114-2126页

作者：吕子旸彭凯平胡传鹏清华大学心理学系北京100084 deutsches Resilienz zentrum (DRZ) Mainz 55131 Germany

社会经济地位(socioeconomic status, SeS)与大脑结构和功能的关系对于理解社会经济因素对心理行为的影响以及预防大脑和心理疾病具有重要意义.在过去十多年中,研究者使用认知神经科学的方法对SeS与大脑的关系进行了探索,发现SeS与大脑... 详细信息

社会经济地位(socioeconomic status, SeS)与大脑结构和功能的关系对于理解社会经济因素对心理行为的影响以及预防大脑和心理疾病具有重要意义.在过去十多年中,研究者使用认知神经科学的方法对SeS与大脑的关系进行了探索,发现SeS与大脑结构和功能之间可能存在相关性,但这些研究的结果却不完全一致.本文从大脑结构与功能两个层次出发,按照认知与情绪两大主题对SeS与大脑关系的认知神经科学研究进行回顾,在此基础上对比不同研究结果的异同之处.结果发现:(1)在脑结构上, SeS水平与海马体(主要负责记忆)、前额叶(参与执行功能等高级认知过程)及皮层下结构(主要包括参与情绪加工的杏仁核等结构)可能存在相关;(2)在脑功能上,不同SeS水平的个体在进行执行功能、学习和记忆等相关任务时,大脑活动模式可能存在差异,同时正性与负性情绪刺激所引发的大脑活动在不同SeS水平的个体上可能有所差异.值得注意的是, SeS与大脑关系的研究中还面临着诸多挑战,如SeS测量的复杂性和全面性、大脑结构与功能自身发展和测量的复杂性、SeS影响大脑机制的多层次性等.未来的研究需要应对上述的挑战,同时考虑文化差异等影响,从而能够更准确地理解SeS与大脑的关系,并为中国社会治理政策提供指导.

关键词：社会经济地位大脑结构大脑功能认知能力情绪加工可重复性

experimental and numerical study on energy dissipation in freely cooling granular gases under microgravity

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Chinese Physics B 2018年第8期27卷 324-330页

作者： Wen-Guang Wang Mei-Ying Hotl Ke Chen Pei-Dong Yu Matthias Sperl Key Laboratory of Soft Matter Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institut fr Materialphysik im Weltraum Deutsches Zentrum fiir Luft-und RaumfahrtKOln 51170Germany

energy dissipation is one of the most important properties of granular gas, which makes Its behavior dltterent trom that of molecular gas. In this work we report our investigations on the freely-cooling evolution of granular gas under microgravity in a drop tower experiment, and also conduct the molecular dynamics （MD） simulation for comparison. While our experimental and simulation results support Haff＇s law that the kinetic energy dissipates with time t as e（t）（1 ＋ t/v） 2, we modify ~＂ by taking into account the friction dissipation during collisions, and study the effects of number density and particle size on the collision frequency. From the standard deviation of the measured velocity distributions we also verify the energy dissipation law, which is in agreement with Haff＇s kinetic energy dissipation.

关键词： granular gas freely coolin microgravity

Breaking barriers:noncanonical inflammasome executes blood–brain barrier disruption

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3541-3543页

作者： Martin Dichgans Jonas J.Neher Yaw Asare Institute for Stroke and Dementia Research(ISD) University HospitalLudwig-Maximilian-University(LMU)MunichGermany deutsches zentrum für Neurodegenerative erkrankungen e.V.(DZNe) MunichGermany Munich Cluster for Systems Neurology(SyNergy) MunichGermany German Center for Cardiovascular Research(DZHK) Partner Site Munich Heart Alliance(MHA)MunichGermany Biomedical Center(BMC) BiochemistryFaculty of MedicineLMU MunichMunichGermany

In a landmark study recently published in Nature,1 Wei and colleagues demonstrate that the activation of GSDMD by the cytosolic lipopolysaccharide(LPS)sensor caspase-11 triggers blood–brain barrier(BBB)breakdown upon LPS challenge independent of TLR4-induced cytokine *** work identifies the noncanonical inflammasome and GSDMD pore formation as a potential target for treating central nervous system(CNS)disorders associated with inflammatory BBB dysfunction.

关键词： inflam barrier canonical

Preparation of Long-range Ordered Nanostructures in Semicrystalline Diblock Copolymer Thin Films Using Micromolding

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Chinese Journal of Polymer Science 2014年第9期32卷 1188-1198页

作者： Peng Zhang Hai-ying Huang Yu Chen Shun Yu Christina Krywka Sarathlal K.Vayalil Stephan V.Roth 何天白 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences deutsches elektronen-Synchrotron Hamburg D-22607 Germany Institute of High energy Physics Chinese Academy of Sciences Institute for Applied and experimental Physics University of Kiel Kiel D-24118 Germany Institute of Materials Research Helmholtz Zentrum Geesthacht D-21502 Geesthacht Germany

Long-range ordered nanostructures are prepared in the poly（styrene）-block-poly（e-caprolactone） diblock copolymer thin films using micromolding. We evaluated the change in crystallinity based on grazing-incidence X-ray diffraction and proved that the crystallinity increased with the decrease of the mold size. This means that ordered nanostructures with atomic length scale order can be adjusted by tuning the mesoscale confinement. The inherent mechanism was the cooperation of geometric confinement, microphase structure and surface-induced ordering of PS-b-PCL in the melt, which paved the way for the subsequent crystal growth. These findings establish a route to promote the cost-effective nanofabrication by combining the mature microfabrication technique with the emerging directed self-assembly of block copolymers.

关键词： Long-range ordered nanostructure Directed self-assembly Surface-induced ordering X-ray.