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World Journal of psychiatry 2015年第1期5卷 88-102页

作者： Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni Service of Interdisciplinary Neuromodulation Laboratory of Neurosciences (LIM-27)Department and Institute of PsychiatryUniversity of Sao Paulo Interdisciplinary Center for Applied Neuromodulation University HospitalUniversity of Sao Paulo Psychology Department Advanced School in NeuropsychologyUniversità degli Studi Milano Bicocca Department of physiology Pharmacology and Neuroscience Sophie Davis School of Biomedical Education City University of New York (CUNY) Obsessive Compulsive Disorder Project (PROTOC) Department and Institute of PsychiatryUniversity of Sao Paulo Unit of psychiatry Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Université de Lyon Université Claude Bernard Lyon I Centre Hospitalier le Vinatier National Institute of Developmental psychiatry for Children and Adolescents (INCT-CNPq) Department of Psychiatry Department and Institute of PsychiatryUniversity of Sao Paulo Santa Casa de Sao Paulo Medical School Institute of Physical medicine and Rehabilitation Clinics Hospital of the University of Sao Paulo Medical School

The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.

关键词： Non-invasive brain stimulation Transcranial direct current stimulation psychiatry disorders Review

Targeting plasminogen activator inhibitor-1 to prevent vascular disease

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泸州医学院学报 2013年第3期36卷 313-313页

作者： Wu Jianbo Li Rong Zhang Xiao Luo Mao Ren Meiping Yan Kai Tammy L.Strawn William P.Fay Drug Discovery Research Center Luzhou Medical College departments of Internal medicine and Medical pharmacology&physiology University of Missouri School of MedicineColumbiaMOUSA.

Plasminogen activator inhibitor-1(PAI-1)is the primary inhibitor of urinary-type and tissue-type plasmino-gen activators and a key regulator of ***-1 also regulates the function of vascular cells,includingvascular smo... 详细信息

关键词：纤溶酶原激活物血管疾病抑制剂纤维蛋白溶酶原血管平滑肌细胞 PAI-1 血纤维蛋白溶酶纤维蛋白溶解

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新型冠状病毒肺炎治疗:羟氯喹与其他

中国药理学与毒理学杂志 2020年第7期34卷 481-489页

作者：于海洋刘培庆周文霞张汉霆山东第一医科大学药理学研究所山东泰安271016 中山大学药学院广东广州510006 军事科学院军事医学研究院毒物药物研究所北京100850 departments of Neuroscience and behavioral medicine&psychiatry the Rockefeller Neurosciences InstituteWest Virginia University Health Sciences CenterMorgantownWV 26506USA

新型冠状病毒肺炎(COVID-19)在全球肆虐,确诊和死亡人数不断攀升,而目前依然还无特异性的治疗药物。氯喹是一种传统的治疗疟疾及自身免疫性疾病的药物,因其在治疗COVID-19中显示出初步疗效而备受关注。羟氯喹是氯喹的衍生物,其临床用药... 详细信息

新型冠状病毒肺炎(COVID-19)在全球肆虐,确诊和死亡人数不断攀升,而目前依然还无特异性的治疗药物。氯喹是一种传统的治疗疟疾及自身免疫性疾病的药物,因其在治疗COVID-19中显示出初步疗效而备受关注。羟氯喹是氯喹的衍生物,其临床用药的安全性高于氯喹,被世界卫生组织列为治疗COVID-19的4种候选试验药物之一,亦被我国国家卫生健康委员会列入试行第六版和第七版COVID-19治疗方案之中。然而,氯喹和羟氯喹治疗COVID-19的临床疗效还存在很大的争议,还缺乏足够的临床资料支持其作为治疗COVID-19的推荐药物。为更清晰地了解氯喹和羟氯喹,本文简要概括COVID-19的病理变化和治疗方案,重点讨论羟氯喹在临床试验中的药效,深入剖析羟氯喹在临床试验中不同结果的潜在原因及可能机制,并对山莨菪碱和抗病毒药物瑞德西韦的潜在治疗作用以及心理干预治疗进行探讨,对COVID-19治疗方案的合理化具有重要的参考价值。

关键词：新型冠状病毒肺炎羟氯喹氯喹瑞德西韦协同试验山莨菪碱

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阿尔茨海默病:与性别、癌症、饮食有关吗?

中国药理学与毒理学杂志 2020年第1期34卷 1-6页

作者：王浩黄晏张汉霆山东第一医科大学药理学研究所山东泰安271016 军事科学院军事医学研究院毒物药物研究所抗毒药物与毒理学国家重点实验室北京100850 departments of Neuroscience and behavioral medicine&psychiatry the Rockefeller Neurosciences InstituteWest Virginia University Health Sciences CenterMorgantownWV 26506-9303USA

阿尔茨海默病(AD)是一种以进行性记忆和认知障碍为主要临床特征的慢性神经退行性疾病,其发病原因尚不清楚。研究显示,AD与性别有关,其发病率女性明显高于男性,接受雄激素剥夺疗法的前列腺癌患者AD发病率也明显增高。此外,研究发现,AD与... 详细信息

阿尔茨海默病(AD)是一种以进行性记忆和认知障碍为主要临床特征的慢性神经退行性疾病,其发病原因尚不清楚。研究显示,AD与性别有关,其发病率女性明显高于男性,接受雄激素剥夺疗法的前列腺癌患者AD发病率也明显增高。此外,研究发现,AD与癌症呈负相关,癌症患者的记忆力要好于非癌症志愿者,AD患者患肿瘤的概率明显偏低。AD与饮食也呈一定的相关性,糖尿病患者的AD风险成倍增加引发人们对高碳饮食的担忧;地中海饮食、适度饮酒(红葡萄酒)和咖啡以及调节肠道菌群等均有利于预防AD,但仍需进一步研究。总之,AD是一种多因素疾病,其防治要“多管齐下”,运用多种防治策略才可能奏效。

关键词：阿尔茨海默病性别癌症饮食

Join us on an amazing journey towards next-generation treatments for CNS disorders:Launch of Neuroprotection,a new high-quality journal in translational neuroscience

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Neuroprotection 2023年第1期1卷 5-8页

作者： Xunming Ji Piotr Walczak Heleen M.M.van Beusekom Ana I.Casas Andrew Clarkson Tracy Farr Jukka Jolkkonen Yajie Liang Michel M.Modo Paulo H.Rosado-de-Castro Karsten Ruscher Yan-Jiang Wang Haitao Wu Marietta Zille Shen Li Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear medicine Center for Advanced Imaging ResearchUniversity of MarylandBaltimoreMarylandUSA Department of Cardiology Erasmus MC RotterdamUniversity Medical Center RotterdamRotterdamThe Netherlands Department of Neurology Center for Translational Neuro‐and Behavioral Sciences(C‐TNBS)University Clinics EssenEssenGermany Department of Anatomy Brain Health Research Center and Brain Research New ZealandDunedinNew Zealand Medical School Queen's Medical CentreUniversity of NottinghamNottinghamUK A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland McGowan Institute for Regenerative medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Anatomy and Department of Radiology School of MedicineInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratory for Experimental Brain Research University of LundLundSweden Department of Neurology Daping HospitalCenter for Clinical NeuroscienceChongqingChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Neurology and psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of WarwickCoventryUK

Translational medicine in neurodegenerative and neurovascular diseases is approaching a breakthrough *** years have led to dramatic progress in both experimental and clinical *** on a much better and continuously increasing understanding of disease mechanisms,progression and pathophysiology,new therapies with an improved translational potential to protect tissue either against acute or chronic degeneration and even approaches potentially capable of repairing damaged brain tissue are emerging.

关键词： cytoprotection nervous system repair neurodegeneration neuroprotection neurovasculardiseases translational research

Negative feedback control of neuronal activity by microglia

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四川生理科学杂志 2020年第4期42卷 515-515页

作者： Ana Badimon Nash Family Department of Neuroscience Icahn School of Medicine at Mount Sinai New York USA Department of psychiatry Icahn School of Medicine at Mount Sinai New York USA Center for Glial Biology Icahn School of Medicine at Mount Sinai New York USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York USA Division of Biology and Biological Engineering California Institute of Technology Pasadena USA Department of Anatomy and Molecular Cell Biology Nagoya University Graduate School of Medicine Nagoya Japan Division of System Neuroscience Kobe University Graduate School of Medicine Kobe Japan Department of pharmacology University of Minnesota Minneapolis USA Center for Brain Immunology and Glia Department of Neuroscience University of Virginia Charlottesville USA Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School Boston USA Department of pharmacology Vanderbilt University Nashville USA Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital Harvard Medical School Boston USA Department of Genetics and Genomic Sciences Icahn Institute of Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York USA Department of Biochemistry and Structural Biology University of Texas Health Science Center San Antonio USA Department of physiology Feinberg School of Medicine Northwestern University Chicago USA Department of Anesthesia Beth Israel Deaconess Medical Center and Harvard Medical School Boston USA Department of medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston USA Vanderbilt Brain Institute Vanderbilt University Nashville USA Vanderbilt Center for Addiction Research Vanderbilt University Nashville USA Department of Molecular physiology and Biophysics Vanderbilt University Nashville USA Department of psychiatry and behavioral Sciences Vanderbilt University Nashville USA Department of Pathology and Immunology Washington

Microglia,the brain's resident macrophages,help to regulate brain function by removing dying neurons,pruning non-functional synapses,and producing ligands that support neuronal *** we show that microglia are also critical modulators of neuronal activity and associated behavioural responses in *** respond to neuronal activation by suppressing neuronal activity,and ablation of microglia amplifies and synchronizes the activity of neurons,leading to *** of neuronal activation by microglia occurs in a highly region-specific fashion and depends on the ability of microglia to sense and catabolize extracellular ATP,which is released upon neuronal activation by neurons and *** triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP;AMP is then converted into adenosine by CD73,which is expressed on microglia as well as other brain *** sensing of ATP,the ensuing microglia-dependent production of adenosine,and the adenosine-mediated suppression of neuronal responses via the adenosine receptor A1R are essential for the regulation of neuronal activity and animal *** findings suggest that this microglia-driven negative feedback mechanism operates similarly to inhibitory neurons and is essential for protecting the brain from excessive activation in health and disease.

关键词： removing converted finding

Trends in the prevalence and incidence of anxiety and depressive symptoms in Iran:findings from KERCADRS

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Family medicine and Community Health 2021年第3期9卷 33-40页

作者： Hamid Najafipour Mohadeseh Shojaei Shahrokhabadi Ghodsyeh Banivaheb Abdolreza Sabahi Mitra Shadkam Ali Mirzazadeh Department of physiology and pharmacology and Cardiovascular Research Center Kerman University of Medical SciencesKermanIran Department of Epidemiology and Biostatistics Jiroft University of Medical SciencesJiroftIran Department of psychiatry and physiology Research center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran Endocrinology and Metabolism Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Department of Epidemiology and Biostatistics University of California San FranciscoSan FranciscoCaliforniaUSA

Objectives Anxiety and depression(A&D)are common mental disorders with high economical and health *** study aimed to investigate the prevalence and the incidence rate of A&D symptoms and their relationship with sociodemographic and other risk factors and comorbidities in adults living in southeastern *** A population-based cohort study with random cluster household survey sampling *** Second round of Kerman Coronary Artery Disease Risk Factors Study(KERCADRS)(2014-2018)performed in Southeastern,*** We recruited 9997 participants(15-80 years)in the second round of the study,from whom 2820 persons were the people who also participated in the first round of KERCADRS in *** age-standardised A&D prevalence was measured among all participants,and the 5-year A&D incidence rate was measured in those who were free from A&D in the first round in 2009-2012 and were at risk of A&D in the *** relationship between A&D and demographic characteristics,smoking,opium use,obesity and physical activity was assessed by logistic regression *** Overall,the prevalence of anxiety(48.1%to 16.4%,p<0.001)and depression(5.9%to 1.3%,p<0.001)decreased between the two *** highest prevalence of anxiety was among widowed(31.4%),unemployed(21.3%),obese(19.4%),and opium users(17.4%).Young adults,women,those divorced or widowed,and those with obesity and low physical activity had a higher chance of developing *** 5-year incidence rate(person/1000 person-years)was 15.0 for anxiety and 3.9 for *** Despite the overall decrease in the prevalence of A&D symptoms in last 5 years in the area,young adults,women,unemployed,opium users,people with low physical activity and those with obesity had a higher chance of developing anxiety and are in need of more targeted interventions.

