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Acta Pharmacologica Sinica 2006年第3期27卷 282-288页

作者： Li-sheng CHU~(2,3) Er-qing WEI~(2,4) Guo-liang YU~2 San-hua FANG~2 Yu ZHOU~2 Meng-ling WANG~2 Wei-ping ZHANG~2 ~2Department of pharmacology,School of Medicine Zhejiang University.Hangzhou 310031.China:~3Department of physiology.Zhejiang College of Traditional Chinese Medicine.Hangzhou 310053,China Department of pharmacology School of Medicine Zhejiang University Hangzhou China Department of physiology Zhejiang College of Traditional Chinese Medicine Hangzhou China

Aim: To determine whether pranlukast, a cysteinyl leukotriene receptor-lantagonist, exerts an anti-inflammatory effect on focal cerebral ischemia in ***: Focal cerebral ischemia in mice was induced by permanent middle cere-bral artery occlusion(MCAO). In addition to neurological deficits, infarct volume,degenerated neurons and endogenous IgG exudation, we detected accumulationof neutrophils and macrophage/microglia in the ischemic brain tissue 72 h afterMCAO. Pranlukast was ip injected 30 min before and after MCAO. Results:Pranlukast significantly attenuated neurological deficits, infarct volume, neurondegeneration and IgG exudation. Importantly, pranlukast(0.01 and 0.1 mg/kg)inhibited myeloperoxidase-positive neutrophil, but not CD11b-positive macroph-age/microglial accumulation in the ischemic cortical tissue. Conclusion: Pranlukastexerts an anti-inflammatory effect on focal cerebral ischemia in the subacute phasethat is limited to neutrophil recruitment through the disrupted blood-brain barrier.

关键词： leukotriene receptor antagonist pranlukast cerebral ischemia neuroprotection inflammation

13-Methyltetradecanoic acid mitigates cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2016年第9期11卷 1431-1437页

作者： Juan Yu Li-nan Yang Yan-yun Wu Bao-hua Li Sheng-mei Weng Chun-lan Hu Yong-ling Han Department of physiology and Pathophysiology School of Basic Medical SciencesFujian Medical University Department of pharmacology School of PharmacyFujian Medical University

13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory, antioxidant and anti-apoptotic effects. Previous studies mainly focused on peripheral nerve injury, but seldom on the central nervous system. We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury, and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor. This study established rat models of middle cerebral artery occlusion/ reperfusion injury by ischemia for 2 hours and reperfusion for 24 hours. At the beginning of reperfusion, 13-methyltetradecanoic acid 10, 40 or 80 mg/kg was injected into the tail vein. Results found that various doses of 13-methyltetradecanoic acid effectively reduced infarct volume, mitigate cerebral edema, and increased the mRNA and protein expression of basic fibroblast growth factor and vascular endothe- lial growth factor at 24 hours of reperfusion. The effect was most significant in the 13-methyltetradecanoic acid 40 and 80 mg/kg groups. The findings suggest that 13-methyltetradecanoic acid can relieve focal ischemia/reperfusion injury immediately after reperfusion, stimu- late the upregulation of basic fibroblast growth factor and vascular endothelial growth factor to exert neuroprotective effects.

关键词： nerve regeneration brain injury 13-methyltetradecanoic acid cerebral ischemia/reperfusion injury basic fibroblast growth factor vascular endothelial growth factor cerebral infarction cerebral edema neural regeneration

Potential Mechanism for Higher Stroke Risk in Diabetes

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神经药理学报 2019年第Z1期 54-55页

作者： SUN Hong-shuo departments of Surgery Physiology and PharmacologyInstitute of Medical ScienceFaculty of MedicineUniversity of Toronto

World Health Organization data show that the risk of cardiovascular and cerebrovascular disease in diabetic patients is 2 to 3 times that of non-diabetic patients,and 50% to 80% of diabetic patients eventually die of heart and cerebrovascular complications. Type 2 diabetes is currently considered as an independent risk factor for cerebral ischemic diseases,and about 20% of ischemic brain diseases are currently considered to be related to diabetes. The application of sulfonylurea drugs has been more than 60 years old. Although sulfonylurea drugs as a proportion of oral hypoglycemic drugs have declined with the continuous R&D and marketing applications of new hypoglycemic drugs,they currently account for the proportion still exceeds 40% and is the most widely used oral hypoglycemic drug. The correlation between the use of rosiglitazone and cardiovascular risk has led to uncertainty about the cardiovascular safety of different hypoglycemic drugs. With the increasing incidence of type 2 diabetes,it has become very important to clarify the vascular effects and safety of hypoglycemic drugs. We discuss the risk of stroke in patients with type 2 diabetes using sulfonylureas.

