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Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease

World Journal of Gastroenterology 2017年第27期23卷 4958-4967页

作者： Uri Netz Jane Victoria Carter Maurice Robert Eichenberger Gerald Wayne Dryden Jianmin Pan Shesh Nath Rai Susan Galandiuk Price Institute of Surgical Research the Hiram C.Polk Jr.MD Department of SurgeryUniversity of Louisville School of Medicine Department of surgery A Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Department of Medicine Division of GastroenterologyHepatology and Nutrition University of Louisville School of Medicine Louisville Department of Bioinformatics and biostatistics University of Louisville School of Public Health and Information Sciences

To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment

关键词： Anti-tumor necrosis factor Fas ligand Antibody Response Crohn’s disease Single nucleotide polymorphisms Genotype Tumor necrosis factor gene

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Effect of the COVID-19 pandemic on patients with presumed diagnosis of acute appendicitis

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World Journal of Clinical Cases 2022年第29期10卷 10487-10500页

作者： Sami Akbulut Adem Tuncer Zeki Ogut Tevfik Tolga Sahin Cemalettin Koc Emek Guldogan Ertugrul Karabulut Elif Seren Tanriverdi Ali Ozer surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey Department of Public Health Inonu University Faculty of MedicineMalatya 44280Turkey Department of surgery Inonu University Faculty of MedicineMalatya 44280Turkey Department of Medical Microbiology Inonu University Medical FacultyMalatya 44280Turkey

BACKGROUND Acute appendicitis(AAp) is the most frequent cause of acute abdominal pain,and appendectomy is the most frequent emergency procedure that is performed *** coronavirus disease 2019(COVID-19) pandemic has caused delays in managing diseases requiring emergency approaches such as AAp and *** To compare the demographic,clinical,and histopathological outcomes of patients with AAp who underwent appendectomy during pre-COVID-19 and COVID-19 *** The demographic,clinical,biochemical,and histopathological parameters were evaluated and compared in patients who underwent appendectomy with the presumed diagnosis of AAp in the pre-COVID-19(October 2018-March 2020) and COVID-19(March 2020-July 2021) *** Admissions to our tertiary care hospital for AAp increased 44.8% in the COVID-19 ***-19(n = 154) and COVID-19(n = 223) periods were compared for various parameters,and we found that there were statistically significant differences in terms of variables such as procedures performed on the weekdays or weekends [odds ratio(OR):1.76;P = 0.018],presence of AAp findings on ultrasonography(OR:15.4;P < 0.001),confirmation of AAp in the histopathologic analysis(OR:2.6;P = 0.003),determination of perforation in the appendectomy specimen(OR:2.2;P = 0.004),the diameter of the appendix(P < 0.001),and hospital stay(P = 0.003).There was no statistically significant difference in terms of interval between the initiation of symptoms and admission to the hospital between the pre-COVID-19(median:24 h;interquartile range:34) and COVID-19(median:36 h;interquartile range:60) periods(P = 0.348).The interval between the initiation of symptoms until the hospital admission was significantly longer in patients with perforated AAp regardless of the COVID-19 or pre-COVID-19 status(P < 0.001).CONCLUSION The present study showed that in the COVID-19 period,the ultrasonographic determination rate of AAp,perforation rate of AAp,and duration of hospital

关键词： SARS-CoV-2 COVID-19 pandemic Acute appendicitis Perforated appendicitis Negative appendectomy

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Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases:A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1281-1294页

作者： Kazuhisa Takeda Yu Sawada Yasuhiro Yabushita Yuki Honma Takafumi Kumamoto Jun Watanabe Ryusei Matsuyama Chikara Kunisaki Toshihiro Misumi Itaru Endo Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Gastroenterological surgery Yokohama City University Graduate School of MedicineYokohama 236-0004Jordan Department of biostatistics Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The liver is the most common metastatic site of colorectal *** is the mainstay of treatment for patients with colorectal liver metastases(CRLMs).However,there are cases of early recurrence after upfront hepatectomy *** selected high-risk patients,neoadjuvant chemotherapy(NAC)may improve longterm *** To determine the efficacy of NAC for initially resectable *** Among 644 patients who underwent their first hepatectomy for CRLMs at our institution,297 resectable cases were stratified into an upfront hepatectomy group(238 patients)and a NAC group(59 patients).Poor prognostic factors for upfront hepatectomy were identified using multivariate logistic regression *** score matching was used to compare clinical outcomes between the upfront hepatectomy and NAC groups,according to the number of poor prognostic *** curves were estimated using the Kaplan-Meier method and compared using the log-rank *** Preoperative carcinoembryonic antigen levels(≥10 ng/mL)(P=0.003),primary histological type(other than well/moderately differentiated)(P=0.04),and primary lymph node metastases(≥1)(P=0.04)were identified as independent poor prognostic factors for overall survival(OS)in the upfront hepatectomy ***-risk status was defined as the presence of two or more risk *** propensity score matching,50 patients were matched in each *** high-risk patients,the 5-year OS rate was significantly higher in the NAC group(13 patients)than in the upfront hepatectomy group(18 patients)(100%vs 34%;P=0.02).CONCLUSION NAC may improve the prognosis of high-risk patients with resectable CRLMs who have two or more risk factors.

