Association of bilirubin and protein thiols in relation to copper and ceruloplasmin in hyperbilirubinemic patients

作     者：Mungli Prakash Jeevan K Shetty Roshan D' Souza Suhasa Upadhya Vijay Kumar 

作者机构：Departmentt of BiochemistryKasturba Medical College 

出 版 物：《海南医学院学报》 (Journal of Hainan Medical University)

年 卷 期：2009年第15卷第1期

页      面：40-44页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100204[医学-神经病学] 100403[医学-营养与食品卫生学] 10[医学] 

主　　题：蛋白质 硫藤黄菌素 血浆铜蓝蛋白 抗氧添加剂 

摘      要：Objective:Bilirubin is a double edged sword in biological system,acting as a toxic molecule and *** bilirubin is proved to show antioxidant activity in vitro and in *** the current work we tried to know the relationship between both conjugated and unconjugated bilirubin with copper and protein thiols in patients with ***:Study was conducted on 56 hyperbilirubinemic cases and 56 healthy *** copper,ceruloplasmin,protein thiols,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,total protein,albumin,AST,ALT and ALP were ***:There was significant increase in serum copper,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,AST,ALT,and ALP,and decrease in serum ceruloplasmin,protein thiols,total protein,and albumin in hyperbilirubinemic cases when compared to healthy *** bilirubin correlated positively with liver enzymes AST and ALP,and negatively with protein thiols,total protein and *** bilirubin correlated positively with *** thiols correlated negatively with copper and positively with ceruloplasmin,and also correlated negatively with liver enzymes like AST,ALT and ALP,and positively with total protein and ***:Combination of elevated levels of trace elements like copper and availability of reducing agent like bilirubin may prove deleterious by generating free radicals.