Autonomic functions and gastric motility in children with functional abdominal pain disorders

作     者：Amaranath Karunanayake Shaman Rajindrajith Hitanadura Asita de Silva Sampath Gunawardena Niranga Manjuri Devanarayana 

作者机构：Department of Physiology Faculty of Medicine University of Ruhuna Department of Paediatrics Faculty of Medicine University of Kelaniya Department of Pharmacology Faculty of Medicine University of Kelaniya Department of Physiology Faculty of Medicine University of Kelaniya 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第1期

页      面：95-106页

核心收录：

学科分类：10[医学] 

基　　金：a Research Grant from the University of Kelaniya Sri Lanka No.RP/03/04/03/01/2013 

主　　题：Abdominal pain Functional gastrointestinal disorders Autonomic function Gastric motility 

摘      要：BACKGROUND Abdominal pain-predominant functional gastrointestinal disorders(AP-FGIDs)are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly *** To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of *** One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive *** The main gastric motility parameters assessed(gastric emptying rate [45.7 vs 59.6 in controls], amplitude [48.7 vs 58.2], frequency of antral contractions [8.3 vs 9.4],and antral motility index [4.1 vs 6.4]) were significantly lower in children with AP-FGIDs(P 0.05). The duration of pain episodes negatively correlated with the parasympathetic tone(maladaptive parasympathetic tone)(P 0.05).CONCLUSION Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction.