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Comparison of Planer Dose Equilibrium and Computed Tomography Dose Index and Implications for Reported Patient Dose Information

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Open Journal of Medical Imaging 2019年第4期9卷 43-51页

作者： Ahmad Albngali Joshua Deslongchamps James Blackwell Andy Shearer Brendan Tuohy Niall Colgan Department of Physics National University of Ireland Galway Ireland departmentt of mathematics National University of Ireland Galway Ireland Department of Medical Physics and Clinical Engineering Galway University Hospitals Galway Ireland

Technical developments are ongoing in CT, and there has been a continually increasing trend in patient prescription, resulting in increased exposure. Currently, doses delivered during CT are generally evaluated using computed tomography dose index (CTDI), which is measured with a 10 cm pencil ionization chamber placed in a 14 cm PMMA phantom. However, shortfalls in CTDI have been identified by the American Association of Physicists in Medicine (AAPM) who have proposed a new method, dose equilibrium (DEq). In this paper, the dose equilibrium was used to estimate the dose in two protocols (thoracic and abdominopelvic) and compared to CTDI values. In addition, a retrospective correction was applied to 20 patient CTDI’s by characterizing the specific DEq profile of the system scans. The results indicated the dose equilibrium estimations of two protocols, thoracic and abdominopelvic, were 29% and 30% respectively, higher than those informed by the CT scanner. In addition, a retrospective dose correction estimation of a random sample of twenty patients demonstrated an annual underestimation in absorbed dose by between 26% and 28%. Continued use of the CTDI method in quality assurance of modern CT could result in greater patient risk. AAPM Task Group 111 presents a more accurate, safer method to estimate dose and its adoption is paramount.

关键词： CT Dosimetry CTDI Method DEq Method CT Scanner

Clinical Pharmacology of Bamboo Grass Extract and Its Constituent Compound,Coenzyme Q10

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Clinical Pharmacology of Bamboo Grass Extract and Its Consti...

Association of bilirubin and protein thiols in relation to copper and ceruloplasmin in hyperbilirubinemic patients

中国中西医结合学会微循环2008学术大会

作者： Kimura I Tsuneki H Sasaoka T Department of Food and Nutrition Science Toyama Collegeand departmentt of Clinical Pharmacology University of ToyamaJapan

Background:Bamboo grass leaves (Sasa kurilensis MAKINO et SHIBATA) have been used as traditional food additives in *** extracts are reported to show anti- sepsis,anti-HIV activity,anti-inflammatory,and radical scavenging,and anti-bacterial lignin-like activities(1).The extract contains an endogenous antioxidant coenzyme

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海南医学院学报 2009年第1期15卷 40-44页

作者： Mungli Prakash Jeevan K Shetty Roshan D' Souza Suhasa Upadhya Vijay Kumar departmentt of Biochemistry Kasturba Medical College

Objective:Bilirubin is a double edged sword in biological system,acting as a toxic molecule and *** bilirubin is proved to show antioxidant activity in vitro and in *** the current work we tried to know the relationship between both conjugated and unconjugated bilirubin with copper and protein thiols in patients with ***:Study was conducted on 56 hyperbilirubinemic cases and 56 healthy *** copper,ceruloplasmin,protein thiols,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,total protein,albumin,AST,ALT and ALP were ***:There was significant increase in serum copper,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,AST,ALT,and ALP,and decrease in serum ceruloplasmin,protein thiols,total protein,and albumin in hyperbilirubinemic cases when compared to healthy *** bilirubin correlated positively with liver enzymes AST and ALP,and negatively with protein thiols,total protein and *** bilirubin correlated positively with *** thiols correlated negatively with copper and positively with ceruloplasmin,and also correlated negatively with liver enzymes like AST,ALT and ALP,and positively with total protein and ***:Combination of elevated levels of trace elements like copper and availability of reducing agent like bilirubin may prove deleterious by generating free radicals.

关键词：蛋白质硫藤黄菌素血浆铜蓝蛋白抗氧添加剂

DNA cleavage mediated by water-soluble manganese corrole

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Chinese Chemical Letters 2011年第1期22卷 101-104页

作者： Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang College of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510641 China Department of Applied Physics South China University of Technology Guangzhou 510641 China State Key Laboratory of Optoelectronics Materials and Technologies/MOE Laboratory of Bioinorganic and Synthetic Chemsitry Sun Yat-Sen University Guangzhou 510275 China departmentt of Pharmacology Guangdong Pharmaceutical University Guangzhou 510006 China Department of Chemistry Michigan State University East Lansing Michigan 48824 USA

The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris（N-methyl-4-pyridyl）- corrolatomanga- nese（III）（MnⅢTMPyC） has been investigated. MnⅢMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra. MnInTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.