关键词： Colorectal neoplasms Neoadjuvant therapy Neoplasm metastasis Prognosis Risk factors Survival

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前列腺癌3T MR直肠内扩散加权成像:肿瘤检测和侵袭性评估

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国际医学放射学杂志 2011年第4期 385-386页

作者： H.A.Vargas O.Akin T.Franiel Y.Mazaheri C.Moskowitz 陈仁彪 departments of Radiology Medical PhysicsEpidemiology and BiostatisticsPathologyUrologyand SurgeryMemorial Sloan-Kettering Cancer Center

目的以全标本包埋逐层切片(whole-mount step-section)病理分析作为参考标准,评估3TMR在T2WI基础上扩散加权(DW)成像对增加前列腺癌检测的价值,同时探讨应用表观扩散系数(ADC)确定肿瘤侵袭性的特点。材料与方法此项回顾性研究符合HIPAA... 详细信息

目的以全标本包埋逐层切片(whole-mount step-section)病理分析作为参考标准,评估3TMR在T2WI基础上扩散加权(DW)成像对增加前列腺癌检测的价值,同时探讨应用表观扩散系数(ADC)确定肿瘤侵袭性的特点。材料与方法此项回顾性研究符合HIPAA并获得机构审查委员会批

关键词：前列腺癌 DW 肿瘤检测 MR 侵袭性

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Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 149-159页

作者： Mengdi Jin Qiong Yu Yahui Liu Weiling Xu Xueqi Fu Bai Ji Department of Hepatobiliary and Pancreatic surgery the First Hospital of Jilin UniversityChangchunJilinChina Department of Epidemiology and biostatistics School of Public HealthJilin UniversityChangchunJilinChina Edmond H.Fischer Signal Transduction Laboratory College of Life SciencesJilin UniversityChangchunJilinChina

Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available ***:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang ***-analysis was performed using Revman 5.3 ***:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this *** with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p<0.05),better overall efficacy(p<0.0001),longer radiofrequency interval(p<0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone *** incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p<0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p<0.001),were significantly higher than those in the RFA-alone ***:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been *** is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients.

关键词： Physical thermal ablation Radiofrequency ablation Microwave ablation Sorafenib Hepatocellular carcinoma Meta-analysis

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Validity,Reliability,and Measurement Invariance of the Thai Smartphone Application-Based Addiction Scale and Bergen Social Media Addiction Scale

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International Journal of Mental Health Promotion 2024年第4期26卷 293-302页

作者： Kamolthip Ruckwongpatr Chirawat Paratthakonkun Usanut Sangtongdee Iqbal Pramukti Ira Nurmala Kanokwan Angkasith Weena Thanachaisakul Jatuphum Ketchatturat Mark DGriffiths Yi-Kai Kao Chung-Ying Lin Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701401Taiwan College of Sports Science and Technology Mahidol UniversityNakhon Pathom73170Thailand Department of Forensic Science Royal Police Cadet AcademyNakhon Pathom73110Thailand School of Computing Engineeringand Digital TechnologyTeesside UniversityMiddlesbroughUK Faculty of Nursing Universitas PadjadjaranWest Java45363Indonesia Division of Health Promotion and Behavioral Sciences Faculty of Public HealthUniversitas AirlanggaSurabaya60115Indonesia Faculty of Education Chiang Mai UniversityChiang Mai50200Thailand Faculty of Education Khon Kaen UniversityKhon Kaen40002Thailand International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14FQUK Division of Colorectal surgery E-DA HospitalKaohsiung82445Taiwan College of Medicine National Cheng Kung UniversityTainan701401Taiwan biostatistics Consulting Center National Cheng Kung University HospitalTainan701401Taiwan

Background:In recent years,there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these ***,there is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in *** present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale(SABAS)and Bergen Social Media Addiction Scale(BSMAS).Method:A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic information,SABAS,BSMAS,and the Internet Gaming Disorder Scale-Short Form(IGDS9-SF).Results:Confirmatory Factor Analyses(CFAs)found that both the SABAS and BSMAS had a one-factor *** demonstrated adequate psychometric properties of both instruments and also supported measurement invariance across ***,scores on the SABAS and BSMAS were correlated with scores on the ***:The results indicated that the SABAS and BSMAS are useful psychometric instruments for assessing the risk of smartphone addiction and social media addiction among Thai young adults.

