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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction

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Neural Regeneration Research 2025年第9期20卷 2464-2479页

作者： Said Hashemolhosseini Lea Gessler Institute of Biochemistry Medical FacultyFriedrich-Alexander-University of Erlangen-NürnbergErlangenGermany

Skeletal muscles are essential for locomotion,posture,and metabolic *** understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways that underlie skeletal muscle *** process of muscle contra ction,orchestrated by a complex interplay of molecular events,is at the core of skeletal muscle *** contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular *** muscle fibers,calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate *** of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction *** development and growth of skeletal muscle are regulated by a network of molecular pathways collectively known as *** regulators coordinate the diffe rentiation of myoblasts into mature muscle *** pathways regulate muscle protein synthesis and hypertrophy in response to mechanical stimuli and nutrient *** ral muscle-related diseases,including congenital myasthenic disorders,sarcopenia,muscular dystrophies,and metabolic myopathies,are underpinned by dys regulated molecular pathways in skeletal *** interventions aimed at preserving muscle mass and function,enhancing regeneration,and improving metabolic health hold promise by targeting specific molecular *** molecular signaling pathways in skeletal muscle include the canonical Wnt signaling pathway,a critical regulator of myogenesis,muscle regeneration,and metabolic function,and the Hippo signaling *** recent years,more details have been uncovered about the role of these two pathways during myogenesis and in developing and adult skeletal muscle fibers,and at the neuromuscular *** fact,research in the last few years now suggests that these two signaling pathways are interconnected and

关键词： canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway myogenesis myotube neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1)

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： Tim Aberle Michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Reviews and prospects in satellite range scheduling problem

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Autonomous Intelligent Systems 2023年第1期3卷 19-33页

作者： Shuwei Li Qingyun Yu Hao Ding College of Electronics and Information Engineering Tongji UniversityShanghai201804China ORIGITECH GmbH Langer Anger 7-9Heidelberg69115Germany

With the increasing number of space satellites,the demand for satellite communication(including maneuvering,command uploading and data downloading)has also grown ***,the actual communication resources of ground station are relatively limited,which leads to an oversubscribed *** to make use of limited ground station resources to complete satellite communication requests more fully and efficiently in the strict visible time is the focus of satellite range scheduling *** paper reviews and looks forward to the research on Satellite Range Scheduling Problem(SRSP).Firstly,SRSP is defined as the scheduling problem of establishing communication between satellites and ground stations,and the classification and development of SRSP are ***,this paper analyzes three common problem description models,and establishes a mathematical model based on the analysis of optimization objectives and ***,this paper classifies and summarizes the common solving methods of SRSP,and analyzes their characteristics and application ***,combined with the work in this paper,the future research direction of SRSP is envisioned.

关键词： Satellite range scheduling Communication resource scheduling Scheduling algorithm Research overview

New and Unusual Cat's Eyes and Asteriated Gems

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维普期刊数据库

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宝石和宝石学杂志（中英文） 2022年第1期24卷 1-11页

作者： Martin P.Steinbach Lore Kiefert Jeanette Fiedler STEINBACH-Gems with a Star Idar-Oberstein 55743Germany Dr.Lore Kiefert Gemmology Consulting Heidelberg 69115Germany DDI-Foundation German Diamond Institute Pforzheim 75172Germany

The article describes 6 types of gemstones which show phenomena such as chatoyancy and *** gemstones have not been described before,either because they come from new sources,or because the phenomenon has not been seen before in the type of gemstone *** from the new sources are star garnet from the Karelia Province in Russia,and star garnet from the Jiangsu Province in *** usually does not show a cat’s eye effect,but the two described samples display a weak cat’s *** unusual white quartz from Brazil with a sharp cat’s eye is described,as well as a star sapphire with two differently coloured stars on each side of the cabochon,as well as a trapiche-type *** stones were tested with gemmological,microscopic,and advanced techniques and the results are presented.

关键词： cat’s eye star asterism chatoyancy quartz grandidierite sapphire garnet

新一代人工肩关节假体置换治疗盂肱关节骨性关节炎

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中华医学杂志 2006年第39期86卷 2741-2748页

作者：唐康来李起鸿 Peter Habermeyer ATOS clinic Bismarckstrasse 9-15D-69115 HeidelbergGermany

目的系统评价新一代的肩关节假体-UNIVERS 3-D 假体置换治疗盂肱关节骨性关节炎的临床效果。方法采用 UNIVERS 3-D 肩关节假体置换治疗74例盂肱关节骨性关节炎,平均随访31.9个月(12～74个月),临床随访包括:功能评估和 X 线摄片。功能评... 详细信息

目的系统评价新一代的肩关节假体-UNIVERS 3-D 假体置换治疗盂肱关节骨性关节炎的临床效果。方法采用 UNIVERS 3-D 肩关节假体置换治疗74例盂肱关节骨性关节炎,平均随访31.9个月(12～74个月),临床随访包括:功能评估和 X 线摄片。功能评估采用 Constant 评分和Constant 修正评分标准;X 线片包括:前后位、轴位和“Y”型位。结果 UNIVERS3-D 假体置换治疗OA 术后 Constant 评分为68.40±16.91,较术前高2倍。去除年龄和性别差异,功能修正评分术前45.29％±19.87％,术后达到92.27％±22.53％。术前93.47％的肱骨头周围有骨赘形成;肩峰下间距平均为10.91 mm±3.03 mm,;盂肱关节间距平均为1.83 mm±1.64 mm。肱骨头的高度和宽度分别为5.71 mm±4.32 mm 和53.34 mm±4.82 mm;36.96％有肱骨头坏死征象;8.69％有肱骨头内囊性变征象;39.13％肩胛盂侧周围有骨赘形成。术后盂肱关节间距显著增宽;术前盂肱关节半脱位得到了有效纠正,未发现盂肱关节间撞击征。术后肩峰下间距与术前相比显著性增宽。手术重建了肱骨头的高度和宽度。假体头-颈-干斜倾角126～142°呈连续变化。术后肱骨假体头-颈-干角没有发现有明显的改变,也没有头-颈-干假体的分离和脱位。除1例肩胛盂呈上斜倾外,其余均为下斜倾,术后较术前的角度要小;而术前、术后前后扭转角没有明显差异。肱骨假体无松动后下沉和倾斜,盂假体无松动后位移和倾斜。肱骨干假体周围 X 线透亮带发生率为5.41％,评分均小于1。透亮带发生最多的部位为 d,c,e 三个区。盂假体周围未发现任何 X 线透亮带。并发症发生率为12.2％。结论UNIVERS 3-D 肩关节假体置换治疗盂肱关节骨性关节炎重建了盂肱关节的解剖关系,术后较术前功能有明显提高,透亮带发生率及并发症率低,临床效果优秀。

关键词：肩关节骨关节炎人工关节

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Assessment of the spatial extent of permafrost in the Upper Indus Basin(UIB)

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Journal of Mountain Science 2023年第6期20卷 1508-1525页

作者： Wasim HASSAN G.JEELANI A.P.DIMRI Marcus NüSSER Department of Earth Sciences University of KashmirSrinagar 190006India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography South Asia Institute(SAI)Heidelberg UniversityHeidelberg 69115Germany Heidelberg Centre for the Environment(HCE) Heidelberg UniversityHeidelberg 69120Germany

Climate change differentially influences the frozen ground,a major dynamic component of the cryosphere,on a local and regional *** the warming climate with pronounced effects reported at higher altitudes,the characterization of the frozen ground is very important in the Upper Indus Basin(UIB),an important and critical region with respect to climate and hydro-glaciological *** this study,the efficiency and reliability of the surface frost number model are assessed in delineating the spatial extent of different classes of frozen ground in the *** daily MODIS land surface temperature(LST)with ground surface temperature(GST)and surface geomorphological expressions as ground validation datasets are used jointly in efficiently determining the extent of different classes of frozen ground(continuous and discontinuous permafrost and seasonal frost).The LST and GST resonate with each other in the annual cycle of temperature variation,however,with mean annual LST exhibiting an offset(cold bias)of 5 to 7℃relative to mean *** study shows that the highest permafrost extent is observed in areas where the lowest thinning rates of glacier ice are reported and vice *** surface frost number model categorizes an area of 38%±3%and 15%±3%in the UIB as permafrost and seasonal frost,*** on the altitude model,the lower limit of alpine permafrost is approximated at a mean altitude of 4919±590 m *** the *** present study acts as preliminary work in the data sparse and inaccessible regions of the UIB in characterizing the frozen and unfrozen ground and may act as a promising input data source in glaciohydro-meteorological models for the Himalaya and *** addition,the study also underlines the consideration of this derelict cryospheric climatic variable in defining and accounting for the sustainable development of socio-economic systems through its intricate ramification on agricultural activity,landscape stability and infrastruc

关键词： Upper Indus Basin Land surface temperature Ground surface temperature Surface frost number Permafrost Seasonal frost