关键词： Corrole Manganese DNA Oxidative cleavage

Reproducing Cochlear Signals by a Minimal Electroacoustic Model

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Open Journal of Biophysics 2012年第2期2卷 33-39页

作者： Giovanna Zimatore Marta Cavagnaro Alessandro Giuliani Alfredo Colosimo Department of Environment and Primary Prevention Istituto Superiore di Sanità (I.S.S.) Rome Italy Department of SAIMLAL Section of Anatomy Sapienza University Rome Italy departmentt of Information Engineering Electronics and Telecommunications Sapienza University Rome Italy Institute of Otolaryngology School of Medicine Catholic University Rome Italy

Transient-Evoked Otoacoustic Emissions (TEOAEs) were studied, with particular reference to their subject-dependent features. To this end, an electric model of the ear was implemented and validated. Simulated and natural TEOAEs were analyzed through a nonlinear analysis technique. The simulated signals were able to reproduce the dynamical features of the experimentally observed TEOAEs and, most importantly, the natural variability among individuals. The unexpected inverse relation between model complexity and adherence to the natural signals is commented.

关键词： Otoacustic Emissions Recurrence Quantification Analysis Biosignals

COMPARISON OF NON PENETRATING FILTRATION SURGERY FOR OPEN ANGLE GLAUCOMA WITH NON ABSORBABLE IM-PLANT (T FLUX) VERSUS TRABECULEC-TOMY: A MULTICENTRIC STUDY

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国际眼科杂志 2003年第1期3卷 55-55页

作者： M.Dal Vecchio B.Brogliatti T.Rolle F.M.Grignolo L.Bauchiero G.Vadala G.Caramello M.Bruni F.Molfino E.Gremmo Eye Clinic University of Turin Eye Clinic University of TurinEye Clinic University of TurinEye Clinic University of TurinEye Departmentt of Civil Hos-pitalEye Departmentt of Civil Hos-pitalEve Department of Santa Croce HospitalEve Department of Santa Croce HospitalEve Department of Santa Croce HospitalOcular Traumathology Department of Ophthalmic Hospital Italy

Purpose: To compare the efficacy and safety of deep sclerectomy with no absorbable implant (T flux) vs trabeculectomy in POAG eyes. Methods: 23 eyes of 19 patients with medically uncontrolled open angle glaucoma underwent to deep sclerectomy with non absorbable implant (T flux). The postoperative IOP values and the frequency of complications were matched with those of a group of 34 eyes of 34 POAG patients operated with trabeculectomy. The examinations were performed before surgery and post-

关键词：开角型青光眼非穿透性滤过术非可吸收埋植物小梁切除术比较研究

细胞遗传学和间期FISH在淋巴瘤诊断中的应用

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中华肿瘤杂志 2007年第1期29卷 45-48页

作者：胡夕春包黎明朱雄增 Irons Richard D 傅华陈燕陈慧赵欣旻杨新苗李进复旦大学附属肿瘤医院肿瘤内科上海200032 复旦大学附属肿瘤医院病理科上海200032 中美联合临床分子医学中心实验室 USA Division of Human Genetics Cincinnati Children＇s Hospital Medical Center and University of Cincinnati USA Department of Pathology School of Medicine University of Colorado Health Sciences Center USA Departmentt of Pharmaceutical Sciences School of Pharmacy University of Colorado Health Sciences Center

目的评估细胞遗传学和荧光原位杂交技术（FISH）对临床和（或）细针穿刺细胞学检查诊断为淋巴瘤或不能除外淋巴瘤病例的价值。方法同时采用常规组织学、免疫组织化学、细胞遗传学检查和间期FISH技术方法，对223例直径≥1．5cm淋巴结的... 详细信息

目的评估细胞遗传学和荧光原位杂交技术（FISH）对临床和（或）细针穿刺细胞学检查诊断为淋巴瘤或不能除外淋巴瘤病例的价值。方法同时采用常规组织学、免疫组织化学、细胞遗传学检查和间期FISH技术方法，对223例直径≥1．5cm淋巴结的手术活检标本进行系统性研究。FISH探针采用直接荧光标记的IGH LSI双色分开探针。结果2例患者的取材因坏死成分较多无法诊断。221例患者的病理诊断中，霍奇金淋巴瘤（HL）44例（19．9％），非霍奇金淋巴瘤（NHL）162例（73．3％），其他恶性病变4例（1．8％），良性病变11例（5．0％）。间期FISH结果显示，HL的免疫球蛋白重链基因（IGH）异常的发生率为13．6％（6／44），NHL为51．2％（83／162），良性病变为0％（0／11），差异有统计学意义（P〈0．001）。细胞遗传学和间期FISH联合检查时，HL和NHL的检出率分别提高到15．9％和77．8％，其中有3例为组织病理学和免疫组化检查不能定性者。结论间期FISH是检测IGH基因异常的快速和敏感的手段。细胞遗传学和间期FISH检测是淋巴瘤诊断的重要辅助手段。

关键词：淋巴瘤鉴别诊断 FISH 细胞遗传学免疫球蛋白重链基因