关键词： prevalence symptoms finding

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磷酸二酯酶:从伟哥到抗阿尔茨海默病药物

中国药理学与毒理学杂志 2019年第10期 790-790页

作者：王浩周延萌侯雪芹张芳芳赵晓民张汉霆山东第一医科大学山东省医学科学院药理学研究所 departments of Neuroscience and behavioral medicine & psychiatry Blanchette Rockefeler Neurosciences InstituteWest Virginia University Health Sciences Center

磷酸二酯酶（PDE）是一个催化第二信使c AMP和/或c GMP水解的超级酶家族。它包括11个家族（PDE1～PDE11）,对调节细胞内cAMP和cGMP水平发挥关键作用。PDE研究半个世纪以来,其靶位功能越发明显并受到重视。尤其是靶位PDE5的伟哥（Viagra,... 详细信息

磷酸二酯酶（PDE）是一个催化第二信使c AMP和/或c GMP水解的超级酶家族。它包括11个家族（PDE1～PDE11）,对调节细胞内cAMP和cGMP水平发挥关键作用。PDE研究半个世纪以来,其靶位功能越发明显并受到重视。尤其是靶位PDE5的伟哥（Viagra,sildenafil;PDE5抑制剂）研制成功,使PDE研究成为国际药物研发的一大热点。PDE4抑制剂罗氟司特（roflumilast,Daxas;）和apremilast（Otezla;）分别成功用于治疗慢性阻塞性肺疾患（COPD）和银屑病及银屑病性关节炎,再次证明PDE作为药物靶标的重要研究价值和临床应用前景。阿尔茨海默病（AD）是一种慢性进行性神经退行性疾病,以记忆和认知能力的进行性减退为主要临床特征。研究表明,PDE2,PDE4,PDE5,PDE7,PDE9和PDE11都不同程度地参与AD学习记忆和认知的调节,其中尤以PDE4作用明显而广泛。PDE4有4种亚型（PDE4A～D）,由不同基因编码。PDE4D研究相对较多。基因敲除或敲减PDE4D可改善AD小鼠的学习记忆障碍及抑郁等行为;对PDE4D有选择性抑制作用的化合物也有类似作用,提示PDE4D可能是治疗AD的重要靶标。然而,PDE4D也参与中枢性呕吐作用的调节。最新研究表明,通过别构抑制PDE4D可以达到既对抗AD小鼠的记忆下降,又不至于产生呕吐等副反应。这可能是抗AD药物研究的一个重要方向。

关键词：磷酸二酯酶阿尔茨海默病记忆抑郁抑制剂

Nature:研究首次证实帕金森病部分上是一种自身免疫疾病

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现代生物医学进展 2017年第27期17卷 I0002-I0002页

作者： David Sulzer, Francesca Garretti, Ellen Kanter, Julian Agin-Liebes, Elizabeth Phillips, Simon Mallal David Sulzer, Roy N. Alcalay, Lucien Cote, Christopher Liong, Elizabeth Phillips, Simon Mallal David Sulzer Curtis McMurtrey, William H. Hildebrand Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Valina L. Dawson Valina L. Dawson, Ted M. Dawson Ted M. Dawson Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette Elizabeth Phillips, Simon Mallal departments of psychiatry Columbia University Division of Molcular Therapeutics New York State Psychiatric Institute New York New York 10032 USA Department of Neurology Columbia University New York New York 10032 USA Department of pharmacology Columbia University New York New York 10032 USA Department of Microbiology and Immunology University of Oklahoma Oklahoma City Oklahoma 73104 USA Neuroregeneration and Stem Cell Program Institute for Cell Engineering and the Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Adrienne Helis Malvin Medical Research Foundation New Orleans Louisiana 70130-2685 USA Department of physiology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Department of pharmacology & Molecular Sciences Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla California 92037 USA Institute for Immunology and Infectious Diseases Murdoch University Perth Western Australia 6150 Australia Vanderbilt University School of medicine Nashville Tennessee 37235 USA

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免... 详细信息

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免疫学研究所等研究机构的研究人员发现首个直接的证据证实自身免疫反应在帕金森病中发挥着作用。

关键词：自身免疫疾病帕金森病神经退行性疾病多巴胺能神经元哥伦比亚大学免疫反应研究人员研究机构