检索结果-南通市图书馆

Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication

World Journal of Gastroenterology 2000年第1期6卷 134-135页

作者： Kong XB Yang ZK Liang LJ Huang JF Lin HL Department of Surgery The First Affiliated HospitalChongqing University of Medical SciencesChongqing 400016China Division of Hepatobiliary Surgery The First Affiliated HospitalSun Yat-Sen University of Medical SciencesGuangzhou 510080Guangdong ProvinceChina departrnent of pathology Sun Yat-Sen University of Medical SciencesGuangzhou 510089Guangdong ProvinceChina

INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycop... 详细信息

关键词： Subject headings liver neoplasms carcinoma hepatocellular P-glycoprotein multidrug resistance-1 gene immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feasibility of differentiating T3 from T4a gastric cancer in different Lauren classification by determining serosa invasion：Diagnostic performance of high enhanced serosa sign

引用

Chinese Journal of Cancer Research 2018年第2期30卷 263-271页

作者： Rui-Jia Sun Lei Tang Ying Chen Xiao-Ting Li Yu Sun Zi-Yu Li Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Radiology Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) departrnent of pathology Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： To study the value of high enhanced serosa sign on contrast-enhanced computed tomography（CT）in differentiating T3 from T4a gastric cancer in different Lauren ***： This study included 276 consecutive patients with surgically confirmed p T3 or p T4a gastric *** pre-operative CT images were reviewed by two radiologists blinded. The demonstration of the high enhanced serosa on CT between T3 and T4a was compared with chi-square test. The diagnostic performance of this sign on CT in the differentiation of T4a from T3 in different Lauren classification was ***： The accuracy, sensitivity, specificity, positive predictive value（PPV） and negative predictive value（NPV） for the judgement of serosa invasion using the high enhanced serosa sign on CT was 74.6%, 63.7%, 83.6%,76.0% and 73.8% by one radiologist and 76.4%, 66.1%, 84.9%, 78.1% and 75.4% by the other *** to the intestinal-type, the sensitivity of the judgement of serosa invasion using the high enhanced serosa sign on CT in diffuse-type was significant higher（80% in both readers）, while the specificity trended to be lower（65.9% and 80.5%, respectively）. There is no significant difference in the accuracy of diagnosis between intestinaltype and diffuse-type of gastric cancers（the P-values of two radiologists were 0.968, 0.591, respectively）. The combination of the high enhanced serosa sign with conventional CT signs is significant different in diagnosis of T3 and T4a（P〈0.001）. The diagnostic accuracy was increased in both radiologists after the combination. The two readers achieved substantial agreement, with Kappa coefficient of 0.63, P〈***： The high enhanced serosa sign on CT is associated with serosa involvement. The sensitivity of the judgement of serosa invasion using this sign on CT in diffuse-type was significant higher than that in intestinal-type.

关键词： Computed tomography gastric cancer staging serosa invasion imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasminogen Activator Inhibitor I as a Poor Prognostic ndicator in Resectable Pancreatic Ductal Adenocarcinoma

引用

Chinese Medical Journal 2018年第24期131卷 2947-2952页

作者： Wen-Jing Liu Li Zhou Zhi-Yong Liang Wei-Xun Zhou Lei You Tai-Ping Zhang Yu-Pei Zhao departrnent of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China Department of pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China

Background:Plasminogen activator inhibitor 1 (PAI-I)was previously established to impact several phenotypes in many kinds of cancer, including pancreatic ***,its prognostic significance in pancreatic ductal adenocarcinoma (PDAC)needs support of further *** study was designed to address the issue. Methods:PAI-1 expression was detected by tissue microarray-based immunohistochemical staining in formalin-fixed paraffin-embedded specimens from 93 PDAC patients with surgical resection from September 2004 to December *** relationships with clinicopathologic variables and tumor-specific survival (TSS)were further evaluated using Chi-square,Kaplan-Meier,log-rank,as well as Cox regression analyses. Results:Expression of PAI-1 was much higher in tumor than that in nontumor tissues,based on comparison of all samples and 74 matched ones (95 [47.5,180]vs.80 [45,95],Z=-2.439,P=0.015 and 100 [46.9,182.5]vs.80 [45,95],Z=-2.594,P =0.009,respectively).In addition,tumoral PAI-1 expression was positively associated with N stage (22/35 for N1 vs.21/51 for N0,x^2 =3.903,P=0.048).Univariate analyses showed that TSS of patients with high PAI-1 tumors was significantly poorer than that of those with low PAI-1 tumors (log rank value =19.00,P <0.0001).In multivariate Cox regression test,PAI-1 expression was identified as an independent predictor for long-term prognosis ofresectable PDAC (hazard ratio =2.559,95% confidence interval =1.499-4.367,P =0.001). Conclusion:These results suggest that expression of PAI-1 is upregulated in PDAC and might serve as a poor prognostic indicator.

关键词： Pancreatic Ductal Adenocarcinoma Plasminogen Activator Inhibitor 1 Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：