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Differentiating between Alzheimer’s disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging

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Neural Regeneration Research 2019年第12期14卷 2141-2146页

作者： Guo-Ping Song Ting-Ting Yao Dan Wang Yue-Hua Li Institute of diagnostic and Interventional radiology Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University

Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between patients with Alzheimer’s disease and those with amnestic mild cognitive impairment has not been characterized. Here, we examined 20 individuals with Alzheimer’s disease (11 men and 9 women, mean 73.2 ± 4.49 years), 20 with amnestic mild cognitive impairment (10 men and 10 women, mean 71.55 ± 4.77 years), and 20 normal controls (11 men and 9 women, mean 70.45 ± 5.04 years). We conducted diffusion kurtosis imaging, using a 3.0 T magnetic resonance scanner, to compare hippocampal differences among the three groups. The results demonstrated that the right hippocampal volume and bilateral mean kurtosis were remarkably smaller in individuals with Alzheimer’s disease compared with those with amnestic mild cognitive impairment and normal controls. Further, the mean kurtosis was lower in the amnestic mild cognitive impairment group compared with the normal control group. The mean diffusion in the left hippocampus was lower in the Alzheimer’s disease group than in the amnestic mild cognitive impairment and normal control groups, while the mean diffusion in the right hippocampus was lower in the Alzheimer’s disease group than in the normal control group. Fractional anisotropy was similar among the three groups. These results verify that bilateral mean kurtosis and mean diffusion are sensitive to the diagnosis of Alzheimer’s disease and amnestic mild cognitive impairment. This study was approved by the Ethics Review Board of Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, China on May 4, 2010 (approval No. 2010(C)-6).

关键词： nerve regeneration magnetic resonance imaging diffusion kurtosis imaging hippocampus amnestic mild cognitive impairment Alzheimer's disease mean kurtosis mean diffusion fractional anisotropy neural regeneration

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Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients

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World Journal of Clinical Oncology 2017年第4期8卷 343-350页

作者： Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres Institute for diagnostic and Interventional radiology University Hospital Frankfurt

AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors *** TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC.

关键词： Colorectal neoplasms Breast neoplasms Neoplasm metastasis Neoplasms Drug therapy

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MRI versus 64-row MDCT for diagnosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第48期15卷 6044-6051页

作者： Michael Bernhard Pitton Roman Kloeckner Sascha Herber Gerd Otto Karl Friedrich Kreitner Christoph Dueber Department of diagnostic and Interventional radiology Johannes Gutenberg-University Department of Transplantation and Hepatobili-opancreatic Surgery University of Mainz

AIM： To compare the diagnostic capability of multidetector computed tomography （MDCT） and magnetic resonance imaging （MRI） for the detection of hepatocellular carcinoma （HCC） tumour nodules and their effect on patient management. METHODS： A total of 28 patients （25 male, 3 female, mean age 67 ± 10.8 years） with biopsy-proven HCC were investigated with 64-row MDCT （slice 3 mm native, arterial and portal-venous phase, 120 mL Iomeprol, 4 mL/s, delay by bolus trigger） and MRI （Tlfs fl2d TE/ TR 2.72/129 ms, T2tse TE/TR 102/4000 ms, 5-phase dynamic contrast-enhanced Tlfs fl3d TE/TR 1.56/4.6, Gadolinium-DTPA, slice 4 mm）. Consensus reading of both modalities was used as reference. Tumour nodules were analyzed with respect to number, size, and location. RESULTS： In total, 162 tumour nodules were detected by consensus reading. MRI detected significantly more tumour nodules （159 vs 123, P 〈 0.001） compared to MDCT, with the best sensitivity for early arterial phase MRI. False-negative CT findings included nodules ≤ 5 mm （n = 5）, ≤ 10 mm （n = 17）, ≤ 15 mm （n= 12）,≤20mm（n=4）,andlnodule〉*** missed 2 nodules ≤ 10 mm and 1 nodule ≤ 15 mm. On MRI, nodule diameters were greater than on CT （29.2 ≤25.1 mm, range 5-140 mm vs 24.1 ± 22.7 mm, range 4-129 mm, P 〈 0.005）. In 2 patients, MDCT showed only unilobar tumour spread, whereas MRI revealed additional nodules in the contralateral lobe. Detection of these nodules could have changed the therapeutic strategy. CONCLUSION： Contrast-enhanced MRI is superior to 64-row MDCT for the detection of HCC nodules. Patients should be allocated to interventional or operative treatment according to a dedicated MRI-protocol.

关键词： American Association for the Study of Liver Diseases European Association for the Study of the Liver Hepatocellular carcinoma Multidetector computed tomography Magnetic resonance imaging

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Post-operative imaging in liver transplantation: State-of-the-art and future perspectives

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World Journal of Gastroenterology 2014年第20期20卷 6180-6200页

作者： Rossano Girometti Giuseppe Como Massimo Bazzocchi Chiara Zuiani Department of Medical and Biological Sciences Institute of Diagnostic Radiology University of Udine 33100 Udine Italy

Orthotopic liver transplantation(OLT)represents a major treatment for end-stage chronic liver disease,as well as selected cases of hepatocellular carcinoma and acute liver *** ever-increasing development of imaging modalities significantly contributed,over the last decades,to the management of recipients both in the pre-operative and post-operative period,thus impacting on graft and patients *** properly used,imaging modalities such as ultrasound,multidetector computed tomography,magnetic resonance imaging(MRI)and procedures of direct cholangiography are capable to provide rapid and reliable recognition and treatment of vascular and biliary complications occurring after *** defined is the role for imaging in assessing primary graft dysfunction(including rejection)or chronic allograft disease after OLT,e.g.,hepatitis C virus(HCV)*** paper:(1)describes specific characteristic of the above imaging modalities and the rationale for their use in clinical practice;(2)illustrates main imaging findings related to post-OLTcomplications in adult patients;and(3)reviews future perspectives emerging in the surveillance of recipients with HCV recurrence,with special emphasis on MRI.

关键词： Orthotopic liver transplantation Ultrasound Computed tomography Magnetic resonance imaging T-tube cholangiography Endoscopic retrograde cholangiography Percutaneous transhepatic cholangiography Orthotopic liver transplantation complications Human C virus recurrence

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Mitigating the impact of mechanisms causing neuronal degeneration

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Neuroprotection 2024年第1期2卷 1-3页

作者： Xunming Ji Piotr Walczak Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBejingChina Center for Advanced Imaging Research Department of Diagnostic Radiology and Nuclear MedicineUniversity of MarylandBaltimoreMarylandUSA School of Life Sciences University of WarwickCoventryUK

Primary and secondary neurodegeneration is a pathological hallmark of numerous central nervous system(CNS)*** many mechanisms leading to neurodegeneration are well understood,previous approaches aiming at providing protection from neurodegeneration were often futile.A potential explanation may be that recent research discovered additional pathomechanisms leading to ***,simply targeting single neurodegenerative mechanisms may only have minor therapeutic *** multiple neurodegenerative mechanisms may be a more viable ***,the restoration of lost brain tissue turned out to be a very complex endeavor.1 Despite making some initial progress with the use of biocompatible scaffolds and hydrogels.

关键词： Alzheimer's disease extracellular vesicles intracranial pressure microglia neurodegeneration stem cells stress stroke vascular dementia

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Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer

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World Journal of Gastroenterology 2020年第20期26卷 2657-2668页

作者： Davide Ippolito Silvia Girolama Drago Anna Pecorelli Cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi Sandro Sironi Department of diagnostic radiology H.S.Gerardo MonzaSan Gerardo HospitalUniversity of Milano-BicoccaMonza 20900Italy Department of diagnostic radiology Papa Giovanni XXIII HospitalUniversity of Milano-BicoccaBergamo 20110Italy

BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and *** treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced *** main aim is to find a reliable tool to predict tumor response in comparison to histopathologic *** To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic *** Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this *** protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability *** of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TR

关键词： Rectal neoplasm Chemotherapy Radiotherapy Tumor staging Treatment response Magnetic resonance imaging

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Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma

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World Journal of Gastroenterology 2003年第1期9卷 94-98页

作者： Jochen Truebenbach Florian Graepler Philippe Pereira Peter Huppert Thomas Eul Gundula Wiemann Claus Claussen Department of diagnostic radiology Eberhard-Karls-University TubingenHoppe-Seyler-Strasse-3Tubingen 72076Germany

AIM:To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide(PIcg)-microspheres in the transarterial chemoembolization (TACE) in ... 详细信息

关键词：肝细胞癌动物模型动脉灌注化疗栓塞介入治疗肿瘤抑制

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Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis:A case report

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World Journal of radiology 2024年第6期16卷 232-240页

