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Evaluation of Serum Soluble CD27 and CXCL10 Levels in Patients With Vitiligo:A Cross-Sectional Study

International Journal of dermatology and Venereology 2024年第2期7卷 89-93页

作者： Marwa A.Aboelmagd Hanan A.Assaf Mohammed H.Hassan Hanan A.Abdelmegeed Ashraf Abdelwahab Department of dermatology Venereology and AndrologyFaculty of MedicineSohag UniversitySohag 82524Egypt Department of Medical Biochemistry Faculty of MedicineSouth Valley UniversityQena 83523Egypt Department of dermatology Sohag Hospital for Mental HealthSohag 82524Egypt

Objective:Vitiligo is a relatively common skin disfiguring disorder that exhibits a fluctuating course between activity and stability,making monitoring and management *** plays a crucial role in the pathogenesis of *** autoimmune disorders have been associated with both CD27 and chemokine(C-X-C motif)ligand 10(CXCL10).However,trials evaluating their role in vitiligo are lacking in the Egyptian *** evaluated the circulating levels of these 2 biomarkers in patients with vitiligo and the possible correlation between their levels and disease ***:This cross-sectional study included 70 patients with vitiligo and 20 healthy *** patients were clinically assessed and then divided into active and stable groups according to clinical signs of activity and Vitiligo Disease Activity *** levels of CD27 and CXCL10 in the serum were assessed using an enzyme-linked immunosorbent assay in both the patients and the controls,then the Mann-Whitney U and Kruskal-Wallis tests were used to analyze the difference between the ***:Active and stable vitiligo patients have significantly higher median serum CXCL10(385.9 and 245.2 pg/mL)and CD27(61.6 and 66.5 ng/mL)levels compared to the controls(193 pg/mL and 52.5 ng/mL,respectively,all P<0.05).In vitiligo cases,although CXCL10 levels significantly increased with disease activity(P<0.001),CD27 levels were comparable between the 2 subgroups(P=0.953).CXCL10 positively correlated with disease activity(r=0.887,P<0.001).CXCL10 had a higher sensitivity and a lower specificity(95.7%and 60.0%,respectively)compared to CD27(71.4%and 75%,respectively)for differentiating cases from ***:There is a possibility that CXCL10 and CD27 are involved in the development and course of vitiligo.

关键词： vitiligo disease activity chemokine(C-X-C motif)ligand 10 CD27

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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

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Sclerotherapy in a case of multiple glomuvenous malformation

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 79-82页

作者： Shufen Wang Sijian Wen Jiarong Liang Hui Lui Xinyu Zhang dermatology and Venereology First Clinical Medical CollegeGuangxi Medical UniversityNanningGuangxi 530021China Department of dermatology and Venereology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530029China

In this study, we present a representative case of multiple glomuvenous malformation in a 12-year-old female patient. Approximately five years ago, the patient developed multiple blue-purple papules and plaques on her hypogastrium and right thigh, which progressively enlarged and presented tenderness. Histopathological examination confirmed the diagnosis of glomuvenous malformation. Following two injections of lauromacrogol, a significant improvement was observed in the lesions, including a resolution of tenderness. These findings suggest that sclerotherapy not only exhibits evident therapeutic efficacy but also effectively alleviates pain while addressing both aesthetic and therapeutic concerns.

关键词： Glomuvenous malformation Sclerotherapy

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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit

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Science China Life Sciences 2024年第10期67卷 2198-2212页

作者： Zhen Li Xuefei Li Jingxia Lin Yangming Wang Huiqing Cao Jiajian Zhou Institute of Molecular Medicine College of Future TechnologyPeking University dermatology Hospital Southern Medical University Beijing Advanced Center of RNA Biology (BEACON) Peking University

Many long noncoding RNAs(lncRNAs) have been identified through siRNA-based screening as essential regulators of embryonic stem cell(ESC) pluripotency. However, the biological and molecular functions of most lncRNAs remain unclear. Here, we employed CRISPR/Cas9-mediated knockout technology to explore the functions of 8 lncRNAs previously reported to promote pluripotency in mouse ESCs. Unexpectedly, all of these lncRNAs were dispensable for pluripotency maintenance and proliferation in mouse ESCs when disrupted individually or in combination. Single-cell transcriptomic analysis also showed that the knockout of these lncRNAs has a minimal impact on pluripotency gene expression and cell identity. We further showed that several small hairpin RNAs(shRNAs) previously used to knock down lncRNAs caused the downregulation of pluripotency genes in the corresponding lncRNA-knockout ESCs, indicating that off-target effects likely responsible for the pluripotency defects caused by these shRNAs. Interestingly, linc1343-knockout and linc1343-knockdown ESCs failed to form cystic structures and exhibited high expression of pluripotency genes during embryoid body(EB) differentiation. By reintroducing RNA products generated from the linc1343 locus, we found that two snoRNAs, Snora73a and Snora73b, but not lncRNAs, could rescue pluripotency silencing defects during EB differentiation of linc1343 knockout ESCs. Our results suggest that the 8 previously annotated pluripotency-regulating lncRNAs have no overt functions in conventional ESC culture; however, we identified snoRNA products derived from an annotated lncRNA locus as essential regulators for silencing pluripotency genes.

关键词： long noncoding RNAs embryonic stem cells CRISPR/Cas9 snoRNAs stem cell differentiation

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Comorbidities of prurigo nodularis in Chinese patients:A multicenter retrospective study

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Chinese Medical Journal 2024年第11期137卷 1360-1362页

作者： Mengting Yin Weilong Zhong Keren Zhou Xia Dou Department of dermatology Peking University Shenzhen HospitalShenzhenGuangdong 518036China National Clinical Research Center for Skin and Immune Diseases Beijing 100034China

Prurigo nodularis(PN),as a subtype of chronic prurigo(CPG),is characterized by nodular lesions and severe pruritus,which signicantly affect patients’quality of life.[1]It has been observed that patients with PN often have comorbidities,including physical and mental diseases.[2]However,information on comorbidities in Chinese PN patients is *** study aims toll this gap by using a representative patient population to provide comprehensive data on comorbidities in Chinese patients with PN.

关键词： patients morbid lesions

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Acrodermatitis Continua of Hallopeau With Excellent Response to Topical Calcipotriol/Betamethasone Ointment:A Report of Two Cases

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International Journal of dermatology and Venereology 2024年第2期7卷 119-120页

作者： Yu-Kun Zhao Hui-Hui Wu Juan-Hua Liu Di-Qing Luo Department of dermatology The East Division of The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510700China

Introduction:Acrodermatitis continua of Hallopeau(ACH)is an uncommon chronic cutaneous *** to date,its treatment is still difficult and frustrating although various topical and systemic agents alone or in different combinations have been tried with variable ***,we report two cases of ACH successfully treated with calcipotriol/betamethasone *** presentation:Two cases of ACH were characterized by thumb involvement alone and showed an excellent response to calcipotriol/betamethasone ointment(1 g:calcipotriol 50µg and betamethasone 0.5 mg).Discussion:Treatment of ACH is challenging for *** systemic therapies and topical drugs have been applied,however,no universally effective treatment regimen has yet been established for long-lasting *** of calcipotriol and betamethasone is more effective in treating psoriasis than the individual components alone,and the current 2 cases with ACH were reported to be treated successfully by the calcipotriol/betamethasone ***:Topical calcipotriol/betamethasone compound is an optional agent for the treatment of ACH with a novel effect.

关键词： pustular eruptions calcipotriol/betamethasone ointment treatment

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Non-invasive imaging of pathological scars using a portable handheld two-photon microscope

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Chinese Medical Journal 2024年第3期137卷 329-337页

作者： Yang Han Yuxuan Sun Feili Yang Qingwu Liu Wenmin Fei Wenzhuo Qiu Junjie Wang Linshuang Li Xuejun Zhang Aimin Wang Yong Cui Graduate School Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of dermatology China-Japan Friendship HospitalBeijing 100029China College of Engineering Peking UniversityBeijing 100871China School of Chemical Biology and Biotechnology State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Department of dermatology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Future Technology Peking UniversityBeijing 100871China Beijing Transcend Vivoscope Biotech Beijing 100085China Department of dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230001China Institute of dermatology Anhui Medical UniversityHefeiAnhui 230001China School of Electronics Peking UniversityBeijing 100871China

Background:Pathological scars are a disorder that can lead to various cosmetic,psychological,and functional problems,and no effective assessment methods are currently *** and treatment of pathological scars are based on cutaneous manifestations.A two-photon microscope(TPM)with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in *** study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar ***:Fifteen patients with pathological scars and three healthy controls were *** was performed using a portable handheld *** indexes were extracted from two dimensional(2D)and three dimensional(3D)perspectives,including collagen depth,dermo-epidermal junction(DEJ)contour ratio,thickness,orientation,and occupation(proportion of collagen fibers in the field of view)of *** depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D *** assessed index differences between scar and normal skin and changes before and after ***:Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen *** indexes were employed to distinguish between normal skin and scar *** significant differences were found in average depth(t=9.917,P<0.001),thickness(t=4.037,P<0.001),occupation(t=2.169,P<0.050),orientation of collagen(t=3.669,P<0.001),and the DEJ contour ratio(t=5.105,P<0.001).Conclusions:Use of portable handheld TPM can distinguish collagen from skin tissues;thus,it is more suitable for scar imaging than reflectance confocal ***,a TPM may be an auxiliary tool for scar treatment selection and assessing treatment efficacy.

关键词： Scars Two-photon microscope Two-photon excitation fluorescence Second harmonic generation microscopy

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Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue XIAO Yan-wei MA Jing-xin WANG Ao-xue Department of dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

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Helicobacter pylori mediated niche environment aberrations promote the progression of gastric cancer

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Genes & Diseases 2024年第5期11卷 113-116页

作者： Teng Yan Hang Sun Yuhui Liao Jiajian Zhou Nanfang Hospital The First School of Clinical MedicineSouthern Medical UniversityGuangzhouGuangdong 510515China dermatology Hospital Southern Medical UniversityGuangzhouGuangdong 510091China

Intestinal metaplasia(IM)is a key stage in the tumorigenic Correa cascade from gastritis to final intestinal-type gastric cancer(GC).1 Helicobacter pylori(***)infection is the most common trigger of IM,and it promotes GC progression through induction of gastric epithelial transition.2 Currently,the mechanism by which *** infection promotes tumorigenesis in IM patients is poorly *** et *** a single-cell transcriptomic atlas on premalignant lesions and identified biomarkers of gastric early-malignant cells,providing an opportunity to explore the molecular mechanism of GC progression at the molecular level.

关键词： gastric pylori Helicobacter

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