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软骨发育不全症病人的颈髓内高信号病变:病因学、发病率和临床意义

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国际医学放射学杂志 2012年第6期 612-612页

作者： P.A.Brouwer C.M.Lubout J.M.van Dijk C.L.Vleggeert-Lankamp 赵阳 Department of neurosurgery Leiden University Medical Centre(LUMC)P.O.Box 9600NL-2300 RCLeidenThe Netherlands

目的软骨发育不全伴轻度延髓受压的病人,颈髓内经常于颅枕交界区下部出现无明显脊髓受压改变(颈髓内高信号病变,CHII)。本研究旨在计算该病变在普通软骨发育不全病人中的患病率以及解释该病发生的原因。方法 18例软骨发育不全伴轻度、... 详细信息

目的软骨发育不全伴轻度延髓受压的病人,颈髓内经常于颅枕交界区下部出现无明显脊髓受压改变(颈髓内高信号病变,CHII)。本研究旨在计算该病变在普通软骨发育不全病人中的患病率以及解释该病发生的原因。方法 18例软骨发育不全伴轻度、无临床症状的延髓受压志愿者进行动态MRI。对CHII病变的存在和头颈交界部延髓受压、弯曲及头颈位置反曲的原因进行了探讨,并对头颈交界区的部分形态特征,以及可能压迫脊髓的情况进行了评估。结果39%的病例存在CHII病变,其中仅1例在头颈交界区存在被压缩的情况。结果显示,CHII病变与压缩间无相关性。除CHII病变部位的颈髓变细外,结果中未显示CHII病变具有相关的形态学特征。结论 CHII病变是软骨发育不全病人常见MRI阳性发现,一般不伴有明显的临床症状或颈髓受压。下一步更深入的研究将集中在发现造成CHII病变的原因及其是否具有必要的临床意义。

关键词：软骨发育不全脊髓型颈椎病先天性脊柱畸形动态MRI 脊髓受压

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关于脑膜瘤磁共振波谱分析的新观点

国际医学放射学杂志 2009年第1期32卷 101-101页

作者： T. Isobe Y. Shibata I. Anno H. Kawamura Y. Yamamoto 王高峰 Department of neurosurgery Institute of Clinical Medicine University of Tsukuba 1-1-1 Tennodai Tsukuba Science City Ibaraki 305-8575 Japan

本研究的目的是阐明脑膜瘤^1H-MRS的某些不甚明了的内容。对31例行单体素。^1H-MRS（点解析波谱序列PRESS，TR／TE分别为2000ms／68ms，2000ms／136ms，2000ms／272ms）扫描的脑膜瘤病人（27例良性和4例非良性脑膜瘤）进行了回顾性分析... 详细信息

本研究的目的是阐明脑膜瘤^1H-MRS的某些不甚明了的内容。对31例行单体素。^1H-MRS（点解析波谱序列PRESS，TR／TE分别为2000ms／68ms，2000ms／136ms，2000ms／272ms）扫描的脑膜瘤病人（27例良性和4例非良性脑膜瘤）进行了回顾性分析。为了证实活体内研究的结果，测定了模型的波谱，且复习了11例病人的病理切片。

关键词：脑膜瘤质子磁共振波谱模型病理

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Assessing structural integrity of the pyramidal tracts with difusion spectrum imaging to predict postoperative motor function in pediatric epilepsy patients with hemispherectomy

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Acta Epileptologica 2023年第1期6卷 25-33页

作者： Huaqiang Zhang Penghu Wei Chao Lu Zhenming Wang Xiaotong Fan Yongzhi Shan Guoguang Zhao Department of neurosurgery Xuanwu HospitalCapital Medical UniversityNo.45Changchun StreetXicheng DistrictBeijing 100053China Department of radiology Xuanwu HospitalCapital Medical UniversityNo.45Changchun StreetXicheng DistrictBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityNo.10West Tou TiaoOuter You’an MenFengtai DistrictBeijing 100069China National Medical Center for Neurological Diseases Beijing 100053China China International Neuroscience Institute Beijing 100053China Clinical Research Center of Epilepsy Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Municipal Geriatric Medical Research Center Beijing 100053China

Background:Hemispherectomy is an efective treatment option for patients with drug-resistant epilepsy caused by hemispheric ***,patients often have deterioration of their motor functions *** spectrum imaging(DSI)was reliable in presenting the natural shape of the white matter *** the same time,the natural sprawl pyramid tract(PT)might be more intuitive for predicting postoperative motor ***,we assessed the motor functions by the natural shape revealed by DSI ***:Ten children with drug-resistant epilepsy who were candidates for hemispherectomy performed DSI PTs tractography and transcranial magnetic stimulation(TMS)for motor *** motor function was evaluated with muscle strength and hand grasping *** tract(PT)structural integrity and TMS mapping results were compared between patients who remained stable and those with deteriorated motor *** operating characteristic(ROC)curves with PTs asymmetric ratio were analyzed to evaluate DSI tractography diagnostic ***:All patients underwent DSI acquisition,while four patients successfully performed *** patient had no response to TMS until the maximal machine output was *** patients failed to perform TMS due to lacking *** patient was contraindicated to *** successfully reconstructed the sharp angle fan-shaped PTs within the *** accurate fber distribution with fber termination and thickness within the lesioned hemisphere was replicated with DSI *** signifcance was found in patients’age,sex,seizure frequency,or medication between patients with stable or deteriorated postoperative motor *** efectively predicted postoperative motor function as stable with damaged PTs,mild deterioration with atrophied PTs,and intact PTs with contralateral innervation confrmed by intracranial *** area under the curve(AUC)of DSI tractography was ***

关键词： Difusion spectrum image Epilepsy Hemispherectomy Motor function

弹簧圈治疗动脉瘤:根据MRA和动脉DSA表现确定进一步的治疗

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国际医学放射学杂志 2013年第1期 77-77页

作者： J.D.Schaafsma B.K.Velthuis R.van den Berg P.A.Brouwer C.B.L.M.Majoie F.Barkhof 刘丽华 Department of Neurology and neurosurgery Rudolf Magnus Institute of NeuroscienceUniversity Medical Center UtrechtHeidelberglaan 100PO Box 855003508 GA Utrechtthe Netherlands

目的评价MRA能否成为DSA的无创性替代手段,随访弹簧圈治疗颅内动脉瘤的病人是否需进一步治疗。材料与方法这项多中心研究经伦理委员会批准。对颅内动脉瘤弹簧圈治疗术后进行DSA随访的病人,在签署知情同意书后进行MRA检查。神经介入放射... 详细信息

目的评价MRA能否成为DSA的无创性替代手段,随访弹簧圈治疗颅内动脉瘤的病人是否需进一步治疗。材料与方法这项多中心研究经伦理委员会批准。对颅内动脉瘤弹簧圈治疗术后进行DSA随访的病人,在签署知情同意书后进行MRA检查。神经介入放射学家针对两种成像方法给予下一步的治疗建议(进一步治疗、继续随访或无需再进行随访)。采用加权κ检验分析根据DSA和MRA发现所确定治疗建议一致性和观察者间的一致性。结果根据DSA和MRA确定的治疗建议具有良好的一致性(κ=0.73;95%CI:0.66～0.80)。310例病人中有34例(11%)根据两种检查的表现需进一步治疗。6例病人(2%)根据DSA表现需进一步治疗,而MRA表现则需进一步随访;但这些病人中没有一例根据MRA表现而排除继续随访。另外6例病人(2%)根据MRA表现需进一步治疗,而DSA检查4例需进一步随访,1例无需再随访,1例病人不能确定。DSA检查后37例病人(12%)需继续随访,而MRA检查后有49例病人(16%)需继续随访(差异4%,95%CI:-0.6%～8.4%)。观察者间的一致性在DSA检查具有良好的一致性(κ=0.73;95%CI:0.64～0.82),而MRA检查具有中度的一致性(κ=0.53;95%CI:0.36～0.70)。结论根据MRA和DSA表现所确定的进一步治疗的病人比例总体相似,仅个别病例存在差异。因此,MRA可作为颅内动脉瘤弹簧圈治疗病人确定进一步治疗决策的随访手段。

关键词： MRA 病人 DSA 弹簧圈

扩散张量纤维示踪成像技术重建皮质脊髓束和弓状纤维束的可靠性:临床应用的预期

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国际医学放射学杂志 2013年第2期 181-181页

作者： G. Kristo A. Leemans B. de Gelder M. Raemaekers G.J. Rutten N. Ramsey 高飞 Rudolf Magnus Institute of Neuroscience and Department of Neurology and Neurosurgery University Medical Center Utrecht Heidelberglaan 100 mail stop G.1243584 CX Utrecht The Netherlands

目的评估基于扩散张量成像(DTI)技术的纤维示踪成像(FT)的可靠性作为该技术临床应用的前提。本研究应用DTI-FT技术重建两条与临床相关的神经束,并评估连续两次重建神经束宏观和微观结构的可再现性。方法应用既定方法重建两次17名健康志... 详细信息

目的评估基于扩散张量成像(DTI)技术的纤维示踪成像(FT)的可靠性作为该技术临床应用的前提。本研究应用DTI-FT技术重建两条与临床相关的神经束,并评估连续两次重建神经束宏观和微观结构的可再现性。方法应用既定方法重建两次17名健康志愿者的皮质脊髓束(CST)、弓状纤维(AF)及其长段(AFl)。应用扩散系数阈值的变异系数(CVs)评估神经束微观结构的可再现性。应用空间相关性和纤维重叠率评估宏观结构的可再现性。结果 CST和AF的空间相关性为68%,与AFl为69%。CST的纤维重叠率为69%,AF为61%,AFl为59%。这是相当于2mm束移位变异。扩散系数阈值的CVs最多为3.4%。结论结果表明重建神经束的微观和宏观结构的变异性较低。宏观结构的可再现性表明此技术可进一步研究,使DTI-FT可用于神经外科手术规划。其微观结构的高再现性表明此技术可在神经病学进行神经机能恢复的评估和预测。要点①扩散张量纤维示踪MR成像被广泛用于神经科学。②纤维束宏观结构的可再现性高达69%。③纤维束微观结构的变异性最多仅为3.4%。④纤维束宏观结构的可再现性表明DTI-FT技术可应用于神经外科。⑤纤维束微观结构的可再现性表明DTI-FT技术可应用于神经病学。

关键词：扩散张量成像-纤维示踪成像神经束特异性分析重复实验可靠性神经病学神经外科

Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗

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