关键词： Potential Mechanism for Higher Stroke Risk in Diabetes

Tissue Distribution of [^3H]—Nicotine in Rats

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Biomedical and Environmental Sciences 1993年第1期6卷 59-64页

作者： PARIMALCHOWDHURY RYUICHIRODOIPHILLIPL.RAYFORD LOUISW.CHANG departments DepartmentsDepartments of Physiology BiopgysicsToxicologyUniversity of Arkansas for Medical Sciences4301W.Markham StLittle RockA R 72205USAof Physiology and BiophysicsUniversity of Arkansan for Medical Sciences4301W.Markham StLittle RockA R 72205USAof Physiology and ToxicologyUniversity of Arkansas for Medical Sciences4301W.Markham StLittle RockA R 72205USA

This study was conducted in adult male Sprague -- Dawley rats to determine the distribution of [3H]-nicotine in blood and tissues following a bolus injection and a constant infusion of pure nicotine. The animals were anesthetized and injected with either 0.5 ml of nicotine solution or given a constant infusion of the same nicotine solution with identical amounts of radioactive nicotine. After sacrifice, blood, brain, trachea, salivery gland, esophagus, lung, heart, liver, fundus, antrum, spleen, pancreas, duodenum, jejunum, ileum, cecum, colon, kidneys, adrenal gland, and testes were collected and measured for radioactivity by scintillation counting. The distribution of nicotine was found highest in kidneys by both routes of administration. Higher accumulations were also found in salivary and adrenal glands, fundus, antrum, duodenum, jejunum, ileum and colon. Retention of nicotine via constant infusion was significantly higher in esophagus, fundus antrum, spleen, cecum, pancreas, testes, heart and muscle when compared with bolus injection. Six-fold increase in retention of blood levels of nicotine were found with constant infusion. (P<0.05). The results indicate that longer retention of nicotine occurs in blood and other specific tissues such as esophagus, fundus, antrum, spleen, cecum, pancreas, testes, heart and muscle via constant exposure. These data may implicate the predisposition of these tissues to pathologic manifestations.

关键词： Tissue Distribution of Nicotine in Rats

Altered thermal sensitivity in facial skin in chronic whiplash-associated disorders

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International Journal of Oral Science 2013年第3期5卷 150-154页

作者： Birgitta Hggman-Henrikson Ewa Lampa Erik Nordh Department of Odontology Clinical Oral Physiology Umea University Department of pharmacology and Clinical Neurosciences Division of Clinical Neurophysiology Ume University

There is a close functional relationship between the jaw and neck regions and it has been suggested that trigeminal sensory impairment can follow whiplash *** of manageable routines for valid assessment of the facial sensory capacity is thus needed for comprehensive evaluations of patients exposed to such *** present study investigated facial thermal thresholds in patients with chronic whiplash-associated disorders（WADs）with both a qualitative method and quantitative sensory testing（QST）.Ten women with pain and dysfunction following a whiplash injury were compared to 10 healthy age-matched *** detection thresholds were assessed by qualitative chair-side testing and by QST according to the *** test sites in the facial skin（overlying each trigeminal branch bilaterally,and the midpoint of the chin）were *** detection warm and cold thresholds were defined as the mean values of 10 individual *** the WAD patients,the qualitative assessment demonstrated both reduced and increased sensitivity compared to the healthy,whereas QST systematically showed significantly higher detection thresholds（i.e.,decreased sensitivity）for both cold and warm *** the individuals who were assessed as having increased sensitivity in the qualitative assessment,the QST displayed either normal or higher thresholds,i.e.,decreased *** results suggest that QST is more sensitive for detecting thermal sensory disturbances in the face than a qualitative *** impaired thermal sensitivity among the patients corroborates the notion of altered thermal detection capacity induced by WAD-related pain.

关键词： jaw neck quantitative sensory testing thermal thresholds trigeminal whiplash injury

Safety of intravitreal triamcinolone acetonide:an electrophysiologic and histopathological study in rabbits

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 790-795页

作者： Laila Hassan M.El-Shazly Amal Ahmad El-Gohary Ghada Ghanem El-Hossary Department of Ophthalmology Memorial Institute of Ophthalmology Department of physiology Research Institute ofOphthalmology Department of pharmacology Research Institute ofOphthalmology

AIM:To evaluate the retinal safety of various doses of intravitreal triamcinolone acetonide(TA)in ***:Thirty New Zealand albino rabbits were divided into five groups(six animals each).In group 1(control group),each animal received a single intravitreal injection of 0.1 mL phosphate buffered *** groups2,3,4 and 5,each rabbit received a single intravitreal injection of 4,8,16 and 32mg of TA,*** dose was contained in 0.1 mL phosphate buffered *** ocular examinations were performed before the injection and on the 1st,3rd,10th and 17th postinjection days.A standard dark adapted electroretinogram(ERG)was obtained before injection and on the 3rd,10th and 17th post-injection ***17d,animals were sacrificed and their eyes prepared for pathological ***:By monitoring ERG as a functional index for the retina,intravitreal injection of 4mg TA showed no significant ERG *** doses of 8,16 and 32,hyper-abnormal responses in a-and b-waves of ERG were detected on the 3rd post-injection *** changes gradually returned back to normal limits *** examination of the retina of all animals showed no pathological ***:High doses of intravitreal TA seemed to have enhancing effects on the retinal function with gradual return to normal limits with no pathological changes detected in examined eyes.

关键词： triamcinolone acetonide intravitreal injection electroretinogram

Brucine N-oxide reduces ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

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中国药理学与毒理学杂志 2017年第5期31卷 479-480页

作者： LIANG Jian-hui WEI Shou-peng LI Yu-ling GONG Qi WANG Yan-ting LIANG Hui LIU Qing ZHANG Han-ting CHEN Feng Andrew J LOWRENCE Department of Molecular and Cellular pharmacology School of Pharmaceutical Sciences Department of pharmacology School of Basic Medicine SciencesPeking University Institute of Psycopharmacology Central Institute of Mental HealthUniversity of Heidelberg departments of Behavioral Medicine & Psychiatry and physiology& pharmacology West Virginia University Health Sciences Center The Florey Institute of Neuroscience and Mental Health University of Melbourne

OBJECTIVE The alcoholism-related social problems have burdened the public health heavily.A better therapy for alcohol dependence as a chronic brain disease is highly required and interests the scientists worldwide. Our group has focused on screening the right drug with low toxicity and a sound curative effect from traditional Chinese medicine. METHODS Alcohol-preferring Fawn-Hooded(FH/Wjd) rat was used as an animal model of alcoholism to evaluate the effects of brucine N-oxide(BNO),an alkoloid naturally existing in the seeds of Strychnos nux-vomica L,on the alcohol-drinking ***,its adverse action and toxicity were investigated. RESULTS Treatment with BNO at the doses of 30,50 and 70 mg · kg^(-1)reduced the voluntary alcohol consumption and preference dosedependently and selectively without altering their water intake,total fluid intake,food consumption,body weight as well as sucrose preference. Remarkably,70 mg·kg^(-1)of BNO did suppress the deprivationinduced elevation of alcohol ingestion. Moreover,BNO used at the same doses as above had no influence on locomotion in an open field test and could not result in the place preference effect. CONCLUSION Taken together,BNO is of some significant pharmacological profiles to inhibit symptoms of alcohol dependence with high safety,and thence may be a potential pharmacotherapy.

关键词： brucine N-oxide ethanol

76nt RNAs are transported axonally into regenerating axons and growth *** are they doing there?

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Neural Regeneration Research 2016年第3期11卷 390-391页

作者： Nicholas A.Ingoglia Binta Jalloh Department of pharmacology and physiology New Jersey Medical SchoolRutgers University Department of Cell Biology Emory University

Successful nerve regeneration requires not only that neurons reconstruct new axons distal to the site of injury,but also those growing axons must navigate through the neuropil to make appropriate synaptic connections with target *** this is an imposing task for the thousands of axons that may occupy a regenerating nerve in the peripheral nervous system or a tract inthe central nervous system, the billions of neurons in the developing brain must accomplish similar tasks making connections that number in the trillions. How do neurons do this？

关键词： reconstruct cones distal doing synaptic axonal regeneration occupy transported likely

Autonomic functions and gastric motility in children with functional abdominal pain disorders

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World Journal of Gastroenterology 2019年第1期25卷 95-106页

作者： Amaranath Karunanayake Shaman Rajindrajith Hitanadura Asita de Silva Sampath Gunawardena Niranga Manjuri Devanarayana Department of physiology Faculty of Medicine University of Ruhuna Department of Paediatrics Faculty of Medicine University of Kelaniya Department of pharmacology Faculty of Medicine University of Kelaniya Department of physiology Faculty of Medicine University of Kelaniya

BACKGROUND Abdominal pain-predominant functional gastrointestinal disorders(AP-FGIDs)are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly *** To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of *** One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive *** The main gastric motility parameters assessed(gastric emptying rate [45.7 vs 59.6 in controls], amplitude [48.7 vs 58.2], frequency of antral contractions [8.3 vs 9.4],and antral motility index [4.1 vs 6.4]) were significantly lower in children with AP-FGIDs(P 0.05). The duration of pain episodes negatively correlated with the parasympathetic tone(maladaptive parasympathetic tone)(P< 0.05).CONCLUSION Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction.

关键词： Abdominal pain Functional gastrointestinal disorders Autonomic function Gastric motility

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-Broto Francisco Segura Ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez Ana Isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity