Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis
作者机构：Department of Hepatobiliary and Pancreatic Surgerythe First Hospital of Jilin UniversityChangchunJilinChina Department of Epidemiology and BiostatisticsSchool of Public HealthJilin UniversityChangchunJilinChina Edmond H.Fischer Signal Transduction LaboratoryCollege of Life SciencesJilin UniversityChangchunJilinChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2021年第9卷第2期
页 面：149-159页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(81802805) the Natural Science Foundation of Jilin Province(20200201490JC) the translation-clinical joint foundation of the First Hospital of Jilin University(No.2020-ZL-04)
主 题：Physical thermal ablation Radiofrequency ablation Microwave ablation Sorafenib Hepatocellular carcinoma Meta-analysis
摘 要：Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available ***:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang ***-analysis was performed using Revman 5.3 ***:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this *** with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p0.05),better overall efficacy(p0.0001),longer radiofrequency interval(p0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone *** incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p0.001),were significantly higher than those in the RFA-alone ***:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been *** is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients.
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