关键词： Factor analysis smartphone addiction social media addiction smartphone application-based addiction scale bergen social media addiction scale psychometric validation

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Comparisons of multiple characteristics between young and old lung cancer patients

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Chinese Medical Journal 2012年第1期125卷 72-80页

作者： JIANG Wei KANG Yue SHI Guang-yue ZHANG Hai-yu CAI Li SUN Xiu-wei SUN Li-chun SUI Guang-jie Department of Medical Oncology the Third Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150081 China The Hospital of Harbin Engineering University Harbin Heilongjiang 150001 China Department of surgery the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Department of biostatistics Harbin Medical University Harbin Heilongjiang 150086 China

Background Risk factors that contribute to younger patients with lung cancer are still relatively *** aim of this study was to compare the clinical characteristics,histological types,stages at diagnosis,treatment modalities and survival rates between young and old patients with lung *** The study was designed as a retrospective review of all lung cancer patients admitted to the Third Affiliated Hospital of Harbin Medical University from 1998 to *** analyses using univariate and multivariate approaches were performed to compare the survival rates between different age groups and to discover potential prognostic *** This research included 3320 patients with primary lung cancer,of whom 626 （18.8%） were 45 years old or younger at the time of *** percentage of smokers and the male to female ratios between the young and old patient groups were 51.27% vs.70.6% （P 〈0.001） and 1.99 vs.2.13 （P=0.4801）,*** young patient group had a higher incidence of adenocarcinoma and fewer *** 1-year,3-year and 5-year survival rates in the young patient group were generally lower than those of the old patient group,with significant differences （P=0.0232）.The clinical stage of the tumor was a prognostic factor for both non-small cell lung cancer patients （P 〈0.0001 ） and small cell lung cancer patients （P=0.0002）.Symptoms,diagnostic method,histology,smoking,treatment modality and body mass index were shown to have significant relationships with the survival of lung cancer patients （P 〈0.05）.Conclusions Patients with lung cancer who are younger than 45 years old might have a significantly poorer prognosis than that of older ***,diagnosis method,histology,smoking,treatment modality and body mass index can be independent prognostic factors for lung cancer.

关键词： lung neoplasm age factor epidemiology survival analysis prognosis

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Short arm cast is as effective as long arm cast in maintaining distal radius fracture reduction:Results of the SLA-VER noninferiority trial

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World Journal of Orthopedics 2022年第9期13卷 802-811页

作者： Giovanni Dib Tommaso Maluta Matteo Cengarle Alice Bernasconi Giulia Marconato Massimo Corain Bruno Magnan Department of Orthopaedics and Trauma surgery University of Verona Medical SchoolAOUI Borgo TrentoVerona 37126Italy MsC biostatistics Evaluative Epidemiology UnitDepartment of ResearchNational Cancer Institute Foundation IRCSSMilano 20133Italy Department of Hand surgery University of Verona Medical SchoolAOUI Borgo RomaVerona 37134Italy

BACKGROUND Distal radius fractures(DRFs)are a common challenge in orthopaedic trauma care,yet for those fractures that are treated nonoperatively,strong evidence to guide cast treatment is still *** To compare the efficacy of below elbow cast(BEC)and above elbow cast(AEC)in maintaining reduction of manipulated *** We conducted a prospective,monocentric,randomized,parallel-group,open label,blinded,noninferiority trial comparing the efficacy of BEC and AEC in the nonoperative treatment of *** hundred and eighty patients>18 years of age diagnosed with DRFs were successfully randomized and included for analysis over a 3-year *** thresholds were defined as a 2 mm difference for radial length(RL),a 3°difference for radial inclination(RI),and volar tilt(VT).The trial is registered at ***(NCT03468023).RESULTS One hundred and forty-three patients were treated with BEC,and 137 were treated with *** mean time of immobilization was 33 *** mean loss of RL,RI,and VT was 1.59 mm,2.83°,and 4.11°for BEC and 1.63 mm,2.54°,and VT loss were respectively 0.04 mm(95%CI:-0.36-0.44),-0.29°(95%CI:-1.03-0.45),and 0.59°(95%CI:-1.39-2.57),and they were all below the prefixed noninferiority *** rate of loss of reduction was *** BEC performs as well as AEC in maintaining the reduction of a manipulated *** more comfortable to patients,BEC may be preferable for nonoperative treatment of DRFs.

关键词： Distal radius fracture Immobilization Below elbow cast Above elbow cast Short arm cast Long arm cast

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Efficacy of exercises in improving the quality of life for chronic kidney disease patients without dialysis

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Chinese Medical Journal 2020年第14期133卷 1738-1740页

作者： Deng-Yan Ma Chong-Cheng Chen Yong-Shu Diao Kun Yang Yi Li Steve Salerno Ping Fu Department of Nephrology/West China School of Nursing West China HospitalSichuan UniversityChengduSichuan 610041China Department of Gastrointestinal surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of biostatistics University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic kidney disease(CKD)is rapidly becoming a major public disease burden,affecting approximately 11%to 13%of the general population.[1]Its related treatments severely influence the physical,psychological,and social well-being of patients by restricting their daily *** has been shown that exercise may have multiple benefits for patients with CKD in terms of improving their physical activity,enhancing cardio-respiratory function,and promoting quality of life(QoL).

关键词： patients dialysis kidney

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Exploring ideal operative time for best outcomes in gastric cancer surgery:A multi-institutional study based on KLASS-07 database

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Chinese Journal of Cancer Research 2023年第6期35卷 660-674页

作者： Shin-Hoo Park Ye-Rim Shin Hoon Hur Chang Min Lee Jae Seok Min Seung Wan Ryu Hyun Dong Chae Oh Jeong Chang-In Choi Kyo-Young Song Ho Goon Kim Ye Seob Jee Kwang Hee Kim Jeong Goo Kim Kyung Sook Yang Hua Huang Sungsoo Park Division of Foregut surgery Korea University College of MedicineSeoul 02841Republic of Korea Division of Foregut surgery Korea University Anam HospitalSeoul 02841Republic of Korea Department of surgery Ajou University School of MedicineSuwon 16499Republic of Korea Division of Foregut surgery Korea University Ansan HospitalAnsan 15355Republic of Korea Department of surgery Dongnam Institute of Radiological and Medical SciencesCancer CenterBusan 46033Republic of Korea Department of surgery Keimyung University Dongsan Medical CenterDaegu 41931Republic of Korea Department of surgery Catholic University of Daegu School of MedicineDaegu 42472Republic of Korea Department of surgery Chonnam National University Medical SchoolHwasun 58128Republic of Korea Department of surgery Pusan National University HospitalPusan 49241Republic of Korea Department of surgery Catholic University of Seoul St Mary’s HospitalSeoul 06591Republic of Korea Department of surgery Chonnam National University Medical SchoolGwangju 61469Republic of Korea Department of surgery Dankook University College of MedicineCheonan 31116Republic of Korea Department of surgery Busan Paik HospitalInje UniversityBusan 14905Republic of Korea Department of surgery Daejeon St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaDaejeon 34943Republic of Korea Department of biostatistics Korea University College of MedicineSeoul 02841Republic of Korea Department of Gastric Cancer and Soft Tissue Sarcoma Fudan University Shanghai Cancer CenterShanghai 200433China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200433China

Objective:While a rushed operation can omit essential procedures,prolonged operative time results in higher ***,the optimal operative time range remains *** study aimed to estimate the ideal operative time range and evaluate its applicability in laparoscopic cancer ***:A prospectively collected multicenter database of 397 patients who underwent laparoscopic distal gastrectomy were retrospectively *** ideal operative time range was statistically calculated by separately analyzing the operative time of uneventful ***,intraoperative and postoperative outcomes were compared among the shorter,ideal,and longer operative time ***:The statistically calculated ideal operative time was 135.4-165.4 *** longer operative time(LOT)group had a lower rate of uneventful,perfect surgery than the ideal or shorter operative time(IOT/SOT)group(2.8%vs.8.8%and 2.2%vs.13.4%,all Psurgery could not be achieved when the operative time exceeded 240 *** of ideal time range,SOT group achieved the highest percentage of uneventful surgery(13.4%),which was possible by surgeon's ability to retrieve a higher number of lymph nodes and perform≥150 gastrectomies ***:Operative time longer than the ideal time range(especially≥240 min)should be *** the essential operative procedure were faithfully conducted without compromising oncological safety,an operative time shorter than the ideal range leaded to a better *** to minimize operative time should be attempted with sufficient surgical experience.

关键词： Operative time laparoscopic surgery gastric cancer gastrectomy morbidity

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