作者： Zhan-Rong Zhang Feng Chen Hui-Juan Chen Department of radiology The Affiliated Hainan Hospital of Hainan Medical University(Hainan General Hospital)Haikou 570311Hainan ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is characterized by diabetes insipidus and is an uncommon *** biopsies still have a certain degree of diagnostic *** present a case in which LCH initially affected the pituitary *** resulted in a misdiagnosis of chronic inflammation upon pathological *** SUMMARY A 25-year-old female exhibited symptoms of diabetes *** resonance imaging revealed an enhanced foci in the pituitary *** surgical resection of the pituitary lesion,the pathological diagnosis was chronic ***,the patient later experienced bone destruction in the skull and lower limb *** the lower limb bone lesion was compared with the initial pituitary lesion,the final diagnosis was modified to *** patient was treated with multiple chemotherapy ***,the patient’s condition gradually worsened,and she eventually passed away at *** LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

关键词： Langerhans cell histiocytosis Pituitary gland Diabetes insipidus Multi-system Misdiagnosis Magnetic resonance imaging Case report

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Study on evaluating involvment of adjacent major vessels by soft tissue masses deep in the extremities using mDixon-MRA

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第1期2卷 53-62页

作者： Minting Zheng Wei Qu Chongyang Fu Lina Zhang Shaowu Wang Department of radiology The Second Affiliated Hospital of Dalian Medical UniversityNo.467 Zhongshan RoadDalianChina116027 Department of radiology First Affiliated Hospital of Dalian Medical UniversityDalianChina116011 Department of Orthopedic First Affiliated Hospital of Dalian Medical UniversityDalianChina116011

Soft tissue masses deep in the extremities pose significant challenges due to their potential involvement with adjacent major vessels,impacting treatment decisions and *** MRI is valuable in diagnosing these masses,specific signs for differential diagnosis are *** study focuses on the utilization of mDixon magnetic resonance angiography(mDixon-MRA)combined with compressed sensing(CS)to assess the involvement of adjacent major blood vessels by soft tissue masses deep in the *** methodology involves preoperative imaging evaluation,including conventional MRI and mdixon-MRA,intraoperative observation,and statistical *** study suggests that combining mDixon-MRA with conventional MRI findings improves diagnostic *** mDixon-MRA with conventional MRI enhances diagnostic accuracy,offering clinicians a reliable method for assessing vascular involvement in soft tissue masses,thereby improving patient outcomes.

关键词： Soft tissue mass involvement of vessels mDixon-MRA

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Four-dimensional flow magnetic resonance imaging incirrhosis

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World Journal of Gastroenterology 2016年第1期22卷 89-102页

作者： Zoran Stankovic University Institute of diagnostic Interventional and Pediatric RadiologyInselspital-University Hospital Bern3010 BernSwitzerland

Since its introduction in the 1970’s,magnetic resonance imaging(MRI)has become a standard imaging *** its broad and standardized application,it is firmly established in the clinical routine and an essential element in cardiovascular and abdominal *** addition to sonography and computer tomography,MRI is a valuable tool for diagnosing cardiovascular and abdominal diseases,for determining disease severity,and for assessing therapeutic *** techniques have improved over the last few decades,revealing not just morphologic information,but functional information about perfusion,diffusion and hemodynamics as ***-dimensional(4D)flow MRI,a time-resolved phase contrast-MRI with three-dimensional(3D)anatomic coverage and velocity encoding along all three flow directions has been used to comprehensively assess complex cardiovascular hemodynamics in multiple regions of the *** technique enables visualization of 3D blood flow patterns and retrospective quantification of blood flow parameters in a region of *** the last few years,4D flow MRI has been increasingly performed in the abdominal *** applying different acceleration techniques,taking 4D flow MRI measurements has dropped to a reasonable scanning time of 8 to 12 *** new developments have encouraged a growing number of patient studies in the literature validating the technique’s potential for enhanced evaluation of blood flow parameters within the liver’s complex vascular *** purpose of this review article is to broaden our understanding of 4D flow MRI for the assessment of liver hemodynamics by providing insights into acquisition,data analysis,visualization and ***,in this article we highlight its development,focussing on the clinical application of the technique.

关键词： Four-dimensional flow magnetic resonanceimaging Phase contrast-magnetic resonance imaging Liver cirrhosis Imaging technique Hemodynamics Bloodflow Visualization Quantification TIPS Splanchnic system

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