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主侧链技术及其能源互联网应用综述

南京师范大学学报（工程技术版） 2023年第3期23卷 9-18页

作者：于伟杭静文郭佳艾崧溥梁宏曹军威国网数字科技控股有限公司北京100053 国网区块链科技(北京)有限公司北京100053 中国信息通信研究院北京泰尔英福科技有限公司iF-labs 北京100083 清华大学北京信息科学与技术国家研究中心北京100084

对主侧链技术的5种模式进行了综述,分析其中的优缺点,重点讨论主侧链技术的应用场景,并结合能源互联网领域发展的最新趋势和需求,认为能源互联网具有分布式、分散、多能源协调和金融市场化的特点,这些特征和区块链技术概念彼此一致,但... 详细信息

对主侧链技术的5种模式进行了综述,分析其中的优缺点,重点讨论主侧链技术的应用场景,并结合能源互联网领域发展的最新趋势和需求,认为能源互联网具有分布式、分散、多能源协调和金融市场化的特点,这些特征和区块链技术概念彼此一致,但很多现有研究是在简单或单一场景下对区块链应用的讨论,有必要对同一场景下、不同场景之间的各个区块链之间的交互进行讨论,以满足相应的信息交互需求.为了满足能源互联网中角色、内容和级别不同的数据和服务交互的不同需求,将侧链技术集成到能源互联网中至关重要.并以两种典型的应用场景为例,给出了侧链技术在能源领域的具体应用架构.

关键词：区块链侧链能源互联网分布式系统

COVID-19 compared to other epidemic coronavirus diseases and theflu

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World Journal of Clinical Infectious Diseases 2020年第1期10卷 1-13页

作者： James A Ayukekbong Michel L Ntemgwa Solange A Ayukekbong Eta E Ashu Terence A Agbor Infection Prevention and Control Unit St Joseph’s HospitalElliot LakeON P5A 2R3Canada EpiTech Public Health NanaimoBC V9R 0H7Canada Natural and Non-prescription Health Products Directorate Health Products and Food BranchHealth CanadaOttawaON K1A 0K9Canada Cancer Care Ontario TorontoON M5P 3L6Canada DynaLIFE Medical labs EdmontonAB T5J 5E2Canada Laboratory Medicine and Pathology University of AlbertaEdmontonAlbertaAB T6G 2R3Canada

Coronaviruses are among the largest group of known positive-sense RNA viruses with a wide range of animal hosts as reservoir. In the last two decades,newly evolved coronaviruses such as the severe acute respiratory syndrome coronavirus(SARS-CoV) which caused the infamous 2002 outbreak, the Middle East respiratory syndrome coronavirus(MERS-CoV) which caused an outbreak in 2012, and now the SARS-CoV-2 [responsible for the current coronavirus disease 2019(COVID-19)] have all posed notable threats to global public ***, how does the current COVID-19 outbreak compare with previous coronaviruses diseases? In this review, we look at the key differences between SARS-CoV, MERS-CoV, and SARS-CoV-2, and examine challenges in determining accurate estimates of the severity of COVID-19. We discuss coronavirus outbreaks in light of key outbreak severity indicators including,disease fatality, pathogen novelty, ease of transmission, geographical range, and outbreak preparedness. Finally, we review clinical trials of emerging treatment modalities and provide recommendations on the control of COVID-19 based on the mode of transmission of the coronaviruses. We also recommend the development and use of a standardized predictive epidemic severity models to inform future epidemic response.

关键词： Severe acute respiratory syndrome,SARS Middle East respiratory syndrome,MERS COVID-19 SARS-CoV2 Coronaviruses Influenza,Flu Respiratory viruses

The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2

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四川生理科学杂志 2022年第7期44卷 1299-1299页

作者： Jonathan E Pekar Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA. Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA. Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA. Department of Computer Science and Engineering University of California San Diego La Jolla CA 92093 USA. Department of Mathematics University of California San Diego La Jolla CA 92093 USA. Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA. W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA. New York City Public Health Laboratory New York City Department of Health and Mental Hygiene New York NY 11101 USA. Department of Microbiology Institute for Viral Diseases Biosafety Center College of Medicine Korea University Seoul South Korea. BK21 Graduate Program Department of Biomedical Sciences Korea University College of Medicine Seoul 02841 Republic of Korea. National Public Health Laboratory National Centre for Infectious Diseases Singapore. Malaysia Genome and Vaccine Institute Jalan Bangi 43000 Kajang Selangor Malaysia. Department of Medicine University of California San Diego La Jolla CA 92093 USA. Department of Microbiology and Immunology School of Medicine Tulane University New Orleans LA 70112 USA. Zalgen labs Frederick MD 21703 USA. Global Virus Network (GVN) Baltimore MD 21201 USA. Sydney Institute for Infectious Diseases School of Life and Environmental Sciences and School of Medical Sciences The University of Sydney Sydney NSW 2006 Australia. Institute of Evolutionary Biology University of Edinburgh King’s Buildings Edinburgh EH9 3FL UK. Department of Biomathematics David Geffen Sch

Understanding the circumstances that lead to pandemics is important for their prevention. Here, we analyze the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic. We show that SARS-CoV-2 genomic diversity before February 2020 likely comprised only two distinct viral lineages, denoted A and B. Phylodynamic rooting methods, coupled with epidemic simulations, reveal that these lineages were the result of at least two separate cross-species transmission events into humans. The first zoonotic transmission likely involved lineage B viruses around 18 November 2019 (23 October-8 December), while the separate introduction of lineage A likely occurred within weeks of this event.

关键词： epidemiology likely acute

The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

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四川生理科学杂志 2022年第7期44卷 1246-1246页

作者： Michael Worobey Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA. Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA. W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA. Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA. Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. Department of Human Genetics University of Utah School of Medicine Salt Lake City UT 84112 USA. Vaccine and Infectious Disease Organization University of Saskatchewan Saskatoon SK S7N 5E3 Canada. Center for Global Health Science and Security Georgetown University Washington DC 20057 USA. Department of Zoology University of Oxford Oxford OX1 3SZ UK. Wildlife Conservation Research Unit Department of Zoology The Recanati-Kaplan Centre University of Oxford Oxford OX13 5QL UK. Pandemic and Disaster Preparedness Centre Erasmus University Medical Center 3015 CE Rotterdam Netherlands. Department of Viroscience Erasmus University Medical Center 3015 CE Rotterdam Netherlands. Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA 90095 USA. Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA. Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA. Department of Medicine University of California San Diego La Jolla CA 92093 USA. Department of Microbiology Immunology and Transplantation Rega Institute for Medical Research KU Leuven 3000 Leuven Belgium. Global Virus Network (GVN) Baltimore MD 21201 USA. MRC-University of Glasgow Center for Virus Research Glasgow G61 1QH UK. Tulane University School of Medicine Department of Mi

Understanding how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in 2019 is critical to preventing zoonotic outbreaks before they become the next *** Huanan Seafood Wholesale Market in Wuhan,China,was identified as a likely source of cases in early reports but later this conclusion became *** show the earliest known COVID-19 cases from December 2019,including those without reported direct links,were geographically centered on this *** report that live SARS-CoV-2 susceptible mammals were sold at the market in late 2019 and,within the market,SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live mammals.

关键词： Market likely Wuhan

Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases